NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21396487|ref|NP_653337|]
View 

protein arginine methyltransferase NDUFAF7, mitochondrial isoform 1 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11446284)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to eukaryotic NADH dehydrogenase complex I assembly factor 7, which is involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex

CATH:  2.20.25.110
EC:  2.1.1.-
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MidA COG1565
SAM-dependent methyltransferase, MidA family [General function prediction only];
41-415 1.84e-95

SAM-dependent methyltransferase, MidA family [General function prediction only];


:

Pssm-ID: 441173  Cd Length: 376  Bit Score: 291.71  E-value: 1.84e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487  41 TPMLRHLMYKIKST-GPITVAEYMKEVLTNPAKGYYV-YRDMLGEKGDFITSPEISQIFGELLGIWFISEWMATGKSTAF 118
Cdd:COG1565   7 TALAALIRARIAAAgGPIPFARYMELALYHPGLGYYStGRDKFGAAGDFITAPELSPLFGELLARQLAQVWEALGAPAPF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 119 QLVELGPGRGTLVGDILRVftqLGSVLKNCD--ISVHLVEVSQKLSEIQALTLTKEKvplernagspvymkgvtksGIPI 196
Cdd:COG1565  87 TLLELGAGRGTLAADILRA---LRALLPGFYaaLRYHIVELSPDLRARQQETLAAFA-------------------PARV 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 197 SWYRDLHDVPKGYS-FYLAHEFFDVLPVHKFQKTPQGWREVFVDIDpqvSDKLRFVLAPSATPA-----EAFIQHDETRD 270
Cdd:COG1565 145 RWLDSLEELPEDFSgVVLANEVLDALPVHQFVRTGGGWRERGVGLD---DGGLVFGLRPLSDPEllaalPALLAPLPEGY 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 271 HVEVCPDAGVIIEELSQRiaLTGGAALVADYGHDGTK-------TDTFRGFCDHKLH-DVLIAPGTADLTADVDFSYLRR 342
Cdd:COG1565 222 VTEVNLAAEAWLATLAAR--LARGAALLIDYGYPASEyyhpqrsGGTLQCYYRHRAHdDPLANPGLQDITAHVDFTALAE 299
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21396487 343 MAQGK-VASLGPIKQHTFLKNMGIDVRLKVLldKSNEPSVRQQLLQGYDMLMNPKKMGERFNFFAL---LPHQRLQG 415
Cdd:COG1565 300 AAEAAgLEVLGYTTQGLFLLALGLLERLAAL--SAGDPAAALALRAAVKRLTLPAEMGELFKVLALgkgLDPPPLPG 374
 
Name Accession Description Interval E-value
MidA COG1565
SAM-dependent methyltransferase, MidA family [General function prediction only];
41-415 1.84e-95

SAM-dependent methyltransferase, MidA family [General function prediction only];


Pssm-ID: 441173  Cd Length: 376  Bit Score: 291.71  E-value: 1.84e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487  41 TPMLRHLMYKIKST-GPITVAEYMKEVLTNPAKGYYV-YRDMLGEKGDFITSPEISQIFGELLGIWFISEWMATGKSTAF 118
Cdd:COG1565   7 TALAALIRARIAAAgGPIPFARYMELALYHPGLGYYStGRDKFGAAGDFITAPELSPLFGELLARQLAQVWEALGAPAPF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 119 QLVELGPGRGTLVGDILRVftqLGSVLKNCD--ISVHLVEVSQKLSEIQALTLTKEKvplernagspvymkgvtksGIPI 196
Cdd:COG1565  87 TLLELGAGRGTLAADILRA---LRALLPGFYaaLRYHIVELSPDLRARQQETLAAFA-------------------PARV 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 197 SWYRDLHDVPKGYS-FYLAHEFFDVLPVHKFQKTPQGWREVFVDIDpqvSDKLRFVLAPSATPA-----EAFIQHDETRD 270
Cdd:COG1565 145 RWLDSLEELPEDFSgVVLANEVLDALPVHQFVRTGGGWRERGVGLD---DGGLVFGLRPLSDPEllaalPALLAPLPEGY 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 271 HVEVCPDAGVIIEELSQRiaLTGGAALVADYGHDGTK-------TDTFRGFCDHKLH-DVLIAPGTADLTADVDFSYLRR 342
Cdd:COG1565 222 VTEVNLAAEAWLATLAAR--LARGAALLIDYGYPASEyyhpqrsGGTLQCYYRHRAHdDPLANPGLQDITAHVDFTALAE 299
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21396487 343 MAQGK-VASLGPIKQHTFLKNMGIDVRLKVLldKSNEPSVRQQLLQGYDMLMNPKKMGERFNFFAL---LPHQRLQG 415
Cdd:COG1565 300 AAEAAgLEVLGYTTQGLFLLALGLLERLAAL--SAGDPAAALALRAAVKRLTLPAEMGELFKVLALgkgLDPPPLPG 374
Methyltransf_28 pfam02636
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
100-354 1.39e-81

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase. In eukaryotes it plays a role in mitochondrial complex I activity.


Pssm-ID: 460634  Cd Length: 247  Bit Score: 251.80  E-value: 1.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487   100 LLGIWFISEWMATGKSTAFQLVELGPGRGTLVGDILRVFTQLGSVLKNCdISVHLVEVSQKLSEIQALTLTKEKvplern 179
Cdd:pfam02636   1 LLARWLLEMWQALGRPYNFRIIELGPGRGTLAADLLRALRKFLPEFYEA-LEYHLVEISPALRARQQQRLAGKA------ 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487   180 agspvymkgvTKSGIPISWYRDLHDVPkGYSFYLAHEFFDVLPVHKFQKTPQGWREVFVDIDPQVSDKLRFVLAPSATPA 259
Cdd:pfam02636  74 ----------PSLGVRVRWLEDLPDIP-FPGFILANEVFDALPVHRFRRTEDGWRERYVGLDPAKDGDFRFVLGPSSTPE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487   260 -EAFIQHDETR----DHVEVCPDAGVIIEELSQRIAltGGAALVADYGHDGT----KTDTFRGFCDHKLH-DVLIAPGTA 329
Cdd:pfam02636 143 lRDYLPKIGPDlppgYRIEIPPAALAWLETIAERLP--RGALLIIDYGYLASeyyrPNGTLRAYYRHRVHdDPLVNPGLQ 220
                         250       260
                  ....*....|....*....|....*..
gi 21396487   330 DLTADVDFSYLRRMA--QGKVASLGPI 354
Cdd:pfam02636 221 DITAHVDFTALAEAAreAGGLDVLGPT 247
 
Name Accession Description Interval E-value
MidA COG1565
SAM-dependent methyltransferase, MidA family [General function prediction only];
41-415 1.84e-95

SAM-dependent methyltransferase, MidA family [General function prediction only];


Pssm-ID: 441173  Cd Length: 376  Bit Score: 291.71  E-value: 1.84e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487  41 TPMLRHLMYKIKST-GPITVAEYMKEVLTNPAKGYYV-YRDMLGEKGDFITSPEISQIFGELLGIWFISEWMATGKSTAF 118
Cdd:COG1565   7 TALAALIRARIAAAgGPIPFARYMELALYHPGLGYYStGRDKFGAAGDFITAPELSPLFGELLARQLAQVWEALGAPAPF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 119 QLVELGPGRGTLVGDILRVftqLGSVLKNCD--ISVHLVEVSQKLSEIQALTLTKEKvplernagspvymkgvtksGIPI 196
Cdd:COG1565  87 TLLELGAGRGTLAADILRA---LRALLPGFYaaLRYHIVELSPDLRARQQETLAAFA-------------------PARV 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 197 SWYRDLHDVPKGYS-FYLAHEFFDVLPVHKFQKTPQGWREVFVDIDpqvSDKLRFVLAPSATPA-----EAFIQHDETRD 270
Cdd:COG1565 145 RWLDSLEELPEDFSgVVLANEVLDALPVHQFVRTGGGWRERGVGLD---DGGLVFGLRPLSDPEllaalPALLAPLPEGY 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487 271 HVEVCPDAGVIIEELSQRiaLTGGAALVADYGHDGTK-------TDTFRGFCDHKLH-DVLIAPGTADLTADVDFSYLRR 342
Cdd:COG1565 222 VTEVNLAAEAWLATLAAR--LARGAALLIDYGYPASEyyhpqrsGGTLQCYYRHRAHdDPLANPGLQDITAHVDFTALAE 299
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21396487 343 MAQGK-VASLGPIKQHTFLKNMGIDVRLKVLldKSNEPSVRQQLLQGYDMLMNPKKMGERFNFFAL---LPHQRLQG 415
Cdd:COG1565 300 AAEAAgLEVLGYTTQGLFLLALGLLERLAAL--SAGDPAAALALRAAVKRLTLPAEMGELFKVLALgkgLDPPPLPG 374
Methyltransf_28 pfam02636
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
100-354 1.39e-81

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase. In eukaryotes it plays a role in mitochondrial complex I activity.


Pssm-ID: 460634  Cd Length: 247  Bit Score: 251.80  E-value: 1.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487   100 LLGIWFISEWMATGKSTAFQLVELGPGRGTLVGDILRVFTQLGSVLKNCdISVHLVEVSQKLSEIQALTLTKEKvplern 179
Cdd:pfam02636   1 LLARWLLEMWQALGRPYNFRIIELGPGRGTLAADLLRALRKFLPEFYEA-LEYHLVEISPALRARQQQRLAGKA------ 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487   180 agspvymkgvTKSGIPISWYRDLHDVPkGYSFYLAHEFFDVLPVHKFQKTPQGWREVFVDIDPQVSDKLRFVLAPSATPA 259
Cdd:pfam02636  74 ----------PSLGVRVRWLEDLPDIP-FPGFILANEVFDALPVHRFRRTEDGWRERYVGLDPAKDGDFRFVLGPSSTPE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21396487   260 -EAFIQHDETR----DHVEVCPDAGVIIEELSQRIAltGGAALVADYGHDGT----KTDTFRGFCDHKLH-DVLIAPGTA 329
Cdd:pfam02636 143 lRDYLPKIGPDlppgYRIEIPPAALAWLETIAERLP--RGALLIIDYGYLASeyyrPNGTLRAYYRHRVHdDPLVNPGLQ 220
                         250       260
                  ....*....|....*....|....*..
gi 21396487   330 DLTADVDFSYLRRMA--QGKVASLGPI 354
Cdd:pfam02636 221 DITAHVDFTALAEAAreAGGLDVLGPT 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH