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Conserved domains on  [gi|22035634|ref|NP_665707|]
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microsomal glutathione S-transferase 1 isoform a [Homo sapiens]

Protein Classification

MAPEG family protein( domain architecture ID 10471516)

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family protein is a membrane associated protein; similar to mammalian prostaglandin E synthase, leukotriene C4 synthase, arachidonate 5-lipoxygenase-activating protein, microsomal glutathione S-transferases, and mitochondrial glutathione S-transferase 3

CATH:  1.20.120.550
Gene Ontology:  GO:0016020
PubMed:  10091672|10673221

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 16-149 8.19e-27

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


:

Pssm-ID: 460074  Cd Length: 127  Bit Score: 97.37  E-value: 8.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22035634    16 FASYATIILSKMMLMSTATAFYRLTRKVFAnpedcvaFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSL 95
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVGD-------GGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGL 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 22035634    96 SGPDPSTAILHFRLFVGARIYHTIAYLTPLPqPNRALSFFVGYGVTLSMAYRLL 149
Cdd:pfam01124  74 TGGSPGLAALLAWAYVVARVLHALGYATGNP-PLRSLGFLLGFLALLALAVLAL 126
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 16-149 8.19e-27

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 97.37  E-value: 8.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22035634    16 FASYATIILSKMMLMSTATAFYRLTRKVFAnpedcvaFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSL 95
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVGD-------GGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGL 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 22035634    96 SGPDPSTAILHFRLFVGARIYHTIAYLTPLPqPNRALSFFVGYGVTLSMAYRLL 149
Cdd:pfam01124  74 TGGSPGLAALLAWAYVVARVLHALGYATGNP-PLRSLGFLLGFLALLALAVLAL 126
COG3686 COG3686
Uncharacterized conserved protein, MAPEG superfamily [Function unknown];
64-149 3.78e-10

Uncharacterized conserved protein, MAPEG superfamily [Function unknown];


Pssm-ID: 442902  Cd Length: 130  Bit Score: 54.44  E-value: 3.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22035634  64 RTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPqPNRALSFFVGYGVTLS 143
Cdd:COG3686  45 PLSGWAARANRAQQNAFEALPLFAAAVLVAHLTGASSATTALLAIAFLAARVLYVPAYLAGLP-PLRSLVWAVGFLCTVA 123


                ....*.
gi 22035634 144 MAYRLL 149
Cdd:COG3686 124 LFVAAL 129
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 16-149 8.19e-27

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 97.37  E-value: 8.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22035634    16 FASYATIILSKMMLMSTATAFYRLTRKVFAnpedcvaFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSL 95
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVGD-------GGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGL 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 22035634    96 SGPDPSTAILHFRLFVGARIYHTIAYLTPLPqPNRALSFFVGYGVTLSMAYRLL 149
Cdd:pfam01124  74 TGGSPGLAALLAWAYVVARVLHALGYATGNP-PLRSLGFLLGFLALLALAVLAL 126
COG3686 COG3686
Uncharacterized conserved protein, MAPEG superfamily [Function unknown];
64-149 3.78e-10

Uncharacterized conserved protein, MAPEG superfamily [Function unknown];


Pssm-ID: 442902  Cd Length: 130  Bit Score: 54.44  E-value: 3.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22035634  64 RTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPqPNRALSFFVGYGVTLS 143
Cdd:COG3686  45 PLSGWAARANRAQQNAFEALPLFAAAVLVAHLTGASSATTALLAIAFLAARVLYVPAYLAGLP-PLRSLVWAVGFLCTVA 123


                ....*.
gi 22035634 144 MAYRLL 149
Cdd:COG3686 124 LFVAAL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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