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Conserved domains on  [gi|255652953|ref|NP_653205|]
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zinc finger CCCH domain-containing protein 18 isoform 2 [Homo sapiens]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 16058599)

zinc finger CCCH domain-containing protein similar to mammalian Zinc finger CCCH domain-containing protein 18 (ZC3H18) that interacts with ZFC3H1 in a RNase-insensitive manner

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|27990022
SCOP:  3001741

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
222-243 2.07e-08

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


:

Pssm-ID: 465626  Cd Length: 22  Bit Score: 50.66  E-value: 2.07e-08
                          10        20
                  ....*....|....*....|..
gi 255652953  222 PTCRFFMKGNCTWGMNCRFIHP 243
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSHD 22
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
222-243 2.07e-08

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 50.66  E-value: 2.07e-08
                          10        20
                  ....*....|....*....|..
gi 255652953  222 PTCRFFMKGNCTWGMNCRFIHP 243
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSHD 22
ZnF_C3H1 smart00356
zinc finger;
215-243 4.82e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.99  E-value: 4.82e-04
                           10        20
                   ....*....|....*....|....*....
gi 255652953   215 DRKVRPrptCRFFMKGNCTWGMNCRFIHP 243
Cdd:smart00356   1 KYKTEL---CKFFKRGYCPRGDRCKFAHP 26
 
Name Accession Description Interval E-value
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
222-243 2.07e-08

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 50.66  E-value: 2.07e-08
                          10        20
                  ....*....|....*....|..
gi 255652953  222 PTCRFFMKGNCTWGMNCRFIHP 243
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSHD 22
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
224-242 7.99e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 43.17  E-value: 7.99e-06
                          10
                  ....*....|....*....
gi 255652953  224 CRFFMKGNCTWGMNCRFIH 242
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
215-243 4.82e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.99  E-value: 4.82e-04
                           10        20
                   ....*....|....*....|....*....
gi 255652953   215 DRKVRPrptCRFFMKGNCTWGMNCRFIHP 243
Cdd:smart00356   1 KYKTEL---CKFFKRGYCPRGDRCKFAHP 26
zf-CCCH_2 pfam14608
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ...
224-243 1.38e-03

RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.


Pssm-ID: 464217  Cd Length: 19  Bit Score: 36.72  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|
gi 255652953  224 CRFFmkGNCTWGMNCRFIHP 243
Cdd:pfam14608   2 CRFG--GNCTFGPKCPFSHP 19
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
221-243 2.98e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 36.02  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|....
gi 255652953  221 RPTCRFFMK-GNCTWGMNCRFIHP 243
Cdd:pfam00642   3 TELCRFFLRtGYCKYGDRCKFAHG 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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