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Conserved domains on  [gi|24644167|ref|NP_649524|]
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Tim17a2 [Drosophila melanogaster]

Protein Classification

Tim17/Tim22/Tim23/Pmp24 domain-containing protein( domain architecture ID 1013)

Tim17/Tim22/Tim23/Pmp24 domain-containing protein similar to Homo sapiens NADH:ubiquinone oxidoreductase subunit A11 and translocase of inner mitochondrial membrane 17B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM22 super family cl02381
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 2-129 2.38e-55

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member TIGR00980:

Pssm-ID: 470560  Cd Length: 170  Bit Score: 174.26  E-value: 2.38e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167     2 EYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRrgLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVS 81
Cdd:TIGR00980   3 EYTREPCPYRILDDFGGAFAMGTIGGSIFQAFKGFRNSPKGEK--LVGAMRAIKTRAPVLGGNFAVWGGLFSTIDCAVVA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 24644167    82 YRQREDSWNAIVSGAATGGILAARNGIRAMANSAFVGCLVLAMLEGAG 129
Cdd:TIGR00980  81 IRKKEDPWNSIISGFLTGAALAVRGGPRAMRGSAILGACILAVIEGVG 128
 
Name Accession Description Interval E-value
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 2-129 2.38e-55

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 174.26  E-value: 2.38e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167     2 EYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRrgLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVS 81
Cdd:TIGR00980   3 EYTREPCPYRILDDFGGAFAMGTIGGSIFQAFKGFRNSPKGEK--LVGAMRAIKTRAPVLGGNFAVWGGLFSTIDCAVVA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 24644167    82 YRQREDSWNAIVSGAATGGILAARNGIRAMANSAFVGCLVLAMLEGAG 129
Cdd:TIGR00980  81 IRKKEDPWNSIISGFLTGAALAVRGGPRAMRGSAILGACILAVIEGVG 128
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 1-132 3.10e-49

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 158.28  E-value: 3.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167    1 MEYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRrgLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMV 80
Cdd:PTZ00236   4 RDLSREPCPDRIIEDMGGAFSMGCIGGFIWHFLKGMRNSPKGER--FSGGFYLLRKRAPILGGNFAIWGGLFSTFDCTLQ 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24644167   81 SYRQREDSWNAIVSGAATGGILAARNGIRAMANSAFVGCLVLAMLEGAGAAV 132
Cdd:PTZ00236  82 YLRGKEDHWNAIASGFFTGGVLAIRGGWRSAVRNAIFGGILLGIIELVSIGM 133
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 12-118 1.78e-29

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 106.10  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167    12 IVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGL--RRGLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVSYRQREDSW 89
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNRPPPLtaKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPW 80

                          90       100
                  ....*....|....*....|....*....
gi 24644167    90 NAIVSGAATGGILaaRNGIRAMANSAFVG 118
Cdd:pfam02466  81 NSIAAGALTGALL--RGGPRAAAVGGAVG 107
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 5-144 2.85e-14

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 68.34  E-value: 2.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167   5 RQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGlrRGLHGGIESVRLRTPAIAGSFA-IWGATFSTVDCVMVSYR 83
Cdd:COG5596  27 RDPCPLEKLADFMKAFSYSCIGKSALSGLKGFRLGGPS--GGFSSSLAYGTGLVHLLGLNFGgVWGGLFSTIDCTPFRLQ 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644167  84 QREDSWNAIVSGAATGGILAARNGIRAMANS---AFVGCLVLAMLEGAGAAVATIYASDGGVKA 144
Cdd:COG5596 105 LKEQLNNAGKRGFFTGKNLGVLGLIYAGINSiitALRAKHDIANAIAAGAFTGAALASSAGPQA 168
 
Name Accession Description Interval E-value
3a0801so1tim17 TIGR00980
mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, ...
 2-129 2.38e-55

mitochondrial import inner membrane translocase subunit tim17; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130053  Cd Length: 170  Bit Score: 174.26  E-value: 2.38e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167     2 EYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRrgLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVS 81
Cdd:TIGR00980   3 EYTREPCPYRILDDFGGAFAMGTIGGSIFQAFKGFRNSPKGEK--LVGAMRAIKTRAPVLGGNFAVWGGLFSTIDCAVVA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 24644167    82 YRQREDSWNAIVSGAATGGILAARNGIRAMANSAFVGCLVLAMLEGAG 129
Cdd:TIGR00980  81 IRKKEDPWNSIISGFLTGAALAVRGGPRAMRGSAILGACILAVIEGVG 128
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 1-132 3.10e-49

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 158.28  E-value: 3.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167    1 MEYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRrgLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMV 80
Cdd:PTZ00236   4 RDLSREPCPDRIIEDMGGAFSMGCIGGFIWHFLKGMRNSPKGER--FSGGFYLLRKRAPILGGNFAIWGGLFSTFDCTLQ 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24644167   81 SYRQREDSWNAIVSGAATGGILAARNGIRAMANSAFVGCLVLAMLEGAGAAV 132
Cdd:PTZ00236  82 YLRGKEDHWNAIASGFFTGGVLAIRGGWRSAVRNAIFGGILLGIIELVSIGM 133
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 12-118 1.78e-29

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 106.10  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167    12 IVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGL--RRGLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVSYRQREDSW 89
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNRPPPLtaKLRLRGALNAVGKRGPSLGNNFAVFGGLYSGIECGLEKYRGKEDPW 80

                          90       100
                  ....*....|....*....|....*....
gi 24644167    90 NAIVSGAATGGILaaRNGIRAMANSAFVG 118
Cdd:pfam02466  81 NSIAAGALTGALL--RGGPRAAAVGGAVG 107
TIM22 COG5596
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 5-144 2.85e-14

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227883  Cd Length: 191  Bit Score: 68.34  E-value: 2.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167   5 RQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGlrRGLHGGIESVRLRTPAIAGSFA-IWGATFSTVDCVMVSYR 83
Cdd:COG5596  27 RDPCPLEKLADFMKAFSYSCIGKSALSGLKGFRLGGPS--GGFSSSLAYGTGLVHLLGLNFGgVWGGLFSTIDCTPFRLQ 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644167  84 QREDSWNAIVSGAATGGILAARNGIRAMANS---AFVGCLVLAMLEGAGAAVATIYASDGGVKA 144
Cdd:COG5596 105 LKEQLNNAGKRGFFTGKNLGVLGLIYAGINSiitALRAKHDIANAIAAGAFTGAALASSAGPQA 168
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 17-118 6.95e-08

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 50.22  E-value: 6.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644167    17 GCAFMMGTMGGSLFQYLKGFRNAPSG--LRRGLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVSYRQREDSWNAIVS 94
Cdd:TIGR00983  39 GTCYLTGLAIGALNGLRLGLKETQSMpwTKLRLNQILNMVTRRGPFWGNTLGILALVYNGINSIIEATRGKHDDFNSVAA 118

                          90       100
                  ....*....|....*....|....
gi 24644167    95 GAATGGILAARNGIRAMANSAFVG 118
Cdd:TIGR00983 119 GALTGALYKSTRGLRGMARSGALG 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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