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Conserved domains on  [gi|260763910|ref|NP_659498|]
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spindle and kinetochore-associated protein 3 isoform 1 [Homo sapiens]

Protein Classification

SKA3_N domain-containing protein( domain architecture ID 10191740)

SKA3_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SKA3_N cd12957
Spindle and kinetochore-associated protein 3, N-terminal domain; SKA3, also called RAMA1 or ...
 3-101 2.42e-50

Spindle and kinetochore-associated protein 3, N-terminal domain; SKA3, also called RAMA1 or C13orf3, is a component of the SKA complex, which is formed by the association of three subunits (SKA1, SKA2, and SKA3). The SKA complex is essential for accurate cell division. It functions with the Ndc80 network to establish stable kinetochore-microtubule interactions, which are crucial for the highly orchestrated chromosome movements during mitosis. The biological unit is a W-shaped homodimer of the three-subunit complex. SKA3 contributes to SAC (spindle-assembly checkpoint) signaling through its interaction with Bub3. This model represents the N-terminal domain of SKA3, which is involved in interactions with SKA1 and SKA2 to form the SKA complex. The C-terminal portion of SKA3 is involved in creating a microtubule-binding surface.


:

Pssm-ID: 240570  Cd Length: 100  Bit Score: 164.88  E-value: 2.42e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763910   3 PIRSFCGKLRSLASTLDCETARLQRALDGEESDF-EDYPMRILYDLHSEVQTLKDDVNILLDKARLENQEGIDFIKATKV 81
Cdd:cd12957    1 VSRNFFSKLRSLALTLEKETSQLERALSGEETEFeEESPMRVLHDLHSDVRTLKGDANNQLDKARSESQELYDFIKACKV 80

                         90       100
                 ....*....|....*....|
gi 260763910  82 LMEKNSMDIMKIREYFQKYG 101
Cdd:cd12957   81 LMQRNAEDIDKIREHFQKYG 100
 
Name Accession Description Interval E-value
SKA3_N cd12957
Spindle and kinetochore-associated protein 3, N-terminal domain; SKA3, also called RAMA1 or ...
 3-101 2.42e-50

Spindle and kinetochore-associated protein 3, N-terminal domain; SKA3, also called RAMA1 or C13orf3, is a component of the SKA complex, which is formed by the association of three subunits (SKA1, SKA2, and SKA3). The SKA complex is essential for accurate cell division. It functions with the Ndc80 network to establish stable kinetochore-microtubule interactions, which are crucial for the highly orchestrated chromosome movements during mitosis. The biological unit is a W-shaped homodimer of the three-subunit complex. SKA3 contributes to SAC (spindle-assembly checkpoint) signaling through its interaction with Bub3. This model represents the N-terminal domain of SKA3, which is involved in interactions with SKA1 and SKA2 to form the SKA complex. The C-terminal portion of SKA3 is involved in creating a microtubule-binding surface.


Pssm-ID: 240570  Cd Length: 100  Bit Score: 164.88  E-value: 2.42e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763910   3 PIRSFCGKLRSLASTLDCETARLQRALDGEESDF-EDYPMRILYDLHSEVQTLKDDVNILLDKARLENQEGIDFIKATKV 81
Cdd:cd12957    1 VSRNFFSKLRSLALTLEKETSQLERALSGEETEFeEESPMRVLHDLHSDVRTLKGDANNQLDKARSESQELYDFIKACKV 80

                         90       100
                 ....*....|....*....|
gi 260763910  82 LMEKNSMDIMKIREYFQKYG 101
Cdd:cd12957   81 LMQRNAEDIDKIREHFQKYG 100
 
Name Accession Description Interval E-value
SKA3_N cd12957
Spindle and kinetochore-associated protein 3, N-terminal domain; SKA3, also called RAMA1 or ...
 3-101 2.42e-50

Spindle and kinetochore-associated protein 3, N-terminal domain; SKA3, also called RAMA1 or C13orf3, is a component of the SKA complex, which is formed by the association of three subunits (SKA1, SKA2, and SKA3). The SKA complex is essential for accurate cell division. It functions with the Ndc80 network to establish stable kinetochore-microtubule interactions, which are crucial for the highly orchestrated chromosome movements during mitosis. The biological unit is a W-shaped homodimer of the three-subunit complex. SKA3 contributes to SAC (spindle-assembly checkpoint) signaling through its interaction with Bub3. This model represents the N-terminal domain of SKA3, which is involved in interactions with SKA1 and SKA2 to form the SKA complex. The C-terminal portion of SKA3 is involved in creating a microtubule-binding surface.


Pssm-ID: 240570  Cd Length: 100  Bit Score: 164.88  E-value: 2.42e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763910   3 PIRSFCGKLRSLASTLDCETARLQRALDGEESDF-EDYPMRILYDLHSEVQTLKDDVNILLDKARLENQEGIDFIKATKV 81
Cdd:cd12957    1 VSRNFFSKLRSLALTLEKETSQLERALSGEETEFeEESPMRVLHDLHSDVRTLKGDANNQLDKARSESQELYDFIKACKV 80

                         90       100
                 ....*....|....*....|
gi 260763910  82 LMEKNSMDIMKIREYFQKYG 101
Cdd:cd12957   81 LMQRNAEDIDKIREHFQKYG 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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