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Conserved domains on  [gi|1937906340|ref|NP_604450|]
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fractalkine precursor [Rattus norvegicus]

Protein Classification

C-C motif chemokine( domain architecture ID 10084524)

C-C motif chemokine recruits and activates leukocytes, and plays a major role in both immune response and inflammation-related diseases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 6.85e-54

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


:

Pssm-ID: 238172  Cd Length: 76  Bit Score: 172.94  E-value: 6.85e-54
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937906340  25 QHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNG 100
Cdd:cd00274     1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 109-334 3.96e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.51  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 109 NVTPRITSTTRGLSPTALAKPESATVEDLTLEPTAISqeaRRPMGTSQEPPAAVTGsfpstskaqdagLAAKPQSTGISE 188
Cdd:pfam05109 386 NRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFS---KAPESTTTSPTLNTTG------------FAAPNTTTGLPS 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 189 VAAVSTTIwpsSAVYQSGSSLWAEEKATESPP-TIALSTQVSTTSSPKQNvGSEGQPPWVQEQDS-----TPE-KSPGPE 261
Cdd:pfam05109 451 STHVPTNL---TAPASTGPTVSTADVTSPTPAgTTSGASPVTPSPSPRDN-GTESKAPDMTSPTSavttpTPNaTSPTPA 526

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937906340 262 ETNPVHTDIFQDRGPGSTVHPSVAPTSSEKTPSPelvASGSQAPKVEEPIHATADPQklSVFITPVPDSQAAT 334
Cdd:pfam05109 527 VTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTP---AVTTPTPNATIPTLGKTSPT--SAVTTPTPNATSPT 594
 
Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 6.85e-54

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 172.94  E-value: 6.85e-54
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937906340  25 QHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNG 100
Cdd:cd00274     1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 36-89 3.65e-18

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 77.67  E-value: 3.65e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1937906340   36 CHKMTS-PIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:smart00199   5 CLSYTSkKIPLKRIKSYYPTSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-89 5.68e-14

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 66.14  E-value: 5.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937906340  30 TKCnitCHKMTS-PIPVTLLIHY--QLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:pfam00048   1 SDC---CLRYSSkPIPLKRVKSYeiQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 109-334 3.96e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.51  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 109 NVTPRITSTTRGLSPTALAKPESATVEDLTLEPTAISqeaRRPMGTSQEPPAAVTGsfpstskaqdagLAAKPQSTGISE 188
Cdd:pfam05109 386 NRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFS---KAPESTTTSPTLNTTG------------FAAPNTTTGLPS 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 189 VAAVSTTIwpsSAVYQSGSSLWAEEKATESPP-TIALSTQVSTTSSPKQNvGSEGQPPWVQEQDS-----TPE-KSPGPE 261
Cdd:pfam05109 451 STHVPTNL---TAPASTGPTVSTADVTSPTPAgTTSGASPVTPSPSPRDN-GTESKAPDMTSPTSavttpTPNaTSPTPA 526

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937906340 262 ETNPVHTDIFQDRGPGSTVHPSVAPTSSEKTPSPelvASGSQAPKVEEPIHATADPQklSVFITPVPDSQAAT 334
Cdd:pfam05109 527 VTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTP---AVTTPTPNATIPTLGKTSPT--SAVTTPTPNATSPT 594
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 122-310 5.77e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 122 SPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAAVTGSFPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSA 201
Cdd:PRK07764  617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGA 696

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 202 V-YQSGSSLWAEEKATESPPTIALSTQVSTTSSPKQNVGSEGQPPwvqeqDSTPEKSPGPEETNPVHTDIFQDRGPGSTV 280
Cdd:PRK07764  697 ApAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL-----PPEPDDPPDPAGAPAQPPPPPAPAPAAAPA 771

                         170       180       190
                  ....*....|....*....|....*....|
gi 1937906340 281 HPSVAPTSSEKTPSPELVASGSQAPKVEEP 310
Cdd:PRK07764  772 AAPPPSPPSEEEEMAEDDAPSMDDEDRRDA 801
 
Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 6.85e-54

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 172.94  E-value: 6.85e-54
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937906340  25 QHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNG 100
Cdd:cd00274     1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 36-89 3.65e-18

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 77.67  E-value: 3.65e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1937906340   36 CHKMTS-PIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:smart00199   5 CLSYTSkKIPLKRIKSYYPTSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 40-90 6.53e-16

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 71.51  E-value: 6.53e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1937906340  40 TSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLD 90
Cdd:cd00272     7 KKRIPLRVLKSYRRTSSSCSKPAVIFKTKRGREVCADPKQKWVQRYMKLLD 57
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 35-90 1.97e-15

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 70.06  E-value: 1.97e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1937906340  35 TCHKMTS-PIPVTLLIHYQLNQ--ESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLD 90
Cdd:cd00169     1 CCLKYTSkPIPPKNIKSYRVQEagGHCSIPAVIFTTKKGRKVCADPKEPWVKDLIQKLD 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-89 5.68e-14

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 66.14  E-value: 5.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937906340  30 TKCnitCHKMTS-PIPVTLLIHY--QLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:pfam00048   1 SDC---CLRYSSkPIPLKRVKSYeiQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
Chemokine_CC_DCCL cd01119
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ...
 42-90 1.63e-10

Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238539  Cd Length: 61  Bit Score: 56.26  E-value: 1.63e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1937906340  42 PIPVTLLI--HYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLD 90
Cdd:cd01119    11 PIPWRVLRgyTYQEISESCDIPAIIFHTRRGRKVCADPKQDWVKRAIQLLS 61
Chemokine_C cd00271
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on ...
 40-99 2.98e-05

Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273) subclass. The two other subclasses each have a single known member: fractalkine for the CX3C (cd00274) class and lymphotactin for the C (cd00271) class. Chemokine_Cs differ structurally since they contain only one of the two disulfide bridges that are conserved in all other chemokines and they possess a unique C-terminal extension, which is required for biological activity and thought to play a role in receptor binding. Lymphotactin, a mediator of mucosal immunity, has been found to chemoattract neutrophils and B cells through the XCR1 receptor and thought to be a factor in acute allograft rejection and inflammatory bowel disease.


Pssm-ID: 238169  Cd Length: 72  Bit Score: 41.76  E-value: 2.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340  40 TSPIPVTLLIHYQLNQESCgkRAIILETRQHRHFCADPKEKWVQDAMKHLDHQtaALTRN 99
Cdd:cd00271    16 TQRLPVQKIKTYTIKEGSV--RAVIFITKRGLKICADPQAKWVKSAVKTIDRR--ASTRK 71
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 109-334 3.96e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.51  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 109 NVTPRITSTTRGLSPTALAKPESATVEDLTLEPTAISqeaRRPMGTSQEPPAAVTGsfpstskaqdagLAAKPQSTGISE 188
Cdd:pfam05109 386 NRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFS---KAPESTTTSPTLNTTG------------FAAPNTTTGLPS 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 189 VAAVSTTIwpsSAVYQSGSSLWAEEKATESPP-TIALSTQVSTTSSPKQNvGSEGQPPWVQEQDS-----TPE-KSPGPE 261
Cdd:pfam05109 451 STHVPTNL---TAPASTGPTVSTADVTSPTPAgTTSGASPVTPSPSPRDN-GTESKAPDMTSPTSavttpTPNaTSPTPA 526

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937906340 262 ETNPVHTDIFQDRGPGSTVHPSVAPTSSEKTPSPelvASGSQAPKVEEPIHATADPQklSVFITPVPDSQAAT 334
Cdd:pfam05109 527 VTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTP---AVTTPTPNATIPTLGKTSPT--SAVTTPTPNATSPT 594
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 122-310 5.77e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 122 SPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAAVTGSFPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSA 201
Cdd:PRK07764  617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGA 696

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937906340 202 V-YQSGSSLWAEEKATESPPTIALSTQVSTTSSPKQNVGSEGQPPwvqeqDSTPEKSPGPEETNPVHTDIFQDRGPGSTV 280
Cdd:PRK07764  697 ApAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL-----PPEPDDPPDPAGAPAQPPPPPAPAPAAAPA 771

                         170       180       190
                  ....*....|....*....|....*....|
gi 1937906340 281 HPSVAPTSSEKTPSPELVASGSQAPKVEEP 310
Cdd:PRK07764  772 AAPPPSPPSEEEEMAEDDAPSMDDEDRRDA 801
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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