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Conserved domains on  [gi|21314846|ref|NP_647459|]
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protein Wnt-9a precursor [Mus musculus]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 64-364 0e+00

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19353:

Pssm-ID: 393294  Cd Length: 298  Bit Score: 602.41  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSA 143
Cdd:cd19353   1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 144 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGS 223
Cdd:cd19353  81 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 224 CTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAGaISPPrgRASGSGGGDPLPRTPELVHLDDSPSFCLAGR 303
Cdd:cd19353 161 CTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGD-ISPP--KKSGAGHSDQIPRTTDLVYIDDSPSFCLMSR 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21314846 304 FSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19353 238 FSPGTSGRRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
 
Name Accession Description Interval E-value
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 64-364 0e+00

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 602.41  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSA 143
Cdd:cd19353   1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 144 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGS 223
Cdd:cd19353  81 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 224 CTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAGaISPPrgRASGSGGGDPLPRTPELVHLDDSPSFCLAGR 303
Cdd:cd19353 161 CTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGD-ISPP--KKSGAGHSDQIPRTTDLVYIDDSPSFCLMSR 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21314846 304 FSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19353 238 FSPGTSGRRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 64-364 8.80e-135

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 386.52  E-value: 8.80e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846    64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNC-TLEGR--YRASLLKRGFKETAFLYAISSAGLTHALAKA 140
Cdd:pfam00110   5 LSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCsTLENKrpVFGKVLKRGTRETAFVYAISSAGVTHAVTRA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846   141 CSAGRMERCTCDEAPDLEN--REAWQWGGCGDNLKYSSKFVKEFL--GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCK 216
Cdd:pfam00110  85 CSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVdaREKKRRDARALMNLHNNEAGRKAVKSNMRTECK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846   217 CHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNeatgEAGAISPprgrasgSGGGDPLPRTPELVHLDDSP 296
Cdd:pfam00110 165 CHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRN----KRGRLVP-------RNSRFKPPTKNDLVYLEKSP 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21314846   297 SFCLAGRF--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:pfam00110 234 DYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
64-364 1.78e-96

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 289.22  E-value: 1.78e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846     64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTHALAKAC 141
Cdd:smart00097   5 LSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVfgKVLRQGTRETAFVYAISSAGVAHAVTRAC 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846    142 SAGRMERCTCDEAP-DLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHG 219
Cdd:smart00097  85 SEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVdARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHG 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846    220 VSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgSTTNEATGEAGAISPPRGRAsgsgggdplPRTPELVHLDDSPSFC 299
Cdd:smart00097 165 VSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-EVDKRGTNKAPVPKNSTFKP---------PTETDLVYLESSPDFC 234

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21314846    300 LAGR--FSPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:smart00097 235 EKNPktGSLGTQGRQCNKTSKgldgCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 64-364 0e+00

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 602.41  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSA 143
Cdd:cd19353   1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHAMAKACSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 144 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGS 223
Cdd:cd19353  81 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLGRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 224 CTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAGaISPPrgRASGSGGGDPLPRTPELVHLDDSPSFCLAGR 303
Cdd:cd19353 161 CTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGD-ISPP--KKSGAGHSDQIPRTTDLVYIDDSPSFCLMSR 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21314846 304 FSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19353 238 FSPGTSGRRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 64-364 1.97e-173

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 484.40  E-value: 1.97e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRyrASLLKRGFKETAFLYAISSAGLTHALAKACSA 143
Cdd:cd19354   1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGR--GSLLKRGFKETAFLYAVSSAALTHSLAKACSS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 144 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLG-RRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSG 222
Cdd:cd19354  79 GRMERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGqKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 223 SCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAGAISPPRGRASGSGGGdplPRTPELVHLDDSPSFCLAG 302
Cdd:cd19354 159 SCAVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHS---PRSTDLVYLEDSPSFCRPS 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21314846 303 RFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19354 236 KYSPGTAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 64-364 7.02e-171

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 477.94  E-value: 7.02e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLeGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSA 143
Cdd:cd19341   1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSL-GKYRINLLKKGYKETAFLYAISSAGLTHSVARACSS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 144 GRMERCTCDEAPDLE-NREAWQWGGCGDNLKYSSKFVKEFLGRR--SSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGV 220
Cdd:cd19341  80 GRLDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQLKkkSGKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 221 SGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEagaiSPPRGRASGSGGGDPLPRTPELVHLDDSPSFCL 300
Cdd:cd19341 160 SGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGG----SQLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCR 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21314846 301 AGRFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19341 236 STRYSPGTKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 64-364 8.80e-135

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 386.52  E-value: 8.80e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846    64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNC-TLEGR--YRASLLKRGFKETAFLYAISSAGLTHALAKA 140
Cdd:pfam00110   5 LSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCsTLENKrpVFGKVLKRGTRETAFVYAISSAGVTHAVTRA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846   141 CSAGRMERCTCDEAPDLEN--REAWQWGGCGDNLKYSSKFVKEFL--GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCK 216
Cdd:pfam00110  85 CSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVdaREKKRRDARALMNLHNNEAGRKAVKSNMRTECK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846   217 CHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNeatgEAGAISPprgrasgSGGGDPLPRTPELVHLDDSP 296
Cdd:pfam00110 165 CHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRN----KRGRLVP-------RNSRFKPPTKNDLVYLEKSP 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21314846   297 SFCLAGRF--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:pfam00110 234 DYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 78-363 8.78e-115

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 335.03  E-value: 8.78e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  78 VAETLVEAVSMSALECQYQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAP 155
Cdd:cd13113   1 LMESIAEGAQLALKECQRQFANRRWNCSTfnEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 156 -DLENREAWQWGGCGDNLKYSSKFVKEFLGRRS---SKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWR 231
Cdd:cd13113  81 qGPEGQGDWTWGGCSDNIKFGIKFSRKFLDAREkkkGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 232 QLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAgaispprgraSGSGGGDPLPRTPELVHLDDSPSFCLAGRF--SPGTA 309
Cdd:cd13113 161 QLPSFREIGDYLKEKYDNAVKVKLNNNGSGLRL----------VPKRSRFRSPTETDLVYLEESPDYCEPNPTlgSLGTA 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21314846 310 GRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 363
Cdd:cd13113 231 GRECNPTSpgpdSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 64-364 6.56e-104

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 308.42  E-value: 6.56e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCT-LEGR----YRASLLKRGFKETAFLYAISSAGLTHALA 138
Cdd:cd19342  10 LTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSsLETKnknpHTSPILSRGYRETAFAYAISAAGVAHQVA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 139 KACSAGRMERCTCDE--APDLENREAWQWGGCGDNLKYSSKFVKEFLG-RRSSKDLRARVDFHNNLVGVKVIKAGVETTC 215
Cdd:cd19342  90 RACSLGKLLSCGCDRsrRGKRSSGNDWKWGGCSHNLDFGEKFSRKFLDsREKARDIHSRMNLHNNRAGRLAVSENMERKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 216 KCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGsTTNEATGEAGAISPPrgrasgsGGGDPLPRTPELVHLDDS 295
Cdd:cd19342 170 KCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVD-QSNLNNGARRRRLTR-------RKRRRRPPKTDLVYYERS 241

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21314846 296 PSFCLAGRF--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19342 242 PNFCEADPSldSPGTRGRVCNKTStgpdSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 55-364 1.30e-102

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 304.92  E-value: 1.30e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  55 HYKACDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGL 133
Cdd:cd19338   3 PNSICRKTRrLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSFGKILKRDTRETAFVYAITSAGV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 134 THALAKACSAGRMERCTCDEA-PDLENREAWQWGGCGDNLKYSSKFVKEFL--GRRSSKDLRARVDFHNNLVGVKVIKAG 210
Cdd:cd19338  83 TYSVTRACSMGELLQCGCDKSkRGKSTEGEWEWGGCSDNVRYGYRKSREFMdaKEKNRSDIRTLMNLHNNEAGRLAVKNN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 211 VETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKV-GSTTNEatgeagAISPPrgrasgsgggDPLPRTP-- 287
Cdd:cd19338 163 MRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVkGSNDGK------SLIPE----------GKTIKPPtk 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 288 -ELVHLDDSPSFCLAGR--FSPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEV 360
Cdd:cd19338 227 eDLVYLEESPDFCEPNKktGSLGTRGRECNRTSMgvdgCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEI 306


                ....
gi 21314846 361 YTCK 364
Cdd:cd19338 307 HTCN 310
WNT1 smart00097
found in Wnt-1;
64-364 1.78e-96

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 289.22  E-value: 1.78e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846     64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTHALAKAC 141
Cdd:smart00097   5 LSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVfgKVLRQGTRETAFVYAISSAGVAHAVTRAC 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846    142 SAGRMERCTCDEAP-DLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHG 219
Cdd:smart00097  85 SEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVdARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHG 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846    220 VSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgSTTNEATGEAGAISPPRGRAsgsgggdplPRTPELVHLDDSPSFC 299
Cdd:smart00097 165 VSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-EVDKRGTNKAPVPKNSTFKP---------PTETDLVYLESSPDFC 234

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21314846    300 LAGR--FSPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:smart00097 235 EKNPktGSLGTQGRQCNKTSKgldgCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 64-364 3.29e-94

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 283.38  E-value: 3.29e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCT---LEGRYRASLlKRGFKETAFLYAISSAGLTHALAKA 140
Cdd:cd19343   1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSsieLAPNFTPDL-TRGTREQAFVYALSSAALTHTIARA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 141 CSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFL------GRRSSKDLRARVDFHNNLVGVKVIKAGVETT 214
Cdd:cd19343  80 CASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTdapekkKKKKKRQARALMNLHNNRVGRKAVRDSLETQ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 215 CKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEagaiSPPRGRASGSGGGDplprtpELVHLDD 294
Cdd:cd19343 160 CKCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRK----LVPKSLKVRPYTKD------DLIYLTK 229

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21314846 295 SPSFCL--AGRFSPGTAGRRC----HREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19343 230 SPDYCLpdEKLGSLGTRGRECnktsVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 64-364 1.77e-93

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 281.92  E-value: 1.77e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRA---SLLKRGFKETAFLYAISSAGLTHALAKA 140
Cdd:cd19334  12 LVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDATvfgKVLLKGSREAAFVYAISSAGVVHAITRA 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 141 CSAGRMERCTCDEAPDLENREA---WQWGGCGDNLKYSSKFVKEFLG--RRSSKDLRARVDFHNNLVGVKVIKAGVETTC 215
Cdd:cd19334  92 CSKGELLNCACDPTKRGKGRDSkgeFDWGGCSDNVKYGINFARKFVDarERRVRDARALMNLHNNRAGRKAVKKNLKLQC 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 216 KCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgsTTNEATGEAGAISPPRGRasgsgggdplPRTPELVHLDDS 295
Cdd:cd19334 172 KCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQV--TMNQSGTNLLAANKGHKK----------PTRSDLVYFESS 239

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21314846 296 PSFCLA--GRFSPGTAGRRCHR----EKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19334 240 PDYCVPnpETGSLGTAGRVCNKtstgTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 64-364 2.96e-93

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 281.04  E-value: 2.96e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTHALAKAC 141
Cdd:cd19344   1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQNVfgKTLSRGTKETAFIYAITSAGVVHAVTRAC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 142 SAGRMERCTCD-EAPDLENREAWQWGGCGDNLKYSSKFVKEFL------GRRSSKDLRARVDFHNNLVGVKVIKAGVETT 214
Cdd:cd19344  81 SAGNLTDCSCDsRRQGQSASEGWKWGGCSDNVDYGIWFARKFVdapeksERKRSRDVRSLMNLHNNEVGRQAIARLMKVK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 215 CKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgSTTNEATGEAGAispprgraSGSGGGDPLPRTpELVHLDD 294
Cdd:cd19344 161 CRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQI-ATKKSKRRLRRR--------ERRKRKVPISKD-ELVYIHK 230

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21314846 295 SPSFCL--AGRFSPGTAGRRCHREKN----CESICCGRGHNTQ-SRVVTRpCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19344 231 SPNYCVrdPKKGILGTSGRECNRTSTgpdsCDLLCCGRGYNTQvVRHVER-CNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 59-364 3.42e-91

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 276.09  E-value: 3.42e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYR--ASLLKRGFKETAFLYAISSAGLTH 135
Cdd:cd19339   2 CNKIPgLTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGERTvfGQELPVGSREAAFTYAITSAGVAY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 136 ALAKACSAGRMERCTCDEAPD--LENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVE 212
Cdd:cd19339  82 AITQACSQGNLSDCGCDKSKKgyGKSDEGWKWGGCSADVKYGLRFSRKFVdAREVKRNARSLMNLHNNEAGRKAVEENLK 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 213 TTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKV----GSTTNEATGEAGAISPPRGRasgsgggdplPRTPE 288
Cdd:cd19339 162 LECKCHGVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVepvrGRRRRRPTFLKLKISRKYKK----------PRPRD 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 289 LVHLDDSPSFCLAGRF--SPGTAGRRCHR----EKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYT 362
Cdd:cd19339 232 LVYLEKSPNYCEKDPLtgSLGTVGRRCNRtstgTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYT 311


                ..
gi 21314846 363 CK 364
Cdd:cd19339 312 CK 313
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 59-364 1.46e-89

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 271.81  E-value: 1.46e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRA--SLLKRGFKETAFLYAISSAGLTH 135
Cdd:cd19337   1 CDQLRgLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTPDSSSVfgPVTNIGTREAAFTYAISAAGVVH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 136 ALAKACSAGRMERCTCDEA--PDLENREaWQWGGCGDNLKYSSKFVKEFLG---------RRSSKDLRARVDFHNNLVGV 204
Cdd:cd19337  81 AIARACREGNLSTCGCSRErrPKDLPRD-WLWGGCGDNIEYGYKFAKEFIDareretnypRHSRELARVLMNLHNNEAGR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 205 KVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgsttneatgeagAISPPRGRASGSGGGDPLP 284
Cdd:cd19337 160 RAVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKV------------KLNRRGTLLRRRNSRFNKP 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 285 RTPELVHLDDSPSFCLAGR--FSPGTAGRRCHRE----KNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQRE 358
Cdd:cd19337 228 TKDDLVYLDDSPDYCERNPktGSLGTKGRECNKTssgtDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIV 307


                ....*.
gi 21314846 359 EVYTCK 364
Cdd:cd19337 308 DVHICK 313
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 59-364 4.30e-86

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 262.64  E-value: 4.30e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTH 135
Cdd:cd19336   1 CESLKgLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTldKEPVFGKVLNQGTREAAFVHAISSAGVAH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 136 ALAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEF-----LGRRSSKDLRARVDFHNNLVGVKVIKAG 210
Cdd:cd19336  81 AVTRACSSGELEKCGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFvdareRRKGRASSSRALMNLHNNEAGRKAIEKN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 211 VETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNeatGEAGAISPPRGRASGSGGGDplprtpeLV 290
Cdd:cd19336 161 MRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEVQQKRI---GSRPVLVPKNPQFKPHTDAD-------LV 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 291 HLDDSPSFC----LAGrfSPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYT 362
Cdd:cd19336 231 YLDSSPDFCepdpKTG--SLGTHGRVCNKTSKaidgCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHT 308


                ..
gi 21314846 363 CK 364
Cdd:cd19336 309 CR 310
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 64-363 2.70e-85

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 260.75  E-value: 2.70e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRAS-----LLKRGFKETAFLYAISSAGLTHALA 138
Cdd:cd19333   1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRGGPnvfgkILNRGCRETAFIYAITSAAVTHSVA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 139 KACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKC 217
Cdd:cd19333  81 RACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVdAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKC 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 218 HGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAGAISPPRGRASGSGGGDPLPRtpELVHLDDSPS 297
Cdd:cd19333 161 HGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLLEPENPNHKPPTSK--DLVYFEESPN 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21314846 298 FCLAGRF--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 363
Cdd:cd19333 239 FCEKNPKlgTLGTRGRECNATSigldGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 67-364 2.33e-79

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 245.76  E-value: 2.33e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  67 KQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRA---SLLKRGFKETAFLYAISSAGLTHALAKACSA 143
Cdd:cd19335  13 KQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSvfgPVLDKASRESAFVHAIASAGVAHAVTRACAE 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 144 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSG 222
Cdd:cd19335  93 GDSTSCGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFAdARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHGLSG 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 223 SCTVRTCWRQLAPFHEVGKHLKHKYETS--LKVgSTTNEATGEAGAISPPRGRASGsgggdplPRTPELVHLDDSPSFCl 300
Cdd:cd19335 173 SCELKTCWWAQPDFRKIGDYLKDKYDSAseMVV-ERHRESRGWVETLRPKYKLFKP-------PTERDLIYYEESPNFC- 243

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21314846 301 agRFSP-----GTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19335 244 --EPNPetgsfGTRGRECNVTShgidGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 81-363 4.26e-79

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 244.51  E-value: 4.26e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  81 TLVEAVSMSAL----ECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDE-AP 155
Cdd:cd19340   8 SLSDSVAAGAQlameECQYQFKWDRWNCPESAFFSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDsKK 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 156 DLENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLA 234
Cdd:cd19340  88 GSKGGEGWTWGGCSDNVKFGERVSKKFLdSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLA 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 235 PFHEVGKHLKHKYETSLKVGSTTNEATGEAGAISpprgrasgsGGGDPLPRTpELVHLDDSPSFCLA----GrfSPGTAG 310
Cdd:cd19340 168 PFREIGTDLKRKYDRAVRVDYENGGLRETNGSRA---------IKLLNIKKN-DLVYLEKSPNYCRAnvtlG--WPGTLG 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21314846 311 RRCHREKN----------CESICCGRGHNTQSRVV--TRPCQCQVRWCCYVECRQCTQREEVYTC 363
Cdd:cd19340 236 RQCSRDKKesvsrwerksCRRLCRACGLKVRKKVVevTSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 59-364 1.12e-74

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 233.67  E-value: 1.12e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRA---SLLKRGFKETAFLYAISSAGLT 134
Cdd:cd19345   6 CDNIPgLVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDRDHSlfgRLLLRSSRESAFVYAISSAGVV 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 135 HALAKACSAGRMERCTCDEAPDLENREA---WQWGGCGDNLKYSSKFVKEFLG--RRSSKDLRARVDFHNNLVGVKVIKA 209
Cdd:cd19345  86 FAITRACSQGELKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDakERKGKDARALMNLHNNRAGRKAVKR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 210 GVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgSTTNEATGEAGAispprgrasgsGGGDPLPRTPEL 289
Cdd:cd19345 166 FMTLECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQV-VMNQDGTGFTVA-----------NKHFKKPTKNDL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 290 VHLDDSPSFCLAGR--FSPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 363
Cdd:cd19345 234 VYFENSPDYCVRDRdaGSLGTAGRVCNRTSrgmdGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTC 313


                .
gi 21314846 364 K 364
Cdd:cd19345 314 K 314
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 64-364 9.61e-73

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 228.33  E-value: 9.61e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCT-LEGR----YRASLLKRGFKETAFLYAISSAGLTHALA 138
Cdd:cd19355  10 LTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSsLETRnkipYESVVFSRGFRESAFAYAIAAAGVVHAVS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 139 KACSAGRMERCTCDeapdlenreaWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKC 217
Cdd:cd19355  90 NACAMGKLKACGCD----------WEWGGCSPDVEYGERFSKDFLdSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKC 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 218 HGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgSTTNEATGEAGAISPPRGRASGSGggdplprtpELVHLDDSPS 297
Cdd:cd19355 160 HGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLI-KPHNRNTGQLEPGHAPHRRRASIN---------DLVYFEKSPD 229

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21314846 298 FCLAGRF--SPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19355 230 FCEREPRldSAGTQGRICNKTSpgmdNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 59-364 1.32e-69

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 221.08  E-value: 1.32e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYR--ASLLKRGFKETAFLYAISSAGLTH 135
Cdd:cd19349   7 CNKIPgLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTvfGKELKVGSREAAFTYAIIAAGVAH 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 136 ALAKACSAGRMERCTCDEAPD--LENREAWQWGGCGDNLKYSSKFVKEFLGRRSSK-DLRARVDFHNNLVGVKVIKAGVE 212
Cdd:cd19349  87 AITAACTQGNLSDCGCDKEKQgqYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKqNARTLMNLHNNEAGRKILEENMK 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 213 TTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTtneatgEAGAISPPRGRASGSGGGDPLPRTPELVHL 292
Cdd:cd19349 167 LECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPV------RASRNKRPTFLKIKKPLSYRKPMDTDLVYI 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21314846 293 DDSPSFCLAGRF--SPGTAGRRCHR----EKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19349 241 EKSPNYCEEDPVtgSVGTQGRMCNKtaqqNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 59-364 1.35e-69

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 220.56  E-value: 1.35e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYR---ASLLKRGFKETAFLYAISSAGLT 134
Cdd:cd19346   6 CDNIPgLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHtvfGRVMLRSSREAAFVYAISSAGVV 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 135 HALAKACSAGRMERCTCD---EAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSS--KDLRARVDFHNNLVGVKVIKA 209
Cdd:cd19346  86 YAITRACSQGELKSCSCDphkRGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKkeKDARALMNLHNNRCGRMAVKR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 210 GVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVgSTTNEATGEAGAispprgrasgsGGGDPLPRTPEL 289
Cdd:cd19346 166 FMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQV-TMNQDGTGFTVA-----------NKNFRKATKTDL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 290 VHLDDSPSFCLAGRF--SPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 363
Cdd:cd19346 234 VYFENSPDYCVMDKSagSLGTAGRVCNKSSRgtdgCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTC 313


                .
gi 21314846 364 K 364
Cdd:cd19346 314 K 314
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 64-364 6.07e-69

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 219.11  E-value: 6.07e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYR--ASLLKRGFKETAFLYAISSAGLTHALAKAC 141
Cdd:cd19350  13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTvfGQELRVGSREAAFTYAITAAGVAHAVTAAC 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 142 SAGRMERCTCDEAPD--LENREAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCH 218
Cdd:cd19350  93 SQGNLSNCGCDREKQgyYNQEEGWKWGGCSADIKYGIDFSRKFVdAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCH 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 219 GVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTtneatgEAGAISPPRGRASGSGGGDPLPRTPELVHLDDSPSF 298
Cdd:cd19350 173 GVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVV------RASRLRQPTFLKIKKRRSYQKPMETDLVYIERSPNY 246

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21314846 299 CL--AGRFSPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19350 247 CEedAATGSVGTQGRLCNRTSphtdGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 59-364 4.70e-67

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 214.16  E-value: 4.70e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTH 135
Cdd:cd19347   1 CSQLAgLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTvdNTSVFGRVMQIGSRETAFTYAISAAGVVN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 136 ALAKACSAGRMERCTCDEA--PDLENREaWQWGGCGDNLKYSSKFVKEFLGRR---------SSKDLRARVDFHNNLVGV 204
Cdd:cd19347  81 AVSRACREGELSTCGCSRAarPKDLPRD-WLWGGCGDNLEYGYRFAKEFVDARerekiyqkgSYESARTLMNLHNNEAGR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 205 KVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNEATGEAGAISPPrgrasgsgggdplP 284
Cdd:cd19347 160 RTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQVNSRFNP-------------P 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 285 RTPELVHLDDSPSFCLAGRF--SPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQRE 358
Cdd:cd19347 227 TTLDLVYIDPSPDYCVRNEStgSLGTQGRLCNKTSEgmdgCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIV 306


                ....*.
gi 21314846 359 EVYTCK 364
Cdd:cd19347 307 DQFVCK 312
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 64-364 2.43e-65

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 209.36  E-value: 2.43e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  64 LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNC-TLEGRYR----ASLLKRGFKETAFLYAISSAGLTHALA 138
Cdd:cd19356  10 LSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCsSLEGGGKlphdSAILKRGFRESAFSFSLLAAGVMHSVA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 139 KACSAGRMERCTCdeapdlenreAWQWGGCGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKC 217
Cdd:cd19356  90 TACSLGKLRGCGC----------EWEWGGCSHDIEFGEKFSRDFLdSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKC 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 218 HGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSLKVGSTTNeatgEAGAISPprgrasgsgGGDPLPRTPELVHLDDSPS 297
Cdd:cd19356 160 HGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNK----NSGVFLP---------RLRPRRLARELVYFEKSPD 226

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21314846 298 FCL--AGRFSPGTAGRRCHREK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCK 364
Cdd:cd19356 227 FCErdPAVDSPGTQGRICNKTSpgmdGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 59-364 9.03e-62

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 200.59  E-value: 9.03e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTL--EGRYRASLLKRGFKETAFLYAISSAGLTH 135
Cdd:cd19348   1 CSQLTgLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTvdNTSVFGRVMQIGSRETAFTYAVSAAGVVN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 136 ALAKACSAGRMERCTCDEA--PDLENREaWQWGGCGDNLKYSSKFVKEFLGRR---------SSKDLRARVDFHNNLVGV 204
Cdd:cd19348  81 AISRACREGELSTCGCSRAarPKDLPRD-WLWGGCGDNVEYGYRFAKEFVDARereknypkgSEEHARTLMNLQNNEAGR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 205 KVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETSlkvgsttneatgEAGAISPPRGRASGSGGGDPlP 284
Cdd:cd19348 160 RAVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSA------------AAMRINRKGKLELVNSRFNP-P 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 285 RTPELVHLDDSPSFCLAGRF--SPGTAGRRCHREKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQRE 358
Cdd:cd19348 227 TAEDLVYIDPSPDYCLRNETtgSLGTQGRLCNKTSEgmdgCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIV 306


                ....*.
gi 21314846 359 EVYTCK 364
Cdd:cd19348 307 DQFVCK 312
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 92-363 2.62e-59

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 194.09  E-value: 2.62e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  92 ECQYQFRFERWNCTLEGRYRASL--LKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLE-NREAWQWGGC 168
Cdd:cd19352  24 ECKYQFAWDRWNCPERALQLSSHsgLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQlGGQGWLWGGC 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 169 GDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKY 247
Cdd:cd19352 104 SDNVGFGEAISKQFVdALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKY 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 248 ETSLKVG---STTNEATGEaGAISPPRGRASgsgggdplprTPELVHLDDSPSFCLAGRF--SPGTAGRRCHR------- 315
Cdd:cd19352 184 HRALKVDllqGAGNSAASR-GAIAETFRSIS----------KKELVHLEDSPDYCLENKTlgLLGTEGRECLKrgkalsk 252

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 21314846 316 --EKNCESIC--CGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 363
Cdd:cd19352 253 weKRSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 92-363 8.14e-53

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 177.02  E-value: 8.14e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846  92 ECQYQFRFERWNCTlEGRYRASL---LKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLE-NREAWQWGG 167
Cdd:cd19351  23 ECKHQFAWERWNCP-ESALQLSThngLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSRNGRtGGRGWIWGG 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 168 CGDNLKYSSKFVKEFL-GRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHK 246
Cdd:cd19351 102 CSDNVEFGERISKQFVdALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQLADFREIGNYLKVK 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21314846 247 YETSLKV---------GSTTNEATGEAGAISPPRGRasgsgggdplprtpELVHLDDSPSFCL--AGRFSPGTAGRRCHR 315
Cdd:cd19351 182 HDQALKLemdkrrmraGNSADNRGAIAEAFGSVAET--------------ELIYLEDSPDYCTknASLGLQGTEGRECLQ 247

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21314846 316 ---------EKNCESIC--CGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTC 363
Cdd:cd19351 248 sgknlsqweRRSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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