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Conserved domains on  [gi|21687127|ref|NP_660308|]
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coiled-coil domain-containing protein 127 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00121 super family cl31754
MAEBL; Provisional
47-163 7.50e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127    47 ESQKEVEKEREAYRRRTAAFQQDLEAKyhaMISENRRAVAQLSLELEK----EQNRTASYREALISQGRKLVEEKKLLEQ 122
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKNMALRKAEEAK---KAEEARIEEVMKLYEEEKkmkaEEAKKAEEAKIKAEELKKAEEEKKKVEQ 1637
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 21687127   123 ERAQVMQEKRQVQPLRSAylsclqREENWQRRARLLLKEFE 163
Cdd:PTZ00121 1638 LKKKEAEEKKKAEELKKA------EEENKIKAAEEAKKAEE 1672
 
Name Accession Description Interval E-value
PTZ00121 PTZ00121
MAEBL; Provisional
47-163 7.50e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127    47 ESQKEVEKEREAYRRRTAAFQQDLEAKyhaMISENRRAVAQLSLELEK----EQNRTASYREALISQGRKLVEEKKLLEQ 122
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKNMALRKAEEAK---KAEEARIEEVMKLYEEEKkmkaEEAKKAEEAKIKAEELKKAEEEKKKVEQ 1637
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 21687127   123 ERAQVMQEKRQVQPLRSAylsclqREENWQRRARLLLKEFE 163
Cdd:PTZ00121 1638 LKKKEAEEKKKAEELKKA------EEENKIKAAEEAKKAEE 1672
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
47-161 4.27e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.18  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127    47 ESQKEVEKEREAYRRRTAAFQQDLEA--KYHAMISENRRAVAQLSLELEKEQNRTASYREalisqgrklvEEKKLLEQER 124
Cdd:pfam17380 375 SRMRELERLQMERQQKNERVRQELEAarKVKILEEERQRKIQQQKVEMEQIRAEQEEARQ----------REVRRLEEER 444
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 21687127   125 AQVMQEKRQVQPLRSAYLSCLQREENWQRRARLLLKE 161
Cdd:pfam17380 445 AREMERVRLEEQERQQQVERLRQQEEERKRKKLELEK 481
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
30-214 6.01e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 38.03  E-value: 6.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127     30 LLVPMLGLAAFRWIWS--RESQKEVEKEREAYRRRTAAFQQDLEAK---YHAMISENRRAVAQLSLELEKEQNRTASYRe 104
Cdd:TIGR00618  168 LLMNLFPLDQYTQLALmeFAKKKSLHGKAELLTLRSQLLTLCTPCMpdtYHERKQVLEKELKHLREALQQTQQSHAYLT- 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127    105 alisQGRKLVEEKKLLEQERAQVMQEKRQVQPLRSAyLSCLQREENWQRRARLLLKEFEAVLTERQNIYCSLFLPRSKRL 184
Cdd:TIGR00618  247 ----QKREAQEEQLKKQQLLKQLRARIEELRAQEAV-LEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMR 321
                          170       180       190
                   ....*....|....*....|....*....|
gi 21687127    185 EIEKSLLVRASVDPVAADLEMAAGLTDIFQ 214
Cdd:TIGR00618  322 SRAKLLMKRAAHVKQQSSIEEQRRLLQTLH 351
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
46-172 7.75e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.61  E-value: 7.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127  46 RESQKEVEKEREAYRRRTAAFQQDLEAKYHA--MISENRRAVAQLSLELEKEQNRTASYREALISQGRKLVEEKKLLEQE 123
Cdd:COG1196 277 EELELELEEAQAEEYELLAELARLEQDIARLeeRRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEA 356
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21687127 124 RAQVMQEKRQVQPLRSAYLSCLQREENWQRRARLLLKEFEAVLTERQNI 172
Cdd:COG1196 357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405
 
Name Accession Description Interval E-value
PTZ00121 PTZ00121
MAEBL; Provisional
47-163 7.50e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 7.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127    47 ESQKEVEKEREAYRRRTAAFQQDLEAKyhaMISENRRAVAQLSLELEK----EQNRTASYREALISQGRKLVEEKKLLEQ 122
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKNMALRKAEEAK---KAEEARIEEVMKLYEEEKkmkaEEAKKAEEAKIKAEELKKAEEEKKKVEQ 1637
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 21687127   123 ERAQVMQEKRQVQPLRSAylsclqREENWQRRARLLLKEFE 163
Cdd:PTZ00121 1638 LKKKEAEEKKKAEELKKA------EEENKIKAAEEAKKAEE 1672
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
47-161 4.27e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.18  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127    47 ESQKEVEKEREAYRRRTAAFQQDLEA--KYHAMISENRRAVAQLSLELEKEQNRTASYREalisqgrklvEEKKLLEQER 124
Cdd:pfam17380 375 SRMRELERLQMERQQKNERVRQELEAarKVKILEEERQRKIQQQKVEMEQIRAEQEEARQ----------REVRRLEEER 444
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 21687127   125 AQVMQEKRQVQPLRSAYLSCLQREENWQRRARLLLKE 161
Cdd:pfam17380 445 AREMERVRLEEQERQQQVERLRQQEEERKRKKLELEK 481
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
30-214 6.01e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 38.03  E-value: 6.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127     30 LLVPMLGLAAFRWIWS--RESQKEVEKEREAYRRRTAAFQQDLEAK---YHAMISENRRAVAQLSLELEKEQNRTASYRe 104
Cdd:TIGR00618  168 LLMNLFPLDQYTQLALmeFAKKKSLHGKAELLTLRSQLLTLCTPCMpdtYHERKQVLEKELKHLREALQQTQQSHAYLT- 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127    105 alisQGRKLVEEKKLLEQERAQVMQEKRQVQPLRSAyLSCLQREENWQRRARLLLKEFEAVLTERQNIYCSLFLPRSKRL 184
Cdd:TIGR00618  247 ----QKREAQEEQLKKQQLLKQLRARIEELRAQEAV-LEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMR 321
                          170       180       190
                   ....*....|....*....|....*....|
gi 21687127    185 EIEKSLLVRASVDPVAADLEMAAGLTDIFQ 214
Cdd:TIGR00618  322 SRAKLLMKRAAHVKQQSSIEEQRRLLQTLH 351
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
46-172 7.75e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.61  E-value: 7.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21687127  46 RESQKEVEKEREAYRRRTAAFQQDLEAKYHA--MISENRRAVAQLSLELEKEQNRTASYREALISQGRKLVEEKKLLEQE 123
Cdd:COG1196 277 EELELELEEAQAEEYELLAELARLEQDIARLeeRRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEA 356
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21687127 124 RAQVMQEKRQVQPLRSAYLSCLQREENWQRRARLLLKEFEAVLTERQNI 172
Cdd:COG1196 357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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