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Conserved domains on  [gi|19923891|ref|NP_612352|]
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kinesin light chain 4 isoform c [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12321303)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
210-285 1.33e-11

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 1.33e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19923891   210 RLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRES 285
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 134-294 6.80e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 6.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 134 EQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSRGQGATAAQQGGYEIPARLRT 213
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 214 LHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSirestLGPDHPA 293
Cdd:COG3914  81 LELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRALA-----LNPDFAE 147


                .
gi 19923891 294 V 294
Cdd:COG3914 148 A 148
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 33-148 1.04e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891     33 LEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQ-VMLALASHLSTVESEKQKLRAQVRR 111
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkELYALANEISRLEQQKQILRERLAN 313

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 19923891    112 LCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLE 148
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK 350
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
210-285 1.33e-11

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 1.33e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19923891   210 RLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRES 285
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 208-294 4.97e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 51.07  E-value: 4.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDAL-SIREST 286
Cdd:NF040586 517 PRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALeRYREVL 596


                 ....*...
gi 19923891  287 LGPDHPAV 294
Cdd:NF040586 597 GGPDHPDT 604
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 208-292 3.24e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 48.76  E-value: 3.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTL 287
Cdd:NF040586 644 PDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALEGLRERL 723


                 ....*
gi 19923891  288 GPDHP 292
Cdd:NF040586 724 GPDHP 728
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 208-294 7.91e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.30  E-value: 7.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRestl 287
Cdd:COG3914 109 PDNAEALFNLGNLLLALGRLEEALAALRRALAL--------NPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD---- 176


                ....*..
gi 19923891 288 gPDHPAV 294
Cdd:COG3914 177 -PDNAEA 182
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 203-292 1.03e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 46.84  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  203 GGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPD-VATMLNiLALVYRDQNKYKEAAHLLNDALS 281
Cdd:NF040586 597 GGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDtLAAALS-LANDLRALGDADEARELAREVLD 675

                         90
                 ....*....|.
gi 19923891  282 IRESTLGPDHP 292
Cdd:NF040586 676 RYRRVLGEDHP 686
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 201-292 1.95e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 46.07  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  201 QQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERT-SGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDA 279
Cdd:NF040586 552 RVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDT 631

                         90
                 ....*....|...
gi 19923891  280 LSIRESTLGPDHP 292
Cdd:NF040586 632 YERYRRRFGPDHP 644
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 216-294 5.51e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.44  E-value: 5.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  216 NLVIQYAAQGRYEVAvpLCKQALEDLERTSGRG------HPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGP 289
Cdd:NF040586 736 NLANDLAALGDLDAA--LGEEALERLRRLLGEDlragpdHPDTLACAANLALDLRATGRTEEAEELRADTLARLRRVLGP 813


                 ....*
gi 19923891  290 DHPAV 294
Cdd:NF040586 814 DHPDT 818
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 134-294 6.80e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 6.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 134 EQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSRGQGATAAQQGGYEIPARLRT 213
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 214 LHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSirestLGPDHPA 293
Cdd:COG3914  81 LELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRALA-----LNPDFAE 147


                .
gi 19923891 294 V 294
Cdd:COG3914 148 A 148
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 223-294 8.70e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.06  E-value: 8.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923891  223 AQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAV 294
Cdd:NF040586 490 ALGRFREALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRT 561
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 223-292 9.01e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.06  E-value: 9.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923891  223 AQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSI--RESTLGPDHP 292
Cdd:NF040586 404 LRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEARELDEDTLERqrRVLGLGEDHP 475
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 33-148 1.04e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891     33 LEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQ-VMLALASHLSTVESEKQKLRAQVRR 111
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkELYALANEISRLEQQKQILRERLAN 313

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 19923891    112 LCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLE 148
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK 350
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
27-151 2.06e-03

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444094 [Multi-domain]  Cd Length: 747  Bit Score: 39.84  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  27 RLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESekQKLR 106
Cdd:COG5283   6 GAVDKPFKSALESAKQRVAALAQALKALEAPTRALARALERAKQAAARLQTKYNKLRQSLQRLRQALDQAGIDT--RQLS 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19923891 107 AQVRRLCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLEFLG 151
Cdd:COG5283  84 AAQRRLRSSLEQTNRQLERQQQRLARLGARQDRLKAARARLQRLA 128
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
210-285 1.33e-11

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 59.32  E-value: 1.33e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19923891   210 RLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRES 285
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_10 pfam13374
Tetratricopeptide repeat;
252-292 1.11e-08

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 50.19  E-value: 1.11e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19923891   252 VATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHP 292
Cdd:pfam13374   1 TASSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHP 41
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 208-294 4.97e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 51.07  E-value: 4.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDAL-SIREST 286
Cdd:NF040586 517 PRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALeRYREVL 596


                 ....*...
gi 19923891  287 LGPDHPAV 294
Cdd:NF040586 597 GGPDHPDT 604
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 208-292 3.24e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 48.76  E-value: 3.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTL 287
Cdd:NF040586 644 PDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALEGLRERL 723


                 ....*
gi 19923891  288 GPDHP 292
Cdd:NF040586 724 GPDHP 728
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 208-294 7.91e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.30  E-value: 7.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRestl 287
Cdd:COG3914 109 PDNAEALFNLGNLLLALGRLEEALAALRRALAL--------NPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD---- 176


                ....*..
gi 19923891 288 gPDHPAV 294
Cdd:COG3914 177 -PDNAEA 182
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 203-292 1.03e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 46.84  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  203 GGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPD-VATMLNiLALVYRDQNKYKEAAHLLNDALS 281
Cdd:NF040586 597 GGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDtLAAALS-LANDLRALGDADEARELAREVLD 675

                         90
                 ....*....|.
gi 19923891  282 IRESTLGPDHP 292
Cdd:NF040586 676 RYRRVLGEDHP 686
TPR_10 pfam13374
Tetratricopeptide repeat;
211-251 1.13e-05

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 41.72  E-value: 1.13e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19923891   211 LRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPD 251
Cdd:pfam13374   2 ASSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 201-292 1.95e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 46.07  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  201 QQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERT-SGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDA 279
Cdd:NF040586 552 RVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDT 631

                         90
                 ....*....|...
gi 19923891  280 LSIRESTLGPDHP 292
Cdd:NF040586 632 YERYRRRFGPDHP 644
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 208-294 6.39e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 6.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRestl 287
Cdd:COG3914 143 PDFAEAYLNLGEALRRLGRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD---- 210


                ....*..
gi 19923891 288 gPDHPAV 294
Cdd:COG3914 211 -PDNADA 216
TPR_12 pfam13424
Tetratricopeptide repeat;
251-296 1.36e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 1.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 19923891   251 DVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVSI 296
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTAT 46
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-283 1.39e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 1.39e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19923891 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIR 283
Cdd:COG0457  39 PDDAEALYNLGLAYLRLGRYEEALADYEQALEL--------DPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-282 2.07e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.92  E-value: 2.07e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19923891 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEdlertsgrGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSI 282
Cdd:COG0457  73 PDDAEALNNLGLALQALGRYEEALEDYDKALE--------LDPDDAEALYNLGLALLELGRYDEAIEAYERALEL 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-282 3.48e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 3.48e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19923891 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSI 282
Cdd:COG0457   5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL 71
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 216-294 5.51e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.44  E-value: 5.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  216 NLVIQYAAQGRYEVAvpLCKQALEDLERTSGRG------HPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGP 289
Cdd:NF040586 736 NLANDLAALGDLDAA--LGEEALERLRRLLGEDlragpdHPDTLACAANLALDLRATGRTEEAEELRADTLARLRRVLGP 813


                 ....*
gi 19923891  290 DHPAV 294
Cdd:NF040586 814 DHPDT 818
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 134-294 6.80e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 6.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 134 EQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSRGQGATAAQQGGYEIPARLRT 213
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 214 LHNLVIQYAAQGRYEVAVPLCKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSirestLGPDHPA 293
Cdd:COG3914  81 LELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLALGRLEEALAALRRALA-----LNPDFAE 147


                .
gi 19923891 294 V 294
Cdd:COG3914 148 A 148
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 223-294 8.70e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.06  E-value: 8.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923891  223 AQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAV 294
Cdd:NF040586 490 ALGRFREALELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRT 561
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 223-292 9.01e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 41.06  E-value: 9.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923891  223 AQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSI--RESTLGPDHP 292
Cdd:NF040586 404 LRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEARELDEDTLERqrRVLGLGEDHP 475
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 33-148 1.04e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891     33 LEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQ-VMLALASHLSTVESEKQKLRAQVRR 111
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkELYALANEISRLEQQKQILRERLAN 313

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 19923891    112 LCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLE 148
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK 350
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
27-151 2.06e-03

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444094 [Multi-domain]  Cd Length: 747  Bit Score: 39.84  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891  27 RLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESekQKLR 106
Cdd:COG5283   6 GAVDKPFKSALESAKQRVAALAQALKALEAPTRALARALERAKQAAARLQTKYNKLRQSLQRLRQALDQAGIDT--RQLS 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19923891 107 AQVRRLCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLEFLG 151
Cdd:COG5283  84 AAQRRLRSSLEQTNRQLERQQQRLARLGARQDRLKAARARLQRLA 128
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
208-287 2.69e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 2.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891 208 PARLRTLHNLVIQYAAQGRYEVAVPLcKQALEDlertsgrgHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTL 287
Cdd:COG3063  23 PDNADALNNLGLLLLEQGRYDEAIAL-EKALKL--------DPNNAEALLNLAELLLELGDYDEALAYLERALELDPSAL 93
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 221-280 5.68e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.00  E-value: 5.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923891   221 YAAQGRYEVAVPLCKQALEdlertSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDAL 280
Cdd:pfam13432   7 ALRAGDYDDAAAALEAALA-----RFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAAL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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