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Conserved domains on  [gi|19921780|ref|NP_610340|]
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uncharacterized protein Dmel_CG14763, isoform A [Drosophila melanogaster]

Protein Classification

Tctex-type family dynein light chain( domain architecture ID 16901468)

Tctex-type family dynein light chain such as Tctex1 domain-containing protein A; dynein light chain is a non-catalytic accessory component of the cytoplasmic dynein complex thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function

CATH:  3.30.1140.40
Gene Ontology:  GO:0005868|GO:0007018|GO:0045505
PubMed:  11278908|36861883
SCOP:  3000821

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 86-186 1.83e-32

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


:

Pssm-ID: 411999  Cd Length: 101  Bit Score: 112.20  E-value: 1.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  86 NKERVENIIKAVMNRHYNDEYmFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKD 165
Cdd:cd21451   2 NPEKVKKIIKEVLEERLENVT-YDPEECAQLCKELSEEIKDRVKELGFDRYKIVVQVTIGEKKGQGVRVASRCLWDPETD 80

                        90       100
                ....*....|....*....|.
gi 19921780 166 GFVTYSVERPSYFAVCTTFYL 186
Cdd:cd21451  81 NFASATFENESLFAVATVFGV 101
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 86-186 1.83e-32

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


Pssm-ID: 411999  Cd Length: 101  Bit Score: 112.20  E-value: 1.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  86 NKERVENIIKAVMNRHYNDEYmFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKD 165
Cdd:cd21451   2 NPEKVKKIIKEVLEERLENVT-YDPEECAQLCKELSEEIKDRVKELGFDRYKIVVQVTIGEKKGQGVRVASRCLWDPETD 80

                        90       100
                ....*....|....*....|.
gi 19921780 166 GFVTYSVERPSYFAVCTTFYL 186
Cdd:cd21451  81 NFASATFENESLFAVATVFGV 101
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 89-184 2.10e-31

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 109.15  E-value: 2.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780    89 RVENIIKAVMNRHYNDEYMFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKDGFV 168
Cdd:pfam03645   1 EVKEIIKEVLEEVLGGGETYDHEKVPQWTKEISEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYA 80

                          90
                  ....*....|....*.
gi 19921780   169 TYSVERPSYFAVCTTF 184
Cdd:pfam03645  81 SYKFENKSLFAVVTVF 96
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 86-186 1.83e-32

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


Pssm-ID: 411999  Cd Length: 101  Bit Score: 112.20  E-value: 1.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  86 NKERVENIIKAVMNRHYNDEYmFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKD 165
Cdd:cd21451   2 NPEKVKKIIKEVLEERLENVT-YDPEECAQLCKELSEEIKDRVKELGFDRYKIVVQVTIGEKKGQGVRVASRCLWDPETD 80

                        90       100
                ....*....|....*....|.
gi 19921780 166 GFVTYSVERPSYFAVCTTFYL 186
Cdd:cd21451  81 NFASATFENESLFAVATVFGV 101
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 89-184 2.10e-31

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 109.15  E-value: 2.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780    89 RVENIIKAVMNRHYNDEYMFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKDGFV 168
Cdd:pfam03645   1 EVKEIIKEVLEEVLGGGETYDHEKVPQWTKEISEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYA 80

                          90
                  ....*....|....*.
gi 19921780   169 TYSVERPSYFAVCTTF 184
Cdd:pfam03645  81 SYKFENKSLFAVVTVF 96
DLC-like_TCTEX1D2 cd21459
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) ...
 88-188 2.86e-19

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins; Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.


Pssm-ID: 412007  Cd Length: 104  Bit Score: 78.29  E-value: 2.86e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  88 ERVENIIKAVMNRH-----YNDEYMfhPKhslhMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDA 162
Cdd:cd21459   5 SKVKEIIHEVLKEKlagktYDPEEA--PQ----WTKEIADEIKDKLKELGFPRYKIVVQVVIGEQRGQGVRVGSRCLWDA 78

                        90       100
                ....*....|....*....|....*.
gi 19921780 163 EKDGFVTYSVERPSYFAVCTTFYLYY 188
Cdd:cd21459  79 DTDNYASEVFINDSLFCVATVFGVYY 104
DLC-like_TCTEX1D1 cd21458
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) ...
 90-189 1.80e-17

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) and similar proteins; Tctex1 domain-containing protein 1 (TCTEX1D1) is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. The model corresponds to the (dynein light chain) DLC-like domain of TCTEX1D1.


Pssm-ID: 412006  Cd Length: 104  Bit Score: 73.86  E-value: 1.80e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  90 VENIIKAVMNRHYNDEyMFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKDGFVT 169
Cdd:cd21458   6 VKNILKDVLESYLQEE-RYEPELCRQMTKTISEVIKARVKDLMLPRYKIIVLVHIGQLNDQGLRVGSRCLWDPANDTFSS 84

                        90       100
                ....*....|....*....|
gi 19921780 170 YSVERPSYFAVCTTFYLYYD 189
Cdd:cd21458  85 YEFRNSSLFAVATVYGVYFE 104
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 76-187 1.62e-16

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 71.59  E-value: 1.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  76 TYRLESKNPLNKERVENIIKAVMNRHYNDeYMFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSM 155
Cdd:cd21460   2 TYRLEPLKKFQPHLVRKKAEEILKEKLKD-IKYDADRCRSLSLSLAADILAAVKELGFDRYKYVVRVFLGEKTGQSVKIA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 19921780 156 VNFLWDAEKDGFVTYSVERPSYFAVCTTFYLY 187
Cdd:cd21460  81 SRAVWDTEKDNWVSATFENESLFAVALVFALY 112
DLC-like_SF cd21449
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 93-184 4.24e-10

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


Pssm-ID: 411997  Cd Length: 96  Bit Score: 54.27  E-value: 4.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  93 IIKAVMNRHYNDEYmFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKDGFVTYSV 172
Cdd:cd21449   5 IIKEVLESILDDKE-YDPLKLKEIAKKISEEIKEKLKELSPSRYKYIVHVTISENNGQGIRADSGCLWDPDTDGFVSEVY 83

                        90
                ....*....|..
gi 19921780 173 ERPSYFAVCTTF 184
Cdd:cd21449  84 ENDNIICTVTVF 95
DLC-like_TCTEX1D4 cd21461
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) ...
 89-189 1.08e-09

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) and similar proteins; Tctex1 domain-containing protein 4 (TCTEX1D4), also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2 and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D4.


Pssm-ID: 412009  Cd Length: 114  Bit Score: 53.51  E-value: 1.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  89 RVENIIKAVMNRHYNDEyMFHPKHSLHMAAQVSEEIKNRIKLDNYDRYRYIVLVTVGEFLMQGLYSMVNFLWDAEKDGFV 168
Cdd:cd21461  15 RVQQILEATLDSYLGGA-RYSPATCGQLSQGLSELVRSKVKDLSPPRYKLVCQVVLGQCGNQGLRVASRCLWDPERDNFA 93

                        90       100
                ....*....|....*....|.
gi 19921780 169 TYSVERPSYFAVCTTFYLYYD 189
Cdd:cd21461  94 SASFQNASLFAVATVHGVYFE 114
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 88-184 1.00e-07

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 47.96  E-value: 1.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921780  88 ERVENIIKAVMNRHYNDEYMFHPKHSlHMAAQVSEEI-KNRIKLDNydRYRYIVLVTvgefLMQ----GLYSMVNFLWDA 162
Cdd:cd21455   1 EEVESIVKEAIEAVLGDKTYSHSKVN-QWSNSIVEEIlKRLAKLNK--PFKYIVTCV----IMQktgaGLHTASSCYWDP 73

                        90       100
                ....*....|....*....|..
gi 19921780 163 EKDGFVTYSVERPSYFAVCTTF 184
Cdd:cd21455  74 TTDGSVTVRWENKTMYCIVTVF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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