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Conserved domains on  [gi|21281681|ref|NP_644807|]
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leucine-rich repeat LGI family member 3 precursor [Homo sapiens]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
112-172 1.13e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.13e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21281681   112 SHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 268-308 9.77e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.93  E-value: 9.77e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   268 QLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYHW 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 410-451 1.90e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 1.90e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   410 QFVAQGEVTqVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRW 451
Cdd:pfam03736   1 KFVPYQTIP-TRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
96-247 3.74e-08

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 3.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21281681  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWALSKFTfrGLKSLTHLSLANNNLQTLPrdIFRPLDILNDLDLRGNSLNcD 175
Cdd:COG4886 213 SGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-D 286

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21281681 176 CKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYL 247
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 455-495 7.49e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.62  E-value: 7.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   455 RFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQW 495
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 314-359 2.16e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.08  E-value: 2.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21281681   314 RFTRLQDIDPQRVRkpnDLEAFRIDGDWYFAVADSSkaGATSLYRW 359
Cdd:pfam03736   1 KFVPYQTIPTRGAR---DVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 501-541 6.00e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 43.23  E-value: 6.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   501 KFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRH 541
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 363-404 1.66e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   363 GFYSHQALHPWhRDTDLEFVDGEGKPRLIVSSSSQAPVIYQW 404
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
112-172 1.13e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.13e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21281681   112 SHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 1.49e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.49e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21281681  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWALSKfTFRGLKSLTHLSLANNNLQTLPrDIFRpLDILNDLDLRGNSL 172
Cdd:COG4886 190 SNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGN-LTNLEELDLSNNQL 262
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 268-308 9.77e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.93  E-value: 9.77e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   268 QLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYHW 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 410-451 1.90e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 1.90e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   410 QFVAQGEVTqVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRW 451
Cdd:pfam03736   1 KFVPYQTIP-TRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-247 3.74e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 3.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21281681  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWALSKFTfrGLKSLTHLSLANNNLQTLPrdIFRPLDILNDLDLRGNSLNcD 175
Cdd:COG4886 213 SGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-D 286

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21281681 176 CKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYL 247
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 455-495 7.49e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.62  E-value: 7.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   455 RFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQW 495
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 314-359 2.16e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.08  E-value: 2.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21281681   314 RFTRLQDIDPQRVRkpnDLEAFRIDGDWYFAVADSSkaGATSLYRW 359
Cdd:pfam03736   1 KFVPYQTIPTRGAR---DVEPFSIGGDLFLAVANFS--GDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 143-218 2.87e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 53.93  E-value: 2.87e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21281681    143 LANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVA---PIYCASPPRFQEHKVQDLPLREFDC 218
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 501-541 6.00e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 43.23  E-value: 6.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   501 KFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRH 541
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 222-262 1.10e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.46  E-value: 1.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   222 DFVLYQTLAFP-AVSAEPFLYSSDLYLALAqPGVSACTILKW 262
Cdd:pfam03736   1 KFVPYQTIPTRgARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
LRRCT smart00082
Leucine rich repeat C-terminal domain;
170-218 1.18e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.18e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 21281681    170 NSLNCDCKVKWLVEWLA---HTNTTVAPiYCASPPRFQEhKVQDLPLREFDC 218
Cdd:smart00082   1 NPFICDCELRWLLRWLQaneHLQDPVDL-RCASPSSLRG-PLLELLHSEFKC 50
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 363-404 1.66e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   363 GFYSHQALHPWhRDTDLEFVDGEGKPRLIVSSSSQAPVIYQW 404
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
135-158 1.75e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 38.49  E-value: 1.75e-04
                           10        20
                   ....*....|....*....|....
gi 21281681    135 LKSLTHLSLANNNLQTLPRDIFRP 158
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-173 3.89e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 3.89e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21281681 108 FTGLSHLQYLFIENNDIWALSKFTF-----RGL-KSLTHLSLANNNLQTLprDIFRPLDILNDLDLRGNSLN 173
Cdd:cd21340  86 LENLTNLEELHIENQRLPPGEKLTFdprslAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
112-172 1.13e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.13e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21281681   112 SHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
96-148 1.16e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 1.16e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 21281681    96 NSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNL 148
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 1.49e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.49e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21281681  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWALSKfTFRGLKSLTHLSLANNNLQTLPrDIFRpLDILNDLDLRGNSL 172
Cdd:COG4886 190 SNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGN-LTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 2.34e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 2.34e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21281681  96 NSNKFTLIgDNAFTGLSHLQYLFIENNDIWALSKfTFRGLKSLTHLSLANNNLQTLPRDIFRpLDILNDLDLRGNSL 172
Cdd:COG4886 167 SNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQL 240
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 268-308 9.77e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.93  E-value: 9.77e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   268 QLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYHW 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 410-451 1.90e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 1.90e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   410 QFVAQGEVTqVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRW 451
Cdd:pfam03736   1 KFVPYQTIP-TRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-247 3.74e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 3.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21281681  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWALSKFTfrGLKSLTHLSLANNNLQTLPrdIFRPLDILNDLDLRGNSLNcD 175
Cdd:COG4886 213 SGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-D 286

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21281681 176 CKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYL 247
Cdd:COG4886 287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 455-495 7.49e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.62  E-value: 7.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   455 RFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQW 495
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 314-359 2.16e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.08  E-value: 2.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 21281681   314 RFTRLQDIDPQRVRkpnDLEAFRIDGDWYFAVADSSkaGATSLYRW 359
Cdd:pfam03736   1 KFVPYQTIPTRGAR---DVEPFSIGGDLFLAVANFS--GDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 143-218 2.87e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 53.93  E-value: 2.87e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21281681    143 LANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVA---PIYCASPPRFQEHKVQDLPLREFDC 218
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 501-541 6.00e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 43.23  E-value: 6.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 21281681   501 KFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRH 541
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 222-262 1.10e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.46  E-value: 1.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   222 DFVLYQTLAFP-AVSAEPFLYSSDLYLALAqPGVSACTILKW 262
Cdd:pfam03736   1 KFVPYQTIPTRgARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
LRRCT smart00082
Leucine rich repeat C-terminal domain;
170-218 1.18e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.18e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 21281681    170 NSLNCDCKVKWLVEWLA---HTNTTVAPiYCASPPRFQEhKVQDLPLREFDC 218
Cdd:smart00082   1 NPFICDCELRWLLRWLQaneHLQDPVDL-RCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
137-173 2.88e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.88e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 21281681   137 SLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLN 173
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
LRR_8 pfam13855
Leucine rich repeat;
68-124 5.57e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.57e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21281681    68 SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDI 124
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 363-404 1.66e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21281681   363 GFYSHQALHPWhRDTDLEFVDGEGKPRLIVSSSSQAPVIYQW 404
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
135-158 1.75e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 38.49  E-value: 1.75e-04
                           10        20
                   ....*....|....*....|....
gi 21281681    135 LKSLTHLSLANNNLQTLPRDIFRP 158
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
135-158 1.75e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 38.49  E-value: 1.75e-04
                           10        20
                   ....*....|....*....|....
gi 21281681    135 LKSLTHLSLANNNLQTLPRDIFRP 158
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 2.40e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 2.40e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21281681  96 NSNKFTLIGDNAFTGLSHLQYLFIENNDiwalskfTFRGLKSLTHLSLANNNLQTLPRDIFRpLDILNDLDLRGNSL 172
Cdd:COG4886  80 LLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQL 148
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 113-150 1.72e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21281681   113 HLQYLFIENNDIWALSkfTFRGLKSLTHLSLANNNLQT 150
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-173 3.89e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 3.89e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21281681 108 FTGLSHLQYLFIENNDIWALSKFTF-----RGL-KSLTHLSLANNNLQTLprDIFRPLDILNDLDLRGNSLN 173
Cdd:cd21340  86 LENLTNLEELHIENQRLPPGEKLTFdprslAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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