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Conserved domains on  [gi|260436860|ref|NP_663782|]
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AP-1 complex subunit beta-1 isoform b [Homo sapiens]

Protein Classification

AP complex subunit beta( domain architecture ID 12024727)

AP (adaptor protein) complex subunit beta is a component of AP complexes that are involved in the formation of clathrin-coated pits and vesicles

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
11-534 0e+00

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 550.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   11 KKGEIFELKAELNS--DKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAV 88
Cdd:pfam01602   2 EKRIQQELARILNSfrDDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   89 NTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDqgFLDTLKDL 168
Cdd:pfam01602  82 NSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRD--FVPELKEL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  169 ISDSNPMVVANAVAALSEIAesHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRL 248
Cdd:pfam01602 160 LSDKDPGVQSAAVALLYEIC--KNDRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLPKELLEDLLNLL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  249 SHANSAVVLSAVKVLMKFMEMLSkdldyygtLLKKLAPPLVTLLSAEPE-LQYVALRNINLIVQKRP-EILKHEMKVFFV 326
Cdd:pfam01602 238 QNSNNAVLYETANTIVHLAPAPE--------LIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEPkAVQHLDLIIFCL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  406 VVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDN---ADELLESFLEGFHDESTQVQL 482
Cdd:pfam01602 390 VVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNgssPPDLLRSILEVFVLESAKVRA 469
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 260436860  483 QLLTAIVKLFLKKPTET--QELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP 534
Cdd:pfam01602 470 AALTALAKLGLTSPEETtqNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLAD 523
B2-adapt-app_C smart01020
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
828-938 3.21e-50

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


:

Pssm-ID: 198088  Cd Length: 111  Bit Score: 172.11  E-value: 3.21e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   828 FVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRI 907
Cdd:smart01020   1 FVEDGQMEREVFLKTWKSLPESNEQQFQLQPNNLNPDTIIKKLQSNNIFTIAKRNVGNQDKLYLSAKLTNGIWILIELTI 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 260436860   908 QPGNPSCTLSLKCRAPEVSQHVYQAYETILK 938
Cdd:smart01020  81 NPGTPNVTLSVKCDSPEVIQLFTQVFEKILS 111
Alpha_adaptinC2 smart00809
Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link ...
719-819 1.20e-20

Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Gamma-adaptin is a subunit of the golgi adaptor. Alpha adaptin is a heterotetramer that regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This Ig-fold domain is found in alpha, beta and gamma adaptins and consists of a beta-sandwich containing 7 strands in 2 beta-sheets in a greek-key topology.. The adaptor appendage contains an additional N-terminal strand.


:

Pssm-ID: 197886 [Multi-domain]  Cd Length: 104  Bit Score: 87.68  E-value: 1.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   719 AMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVhAPLSPNQTVEISLPLSTVGS--- 795
Cdd:smart00809   1 AYEKNGLQIGFKFERRPGLIRITLTFTNKSPSPITNFSFQAAVPKSLKLQLQPPSS-PTLPPGGQITQVLKVENPGKfpl 79
                           90       100
                   ....*....|....*....|....*
gi 260436860   796 VMKMEPLNNLQV-AVKNNIDVFYFS 819
Cdd:smart00809  80 RLRLRLSYLLGGsAVTEQGDVLKFP 104
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
11-534 0e+00

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 550.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   11 KKGEIFELKAELNS--DKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAV 88
Cdd:pfam01602   2 EKRIQQELARILNSfrDDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   89 NTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDqgFLDTLKDL 168
Cdd:pfam01602  82 NSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRD--FVPELKEL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  169 ISDSNPMVVANAVAALSEIAesHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRL 248
Cdd:pfam01602 160 LSDKDPGVQSAAVALLYEIC--KNDRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLPKELLEDLLNLL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  249 SHANSAVVLSAVKVLMKFMEMLSkdldyygtLLKKLAPPLVTLLSAEPE-LQYVALRNINLIVQKRP-EILKHEMKVFFV 326
Cdd:pfam01602 238 QNSNNAVLYETANTIVHLAPAPE--------LIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEPkAVQHLDLIIFCL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  406 VVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDN---ADELLESFLEGFHDESTQVQL 482
Cdd:pfam01602 390 VVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNgssPPDLLRSILEVFVLESAKVRA 469
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 260436860  483 QLLTAIVKLFLKKPTET--QELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP 534
Cdd:pfam01602 470 AALTALAKLGLTSPEETtqNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLAD 523
PTZ00429 PTZ00429
beta-adaptin; Provisional
2-706 4.43e-157

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 480.20  E-value: 4.43e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   2 TDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81
Cdd:PTZ00429  21 TGSKYFAQTRRGEGAELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQP 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  82 DMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGF 161
Cdd:PTZ00429 101 EKALLAVNTFLQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHDDMQLFYQQDF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 162 LDTLKDLISDSNPMVVANAVAALSEIAESHPSSnlLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSIC 241
Cdd:PTZ00429 181 KKDLVELLNDNNPVVASNAAAIVCEVNDYGSEK--IESSNEWVNRLVYHLPECNEWGQLYILELLAAQRPSDKESAETLL 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 242 ERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDL-DYYGTllkKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHE 320
Cdd:PTZ00429 259 TRVLPRMSHQNPAVVMGAIKVVANLASRCSQELiERCTV---RVNTALLTLSRRDAETQYIVCKNIHALLVIFPNLLRTN 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 321 MKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
Cdd:PTZ00429 336 LDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASLAIKVDSVAPDCANLLLQIVD 415
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 401 TKVNYVVQeAIVVIKDIFRKYPNKYesVIATLCEN--LDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDEST 478
Cdd:PTZ00429 416 RRPELLPQ-VVTAAKDIVRKYPELL--MLDTLVTDygADEVVEEEAKVSLLWMLGEYCDFIENGKDIIQRFIDTIMEHEQ 492
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 479 QVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAA--KEVVLAEKPLISEETDLIE 556
Cdd:PTZ00429 493 RVQLAILSAAVKMFLRDPQGMEPQLNRVLETVTTHSDDPDVRDRAFAYWRLLSKGITVAqmKKVVHGQMVPVNVDSTFSD 572
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 557 PTLLDELICYIGTLASVYHKPPSAFveggrgvvhksLPP-----RTASSESAESPETAPTGAPP--GEQ-----PDVIPA 624
Cdd:PTZ00429 573 AMTMADLKKSLNTAAIVFARPYQSF-----------LPPygladVELDEEDTEDDDAVELPSTPsmGTQdgspaPSAAPA 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 625 QGDLLGDLLNLDLGP--PVSGPPLATSSVQMGavDLLgGGLDSLIGGTN--FVAPPTAAVPANLGAPIgSGLSDLFDLTS 700
Cdd:PTZ00429 642 GYDIFEFAGDGTGAPhpVASGSNGAQHADPLG--DLF-SGLPSTVGASSpaFQAASGSQAPASPPTAA-SAIEDLFANGM 717

                 ....*.
gi 260436860 701 GVGTLS 706
Cdd:PTZ00429 718 GSGSQT 723
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
38-601 5.62e-146

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 451.49  E-value: 5.62e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  38 IASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDK 117
Cdd:COG5096   44 IAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTLSLLRVKE 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 118 ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAEShPSSNLL 197
Cdd:COG5096  124 LLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLIDILKELVADSDPIVIANALASLAEIDPE-LAHGYS 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 198 DLNPQSINKLLTALNEC-TEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDldy 276
Cdd:COG5096  203 LEVILRIPQLDLLSLSVsTEWLLLIILEVLTERVPTTPDSAEDFEERLSPPLQHNNAEVLLIAVKVILRLLVFLPSN--- 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 277 ygTLLKKLAPPLVTLLS-AEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVL 355
Cdd:COG5096  280 --NLFLISSPPLVTLLAkPESLIQYVLRRNIQIDLEVCSKLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLSQIL 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 356 AELKEYATE--VDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL---IQTKVNYVVQEA-----IVVIK---DIFRKYP 422
Cdd:COG5096  358 LELIYYIAEnhIDAEMVSEAIKALGDLASKAESSVNDCISELLELlegVWIRGSYIVQEVrivdcISVIRisvLVLRILP 437
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 423 NKYESVIAT-LCENLDSLD----EPEARAAM-----IWIVGEYAERI-DNADELLESFLEGFHDESTQVQLQLLTAIVKL 491
Cdd:COG5096  438 NEYPKILLRgLYALEETLElqsrEPRAKSVTdkylgAWLLGEFSDIIpRLEPELLRIAISNFVDETLEVQYTILMSSVKL 517
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 492 FLKKPTETQ----ELVQQVLSLATQDSDNPDLRDRGYIYWRLLST-DPVAAKEVVLAEKPLIS-----EETDLIE--PTL 559
Cdd:COG5096  518 IANSIRKAKqcnsELDQDVLRRCFDYVLVPDLRDRARMYSRLLSTpLPEFSDPILCEAKKSNSqfeiiLSALLTNqtPEL 597
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 260436860 560 LDELICYI--GTLASVYHKPPSAFVEGGR--------------GVVHKSLPPRTASSE 601
Cdd:COG5096  598 LENLRLDFtlGTLSTIPLKPIFNLRKGAVvlqqvtvkkpnaelGFITGNINPSGAANE 655
B2-adapt-app_C smart01020
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
828-938 3.21e-50

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 198088  Cd Length: 111  Bit Score: 172.11  E-value: 3.21e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   828 FVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRI 907
Cdd:smart01020   1 FVEDGQMEREVFLKTWKSLPESNEQQFQLQPNNLNPDTIIKKLQSNNIFTIAKRNVGNQDKLYLSAKLTNGIWILIELTI 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 260436860   908 QPGNPSCTLSLKCRAPEVSQHVYQAYETILK 938
Cdd:smart01020  81 NPGTPNVTLSVKCDSPEVIQLFTQVFEKILS 111
B2-adapt-app_C pfam09066
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
829-937 4.35e-40

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerization. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 462667  Cd Length: 111  Bit Score: 143.56  E-value: 4.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  829 VEDGKMDRQMFLATWKDIPNENEAQFQIRD-CPLNAEAASSKLQSSNIFTVAKRNVEG-QDMLYQSLKLTNGIWVLAELR 906
Cdd:pfam09066   1 VEDGKLDREVFLETWKSLPDSNELSLTLQNlASVSPDAIEQKLQANNIFTIAKRGVEGpQEKLYFSAKLTNGILFLVELT 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 260436860  907 IQPGNPSCTLSLKCRAPEVSQHVYQAYETIL 937
Cdd:pfam09066  81 INTPGSNVKLSVKSEDPEVAPLFLQLFESIL 111
Alpha_adaptinC2 smart00809
Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link ...
719-819 1.20e-20

Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Gamma-adaptin is a subunit of the golgi adaptor. Alpha adaptin is a heterotetramer that regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This Ig-fold domain is found in alpha, beta and gamma adaptins and consists of a beta-sandwich containing 7 strands in 2 beta-sheets in a greek-key topology.. The adaptor appendage contains an additional N-terminal strand.


Pssm-ID: 197886 [Multi-domain]  Cd Length: 104  Bit Score: 87.68  E-value: 1.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   719 AMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVhAPLSPNQTVEISLPLSTVGS--- 795
Cdd:smart00809   1 AYEKNGLQIGFKFERRPGLIRITLTFTNKSPSPITNFSFQAAVPKSLKLQLQPPSS-PTLPPGGQITQVLKVENPGKfpl 79
                           90       100
                   ....*....|....*....|....*
gi 260436860   796 VMKMEPLNNLQV-AVKNNIDVFYFS 819
Cdd:smart00809  80 RLRLRLSYLLGGsAVTEQGDVLKFP 104
Alpha_adaptinC2 pfam02883
Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud ...
713-819 1.17e-12

Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins.


Pssm-ID: 460735  Cd Length: 111  Bit Score: 65.04  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  713 KAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFG---LAPAAPLQVHAplSPNQTVEISLP 789
Cdd:pfam02883   1 PPVVLYESDGLQIGFSFERSRRPGQIRITLTFTNKSSSPISNFSFQAAVPKSLklqLQPPSSNVLPP--NPGGQITQVLL 78
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 260436860  790 LSTvgsVMKMEPLNNLQV------AVKNNIDVFYFS 819
Cdd:pfam02883  79 IEN---PGKKPLRMRLKIsylnggAVQEQGDVLKFP 111
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
11-534 0e+00

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 550.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   11 KKGEIFELKAELNS--DKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAV 88
Cdd:pfam01602   2 EKRIQQELARILNSfrDDPRKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   89 NTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDqgFLDTLKDL 168
Cdd:pfam01602  82 NSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRD--FVPELKEL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  169 ISDSNPMVVANAVAALSEIAesHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRL 248
Cdd:pfam01602 160 LSDKDPGVQSAAVALLYEIC--KNDRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLPKELLEDLLNLL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  249 SHANSAVVLSAVKVLMKFMEMLSkdldyygtLLKKLAPPLVTLLSAEPE-LQYVALRNINLIVQKRP-EILKHEMKVFFV 326
Cdd:pfam01602 238 QNSNNAVLYETANTIVHLAPAPE--------LIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEPkAVQHLDLIIFCL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
Cdd:pfam01602 310 KTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  406 VVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDN---ADELLESFLEGFHDESTQVQL 482
Cdd:pfam01602 390 VVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPNgssPPDLLRSILEVFVLESAKVRA 469
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 260436860  483 QLLTAIVKLFLKKPTET--QELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDP 534
Cdd:pfam01602 470 AALTALAKLGLTSPEETtqNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLAD 523
PTZ00429 PTZ00429
beta-adaptin; Provisional
2-706 4.43e-157

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 480.20  E-value: 4.43e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   2 TDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQP 81
Cdd:PTZ00429  21 TGSKYFAQTRRGEGAELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQP 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  82 DMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGF 161
Cdd:PTZ00429 101 EKALLAVNTFLQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHDDMQLFYQQDF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 162 LDTLKDLISDSNPMVVANAVAALSEIAESHPSSnlLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSIC 241
Cdd:PTZ00429 181 KKDLVELLNDNNPVVASNAAAIVCEVNDYGSEK--IESSNEWVNRLVYHLPECNEWGQLYILELLAAQRPSDKESAETLL 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 242 ERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDL-DYYGTllkKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHE 320
Cdd:PTZ00429 259 TRVLPRMSHQNPAVVMGAIKVVANLASRCSQELiERCTV---RVNTALLTLSRRDAETQYIVCKNIHALLVIFPNLLRTN 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 321 MKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
Cdd:PTZ00429 336 LDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASLAIKVDSVAPDCANLLLQIVD 415
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 401 TKVNYVVQeAIVVIKDIFRKYPNKYesVIATLCEN--LDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDEST 478
Cdd:PTZ00429 416 RRPELLPQ-VVTAAKDIVRKYPELL--MLDTLVTDygADEVVEEEAKVSLLWMLGEYCDFIENGKDIIQRFIDTIMEHEQ 492
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 479 QVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAA--KEVVLAEKPLISEETDLIE 556
Cdd:PTZ00429 493 RVQLAILSAAVKMFLRDPQGMEPQLNRVLETVTTHSDDPDVRDRAFAYWRLLSKGITVAqmKKVVHGQMVPVNVDSTFSD 572
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 557 PTLLDELICYIGTLASVYHKPPSAFveggrgvvhksLPP-----RTASSESAESPETAPTGAPP--GEQ-----PDVIPA 624
Cdd:PTZ00429 573 AMTMADLKKSLNTAAIVFARPYQSF-----------LPPygladVELDEEDTEDDDAVELPSTPsmGTQdgspaPSAAPA 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 625 QGDLLGDLLNLDLGP--PVSGPPLATSSVQMGavDLLgGGLDSLIGGTN--FVAPPTAAVPANLGAPIgSGLSDLFDLTS 700
Cdd:PTZ00429 642 GYDIFEFAGDGTGAPhpVASGSNGAQHADPLG--DLF-SGLPSTVGASSpaFQAASGSQAPASPPTAA-SAIEDLFANGM 717

                 ....*.
gi 260436860 701 GVGTLS 706
Cdd:PTZ00429 718 GSGSQT 723
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
38-601 5.62e-146

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 451.49  E-value: 5.62e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  38 IASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDK 117
Cdd:COG5096   44 IAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFALRTLSLLRVKE 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 118 ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAEShPSSNLL 197
Cdd:COG5096  124 LLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLIDILKELVADSDPIVIANALASLAEIDPE-LAHGYS 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 198 DLNPQSINKLLTALNEC-TEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDldy 276
Cdd:COG5096  203 LEVILRIPQLDLLSLSVsTEWLLLIILEVLTERVPTTPDSAEDFEERLSPPLQHNNAEVLLIAVKVILRLLVFLPSN--- 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 277 ygTLLKKLAPPLVTLLS-AEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVL 355
Cdd:COG5096  280 --NLFLISSPPLVTLLAkPESLIQYVLRRNIQIDLEVCSKLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLSQIL 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 356 AELKEYATE--VDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL---IQTKVNYVVQEA-----IVVIK---DIFRKYP 422
Cdd:COG5096  358 LELIYYIAEnhIDAEMVSEAIKALGDLASKAESSVNDCISELLELlegVWIRGSYIVQEVrivdcISVIRisvLVLRILP 437
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 423 NKYESVIAT-LCENLDSLD----EPEARAAM-----IWIVGEYAERI-DNADELLESFLEGFHDESTQVQLQLLTAIVKL 491
Cdd:COG5096  438 NEYPKILLRgLYALEETLElqsrEPRAKSVTdkylgAWLLGEFSDIIpRLEPELLRIAISNFVDETLEVQYTILMSSVKL 517
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 492 FLKKPTETQ----ELVQQVLSLATQDSDNPDLRDRGYIYWRLLST-DPVAAKEVVLAEKPLIS-----EETDLIE--PTL 559
Cdd:COG5096  518 IANSIRKAKqcnsELDQDVLRRCFDYVLVPDLRDRARMYSRLLSTpLPEFSDPILCEAKKSNSqfeiiLSALLTNqtPEL 597
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 260436860 560 LDELICYI--GTLASVYHKPPSAFVEGGR--------------GVVHKSLPPRTASSE 601
Cdd:COG5096  598 LENLRLDFtlGTLSTIPLKPIFNLRKGAVvlqqvtvkkpnaelGFITGNINPSGAANE 655
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
101-265 5.79e-80

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 256.23  E-value: 5.79e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  101 LIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLhdINAQLVEDQGFLDTLKDLISDSNPMVVANA 180
Cdd:pfam12717   1 LIRALAIRTMGCIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKL--ILPDMVKVKGFISELAKLLEDPNPMVVANA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  181 VAALSEIAESHPSsNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAV 260
Cdd:pfam12717  79 LAALTEISEKDPN-AIYNLLPDIISKLSDALNECSEWGQIYILDFLASYIPKDKQEAESLVEKLCPRLQHANSAVVLRAI 157

                  ....*
gi 260436860  261 KVLMK 265
Cdd:pfam12717 158 KVILS 162
B2-adapt-app_C smart01020
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
828-938 3.21e-50

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 198088  Cd Length: 111  Bit Score: 172.11  E-value: 3.21e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   828 FVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRI 907
Cdd:smart01020   1 FVEDGQMEREVFLKTWKSLPESNEQQFQLQPNNLNPDTIIKKLQSNNIFTIAKRNVGNQDKLYLSAKLTNGIWILIELTI 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 260436860   908 QPGNPSCTLSLKCRAPEVSQHVYQAYETILK 938
Cdd:smart01020  81 NPGTPNVTLSVKCDSPEVIQLFTQVFEKILS 111
B2-adapt-app_C pfam09066
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
829-937 4.35e-40

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerization. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 462667  Cd Length: 111  Bit Score: 143.56  E-value: 4.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  829 VEDGKMDRQMFLATWKDIPNENEAQFQIRD-CPLNAEAASSKLQSSNIFTVAKRNVEG-QDMLYQSLKLTNGIWVLAELR 906
Cdd:pfam09066   1 VEDGKLDREVFLETWKSLPDSNELSLTLQNlASVSPDAIEQKLQANNIFTIAKRGVEGpQEKLYFSAKLTNGILFLVELT 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 260436860  907 IQPGNPSCTLSLKCRAPEVSQHVYQAYETIL 937
Cdd:pfam09066  81 INTPGSNVKLSVKSEDPEVAPLFLQLFESIL 111
Alpha_adaptinC2 smart00809
Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link ...
719-819 1.20e-20

Adaptin C-terminal domain; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Gamma-adaptin is a subunit of the golgi adaptor. Alpha adaptin is a heterotetramer that regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This Ig-fold domain is found in alpha, beta and gamma adaptins and consists of a beta-sandwich containing 7 strands in 2 beta-sheets in a greek-key topology.. The adaptor appendage contains an additional N-terminal strand.


Pssm-ID: 197886 [Multi-domain]  Cd Length: 104  Bit Score: 87.68  E-value: 1.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   719 AMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVhAPLSPNQTVEISLPLSTVGS--- 795
Cdd:smart00809   1 AYEKNGLQIGFKFERRPGLIRITLTFTNKSPSPITNFSFQAAVPKSLKLQLQPPSS-PTLPPGGQITQVLKVENPGKfpl 79
                           90       100
                   ....*....|....*....|....*
gi 260436860   796 VMKMEPLNNLQV-AVKNNIDVFYFS 819
Cdd:smart00809  80 RLRLRLSYLLGGsAVTEQGDVLKFP 104
Alpha_adaptinC2 pfam02883
Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud ...
713-819 1.17e-12

Adaptin C-terminal domain; Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins.


Pssm-ID: 460735  Cd Length: 111  Bit Score: 65.04  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  713 KAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFG---LAPAAPLQVHAplSPNQTVEISLP 789
Cdd:pfam02883   1 PPVVLYESDGLQIGFSFERSRRPGQIRITLTFTNKSSSPISNFSFQAAVPKSLklqLQPPSSNVLPP--NPGGQITQVLL 78
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 260436860  790 LSTvgsVMKMEPLNNLQV------AVKNNIDVFYFS 819
Cdd:pfam02883  79 IEN---PGKKPLRMRLKIsylnggAVQEQGDVLKFP 111
HEAT COG1413
HEAT repeat [General function prediction only];
87-212 2.64e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.95  E-value: 2.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  87 AVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITeylcEPLRKCLKDEDPYVRKTAAVCVAKLHDINAqlvedqgfLDTLK 166
Cdd:COG1413   17 AVPALIAALADEDPDVRAAAARALGRLGDPRAV----PALLEALKDPDPEVRAAAAEALGRIGDPEA--------VPALI 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 260436860 167 DLISDSNPMVVANAVAALSEIAeshpssnlldlNPQSINKLLTALN 212
Cdd:COG1413   85 AALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALK 119
HEAT COG1413
HEAT repeat [General function prediction only];
102-265 5.39e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.18  E-value: 5.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 102 IRALAVRTMGCIRVDKITEylcePLRKCLKDEDPYVRKTAAVCVAKLHDINAqlvedqgfLDTLKDLISDSNPMVVANAV 181
Cdd:COG1413    1 VRRAAARALGRLGDPAAVP----ALIAALADEDPDVRAAAARALGRLGDPRA--------VPALLEALKDPDPEVRAAAA 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 182 AALSEIAeshpssnlldlNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAqsicerVTPRLSHANSAVVLSAVK 261
Cdd:COG1413   69 EALGRIG-----------DPEAVPALIAALKDEDPEVRRAAAEALGRLGDPAAVPA------LLEALKDPDWEVRRAAAR 131

                 ....
gi 260436860 262 VLMK 265
Cdd:COG1413  132 ALGR 135
SEC21 COG5240
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion];
45-567 2.97e-09

Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion];


Pssm-ID: 227565 [Multi-domain]  Cd Length: 898  Bit Score: 61.17  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  45 KDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDmAIMAVNTFVKDCEDPNP-LIRALAVRTMGCIrVDKITEYLC 123
Cdd:COG5240   61 ATATNLFFAILKLFQHKDLYLRQCVYSAIKELSKLTED-VLMGTSSIMKDLNGGVPdDVKPMAIRSLFSV-IDGETVYDF 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 124 EPLRKCLKDEDPYVRKTAAVCVA-KLHDINAQLVEDqgFLDTLKDLISD--SNPMVVANAvaalseiaESHPSSNllDLN 200
Cdd:COG5240  139 ERYLNQAFVSTSMARRSAALVVAyHLLPNNFNQTKR--WLNETQEAVLDlkQFPNQHGNE--------GYEPNGN--PIS 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 201 PQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVL---------MKFME--- 268
Cdd:COG5240  207 QYHALGLLYQSKRTDKMAQLKLVEHFRGNASMKNQLAGVLLVRATVELLKENSQALLQLRPFLnswlsdkfeMVFLEaar 286
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 269 -MLSKDLDYYGT-LLKKLAPPLVTLLSA-EPELQYVALRNINLIVQKRPEIL---KHEMKVFFVKYNDPIyvKLEKLDIM 342
Cdd:COG5240  287 aVCALSEENVGSqFVDQTVSSLRTFLKStRVVLRFSAMRILNQLAMKYPQKVsvcNKEVESLISDENRTI--STYAITTL 364
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 343 IRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV-VIKDIFRKY 421
Cdd:COG5240  365 LKTGTEETIDRLVNLIPSFVHDMSDGFKIIAIDALRSLSLLFPSKKLSYLDFLGSSLLQEGGLEFKKYMVdAISDAMEND 444
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860 422 PNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTET-Q 500
Cdd:COG5240  445 PDSKERALEVLCTFIEDCEYHQITVRILGILGREGPRAKTPGKYVRHIYNRLILENNIVRSAAVQALSKFALNISDVVsP 524
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 260436860 501 ELVQQVLSLATQDSDNpDLRDRGYIYWRLLstdpvaakEVVLAEKPLISEETDLIEPTLLDELICYI 567
Cdd:COG5240  525 QSVENALKRCLNDQDD-EVRDRASFLLRNM--------RLSDACEPLFSSDELGDIPSLELELIGYI 582
HEAT COG1413
HEAT repeat [General function prediction only];
87-188 1.09e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.63  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  87 AVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEylcePLRKCLKDEDPYVRKTAAVCVAKLHDINAqlvedqgfLDTLK 166
Cdd:COG1413   48 AVPALLEALKDPDPEVRAAAAEALGRIGDPEAVP----ALIAALKDEDPEVRRAAAEALGRLGDPAA--------VPALL 115
                         90       100
                 ....*....|....*....|..
gi 260436860 167 DLISDSNPMVVANAVAALSEIA 188
Cdd:COG1413  116 EALKDPDWEVRRAAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
96-185 1.79e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 52.34  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860   96 EDPNPLIRALAVRTMGCIRVDKITEylcePLRKCLKDEDPYVRKTAAVCVAKLHDINAqlvedqgfLDTLKDLI-SDSNP 174
Cdd:pfam13646  10 RDPDPEVRAAAIRALGRIGDPEAVP----ALLELLKDEDPAVRRAAAEALGKIGDPEA--------LPALLELLrDDDDD 77
                          90
                  ....*....|.
gi 260436860  175 MVVANAVAALS 185
Cdd:pfam13646  78 VVRAAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
124-217 1.40e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.25  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260436860  124 EPLRKCL-KDEDPYVRKTAAVCVAKLHDinaqlvedQGFLDTLKDLISDSNPMVVANAVAALSEIAEshpssnlldlnPQ 202
Cdd:pfam13646   2 PALLQALlRDPDPEVRAAAIRALGRIGD--------PEAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PE 62
                          90
                  ....*....|....*
gi 260436860  203 SINKLLTALNECTEW 217
Cdd:pfam13646  63 ALPALLELLRDDDDD 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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