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Conserved domains on  [gi|126131102|ref|NP_619639|]
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fibrocystin isoform 1 [Homo sapiens]

Protein Classification

IPT_PCSR and G8 domain-containing protein( domain architecture ID 11535905)

protein containing domains IPT_PCSR, TIG, G8, and Beta_helix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1933-2049 5.68e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 5.68e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1933 SWFPERLPQDGDNVTVENGQLLLLDTNTSILNLLHIKgGKLIFMAPGPIELRAHAILVSdGGELRIGSEDKPFQGRAQIT 2012
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 126131102  2013 LYGSSY--STPFFPYGVKFLAVRN-GTLSLHGSLPEVIVT 2049
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWT 118
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2749-2872 1.91e-31

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 121.17  E-value: 1.91e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2749 WGGYNntIPGPGDDVLILPNRTVLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLekEQKLLI 2828
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPF--QGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 126131102  2829 LLRASEGvfCDRMNGIHIDPGTIGV--YGKVHLYSAYPKNSWTHLG 2872
Cdd:pfam10162   78 TLHGRPE--LDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1197-1294 9.95e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNr 1276
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG-------EGPVEVTVDG- 73

                          90
                  ....*....|....*...
gi 126131102 1277 ffARGPSPSLVGKGFTFM 1294
Cdd:cd00603    74 --ANVSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 260-339 1.11e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  260 EILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECTTRApgkdvrLTTPQPGNRGLLFEVGD 336
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSprvRVTVGGVPCKVLNVSSTEIVCRTPA------AATPGEGPVEVTVDGAN 75


                  ...
gi 126131102  337 AVE 339
Cdd:cd00603    76 VSA 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1389-1479 3.49e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 3.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1389 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLsGPFTCVILSLGDHTILCQVSLEGDPLPGasfSLNVTVLVNGL 1468
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGEG---PVEVTVDGANV 76

                          90
                  ....*....|.
gi 126131102 1469 tSECQGNCTLF 1479
Cdd:cd00603    77 -SARVLSNTTF 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1019-1103 1.37e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1019 PRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSYSCAINVatSNSSRIQCKVPPRGKDG---RIVNVTVIRGDY 1092
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGegpVEVTVDGANVSA 78

                          90
                  ....*....|.
gi 126131102 1093 SAVLPRAFTYV 1103
Cdd:cd00603    79 RVLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 931-1004 5.43e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 5.43e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126131102   931 PCVHSVW-YSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGL 1004
Cdd:pfam01833    1 PVITSISpSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1108-1192 9.94e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 9.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1108 PVIVTLSRNISNIAGGETLVIGVARLmNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQG 1187
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 126131102  1188 VDLHI 1192
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1486-1569 7.08e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 7.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1486 PVMDALSTNTS--GSLTTVLIRGQRLATTADEPMVFVDDQlPCNVTFFNASHVVCQTRDLAPGPHYLSVFYtRNGYACSG 1563
Cdd:pfam01833    1 PVITSISPSSGpaSGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISSS 78


                   ....*.
gi 126131102  1564 NVSRHF 1569
Cdd:pfam01833   79 PLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1573-1640 9.50e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 9.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126131102 1573 PQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1640
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV 69
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3002-3177 1.63e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.87  E-value: 1.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  3002 SSVEFSNVSAGSwIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TVTNNLvvlmtqpaWSTIWVAG 3080
Cdd:pfam13229    1 SGILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNT--------ISNNGGGG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  3081 IKVNQVKDINLHGNVVAGSERLGFHIrghkCSSCELLWSDNVAHS-SLHGLHLYKESG---LDNCTrisgflAFKNFDYG 3156
Cdd:pfam13229   72 IALRGSSNNLIENNTISNNGGAGIYL----SDSSNNTIENNIIHNnGGSGIVIEDSSNnvtISNNT------VTNNKGAG 141

                          170       180
                   ....*....|....*....|.
gi 126131102  3157 amLHVENSveIENITLVDNTI 3177
Cdd:pfam13229  142 --ILIVGG--SSNNTVENNTF 158
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2197-2348 9.42e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 44.52  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 2197 SQVQLKGVQFQVLGQAFHKHLSSLTLVGAmRESFIQGCTVRNSFSrGLSMCGTLGLKVDSNVFYNIlghallvgtcTEMR 2276
Cdd:COG3420    78 DNVTVRGLTITGSGDSLTDDDAGIYVRGA-DNAVIENNRIENNLF-GIYLEGSDNNVIRNNTISGN----------RDLR 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126131102 2277 YISWEAIHGrkddWSGHGNIIRNNVIIQVSGaeglsnpemltpsGIYI-CSPTNVIEGNRVCGAGYGyfFHLM 2348
Cdd:COG3420   146 ADRGNGIHL----WNSPGNVIEGNTISGGRD-------------GIYLeFSDNNVIRNNTIRNLRYG--IHYM 199
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2290-2447 9.54e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 39.70  E-value: 9.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2290 WSGHGNIIRNNVIIQVSGaeglsnpemltpSGIYI-CSPTNVIEGNRVcgAGYGYFFHLMTNQTSqaplLSFTQNIAHSC 2368
Cdd:pfam13229    6 NGSSNATIKNNTISNNGG------------YGIYLrGSSNATIENNTI--TNNGGDGIEISGSSN----NTISNNTISNN 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2369 TRYGLFVYPkfqppwdnvTGTTLFQSFTVWESAG-GAQIFRSSNLRLKNFKVYSCRDFGIDVLESDANTSVTDSLLLGHF 2447
Cdd:pfam13229   68 GGGGIALRG---------SSNNLIENNTISNNGGaGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTNNK 138
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1933-2049 5.68e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 5.68e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1933 SWFPERLPQDGDNVTVENGQLLLLDTNTSILNLLHIKgGKLIFMAPGPIELRAHAILVSdGGELRIGSEDKPFQGRAQIT 2012
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 126131102  2013 LYGSSY--STPFFPYGVKFLAVRN-GTLSLHGSLPEVIVT 2049
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWT 118
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2749-2872 1.91e-31

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 121.17  E-value: 1.91e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2749 WGGYNntIPGPGDDVLILPNRTVLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLekEQKLLI 2828
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPF--QGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 126131102  2829 LLRASEGvfCDRMNGIHIDPGTIGV--YGKVHLYSAYPKNSWTHLG 2872
Cdd:pfam10162   78 TLHGRPE--LDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1197-1294 9.95e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNr 1276
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG-------EGPVEVTVDG- 73

                          90
                  ....*....|....*...
gi 126131102 1277 ffARGPSPSLVGKGFTFM 1294
Cdd:cd00603    74 --ANVSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 260-339 1.11e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  260 EILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECTTRApgkdvrLTTPQPGNRGLLFEVGD 336
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSprvRVTVGGVPCKVLNVSSTEIVCRTPA------AATPGEGPVEVTVDGAN 75


                  ...
gi 126131102  337 AVE 339
Cdd:cd00603    76 VSA 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1389-1479 3.49e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 3.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1389 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLsGPFTCVILSLGDHTILCQVSLEGDPLPGasfSLNVTVLVNGL 1468
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGEG---PVEVTVDGANV 76

                          90
                  ....*....|.
gi 126131102 1469 tSECQGNCTLF 1479
Cdd:cd00603    77 -SARVLSNTTF 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1019-1103 1.37e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1019 PRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSYSCAINVatSNSSRIQCKVPPRGKDG---RIVNVTVIRGDY 1092
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGegpVEVTVDGANVSA 78

                          90
                  ....*....|.
gi 126131102 1093 SAVLPRAFTYV 1103
Cdd:cd00603    79 RVLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1389-1467 3.11e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 3.11e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126131102  1389 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGpFTCVILSLGDHTILCQVSlegdplPGASFSLNVTVLVNG 1467
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGG-TPCTVISVSSTTIVCTTP------PGTSGLVNVSVTVGG 72
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 931-1004 5.43e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 5.43e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126131102   931 PCVHSVW-YSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGL 1004
Cdd:pfam01833    1 PVITSISpSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1108-1192 9.94e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 9.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1108 PVIVTLSRNISNIAGGETLVIGVARLmNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQG 1187
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 126131102  1188 VDLHI 1192
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1486-1569 7.08e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 7.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1486 PVMDALSTNTS--GSLTTVLIRGQRLATTADEPMVFVDDQlPCNVTFFNASHVVCQTRDLAPGPHYLSVFYtRNGYACSG 1563
Cdd:pfam01833    1 PVITSISPSSGpaSGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISSS 78


                   ....*.
gi 126131102  1564 NVSRHF 1569
Cdd:pfam01833   79 PLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 261-321 4.62e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 50.14  E-value: 4.62e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126131102   261 ILSVFPETGSLGGRTNITITGDFF---DNSAQVTIAGIPCDIRHVSPRKIECTTRA-PGKDVRLT 321
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPgTSGLVNVS 67
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1573-1640 9.50e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 9.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126131102 1573 PQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1640
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV 69
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3002-3177 1.63e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.87  E-value: 1.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  3002 SSVEFSNVSAGSwIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TVTNNLvvlmtqpaWSTIWVAG 3080
Cdd:pfam13229    1 SGILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNT--------ISNNGGGG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  3081 IKVNQVKDINLHGNVVAGSERLGFHIrghkCSSCELLWSDNVAHS-SLHGLHLYKESG---LDNCTrisgflAFKNFDYG 3156
Cdd:pfam13229   72 IALRGSSNNLIENNTISNNGGAGIYL----SDSSNNTIENNIIHNnGGSGIVIEDSSNnvtISNNT------VTNNKGAG 141

                          170       180
                   ....*....|....*....|.
gi 126131102  3157 amLHVENSveIENITLVDNTI 3177
Cdd:pfam13229  142 --ILIVGG--SSNNTVENNTF 158
IPT smart00429
ig-like, plexins, transcription factors;
260-311 2.39e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.39e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 126131102    260 EILSVFPETGSLGGRTNITITGDFFDNSAQVTI----AGIPCDIRHVSPRKIECTT 311
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgvGEAPCTFSPSSSTAIVCKT 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1578-1642 1.32e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.32e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126131102  1578 YFPKNFSLHGGSLLTIEGTGLR-GQNTTSVYIDQQTCLTVNIGAELIRCIVPTG-NGSVALEIEVDG 1642
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGG 72
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3017-3179 4.34e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 45.68  E-value: 4.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 3017 SSTLHQSCGGGIHAAASHGVLLNDNIVFGTAgHGIDLEGQAY-TVTNNLVVlmTQPAWSTIWVAGIKVNQVKDINLHGNV 3095
Cdd:COG3420    90 SGDSLTDDDAGIYVRGADNAVIENNRIENNL-FGIYLEGSDNnVIRNNTIS--GNRDLRADRGNGIHLWNSPGNVIEGNT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 3096 VAGSeRLGFHIrghkCSSCELLWSDNVAHSSLHGLHLYKESG--------LDNCT----------RISGFLAFKNFDYGA 3157
Cdd:COG3420   167 ISGG-RDGIYL----EFSDNNVIRNNTIRNLRYGIHYMYSNDnlvegntfRDNGAgialmyskgnTVRGNTILGNSGYGI 241

                         170       180
                  ....*....|....*....|..
gi 126131102 3158 MLHVENSVEIENITLVDNTIGL 3179
Cdd:COG3420   242 LLKESSDSVIEGNTISGNGKGI 263
IPT smart00429
ig-like, plexins, transcription factors;
1197-1294 4.95e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 41.64  E-value: 4.95e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102   1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVL-VGNRSCDIVNLTEASIWCETLPAPQIPdagaptvpaaVEVWAGN 1275
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgVGEAPCTFSPSSSTAIVCKTPPYHNIP----------GSVPVRT 72

                            90
                    ....*....|....*....
gi 126131102   1276 RFFARGPSPSLvGKGFTFM 1294
Cdd:smart00429   73 VGLRNGGVPSS-PQPFTYV 90
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2197-2348 9.42e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 44.52  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 2197 SQVQLKGVQFQVLGQAFHKHLSSLTLVGAmRESFIQGCTVRNSFSrGLSMCGTLGLKVDSNVFYNIlghallvgtcTEMR 2276
Cdd:COG3420    78 DNVTVRGLTITGSGDSLTDDDAGIYVRGA-DNAVIENNRIENNLF-GIYLEGSDNNVIRNNTISGN----------RDLR 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126131102 2277 YISWEAIHGrkddWSGHGNIIRNNVIIQVSGaeglsnpemltpsGIYI-CSPTNVIEGNRVCGAGYGyfFHLM 2348
Cdd:COG3420   146 ADRGNGIHL----WNSPGNVIEGNTISGGRD-------------GIYLeFSDNNVIRNNTIRNLRYG--IHYM 199
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1200-1255 9.70e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.89  E-value: 9.70e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 126131102  1200 SIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAP 1255
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT 60
IPT smart00429
ig-like, plexins, transcription factors;
1389-1445 1.89e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.10  E-value: 1.89e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 126131102   1389 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVDLSGPFtCVILSLGDHTILCQV 1445
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAP-CTFSPSSSTAIVCKT 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1019-1102 7.73e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 38.20  E-value: 7.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1019 PRLDMVEPSRAADIGGLWATIRGSSLEGVS---LILFGSYSCAINvaTSNSSRIQCKVPPRGKDGRIVNVTViRGDYSAV 1095
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVI--SVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISS 77


                   ....*..
gi 126131102  1096 LPRAFTY 1102
Cdd:pfam01833   78 SPLTFTY 84
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2290-2447 9.54e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 39.70  E-value: 9.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2290 WSGHGNIIRNNVIIQVSGaeglsnpemltpSGIYI-CSPTNVIEGNRVcgAGYGYFFHLMTNQTSqaplLSFTQNIAHSC 2368
Cdd:pfam13229    6 NGSSNATIKNNTISNNGG------------YGIYLrGSSNATIENNTI--TNNGGDGIEISGSSN----NTISNNTISNN 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2369 TRYGLFVYPkfqppwdnvTGTTLFQSFTVWESAG-GAQIFRSSNLRLKNFKVYSCRDFGIDVLESDANTSVTDSLLLGHF 2447
Cdd:pfam13229   68 GGGGIALRG---------SSNNLIENNTISNNGGaGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTNNK 138
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1933-2049 5.68e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 5.68e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1933 SWFPERLPQDGDNVTVENGQLLLLDTNTSILNLLHIKgGKLIFMAPGPIELRAHAILVSdGGELRIGSEDKPFQGRAQIT 2012
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 126131102  2013 LYGSSY--STPFFPYGVKFLAVRN-GTLSLHGSLPEVIVT 2049
Cdd:pfam10162   79 LHGRPEldDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWT 118
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2749-2872 1.91e-31

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 121.17  E-value: 1.91e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2749 WGGYNntIPGPGDDVLILPNRTVLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLekEQKLLI 2828
Cdd:pfam10162    2 WGGGV--VPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPF--QGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 126131102  2829 LLRASEGvfCDRMNGIHIDPGTIGV--YGKVHLYSAYPKNSWTHLG 2872
Cdd:pfam10162   78 TLHGRPE--LDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1197-1294 9.95e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 69.41  E-value: 9.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNr 1276
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG-------EGPVEVTVDG- 73

                          90
                  ....*....|....*...
gi 126131102 1277 ffARGPSPSLVGKGFTFM 1294
Cdd:cd00603    74 --ANVSARVLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 260-339 1.11e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  260 EILSVFPETGSLGGRTNITITGDFFDNSA---QVTIAGIPCDIRHVSPRKIECTTRApgkdvrLTTPQPGNRGLLFEVGD 336
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSprvRVTVGGVPCKVLNVSSTEIVCRTPA------AATPGEGPVEVTVDGAN 75


                  ...
gi 126131102  337 AVE 339
Cdd:cd00603    76 VSA 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1389-1479 3.49e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 3.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1389 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLsGPFTCVILSLGDHTILCQVSLEGDPLPGasfSLNVTVLVNGL 1468
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTPAAATPGEG---PVEVTVDGANV 76

                          90
                  ....*....|.
gi 126131102 1469 tSECQGNCTLF 1479
Cdd:cd00603    77 -SARVLSNTTF 86
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1389-1479 1.51e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 60.17  E-value: 1.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1389 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRsVRVDLSGPFTCVILSLGDHTILCQVSLEGDPLPGasfslNVTVLVNGL 1468
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN-LRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGPG-----PVEVTVDRG 74

                          90
                  ....*....|.
gi 126131102 1469 TSECQGNCTLF 1479
Cdd:cd00102    75 NGGITSSPLTF 85
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1019-1103 1.37e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1019 PRLDMVEPSRAADIGGLWATIRGSSLEGVSL---ILFGSYSCAINVatSNSSRIQCKVPPRGKDG---RIVNVTVIRGDY 1092
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVLN--VSSTEIVCRTPAAATPGegpVEVTVDGANVSA 78

                          90
                  ....*....|.
gi 126131102 1093 SAVLPRAFTYV 1103
Cdd:cd00603    79 RVLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1389-1467 3.11e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 3.11e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126131102  1389 PRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGpFTCVILSLGDHTILCQVSlegdplPGASFSLNVTVLVNG 1467
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGG-TPCTVISVSSTTIVCTTP------PGTSGLVNVSVTVGG 72
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 260-313 3.27e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 56.32  E-value: 3.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 126131102  260 EILSVFPETGSLGGRTNITITGDFFDNSAQVTI---AGIPCDIRHVSPRKIECTTRA 313
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLRVtfgGGVPCSVLSVSSTAIVCTTPP 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 931-1004 5.43e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.53  E-value: 5.43e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126131102   931 PCVHSVW-YSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCKVIFSNQTNVVCQTDLLPVGMHRILMLVRPSGL 1004
Cdd:pfam01833    1 PVITSISpSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1108-1192 9.94e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 9.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1108 PVIVTLSRNISNIAGGETLVIGVARLmNYTDLDVEVHVQDALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQG 1187
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 126131102  1188 VDLHI 1192
Cdd:pfam01833   80 LTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1197-1294 1.82e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.39  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWAGNR 1276
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPG-------PGPVEVTVDRG 74

                          90
                  ....*....|....*...
gi 126131102 1277 FFARGPSPslvgKGFTFM 1294
Cdd:cd00102    75 NGGITSSP----LTFTYV 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1486-1569 7.08e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 7.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1486 PVMDALSTNTS--GSLTTVLIRGQRLATTADEPMVFVDDQlPCNVTFFNASHVVCQTRDLAPGPHYLSVFYtRNGYACSG 1563
Cdd:pfam01833    1 PVITSISPSSGpaSGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISSS 78


                   ....*.
gi 126131102  1564 NVSRHF 1569
Cdd:pfam01833   79 PLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 261-321 4.62e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 50.14  E-value: 4.62e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126131102   261 ILSVFPETGSLGGRTNITITGDFF---DNSAQVTIAGIPCDIRHVSPRKIECTTRA-PGKDVRLT 321
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPgTSGLVNVS 67
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 260-316 8.67e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.62  E-value: 8.67e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126131102  260 EILSVFPETGSLGGRTNITITG-----DFFDNSAQVTIAGIPCDI---RHVSPRKIECTTRAPGK 316
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGsnlglRKNDVRHGVRVGGVPCNPeppEYSSSEKIVCTTGPAGN 66
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1573-1640 9.50e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 49.38  E-value: 9.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126131102 1573 PQVFHYFPKNFSLHGGSLLTIEGTGL-RGQNTTSVYIDQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1640
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV 69
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1019-1104 1.34e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 49.00  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1019 PRLDMVEPSRAADIGGLWATIRGSSLEGVSLI---LFGSYSCAINVatSNSSRIQCKVPPRGKDGRI-VNVTVIRGDYSA 1094
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLrvtFGGGVPCSVLS--VSSTAIVCTTPPYANPGPGpVEVTVDRGNGGI 78

                          90
                  ....*....|.
gi 126131102 1095 VL-PRAFTYVS 1104
Cdd:cd00102    79 TSsPLTFTYVP 89
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3002-3177 1.63e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.87  E-value: 1.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  3002 SSVEFSNVSAGSwIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TVTNNLvvlmtqpaWSTIWVAG 3080
Cdd:pfam13229    1 SGILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNnTISNNT--------ISNNGGGG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  3081 IKVNQVKDINLHGNVVAGSERLGFHIrghkCSSCELLWSDNVAHS-SLHGLHLYKESG---LDNCTrisgflAFKNFDYG 3156
Cdd:pfam13229   72 IALRGSSNNLIENNTISNNGGAGIYL----SDSSNNTIENNIIHNnGGSGIVIEDSSNnvtISNNT------VTNNKGAG 141

                          170       180
                   ....*....|....*....|.
gi 126131102  3157 amLHVENSveIENITLVDNTI 3177
Cdd:pfam13229  142 --ILIVGG--SSNNTVENNTF 158
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 261-313 1.97e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 48.37  E-value: 1.97e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 126131102  261 ILSVFPETGSLGGRTNITITGDFFD--NSAQVTIAGIPCDIRHVSPRKIECTTRA 313
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLNagSSVRVTVGGQPCKILSVSSSQIVCLTPP 57
IPT smart00429
ig-like, plexins, transcription factors;
260-311 2.39e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.39e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 126131102    260 EILSVFPETGSLGGRTNITITGDFFDNSAQVTI----AGIPCDIRHVSPRKIECTT 311
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgvGEAPCTFSPSSSTAIVCKT 58
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1578-1642 1.32e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.32e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126131102  1578 YFPKNFSLHGGSLLTIEGTGLR-GQNTTSVYIDQQTCLTVNIGAELIRCIVPTG-NGSVALEIEVDG 1642
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGG 72
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1573-1640 6.21e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 44.37  E-value: 6.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126131102 1573 PQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYI-DQQTCLTVNIGAELIRCIVPTGNGSVALEIEV 1640
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEV 69
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1197-1294 8.84e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 44.23  E-value: 8.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVW--VLVGNRSCdIVNLTEASIW----CETlpapqiPDAGAPTVPAAVE 1270
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhgVRVGGVPC-NPEPPEYSSSekivCTT------GPAGNPVFNGPVE 74

                          90       100
                  ....*....|....*....|....
gi 126131102 1271 VWAGNRFFaRGPSPslvgKGFTFM 1294
Cdd:cd01180    75 VTVGHGSF-RTESS----EGFSFV 93
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1587-1642 1.94e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 42.98  E-value: 1.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 126131102 1587 GGSLLTIEGTGLRGQNTTSVYIDQQTCLTVNIGAELIRCIVP--TGNGSVALEIEVDG 1642
Cdd:cd01179    15 GGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPpsASPGEAPVKVLIDG 72
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3017-3179 4.34e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 45.68  E-value: 4.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 3017 SSTLHQSCGGGIHAAASHGVLLNDNIVFGTAgHGIDLEGQAY-TVTNNLVVlmTQPAWSTIWVAGIKVNQVKDINLHGNV 3095
Cdd:COG3420    90 SGDSLTDDDAGIYVRGADNAVIENNRIENNL-FGIYLEGSDNnVIRNNTIS--GNRDLRADRGNGIHLWNSPGNVIEGNT 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 3096 VAGSeRLGFHIrghkCSSCELLWSDNVAHSSLHGLHLYKESG--------LDNCT----------RISGFLAFKNFDYGA 3157
Cdd:COG3420   167 ISGG-RDGIYL----EFSDNNVIRNNTIRNLRYGIHYMYSNDnlvegntfRDNGAgialmyskgnTVRGNTILGNSGYGI 241

                         170       180
                  ....*....|....*....|..
gi 126131102 3158 MLHVENSVEIENITLVDNTIGL 3179
Cdd:COG3420   242 LLKESSDSVIEGNTISGNGKGI 263
IPT smart00429
ig-like, plexins, transcription factors;
1197-1294 4.95e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 41.64  E-value: 4.95e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102   1197 EVFSIEPCCGSLLGGTILSISGIGFSRDPALVWVL-VGNRSCDIVNLTEASIWCETLPAPQIPdagaptvpaaVEVWAGN 1275
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgVGEAPCTFSPSSSTAIVCKTPPYHNIP----------GSVPVRT 72

                            90
                    ....*....|....*....
gi 126131102   1276 RFFARGPSPSLvGKGFTFM 1294
Cdd:smart00429   73 VGLRNGGVPSS-PQPFTYV 90
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2197-2348 9.42e-04

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 44.52  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 2197 SQVQLKGVQFQVLGQAFHKHLSSLTLVGAmRESFIQGCTVRNSFSrGLSMCGTLGLKVDSNVFYNIlghallvgtcTEMR 2276
Cdd:COG3420    78 DNVTVRGLTITGSGDSLTDDDAGIYVRGA-DNAVIENNRIENNLF-GIYLEGSDNNVIRNNTISGN----------RDLR 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126131102 2277 YISWEAIHGrkddWSGHGNIIRNNVIIQVSGaeglsnpemltpsGIYI-CSPTNVIEGNRVCGAGYGyfFHLM 2348
Cdd:COG3420   146 ADRGNGIHL----WNSPGNVIEGNTISGGRD-------------GIYLeFSDNNVIRNNTIRNLRYG--IHYM 199
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1200-1255 9.70e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 40.89  E-value: 9.70e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 126131102  1200 SIEPCCGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAP 1255
Cdd:pfam01833    5 SISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT 60
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1019-1103 1.62e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 40.38  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1019 PRLDMVEPSRAADIGGLWATIRGSSLeGVSL------ILFGSYSCAINVAT-SNSSRIQCKVPPRGKDGR--IVNVTVIR 1089
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNL-GLRKndvrhgVRVGGVPCNPEPPEySSSEKIVCTTGPAGNPVFngPVEVTVGH 79

                          90
                  ....*....|....
gi 126131102 1090 GDYSAVLPRAFTYV 1103
Cdd:cd01180    80 GSFRTESSEGFSFV 93
IPT smart00429
ig-like, plexins, transcription factors;
1389-1445 1.89e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.10  E-value: 1.89e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 126131102   1389 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVDLSGPFtCVILSLGDHTILCQV 1445
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAP-CTFSPSSSTAIVCKT 58
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1198-1275 2.09e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 39.90  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1198 VFSIEPCCGSLLGGTILSISG----IGFSRDpalvwVLVGNRSCDIVNLTEASIWCETLPAPQIPdagaptvPAAVEVWA 1273
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGkhlnAGSSVR-----VTVGGQPCKILSVSSSQIVCLTPPSASPG-------EAPVKVLI 70


                  ..
gi 126131102 1274 GN 1275
Cdd:cd01179    71 DG 72
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1389-1467 3.12e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 39.51  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1389 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVdlsGPFTCVILSLGDHTILCQVSLEGDPLPGasfslNVTVLVNG 1467
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAgSSVRVTV---GGQPCKILSVSSSQIVCLTPPSASPGEA-----PVKVLIDG 72
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2991-3109 5.68e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.47  E-value: 5.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2991 VEIQNFGSPLYSSVEFSNV---------SAGSWIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAY-TV 3060
Cdd:pfam13229   26 IYLRGSSNATIENNTITNNggdgieisgSSNNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAGIYLSDSSNnTI 105

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 126131102  3061 TNNLVVLMTQpawstiwvAGIKVNQVKD-INLHGNVVAGSERLGFHIRGH 3109
Cdd:pfam13229  106 ENNIIHNNGG--------SGIVIEDSSNnVTISNNTVTNNKGAGILIVGG 147
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1389-1462 6.94e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.84  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102 1389 PRIMAIFPSQGSACGGTILTVRG----LLLNSRRRSVRVdlsGPFTCVILSLGDHT---ILCQVSLEGDPLPGASFSLNV 1461
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGsnlgLRKNDVRHGVRV---GGVPCNPEPPEYSSsekIVCTTGPAGNPVFNGPVEVTV 77


                  .
gi 126131102 1462 T 1462
Cdd:cd01180    78 G 78
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1389-1453 7.19e-03

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 38.94  E-value: 7.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126131102 1389 PRIMAIFPSQGSACGGTILTVRGLLLNS-RRRSVRVDLSGPFT--CVILSlgDHTILCQV-SLEGDPLP 1453
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTvQEPRIRVKYGGVEKtsCKVRN--STLMTCPApSLALLNRS 67
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1019-1102 7.73e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 38.20  E-value: 7.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  1019 PRLDMVEPSRAADIGGLWATIRGSSLEGVS---LILFGSYSCAINvaTSNSSRIQCKVPPRGKDGRIVNVTViRGDYSAV 1095
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVI--SVSSTTIVCTTPPGTSGLVNVSVTV-GGGGISS 77


                   ....*..
gi 126131102  1096 LPRAFTY 1102
Cdd:pfam01833   78 SPLTFTY 84
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2290-2447 9.54e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 39.70  E-value: 9.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2290 WSGHGNIIRNNVIIQVSGaeglsnpemltpSGIYI-CSPTNVIEGNRVcgAGYGYFFHLMTNQTSqaplLSFTQNIAHSC 2368
Cdd:pfam13229    6 NGSSNATIKNNTISNNGG------------YGIYLrGSSNATIENNTI--TNNGGDGIEISGSSN----NTISNNTISNN 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126131102  2369 TRYGLFVYPkfqppwdnvTGTTLFQSFTVWESAG-GAQIFRSSNLRLKNFKVYSCRDFGIDVLESDANTSVTDSLLLGHF 2447
Cdd:pfam13229   68 GGGGIALRG---------SSNNLIENNTISNNGGaGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTNNK 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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