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Conserved domains on  [gi|21389517|ref|NP_653328|]
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gamma-crystallin N isoform a [Homo sapiens]

Protein Classification

Crystall domain-containing protein( domain architecture ID 10440397)

Crystall domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 7-88 2.18e-41

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 134.16  E-value: 2.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389517     7 KITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCR 86
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                  ..
gi 21389517    87 PV 88
Cdd:pfam00030  81 PI 82
Crystall super family cl02528
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 96-136 4.96e-07

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


The actual alignment was detected with superfamily member pfam00030:

Pssm-ID: 470604  Cd Length: 82  Bit Score: 45.56  E-value: 4.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21389517    96 RLEIFEGCNFTGQCLEFLEDSPFLQSRGWvKNCVNTIKVYG 136
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGF-NSRVNSIRVLS 40
 
Name Accession Description Interval E-value
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 7-88 2.18e-41

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 134.16  E-value: 2.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389517     7 KITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCR 86
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                  ..
gi 21389517    87 PV 88
Cdd:pfam00030  81 PI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 7-88 4.96e-34

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 115.30  E-value: 4.96e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389517      7 KITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCR 86
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIR 80


                   ..
gi 21389517     87 PV 88
Cdd:smart00247  81 RI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 96-136 4.96e-07

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 45.56  E-value: 4.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21389517    96 RLEIFEGCNFTGQCLEFLEDSPFLQSRGWvKNCVNTIKVYG 136
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGF-NSRVNSIRVLS 40
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 96-141 3.45e-05

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 40.57  E-value: 3.45e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 21389517     96 RLEIFEGCNFTGQCLEFLEDSPFLQSRGWvKNCVNTIKVygDGAAW 141
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGS-RDNVSSVRV--ESGCW 43
 
Name Accession Description Interval E-value
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 7-88 2.18e-41

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 134.16  E-value: 2.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389517     7 KITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCR 86
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLR 80


                  ..
gi 21389517    87 PV 88
Cdd:pfam00030  81 PI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 7-88 4.96e-34

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 115.30  E-value: 4.96e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389517      7 KITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCR 86
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIR 80


                   ..
gi 21389517     87 PV 88
Cdd:smart00247  81 RI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
 96-136 4.96e-07

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 45.56  E-value: 4.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21389517    96 RLEIFEGCNFTGQCLEFLEDSPFLQSRGWvKNCVNTIKVYG 136
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGF-NSRVNSIRVLS 40
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
 96-141 3.45e-05

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 40.57  E-value: 3.45e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 21389517     96 RLEIFEGCNFTGQCLEFLEDSPFLQSRGWvKNCVNTIKVygDGAAW 141
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGS-RDNVSSVRV--ESGCW 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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