NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|33285015|ref|NP_653199|]
View 

leucine-rich repeat-containing protein 28 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 2.28e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 2.28e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  38 EGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPl 197
Cdd:COG4886 167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                       170       180
                ....*....|....*....|....
gi 33285015 198 DLGRSRELQYVYVDNNiHLKGLPS 221
Cdd:COG4886 245 ELGNLTNLEELDLSNN-QLTDLPP 267
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 2.28e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 2.28e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  38 EGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPl 197
Cdd:COG4886 167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                       170       180
                ....*....|....*....|....
gi 33285015 198 DLGRSRELQYVYVDNNiHLKGLPS 221
Cdd:COG4886 245 ELGNLTNLEELDLSNN-QLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-306 4.21e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.74  E-value: 4.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   46 LYMKRNSLTSLPENLAQklpNLVELYLHSNNIVVVPEAIGSLVklQCLDLSDNALeIVCPEigrlralrhlrlannqlqF 125
Cdd:PRK15370 204 LILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTI--QEMELSINRI-TELPE------------------R 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  126 LPpevgdlKELQTLDISTNRLLTLPERLHMclSLQYLTVDRNRLWYVPRHlcqLPS-LNELSMAGNRLAFLPLDLgrSRE 204
Cdd:PRK15370 260 LP------SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAH---LPSgITHLNVQSNSLTALPETL--PPG 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  205 LQYVYVDNNIhLKGLPSYLynkvigcsgcgaPiqvSEVKLLSFSSGQRTVF---LPAEVKAIGTEHDHVLPLQE---LAM 278
Cdd:PRK15370 327 LKTLEAGENA-LTSLPASL------------P---PELQVLDVSKNQITVLpetLPPTITTLDVSRNALTNLPEnlpAAL 390

                        250       260
                 ....*....|....*....|....*...
gi 33285015  279 RGLYHTYHSLLKdlnflSPISLPRSLLE 306
Cdd:PRK15370 391 QIMQASRNNLVR-----LPESLPHFRGE 413
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-190 1.60e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  38 EGLQYLERLYMKRNSLTSLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpeigrlralrhlr 117
Cdd:cd21340  43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP---------------- 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33285015 118 lANNQLQFLPPEVGDLKE-LQTLDISTNRLLTLpERLHMCLSLQYLTVDRNRLW---YVPRHLCQLPSLNELSMAGN 190
Cdd:cd21340 104 -PGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
43-100 1.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 33285015    43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 2.28e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 2.28e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  38 EGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPl 197
Cdd:COG4886 167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                       170       180
                ....*....|....*....|....
gi 33285015 198 DLGRSRELQYVYVDNNiHLKGLPS 221
Cdd:COG4886 245 ELGNLTNLEELDLSNN-QLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-169 3.59e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 3.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVK 89
Cdd:COG4886 131 ELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTN 206

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  90 LQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPpEVGDLKELQTLDISTNRLLTLPERLHMClSLQYLTVDRNRL 169
Cdd:COG4886 207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLT-NLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-306 4.21e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.74  E-value: 4.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   46 LYMKRNSLTSLPENLAQklpNLVELYLHSNNIVVVPEAIGSLVklQCLDLSDNALeIVCPEigrlralrhlrlannqlqF 125
Cdd:PRK15370 204 LILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTI--QEMELSINRI-TELPE------------------R 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  126 LPpevgdlKELQTLDISTNRLLTLPERLHMclSLQYLTVDRNRLWYVPRHlcqLPS-LNELSMAGNRLAFLPLDLgrSRE 204
Cdd:PRK15370 260 LP------SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAH---LPSgITHLNVQSNSLTALPETL--PPG 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  205 LQYVYVDNNIhLKGLPSYLynkvigcsgcgaPiqvSEVKLLSFSSGQRTVF---LPAEVKAIGTEHDHVLPLQE---LAM 278
Cdd:PRK15370 327 LKTLEAGENA-LTSLPASL------------P---PELQVLDVSKNQITVLpetLPPTITTLDVSRNALTNLPEnlpAAL 390

                        250       260
                 ....*....|....*....|....*...
gi 33285015  279 RGLYHTYHSLLKdlnflSPISLPRSLLE 306
Cdd:PRK15370 391 QIMQASRNNLVR-----LPESLPHFRGE 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-149 1.44e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVK 89
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEEL---GNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLTN 229

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  90 LQCLDLSDNALEIVcPEIGRLRALRHLRLANNQLQFLPPEvGDLKELQTLDISTNRLLTL 149
Cdd:COG4886 230 LETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL 287
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-223 2.83e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 2.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015    3 SELC------KTISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-YLERLYMKRNSLTSLPENlaqkLPNLVE-LYLHS 74
Cdd:PRK15370 181 TELRlkilglTTIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   75 NNIVVVPEAIGSlvKLQCLDLSDNALEIVcPEiGRLRALRHLRLANNQLQFLPPEVGdlKELQTLDISTNRLLTLPERLH 154
Cdd:PRK15370 251 NRITELPERLPS--ALQSLDLFHNKISCL-PE-NLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33285015  155 MclSLQYLTVDRNRLWYVPRHLCqlPSLNELSMAGNRLAFLPLDLGRSreLQYVYVDNNIhLKGLPSYL 223
Cdd:PRK15370 325 P--GLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPT--ITTLDVSRNA-LTNLPENL 386
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
11-176 8.74e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 8.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   11 VARLEKHKNLFLNYRNLHHFPLELLKD---EGLQYLErlyMKRNSLTSLPENLAQklpNLVELYLHSNNIVVVPEAIGsl 87
Cdd:PRK15370 253 ITELPERLPSALQSLDLFHNKISCLPEnlpEELRYLS---VYDNSIRTLPAHLPS---GITHLNVQSNSLTALPETLP-- 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   88 VKLQCLDLSDNAL----EIVCPEIgrlralRHLRLANNQLQFLPPEVGdlKELQTLDISTNRLLTLPERLHMclSLQYLT 163
Cdd:PRK15370 325 PGLKTLEAGENALtslpASLPPEL------QVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQ 394

                        170
                 ....*....|...
gi 33285015  164 VDRNRLWYVPRHL 176
Cdd:PRK15370 395 ASRNNLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-225 3.66e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 3.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   39 GLQYLERLYMKRNSLT-SLPENLAQKLPNLVELYLhSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCP-EIGRLRALRHL 116
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNL-SNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPnDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  117 RLANNQLQ-FLPPEVGDLKELQTLDISTNRLL-TLPERLHMCLSLQYLTVDRNRL-WYVPRHLCQLPSLNELSMAGNRLA 193
Cdd:PLN00113 170 DLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLsGEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190
                 ....*....|....*....|....*....|...
gi 33285015  194 F-LPLDLGRSRELQYVYVDNNIHLKGLPSYLYN 225
Cdd:PLN00113 250 GpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-221 7.46e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 7.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   12 ARLEKHKNL---FLNYRNLH-HFPLELLKDEGLQYLERLYmkrNSLT-SLPENLAQkLPNLVELYLHSNNIV-VVPEAIG 85
Cdd:PLN00113 206 RELGQMKSLkwiYLGYNNLSgEIPYEIGGLTSLNHLDLVY---NNLTgPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   86 SLVKLQCLDLSDNALEIVCPE--IGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLL-TLPERLHMCLSLQYL 162
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPElvIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVL 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33285015  163 TVDRNRL-WYVPRHLCQLPSLNELSMAGNRL-AFLPLDLGRSRELQYVYVDNNiHLKG-LPS 221
Cdd:PLN00113 362 DLSTNNLtGEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDN-SFSGeLPS 422
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-151 1.29e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 1.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTSLPEnLAQkLPNLVELYLHSNNIVVVPEaIGSLVK 89
Cdd:COG4886 200 PLGNLTNLEELDLSGNQLTDLPEPL---ANLTNLETLDLSNNQLTDLPE-LGN-LTNLEELDLSNNQLTDLPP-LANLTN 273

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33285015  90 LQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPE 151
Cdd:COG4886 274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-225 2.46e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 2.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  74 SNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLperl 153
Cdd:COG4886  36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN---- 111

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33285015 154 hmCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNiHLKGLPSYLYN 225
Cdd:COG4886 112 --LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN-QLTDLPEELGN 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-190 1.60e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  38 EGLQYLERLYMKRNSLTSLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpeigrlralrhlr 117
Cdd:cd21340  43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP---------------- 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33285015 118 lANNQLQFLPPEVGDLKE-LQTLDISTNRLLTLpERLHMCLSLQYLTVDRNRLW---YVPRHLCQLPSLNELSMAGN 190
Cdd:cd21340 104 -PGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-220 1.68e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.16  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   43 LERLYMKRNSLTSLPenlaQKLPNLVELYLHSNNIVVVPEAIGSLVKL-----------------QCLDLSDNALEIVcP 105
Cdd:PRK15387 244 LRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlppglQELSVSDNQLASL-P 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  106 EIgrLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHmclslqyltvdrnRLWYVPRHLCQLPS---- 181
Cdd:PRK15387 319 AL--PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELY-------------KLWAYNNRLTSLPAlpsg 383

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 33285015  182 LNELSMAGNRLAFLPLdlgRSRELQYVYVDNNiHLKGLP 220
Cdd:PRK15387 384 LKELIVSGNRLTSLPV---LPSELKELMVSGN-RLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
43-100 1.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 33285015    43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-193 1.10e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   43 LERLYMKRNSLTSLPenlaqKLPN-LVELYLHSNNIVVVPEAIGSLvklQCLDLSDNALEIVcPEIgrLRALRHLRLANN 121
Cdd:PRK15387 304 LQELSVSDNQLASLP-----ALPSeLCKLWAYNNQLTSLPTLPSGL---QELSVSDNQLASL-PTL--PSELYKLWAYNN 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  122 QLQFLPPEVGDLKEL-----------------QTLDISTNRLLTLPERLHMCLSLqylTVDRNRLWYVPRHLCQLPSLNE 184
Cdd:PRK15387 373 RLTSLPALPSGLKELivsgnrltslpvlpselKELMVSGNRLTSLPMLPSGLLSL---SVYRNQLTRLPESLIHLSSETT 449


                 ....*....
gi 33285015  185 LSMAGNRLA 193
Cdd:PRK15387 450 VNLEGNPLS 458
LRR_8 pfam13855
Leucine rich repeat;
18-77 1.47e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015    18 KNLFLNYRNLHHFPLELLKdeGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI 77
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFK--GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 125-200 8.19e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 8.19e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33285015  125 FLPPEVGDLKELQTLDISTNRLL-TLPERLHMCLSLQYLTVDRNRL-WYVPRHLCQLPSLNELSMAGNRLA-FLPLDLG 200
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
123-221 1.18e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  123 LQFLPPEvgdlkeLQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQL--------------PSLNELSMA 188
Cdd:PRK15387 237 LPALPPE------LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlpPGLQELSVS 310

                         90       100       110
                 ....*....|....*....|....*....|...
gi 33285015  189 GNRLAFLPldlGRSRELQYVYVDNNiHLKGLPS 221
Cdd:PRK15387 311 DNQLASLP---ALPSELCKLWAYNN-QLTSLPT 339
PLN03150 PLN03150
hypothetical protein; Provisional
 79-169 2.73e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   79 VVPEAIGSLVKLQCLDLSDNALEIVcpeigrlralrhlrlannqlqfLPPEVGDLKELQTLDISTNRLL-TLPERLHMCL 157
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRGN----------------------IPPSLGSITSLEVLDLSYNSFNgSIPESLGQLT 490

                         90
                 ....*....|..
gi 33285015  158 SLQYLTVDRNRL 169
Cdd:PLN03150 491 SLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-221 2.83e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015   43 LERLYMKRNSLT-SLPENLAQKlpNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNALEIVCPEigrlralrhlrlan 120
Cdd:PLN00113 454 LQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPD-------------- 517

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  121 nqlqflppEVGDLKELQTLDISTNRLLTlperlhmclslqyltvdrnrlwYVPRHLCQLPSLNELSMAGNRLAF-LPLDL 199
Cdd:PLN00113 518 --------ELSSCKKLVSLDLSHNQLSG----------------------QIPASFSEMPVLSQLDLSQNQLSGeIPKNL 567

                        170       180
                 ....*....|....*....|...
gi 33285015  200 GRSRELQYVYVDNNiHLKG-LPS 221
Cdd:PLN00113 568 GNVESLVQVNISHN-HLHGsLPS 589
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-192 4.29e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 4.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015  46 LYMKRNSLTSLpENLAQkLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEIVCPeIGRLRALRHLRLANNQLQF 125
Cdd:cd21340   7 LYLNDKNITKI-DNLSL-CKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33285015 126 LppE-VGDLKELQTLDISTNRL-----LTLPERLHMCL--SLQYLTVDRNRLWYVpRHLCQLPSLNELSMAGNRL 192
Cdd:cd21340  83 V--EgLENLTNLEELHIENQRLppgekLTFDPRSLAALsnSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQI 154
LRR_8 pfam13855
Leucine rich repeat;
65-146 5.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33285015    65 PNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSdnaleivcpeigrlralrhlrlaNNQLQFLPPEV-GDLKELQTLDIS 142
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLS-----------------------NNLLTTLSPGAfSGLPSLRYLDLS 57


                  ....
gi 33285015   143 TNRL 146
Cdd:pfam13855  58 GNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
25-98 5.25e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.44  E-value: 5.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33285015    25 RNLHHFPLellkdegLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI--VVVPEAIGSLVKLQCLDLSDN 98
Cdd:pfam14580  55 RKLDGFPL-------LRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLqeLGDLDPLASLKKLTFLSLLRN 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH