NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24661892|ref|NP_648354|]
View 

uncharacterized protein Dmel_CG6749 [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
199-452 2.27e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 199 LILNDNQLIQLDVNAFRGLHGLLELQLSGNrlssiglETFQPLAQLRKLNLSQNALDALrPNVFGAVQNfvlhLQQLDLS 278
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTN----LKELDLS 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 279 GNRIRLLfDNQFRVLARLQMLDVSRNSIASLsPAHFVGLGSLRKLYLQYNAILEIkPATFAALLNLDTLDLSYNNLEFLE 358
Cdd:COG4886 145 NNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 359 EQIfggNTLPRMRRLNLNGNRMKHLHPLAfsSLPFLEYLKLGHNELKSLDVrmFAPMRRLQKLHLGHNLLEEINLDVLES 438
Cdd:COG4886 222 EPL---ANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELEL 294

                       250
                ....*....|....
gi 24661892 439 LSSVQEILVDNNRL 452
Cdd:COG4886 295 LLGLNSLLLLLLLL 308
LRR_8 super family cl38440
Leucine rich repeat;
104-164 8.72e-04

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 8.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661892   104 PNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL 164
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
199-452 2.27e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 199 LILNDNQLIQLDVNAFRGLHGLLELQLSGNrlssiglETFQPLAQLRKLNLSQNALDALrPNVFGAVQNfvlhLQQLDLS 278
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTN----LKELDLS 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 279 GNRIRLLfDNQFRVLARLQMLDVSRNSIASLsPAHFVGLGSLRKLYLQYNAILEIkPATFAALLNLDTLDLSYNNLEFLE 358
Cdd:COG4886 145 NNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 359 EQIfggNTLPRMRRLNLNGNRMKHLHPLAfsSLPFLEYLKLGHNELKSLDVrmFAPMRRLQKLHLGHNLLEEINLDVLES 438
Cdd:COG4886 222 EPL---ANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELEL 294

                       250
                ....*....|....
gi 24661892 439 LSSVQEILVDNNRL 452
Cdd:COG4886 295 LLGLNSLLLLLLLL 308
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-428 3.15e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 3.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  150 NLRKLIYANFSHNALKQcDLPHMPL-LNRLELGHNRLVNAT----FGVC--PQLQELILNDNQLIQlDVNAFRGLHG-LL 221
Cdd:PLN00113 282 SLQKLISLDLSDNSLSG-EIPELVIqLQNLEILHLFSNNFTgkipVALTslPRLQVLQLWSNKFSG-EIPKNLGKHNnLT 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  222 ELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFV-LHLQQ-------------------LDLSGNR 281
Cdd:PLN00113 360 VLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRrVRLQDnsfsgelpseftklplvyfLDISNNN 439

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  282 IRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFvGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNL--EFLEE 359
Cdd:PLN00113 440 LQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsgEIPDE 518

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24661892  360 QifggNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLL 428
Cdd:PLN00113 519 L----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
194-254 6.20e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 6.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661892   194 PQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNAL 254
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 190-384 4.39e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 4.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 190 FGVCPQLQELILNDNQLIQLDvnAFRGLHGLLELQLSGNRLSSIgletfqplaqlrklnlsQNaLDALRpnvfgavqnfv 269
Cdd:cd21340  20 LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-----------------EN-LENLV----------- 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 270 lHLQQLDLSGNRIR-------------LLFDNQfrVLARLQMLDVSRNSIASLSPahfvglgSLRKLYLQYNAILEIKPa 336
Cdd:cd21340  69 -NLKKLYLGGNRISvveglenltnleeLHIENQ--RLPPGEKLTFDPRSLAALSN-------SLRVLNISGNNIDSLEP- 137

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24661892 337 tFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLH 384
Cdd:cd21340 138 -LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
104-164 8.72e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 8.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661892   104 PNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL 164
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-162 5.86e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.86e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24661892 100 FSILPNLRQLNLSGCGLVDIRGnhFAPESALQRIDFSHNQMELLDR--DFFGNLRKLIYANFSHN 162
Cdd:cd21340 116 AALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
199-452 2.27e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 199 LILNDNQLIQLDVNAFRGLHGLLELQLSGNrlssiglETFQPLAQLRKLNLSQNALDALrPNVFGAVQNfvlhLQQLDLS 278
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTN----LKELDLS 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 279 GNRIRLLfDNQFRVLARLQMLDVSRNSIASLsPAHFVGLGSLRKLYLQYNAILEIkPATFAALLNLDTLDLSYNNLEFLE 358
Cdd:COG4886 145 NNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 359 EQIfggNTLPRMRRLNLNGNRMKHLHPLAfsSLPFLEYLKLGHNELKSLDVrmFAPMRRLQKLHLGHNLLEEINLDVLES 438
Cdd:COG4886 222 EPL---ANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELEL 294

                       250
                ....*....|....
gi 24661892 439 LSSVQEILVDNNRL 452
Cdd:COG4886 295 LLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-460 4.81e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 4.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  43 ASLQDLVDLGAENWHTLAIRNVQTELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCglvdirgN 122
Cdd:COG4886  35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------E 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 123 HFAPESALQRIDFSHNQMELLDrDFFGNLRKLIYANFSHNALKqcDLPhmpllnrlelghnrlvnATFGVCPQLQELILN 202
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLT--DLP-----------------EPLGNLTNLKSLDLS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 203 DNQLIQLDvNAFRGLHGLLELQLSGNRLSSIGlETFQPLAQLRKLNLSQNALDALrPNVFGAVQNfvlhLQQLDLSGNRI 282
Cdd:COG4886 168 NNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTN----LETLDLSNNQL 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 283 RLLFDnqFRVLARLQMLDVSRNSIASLSPAhfVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIF 362
Cdd:COG4886 241 TDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 363 GGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSV 442
Cdd:COG4886 317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396

                       410
                ....*....|....*...
gi 24661892 443 QEILVDNNRLTFLAKVNV 460
Cdd:COG4886 397 TAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-428 3.15e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 3.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  150 NLRKLIYANFSHNALKQcDLPHMPL-LNRLELGHNRLVNAT----FGVC--PQLQELILNDNQLIQlDVNAFRGLHG-LL 221
Cdd:PLN00113 282 SLQKLISLDLSDNSLSG-EIPELVIqLQNLEILHLFSNNFTgkipVALTslPRLQVLQLWSNKFSG-EIPKNLGKHNnLT 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  222 ELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFV-LHLQQ-------------------LDLSGNR 281
Cdd:PLN00113 360 VLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRrVRLQDnsfsgelpseftklplvyfLDISNNN 439

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  282 IRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFvGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNL--EFLEE 359
Cdd:PLN00113 440 LQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsgEIPDE 518

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24661892  360 QifggNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLL 428
Cdd:PLN00113 519 L----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
177-508 1.91e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 66.64  E-value: 1.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  177 RLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNafrgLHG-LLELQLSGNRLSSIGlETFQPLAQLrkLNLSQNALD 255
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN----LQGnIKTLYANSNQLTSIP-ATLPDTIQE--MELSINRIT 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  256 ALRPNVFGAvqnfvlhLQQLDLSGNRIRLLFDNqfrVLARLQMLDVSRNSIASLsPAHFVglGSLRKLYLQYNAiLEIKP 335
Cdd:PRK15370 255 ELPERLPSA-------LQSLDLFHNKISCLPEN---LPEELRYLSVYDNSIRTL-PAHLP--SGITHLNVQSNS-LTALP 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  336 ATFAalLNLDTLDLSYNNLEFLEEQIfggntLPRMRRLNLNGNRMKHLhPlafSSLPfleylklghnelksldvrmfaPM 415
Cdd:PRK15370 321 ETLP--PGLKTLEAGENALTSLPASL-----PPELQVLDVSKNQITVL-P---ETLP---------------------PT 368

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  416 rrLQKLHLGHNLLeeINLDvlESLSSVQEIL-VDNNRLTFLAKVNVSF----PNLKRVAIEGNPWQCPCFVKLQHWLATR 490
Cdd:PRK15370 369 --ITTLDVSRNAL--TNLP--ENLPAALQIMqASRNNLVRLPESLPHFrgegPQPTRIIVEYNPFSERTIQNMQRLMSSV 442

                        330
                 ....*....|....*...
gi 24661892  491 DvvylrdntgyYKGERPL 508
Cdd:PRK15370 443 G----------YQGPRVL 450
LRR_8 pfam13855
Leucine rich repeat;
194-254 6.20e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 6.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661892   194 PQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNAL 254
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
368-428 1.83e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.83e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661892   368 PRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLL 428
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
271-330 1.39e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.39e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892   271 HLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAI 330
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
319-380 2.92e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24661892   319 SLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGntLPRMRRLNLNGNRM 380
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 79-428 4.31e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892   79 LANLLDLDL-----TGAAPINVHTngFSilpNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRK 153
Cdd:PLN00113 139 IPNLETLDLsnnmlSGEIPNDIGS--FS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  154 LIYANFSHNALK---QCDLPHMPLLNRLELGHNRL---VNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSG 227
Cdd:PLN00113 214 LKWIYLGYNNLSgeiPYEIGGLTSLNHLDLVYNNLtgpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSD 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  228 NRLSS------IGLETFQ------------------PLAQLRKLNLSQNALDALRPNVFGAVQNF-VLHLQQLDLSGNRI 282
Cdd:PLN00113 294 NSLSGeipelvIQLQNLEilhlfsnnftgkipvaltSLPRLQVLQLWSNKFSGEIPKNLGKHNNLtVLDLSTNNLTGEIP 373

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  283 RLLFDNqfrvlARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNN--------- 353
Cdd:PLN00113 374 EGLCSS-----GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNlqgrinsrk 448

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  354 -----LEFLE---EQIFGGntLP------RMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQ 419
Cdd:PLN00113 449 wdmpsLQMLSlarNKFFGG--LPdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLV 526


                 ....*....
gi 24661892  420 KLHLGHNLL 428
Cdd:PLN00113 527 SLDLSHNQL 535
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 190-384 4.39e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 4.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 190 FGVCPQLQELILNDNQLIQLDvnAFRGLHGLLELQLSGNRLSSIgletfqplaqlrklnlsQNaLDALRpnvfgavqnfv 269
Cdd:cd21340  20 LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-----------------EN-LENLV----------- 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 270 lHLQQLDLSGNRIR-------------LLFDNQfrVLARLQMLDVSRNSIASLSPahfvglgSLRKLYLQYNAILEIKPa 336
Cdd:cd21340  69 -NLKKLYLGGNRISvveglenltnleeLHIENQ--RLPPGEKLTFDPRSLAALSN-------SLRVLNISGNNIDSLEP- 137

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24661892 337 tFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLH 384
Cdd:cd21340 138 -LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 285-426 5.87e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 5.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 285 LFDNQFRV------LARLQMLDVSRNSIASLSpaHFVGLGSLRKLYLQYNAILEIKpaTFAALLNLDTLDLSYNNLEFLE 358
Cdd:cd21340  31 LYDNKITKienlefLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGE 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24661892 359 EQIFGGNTL----PRMRRLNLNGNRMKHLHPLAfsSLPFLEYLKLGHNELKSLD--VRMFAPMRRLQKLHLGHN 426
Cdd:cd21340 107 KLTFDPRSLaalsNSLRVLNISGNNIDSLEPLA--PLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
295-354 6.46e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 6.46e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892   295 RLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNL 354
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
343-404 1.39e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.39e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24661892   343 NLDTLDLSYNNLEFLEEQIFGGntLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNEL 404
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 223-453 5.09e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 5.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  223 LQLSGNRLS-SIGLETFQPLAQLRKLNLSQNALDALRPNvfgavqNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDV 301
Cdd:PLN00113  98 INLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPR------GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  302 SRN--------SIASLSPAHFVGLGS----------------LRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFL 357
Cdd:PLN00113 172 GGNvlvgkipnSLTNLTSLEFLTLASnqlvgqiprelgqmksLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGP 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  358 EEQIFGgnTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLE 437
Cdd:PLN00113 252 IPSSLG--NLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT 329

                        250
                 ....*....|....*.
gi 24661892  438 SLSSVQEILVDNNRLT 453
Cdd:PLN00113 330 SLPRLQVLQLWSNKFS 345
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 304-474 4.36e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 4.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 304 NSIASLSpahfvGLGSLRKL---YLQYNAILEIKPatFAALLNLDTLDLSYNNLEFLEeqifGGNTLPRMRRLNLNGNRM 380
Cdd:cd21340  34 NKITKIE-----NLEFLTNLthlYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE----GLENLTNLEELHIENQRL 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 381 KHLHPLAF------SSLPFLEYLKLGHNELKSLDvrMFAPMRRLQKLHLGHNLLEEINlDVLESLSsvqeilvdnnrltf 454
Cdd:cd21340 103 PPGEKLTFdprslaALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLE-ELLDLLS-------------- 165

                       170       180
                ....*....|....*....|
gi 24661892 455 lakvnvSFPNLKRVAIEGNP 474
Cdd:cd21340 166 ------SWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
219-282 5.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24661892   219 GLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFgavQNFVlHLQQLDLSGNRI 282
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
394-452 6.71e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24661892   394 LEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL 452
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 172-373 8.37e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 8.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  172 MPLLNRLELGHNRL---VNATFGVCPQLQELILNDNQLIQLDVNAFRGlHGLLELQLSGNRLSSIGLETFQPLAQLRKLN 248
Cdd:PLN00113 427 LPLVYFLDISNNNLqgrINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLK 505

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  249 LSQNALDALRPNVFGAVQNFVlhlqQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYN 328
Cdd:PLN00113 506 LSENKLSGEIPDELSSCKKLV----SLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 24661892  329 AILEIKPATfAALLNLDTLDLSYNNLefleeqIFGGNT---LPRMRRL 373
Cdd:PLN00113 582 HLHGSLPST-GAFLAINASAVAGNID------LCGGDTtsgLPPCKRV 622
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 194-455 4.08e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 4.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 194 PQLQELILNDNQLIQLDVN------AFRGLHGLLELQLSGNRLSSIGLETFQPLAQ---LRKLNLSQNAL-DALRPNVFG 263
Cdd:cd00116  51 PSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgDRGLRLLAK 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 264 AVQNFVLHLQQLDLSGNRI--RLLFD--NQFRVLARLQMLDVSRNSIaslspahfvglgslrklylQYNAILEIKPAtFA 339
Cdd:cd00116 131 GLKDLPPALEKLVLGRNRLegASCEAlaKALRANRDLKELNLANNGI-------------------GDAGIRALAEG-LK 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 340 ALLNLDTLDLSYNNLEFLEEQIFGGntlprmrrlnlngnrmkhlhplAFSSLPFLEYLKLGHNELKSLDVR-----MFAP 414
Cdd:cd00116 191 ANCNLEVLDLNNNGLTDEGASALAE----------------------TLASLKSLEVLNLGDNNLTDAGAAalasaLLSP 248

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 24661892 415 MRRLQKLHLGHNlleEINLDVLESLSSVQEilvDNNRLTFL 455
Cdd:cd00116 249 NISLLTLSLSCN---DITDDGAKDLAEVLA---EKESLLEL 283
PLN03150 PLN03150
hypothetical protein; Provisional
 247-342 6.77e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.04  E-value: 6.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  247 LNLSQNALDALRPNVFGAVQnfvlHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQ 326
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLR----HLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498

                         90
                 ....*....|....*.
gi 24661892  327 YNAILEIKPATFAALL 342
Cdd:PLN03150 499 GNSLSGRVPAALGGRL 514
LRR_8 pfam13855
Leucine rich repeat;
173-230 9.67e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661892   173 PLLNRLELGHNRLVN---ATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRL 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSlddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 161-282 1.05e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 161 HNAL-KQCDLPHMPLLNRLELGHNRL-VNATFGVCPQLQELILNDNQL-----IQLDVNAFRGL-HGLLELQLSGNRLSS 232
Cdd:cd21340  55 NNQIeKIENLENLVNLKKLYLGGNRIsVVEGLENLTNLEELHIENQRLppgekLTFDPRSLAALsNSLRVLNISGNNIDS 134

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24661892 233 igLETFQPLAQLRKLNLSQNALDALRpNVFGAVQNFVlHLQQLDLSGNRI 282
Cdd:cd21340 135 --LEPLAPLRNLEQLDASNNQISDLE-ELLDLLSSWP-SLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
104-164 8.72e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 8.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661892   104 PNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL 164
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 275-392 1.70e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  275 LDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIaslspahfvglgslrklylqYNAIleikPATFAALLNLDTLDLSYNNL 354
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSI--------------------RGNI----PPSLGSITSLEVLDLSYNSF 478

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 24661892  355 EFLEEQIFGgnTLPRMRRLNLNGNRMKHLHPLAFSSLP 392
Cdd:PLN03150 479 NGSIPESLG--QLTSLRILNLNGNSLSGRVPAALGGRL 514
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 194-360 1.84e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 194 PQLQELILNDNQLiqldvnAFRGLHGLLE----------LQLSGNRLSSIGL----ETFQPLAQLRKLNLSQNALDALrp 259
Cdd:COG5238 236 KSLTTLDLSNNQI------GDEGVIALAEalknnttvetLYLSGNQIGAEGAialaKALQGNTTLTSLDLSVNRIGDE-- 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892 260 nvfGAVqNFVLHLQQ------LDLSGNRI-----RLLFDNqFRVLARLQMLDVSRNSI----ASLSPAHFVGLGSLRKLY 324
Cdd:COG5238 308 ---GAI-ALAEGLQGnktlhtLNLAYNGIgaqgaIALAKA-LQENTTLHSLDLSDNQIgdegAIALAKYLEGNTTLRELN 382

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 24661892 325 LQYNAILEIKPATFAALLN---LDTLDLSYNNLEFLEEQ 360
Cdd:COG5238 383 LGKNNIGKQGAEALIDALQtnrLHTLILDGNLIGAEAQQ 421
PLN03150 PLN03150
hypothetical protein; Provisional
 362-428 2.14e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 2.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892  362 FGGNTLPRMRRL---NLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLL 428
Cdd:PLN03150 433 FIPNDISKLRHLqsiNLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
LRR_9 pfam14580
Leucine-rich repeat;
369-474 2.46e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892   369 RMRRLNLNGNRMKHLHPLAfSSLPFLEYLKLGHNELKSLDvrMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVD 448
Cdd:pfam14580  20 RERELDLRGYKIPIIENLG-ATLDQFDTIDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILT 96

                          90       100
                  ....*....|....*....|....*...
gi 24661892   449 NNRLTFLAKVN--VSFPNLKRVAIEGNP 474
Cdd:pfam14580  97 NNNLQELGDLDplASLKKLTFLSLLRNP 124
LRR_9 pfam14580
Leucine-rich repeat;
339-426 5.59e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.21  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661892   339 AALLNLDTLDLSYNNLEFLEeqifGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSL-DVRMFAPMRR 417
Cdd:pfam14580  39 ATLDQFDTIDFSDNEIRKLD----GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgDLDPLASLKK 114


                  ....*....
gi 24661892   418 LQKLHLGHN 426
Cdd:pfam14580 115 LTFLSLLRN 123
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-162 5.86e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.86e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24661892 100 FSILPNLRQLNLSGCGLVDIRGnhFAPESALQRIDFSHNQMELLDR--DFFGNLRKLIYANFSHN 162
Cdd:cd21340 116 AALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH