N-terminal HEAT repeat domain of inner kinetochore subunit CTF3 and similar proteins; CTF3 ...
8-516
0e+00
N-terminal HEAT repeat domain of inner kinetochore subunit CTF3 and similar proteins; CTF3 (also called CENP-I homolog, chromosome loss protein 3, chromosome transmission fidelity protein 3, or constitutive centromere-associated network protein CTF3) is a component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. It is required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation. The kinetochore is a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. CTF3 is a component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. This model corresponds to the N-terminal HEAT repeat domain of CTF3, which interacts with another four kinetochore subunits, WIP1, CNN1, MCM16 and MCM22.
The actual alignment was detected with superfamily member pfam07778:
Pssm-ID: 447084 Cd Length: 515 Bit Score: 883.84 E-value: 0e+00
Mis6; Mis6 is an essential centromere connector protein acting during G1-S phase of the cell ...
8-516
0e+00
Mis6; Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.
Pssm-ID: 429654 Cd Length: 515 Bit Score: 883.84 E-value: 0e+00
N-terminal HEAT repeat domain of inner kinetochore subunit CTF3 and similar proteins; CTF3 ...
76-259
3.22e-33
N-terminal HEAT repeat domain of inner kinetochore subunit CTF3 and similar proteins; CTF3 (also called CENP-I homolog, chromosome loss protein 3, chromosome transmission fidelity protein 3, or constitutive centromere-associated network protein CTF3) is a component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. It is required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation. The kinetochore is a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. CTF3 is a component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. This model corresponds to the N-terminal HEAT repeat domain of CTF3, which interacts with another four kinetochore subunits, WIP1, CNN1, MCM16 and MCM22.
Pssm-ID: 439352 Cd Length: 219 Bit Score: 127.31 E-value: 3.22e-33
Mis6; Mis6 is an essential centromere connector protein acting during G1-S phase of the cell ...
8-516
0e+00
Mis6; Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.
Pssm-ID: 429654 Cd Length: 515 Bit Score: 883.84 E-value: 0e+00
N-terminal HEAT repeat domain of inner kinetochore subunit CTF3 and similar proteins; CTF3 ...
76-259
3.22e-33
N-terminal HEAT repeat domain of inner kinetochore subunit CTF3 and similar proteins; CTF3 (also called CENP-I homolog, chromosome loss protein 3, chromosome transmission fidelity protein 3, or constitutive centromere-associated network protein CTF3) is a component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. It is required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation. The kinetochore is a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. CTF3 is a component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. This model corresponds to the N-terminal HEAT repeat domain of CTF3, which interacts with another four kinetochore subunits, WIP1, CNN1, MCM16 and MCM22.
Pssm-ID: 439352 Cd Length: 219 Bit Score: 127.31 E-value: 3.22e-33
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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