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Conserved domains on  [gi|21357749|ref|NP_651619|]
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beaten path VI, isoform A [Drosophila melanogaster]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 67-144 2.18e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20946:

Pssm-ID: 472250  Cd Length: 102  Bit Score: 45.61  E-value: 2.18e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21357749  67 NAATLSCQYDLEQAAlYAVRWYFGQEEFYRYVPREAKPTFVFAvaginvDLANSDATSVTLKGVTRELSGSYQCEVSE 144
Cdd:cd20946  15 QEVILSCKTPKKTSS-PRVEWKKLQRDVTFVVFQNNKIQGDYK------GRAEILGTNITIKNVTRSDSGKYRCEVSA 85
 
Name Accession Description Interval E-value
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 67-144 2.18e-06

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 45.61  E-value: 2.18e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21357749  67 NAATLSCQYDLEQAAlYAVRWYFGQEEFYRYVPREAKPTFVFAvaginvDLANSDATSVTLKGVTRELSGSYQCEVSE 144
Cdd:cd20946  15 QEVILSCKTPKKTSS-PRVEWKKLQRDVTFVVFQNNKIQGDYK------GRAEILGTNITIKNVTRSDSGKYRCEVSA 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 66-142 2.21e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357749    66 GNAATLSCQY-DLEQAALYAVRWYFGQ------EEFYRYVPREAKPTFVFAVAGiNVDLANSDAtSVTLKGVTRELSGSY 138
Cdd:pfam07686  11 GGSVTLPCTYsSSMSEASTSVYWYRQPpgkgptFLIAYYSNGSEEGVKKGRFSG-RGDPSNGDG-SLTIQNLTLSDSGTY 88


                  ....
gi 21357749   139 QCEV 142
Cdd:pfam07686  89 TCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 63-154 8.95e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 8.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357749     63 VLMGNAATLSCQYdlEQAALYAVRWYFGQEEFYRYVPReakptfvfavagINVDlANSDATSVTLKGVTRELSGSYQCEV 142
Cdd:smart00410   6 VKEGESVTLSCEA--SGSPPPEVTWYKQGGKLLAESGR------------FSVS-RSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|..
gi 21357749    143 SEDAPLFHTEIR 154
Cdd:smart00410  71 TNSSGSASSGTT 82
 
Name Accession Description Interval E-value
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 67-144 2.18e-06

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 45.61  E-value: 2.18e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21357749  67 NAATLSCQYDLEQAAlYAVRWYFGQEEFYRYVPREAKPTFVFAvaginvDLANSDATSVTLKGVTRELSGSYQCEVSE 144
Cdd:cd20946  15 QEVILSCKTPKKTSS-PRVEWKKLQRDVTFVVFQNNKIQGDYK------GRAEILGTNITIKNVTRSDSGKYRCEVSA 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 66-142 2.21e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357749    66 GNAATLSCQY-DLEQAALYAVRWYFGQ------EEFYRYVPREAKPTFVFAVAGiNVDLANSDAtSVTLKGVTRELSGSY 138
Cdd:pfam07686  11 GGSVTLPCTYsSSMSEASTSVYWYRQPpgkgptFLIAYYSNGSEEGVKKGRFSG-RGDPSNGDG-SLTIQNLTLSDSGTY 88


                  ....
gi 21357749   139 QCEV 142
Cdd:pfam07686  89 TCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 63-154 8.95e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 8.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357749     63 VLMGNAATLSCQYdlEQAALYAVRWYFGQEEFYRYVPReakptfvfavagINVDlANSDATSVTLKGVTRELSGSYQCEV 142
Cdd:smart00410   6 VKEGESVTLSCEA--SGSPPPEVTWYKQGGKLLAESGR------------FSVS-RSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|..
gi 21357749    143 SEDAPLFHTEIR 154
Cdd:smart00410  71 TNSSGSASSGTT 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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