NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21687149|ref|NP_660321|]
View 

germinal center-associated signaling and motility-like protein isoform a [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HGAL super family cl24288
Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between ...
 48-134 2.24e-31

Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.


The actual alignment was detected with superfamily member pfam15666:

Pssm-ID: 464789  Cd Length: 88  Bit Score: 107.16  E-value: 2.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687149    48 QEVSSTSNQENENGSGSEEVCYTVINH-IPHQRSSLSSNDDGYENIDSLTRKVRQFRERSETEYALLR-TSVSRPCSCTh 125
Cdd:pfam15666   1 KGMSSAPIQDNADQSYSEELCYTLINHkVLGRRPSGNSAEEYYENISCKTERPRESLGGTETEYSLLRvPSTPRHPPSP- 79


                  ....*....
gi 21687149   126 EHDYEVVFP 134
Cdd:pfam15666  80 EDEYELLMP 88
 
Name Accession Description Interval E-value
HGAL pfam15666
Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between ...
 48-134 2.24e-31

Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.


Pssm-ID: 464789  Cd Length: 88  Bit Score: 107.16  E-value: 2.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687149    48 QEVSSTSNQENENGSGSEEVCYTVINH-IPHQRSSLSSNDDGYENIDSLTRKVRQFRERSETEYALLR-TSVSRPCSCTh 125
Cdd:pfam15666   1 KGMSSAPIQDNADQSYSEELCYTLINHkVLGRRPSGNSAEEYYENISCKTERPRESLGGTETEYSLLRvPSTPRHPPSP- 79


                  ....*....
gi 21687149   126 EHDYEVVFP 134
Cdd:pfam15666  80 EDEYELLMP 88
 
Name Accession Description Interval E-value
HGAL pfam15666
Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between ...
 48-134 2.24e-31

Germinal center-associated lymphoma; HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.


Pssm-ID: 464789  Cd Length: 88  Bit Score: 107.16  E-value: 2.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687149    48 QEVSSTSNQENENGSGSEEVCYTVINH-IPHQRSSLSSNDDGYENIDSLTRKVRQFRERSETEYALLR-TSVSRPCSCTh 125
Cdd:pfam15666   1 KGMSSAPIQDNADQSYSEELCYTLINHkVLGRRPSGNSAEEYYENISCKTERPRESLGGTETEYSLLRvPSTPRHPPSP- 79


                  ....*....
gi 21687149   126 EHDYEVVFP 134
Cdd:pfam15666  80 EDEYELLMP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH