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Conserved domains on  [gi|109240536|ref|NP_653223|]
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DC-STAMP domain-containing protein 2 [Homo sapiens]

Protein Classification

DC-STAMP domain-containing protein( domain architecture ID 10544533)

DC-STAMP domain-containing protein similar to human dendritic cell-specific transmembrane protein (DC-STAMP) and osteoclast stimulatory transmembrane protein (OC-STAMP) that work together to modulate cell-cell fusion in both osteoclasts and foreign body giant cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DC_STAMP pfam07782
DC-STAMP-like protein; This is a family of sequences which are similar to a region of the ...
 354-544 6.96e-68

DC-STAMP-like protein; This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.


:

Pssm-ID: 462265  Cd Length: 191  Bit Score: 222.10  E-value: 6.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109240536  354 YDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPPGSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVL 433
Cdd:pfam07782   1 FDNIYITKQFRRIDERRKRQGKPTVLPLTKRERKKYIKPTSLRLTRKERKRLLLSLLPLLLHLLTLAVIIALDYLLYWLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109240536  434 DLARHQLQGEIVARSPVLVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYGLCFFI 513
Cdd:pfam07782  81 DSVRKHAQQLPDLEVPLYVSVKVNGTGFIADLLRDLVNAFNPLSRIWISLDNQKCLPKPSLPDYSVYLQIGLLYLLAWLL 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 109240536  514 TLFGSYVSRLRRVICASYYPSREQERISYLY 544
Cdd:pfam07782 161 VLLEAYALRLRRLICASFYPDREKERILYLY 191
 
Name Accession Description Interval E-value
DC_STAMP pfam07782
DC-STAMP-like protein; This is a family of sequences which are similar to a region of the ...
 354-544 6.96e-68

DC-STAMP-like protein; This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.


Pssm-ID: 462265  Cd Length: 191  Bit Score: 222.10  E-value: 6.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109240536  354 YDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPPGSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVL 433
Cdd:pfam07782   1 FDNIYITKQFRRIDERRKRQGKPTVLPLTKRERKKYIKPTSLRLTRKERKRLLLSLLPLLLHLLTLAVIIALDYLLYWLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109240536  434 DLARHQLQGEIVARSPVLVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYGLCFFI 513
Cdd:pfam07782  81 DSVRKHAQQLPDLEVPLYVSVKVNGTGFIADLLRDLVNAFNPLSRIWISLDNQKCLPKPSLPDYSVYLQIGLLYLLAWLL 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 109240536  514 TLFGSYVSRLRRVICASYYPSREQERISYLY 544
Cdd:pfam07782 161 VLLEAYALRLRRLICASFYPDREKERILYLY 191
 
Name Accession Description Interval E-value
DC_STAMP pfam07782
DC-STAMP-like protein; This is a family of sequences which are similar to a region of the ...
 354-544 6.96e-68

DC-STAMP-like protein; This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.


Pssm-ID: 462265  Cd Length: 191  Bit Score: 222.10  E-value: 6.96e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109240536  354 YDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPPGSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVL 433
Cdd:pfam07782   1 FDNIYITKQFRRIDERRKRQGKPTVLPLTKRERKKYIKPTSLRLTRKERKRLLLSLLPLLLHLLTLAVIIALDYLLYWLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109240536  434 DLARHQLQGEIVARSPVLVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYGLCFFI 513
Cdd:pfam07782  81 DSVRKHAQQLPDLEVPLYVSVKVNGTGFIADLLRDLVNAFNPLSRIWISLDNQKCLPKPSLPDYSVYLQIGLLYLLAWLL 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 109240536  514 TLFGSYVSRLRRVICASYYPSREQERISYLY 544
Cdd:pfam07782 161 VLLEAYALRLRRLICASFYPDREKERILYLY 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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