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Conserved domains on  [gi|226958485|ref|NP_666043|]
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zinc finger CCCH domain-containing protein 7A [Mus musculus]

Protein Classification

3a0801s09 and zf-C2H2_jaz domain-containing protein( domain architecture ID 13518792)

3a0801s09 and zf-C2H2_jaz domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-169 2.74e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 48.06  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485    6 EERRKRQHSIKEGLQF-------------IQSPLSYPGTQEQYAVYLHALVRN-----LFNEGNDIYRECDWRGSLIQYS 67
Cdd:TIGR00990  72 KERRKRKQAEKETEGKteekkstapknapVEPADELPEIDESSVANLSEEERKkyaakLKEKGNKAYRNKDFNKAIKLYS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485   68 EALsianyakseeILIPTEIIEKlriNRIACYSNMGLRDEVLEDCNAVLSVNASNCKALYRKAKALSDLGHYREA-YDAV 146
Cdd:TIGR00990 152 KAI----------ECKPDPVYYS---NRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLT 218

                         170       180
                  ....*....|....*....|...
gi 226958485  147 AKCSLAVPQDEHVIKLTQELAQK 169
Cdd:TIGR00990 219 ASCIIDGFRNEQSAQAVERLLKK 241
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 856-881 1.61e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.76  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958485  856 FHCWMCGKNCNSEKQWQDHISSEKHK 881
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKHK 27
 
Name Accession Description Interval E-value
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-169 2.74e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 48.06  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485    6 EERRKRQHSIKEGLQF-------------IQSPLSYPGTQEQYAVYLHALVRN-----LFNEGNDIYRECDWRGSLIQYS 67
Cdd:TIGR00990  72 KERRKRKQAEKETEGKteekkstapknapVEPADELPEIDESSVANLSEEERKkyaakLKEKGNKAYRNKDFNKAIKLYS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485   68 EALsianyakseeILIPTEIIEKlriNRIACYSNMGLRDEVLEDCNAVLSVNASNCKALYRKAKALSDLGHYREA-YDAV 146
Cdd:TIGR00990 152 KAI----------ECKPDPVYYS---NRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLT 218

                         170       180
                  ....*....|....*....|...
gi 226958485  147 AKCSLAVPQDEHVIKLTQELAQK 169
Cdd:TIGR00990 219 ASCIIDGFRNEQSAQAVERLLKK 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 32-210 1.27e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485  32 QEQYAVYLHALVRN------LFNEGNDIYRECDWRGSLIQYSEALSIA-NYAKseeilipteiiekLRINRIACYSNMGL 104
Cdd:COG3914   95 EEALALYRRALALNpdnaeaLFNLGNLLLALGRLEEALAALRRALALNpDFAE-------------AYLNLGEALRRLGR 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485 105 RDEVLEDCNAVLSVNASNCKALYRKAKALSDLGHYREAYDAVAKCSLAVPQDEHVI-KLTQELAQKLGFKIRKAYVRAEH 183
Cdd:COG3914  162 LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHsNLLFALRQACDWEVYDRFEELLA 241

                        170       180
                 ....*....|....*....|....*..
gi 226958485 184 LLKAVPGDGAPKAVNYSVEDIEPDLLA 210
Cdd:COG3914  242 ALARGPSELSPFALLYLPDDDPAELLA 268
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 856-881 1.61e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.76  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958485  856 FHCWMCGKNCNSEKQWQDHISSEKHK 881
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 855-884 3.02e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.08  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 226958485   855 DFHCWMCGKNCNSEKQWQDHISSEKHKEKV 884
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
 
Name Accession Description Interval E-value
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 6-169 2.74e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 48.06  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485    6 EERRKRQHSIKEGLQF-------------IQSPLSYPGTQEQYAVYLHALVRN-----LFNEGNDIYRECDWRGSLIQYS 67
Cdd:TIGR00990  72 KERRKRKQAEKETEGKteekkstapknapVEPADELPEIDESSVANLSEEERKkyaakLKEKGNKAYRNKDFNKAIKLYS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485   68 EALsianyakseeILIPTEIIEKlriNRIACYSNMGLRDEVLEDCNAVLSVNASNCKALYRKAKALSDLGHYREA-YDAV 146
Cdd:TIGR00990 152 KAI----------ECKPDPVYYS---NRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlLDLT 218

                         170       180
                  ....*....|....*....|...
gi 226958485  147 AKCSLAVPQDEHVIKLTQELAQK 169
Cdd:TIGR00990 219 ASCIIDGFRNEQSAQAVERLLKK 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 32-210 1.27e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485  32 QEQYAVYLHALVRN------LFNEGNDIYRECDWRGSLIQYSEALSIA-NYAKseeilipteiiekLRINRIACYSNMGL 104
Cdd:COG3914   95 EEALALYRRALALNpdnaeaLFNLGNLLLALGRLEEALAALRRALALNpDFAE-------------AYLNLGEALRRLGR 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485 105 RDEVLEDCNAVLSVNASNCKALYRKAKALSDLGHYREAYDAVAKCSLAVPQDEHVI-KLTQELAQKLGFKIRKAYVRAEH 183
Cdd:COG3914  162 LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHsNLLFALRQACDWEVYDRFEELLA 241

                        170       180
                 ....*....|....*....|....*..
gi 226958485 184 LLKAVPGDGAPKAVNYSVEDIEPDLLA 210
Cdd:COG3914  242 ALARGPSELSPFALLYLPDDDPAELLA 268
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
46-216 2.37e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485  46 LFNEGNDIYRECDWRGSLIQYSEALSIA-NYAKSeeilipteiieklRINRIACYSNMGLRDEVLEDCNAVLSVNASNCK 124
Cdd:COG0457   79 LNNLGLALQALGRYEEALEDYDKALELDpDDAEA-------------LYNLGLALLELGRYDEAIEAYERALELDPDDAD 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958485 125 ALYRKAKALSDLGHYREAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVRAEHLLKAVPGDGAPKAVNYSVEDI 204
Cdd:COG0457  146 ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLL 225

                        170
                 ....*....|..
gi 226958485 205 EPDLLAPRQEAL 216
Cdd:COG0457  226 ALALLLALRLAA 237
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
65-142 6.76e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 6.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226958485  65 QYSEAlsIANYAKSEEIlIPTEIieKLRINRIACYSNMGLRDEVLEDCNAVLSVNASNCKALYRKAKALSDLGHYREA 142
Cdd:COG0457   23 RYEEA--IEDYEKALEL-DPDDA--EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 856-881 1.61e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.76  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 226958485  856 FHCWMCGKNCNSEKQWQDHISSEKHK 881
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 855-884 3.02e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.08  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 226958485   855 DFHCWMCGKNCNSEKQWQDHISSEKHKEKV 884
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 856-880 4.28e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.55  E-value: 4.28e-03
                          10        20
                  ....*....|....*....|....*
gi 226958485  856 FHCWMCGKNCNSEKQWQDHISSEKH 880
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
93-142 8.05e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 8.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 226958485  93 INRIACYSNMGLRDEVLEDCNAVLSVNASNCKALYRKAKALSDLGHYREA 142
Cdd:COG0457   12 NNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEA 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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