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CMRF35-like molecule 1 isoform 2 precursor [Mus musculus]
Ig_pIgR_like and SIT domain-containing protein( domain architecture ID 10146073)
Ig_pIgR_like and SIT domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
IgV_pIgR_like | cd05716 | Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ... |
24-125 | 1.21e-32 | |||
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others. : Pssm-ID: 409381 Cd Length: 100 Bit Score: 116.73 E-value: 1.21e-32
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SIT | pfam15330 | SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ... |
206-292 | 5.95e-27 | |||
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation. : Pssm-ID: 464650 Cd Length: 114 Bit Score: 102.46 E-value: 5.95e-27
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Name | Accession | Description | Interval | E-value | |||
IgV_pIgR_like | cd05716 | Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ... |
24-125 | 1.21e-32 | |||
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others. Pssm-ID: 409381 Cd Length: 100 Bit Score: 116.73 E-value: 1.21e-32
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SIT | pfam15330 | SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ... |
206-292 | 5.95e-27 | |||
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation. Pssm-ID: 464650 Cd Length: 114 Bit Score: 102.46 E-value: 5.95e-27
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V-set | pfam07686 | Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ... |
24-123 | 1.41e-17 | |||
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others. Pssm-ID: 462230 Cd Length: 109 Bit Score: 77.11 E-value: 1.41e-17
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IG_like | smart00410 | Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG. |
26-109 | 7.94e-06 | |||
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG. Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 43.65 E-value: 7.94e-06
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Name | Accession | Description | Interval | E-value | |||
IgV_pIgR_like | cd05716 | Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ... |
24-125 | 1.21e-32 | |||
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others. Pssm-ID: 409381 Cd Length: 100 Bit Score: 116.73 E-value: 1.21e-32
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SIT | pfam15330 | SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ... |
206-292 | 5.95e-27 | |||
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation. Pssm-ID: 464650 Cd Length: 114 Bit Score: 102.46 E-value: 5.95e-27
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V-set | pfam07686 | Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ... |
24-123 | 1.41e-17 | |||
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others. Pssm-ID: 462230 Cd Length: 109 Bit Score: 77.11 E-value: 1.41e-17
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IG_like | smart00410 | Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG. |
26-109 | 7.94e-06 | |||
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG. Pssm-ID: 214653 [Multi-domain] Cd Length: 85 Bit Score: 43.65 E-value: 7.94e-06
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IgV | cd00099 | Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ... |
26-124 | 4.28e-04 | |||
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other. Pssm-ID: 409355 [Multi-domain] Cd Length: 111 Bit Score: 39.24 E-value: 4.28e-04
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