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Conserved domains on  [gi|281361372|ref|NP_649823|]
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uncharacterized protein Dmel_CG8159 [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12222075)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-78 1.52e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 214871  Cd Length: 73  Bit Score: 59.45  E-value: 1.52e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281361372     5 VCRVCASSTDNSKSLkLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFRDRCLRSQKIFEE 78
Cdd:smart00868   1 VCRLCLSESENLVSI-FDESSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-322 2.39e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361372 197 CGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSSGELKG-------HQVMHTGDRKFQCRY--CDRTYVNYSGRLRHE 267
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHI 408

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281361372 268 RTHTNDRP--FICAQCGKSFTNSYILKNHMLIHTGERLFRCElCHRSFARPTHLKTH 322
Cdd:COG5048  409 ITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-78 1.52e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 59.45  E-value: 1.52e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281361372     5 VCRVCASSTDNSKSLkLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFRDRCLRSQKIFEE 78
Cdd:smart00868   1 VCRLCLSESENLVSI-FDESSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-79 4.11e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 58.62  E-value: 4.11e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281361372    5 VCRVCASSTDNSKSLKLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFRDRCLRSQKIFEES 79
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-322 2.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361372 197 CGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSSGELKG-------HQVMHTGDRKFQCRY--CDRTYVNYSGRLRHE 267
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHI 408

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281361372 268 RTHTNDRP--FICAQCGKSFTNSYILKNHMLIHTGERLFRCElCHRSFARPTHLKTH 322
Cdd:COG5048  409 ITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 274-336 2.03e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 2.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281361372 274 RPFiCAQCGKSFTNSYILknhmLIHTGERLFRCELCHRSFARPTHLKTHFrSNTHKHNLEKSM 336
Cdd:cd20908    1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVHC-LQVHKETLTKVP 57
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-315 5.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.67e-04
                          10        20
                  ....*....|....*....|....*
gi 281361372  291 LKNHMLIHTGERLFRCELCHRSFAR 315
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-78 1.52e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 59.45  E-value: 1.52e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281361372     5 VCRVCASSTDNSKSLkLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFRDRCLRSQKIFEE 78
Cdd:smart00868   1 VCRLCLSESENLVSI-FDESSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-79 4.11e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 58.62  E-value: 4.11e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281361372    5 VCRVCASSTDNSKSLKLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISFRDRCLRSQKIFEES 79
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-322 2.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361372 197 CGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSSGELKG-------HQVMHTGDRKFQCRY--CDRTYVNYSGRLRHE 267
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHI 408

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 281361372 268 RTHTNDRP--FICAQCGKSFTNSYILKNHMLIHTGERLFRCElCHRSFARPTHLKTH 322
Cdd:COG5048  409 ITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 274-336 2.03e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 2.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281361372 274 RPFiCAQCGKSFTNSYILknhmLIHTGERLFRCELCHRSFARPTHLKTHFrSNTHKHNLEKSM 336
Cdd:cd20908    1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVHC-LQVHKETLTKVP 57
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-352 5.00e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 5.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361372 191 VFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCEL--CPARFLSSGELKGHQVMHTGDRKFQCRYCDRTYVNY-SGRLRHE 267
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361372 268 RTHTNDRPFICAQCGKSFTNSYILKNHMLIHTgerLFRCELCHR----SFARPTHLKTHFRSNTHKHNLEKSMADAGGVQ 343
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189


                 ....*....
gi 281361372 344 LSPSQSADQ 352
Cdd:COG5048  190 SNVSTSIPS 198
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-315 5.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.67e-04
                          10        20
                  ....*....|....*....|....*
gi 281361372  291 LKNHMLIHTGERLFRCELCHRSFAR 315
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 304-328 1.23e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.93  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|....*
gi 281361372  304 FRCELCHRSFARPTHLKTHFRSNTH 328
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
206-231 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 281361372  206 SFDRHLRKHSGIRPFQCELCPARFLS 231
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-287 2.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.52e-03
                          10        20
                  ....*....|....*....|...
gi 281361372  265 RHERTHTNDRPFICAQCGKSFTN 287
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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