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Conserved domains on  [gi|20143912|ref|NP_599027|]
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WD repeat and SOCS box-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-242 9.94e-60

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 9.94e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319 152 GKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHlfppptpifaggaNDRWVRSVSF 173
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG-------------HSGGVNSVAF 296

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143912 174 SHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 242
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTltGHTGAVRSVAFSPDGKTLASGSDDGTVRLWdlATGELLRTLT 369
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 236-275 4.10e-24

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239715  Cd Length: 40  Bit Score: 91.41  E-value: 4.10e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20143912 236 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 275
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-242 9.94e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 9.94e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319 152 GKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHlfppptpifaggaNDRWVRSVSF 173
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG-------------HSGGVNSVAF 296

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143912 174 SHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 242
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTltGHTGAVRSVAFSPDGKTLASGSDDGTVRLWdlATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-233 1.28e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.20  E-value: 1.28e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVS 172
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGH--------------ENGVNSVA 226

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143912 173 FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFWA 233
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGKRLASGSADGTIRIWD 289
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 236-275 4.10e-24

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 91.41  E-value: 4.10e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20143912 236 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 275
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 232-274 1.11e-15

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.25  E-value: 1.11e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 20143912    232 WATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 274
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 29-145 1.95e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.60  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912   29 DLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV------LRGHQNWVYSCAFSPDS-SMLCSVGASKAVFLWNMDKYT 101
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 20143912  102 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDIL 145
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 237-271 4.08e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.01  E-value: 4.08e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20143912   237 QVPSLQHLCRMSIRRVMPT---QEVQELPIPSKLLEFL 271
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-138 7.83e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 7.83e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 20143912    103 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 138
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-138 1.03e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 20143912   103 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 138
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-242 9.94e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 9.94e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319 152 GKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHlfppptpifaggaNDRWVRSVSF 173
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG-------------HSGGVNSVAF 296

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143912 174 SHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGLCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 242
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTltGHTGAVRSVAFSPDGKTLASGSDDGTVRLWdlATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
14-242 3.69e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.51  E-value: 3.69e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHlfppptpifaggaNDRWVRSVSF 173
Cdd:COG2319 188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG-------------HSGSVRSVAF 254

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143912 174 SHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 242
Cdd:COG2319 255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWdlATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
14-232 6.40e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.43  E-value: 6.40e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVS 172
Cdd:COG2319 272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVA 337

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20143912 173 FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
Cdd:COG2319 338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGavTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
14-243 1.43e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 1.43e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319  68 GALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVS 172
Cdd:COG2319 146 LWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVA 211

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20143912 173 FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQH 243
Cdd:COG2319 212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTG 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-233 1.28e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.20  E-value: 1.28e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVS 172
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGH--------------ENGVNSVA 226

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143912 173 FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFWA 233
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
14-195 2.87e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 2.87e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRL-LASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVS 172
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtGH--------------TGAVTSVA 379

                       170       180
                ....*....|....*....|...
gi 20143912 173 FSHDGLHVASLADDKMVRFWRID 195
Cdd:COG2319 380 FSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-242 4.85e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.66  E-value: 4.85e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  12 EIGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLKDdGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 91
Cdd:cd00200  39 ETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  92 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRS 170
Cdd:cd00200 117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLtGH--------------TGEVNS 182

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20143912 171 VSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 242
Cdd:cd00200 183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYLLASGSEDGTIRVWdlRTGECVQTLS 258
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-232 2.35e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.12  E-value: 2.35e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  20 LVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 99
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912 100 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLfppptpifaggandRWVRSVSFSHDGL 178
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGHT--------------DWVNSVAFSPDGT 148

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20143912 179 HVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 232
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
14-243 1.72e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.28  E-value: 1.72e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGsLILVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319  26 GALLLLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDA-AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVS 172
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGH--------------SGAVTSVA 169

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20143912 173 FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQH 243
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGavRSVAFSPDGKLLASGSADGTVRLWdlATGKLLRTLTG 244
WD40 COG2319
WD40 repeat [General function prediction only];
14-141 5.85e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 5.85e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVF 93
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 20143912  94 LWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 141
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-138 9.85e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 9.85e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  12 EIGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 91
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDL-STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 20143912  92 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 138
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-242 2.90e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 2.90e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  40 LVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFS 119
Cdd:COG2319   9 LAAASADLALALLAA-ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912 120 PDGALLATASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDY 198
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 20143912 199 PVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 242
Cdd:COG2319 154 LLRTLTGHSGavTSVAFSPDGKLLASGSDDGTVRLWdlATGKLLRTLT 201
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 236-275 4.10e-24

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 91.41  E-value: 4.10e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 20143912 236 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 275
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 236-274 8.61e-22

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 85.17  E-value: 8.61e-22
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 20143912 236 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 274
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-232 1.35e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912 102 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GH-------LFPPPTPIFAGGANDR------- 166
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHtgpvrdvAASADGTYLASGSSDKtirlwdl 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912 167 --------------WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVY 230
Cdd:cd00200  81 etgecvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTFVASSSQDGTIK 160


                ..
gi 20143912 231 FW 232
Cdd:cd00200 161 LW 162
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 232-274 1.11e-15

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.25  E-value: 1.11e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 20143912    232 WATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 274
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 237-274 7.04e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 58.64  E-value: 7.04e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 20143912 237 QVPSLQHLCRMSIRRVM---PTQEVQELPIPSKLLEFLSYR 274
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 237-274 2.10e-10

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 54.52  E-value: 2.10e-10
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 20143912 237 QVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 274
Cdd:cd03717   2 SVRSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 236-274 4.42e-10

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 53.75  E-value: 4.42e-10
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 20143912 236 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 274
Cdd:cd03745   1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
PTZ00421 PTZ00421
coronin; Provisional
 29-145 1.95e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.60  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912   29 DLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV------LRGHQNWVYSCAFSPDS-SMLCSVGASKAVFLWNMDKYT 101
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 20143912  102 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDIL 145
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 236-274 2.81e-09

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 51.73  E-value: 2.81e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 20143912 236 RQVPSLQHLCRMSIRRVMPTQ---EVQELPIPSKLLEFLSYR 274
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 239-274 3.21e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 51.26  E-value: 3.21e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 20143912    239 PSLQHLCRMSIRRVMPTqeVQELPIPSKLLEFLSYR 274
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--IDKLPLPPRLKDYLLYY 34
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 237-271 4.08e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.01  E-value: 4.08e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20143912   237 QVPSLQHLCRMSIRRVMPT---QEVQELPIPSKLLEFL 271
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
PTZ00420 PTZ00420
coronin; Provisional
 17-187 2.36e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.57  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912   17 LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMK-------VLRGHQNWVYSCAFSP-DSSMLCSVGA 88
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIIDWNPmNYYIMCSSGF 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912   89 SKAVFLWNMD------KYTMIRKLEGHHHDVvacdfspDGALLATASYDTRVYIWDPHNGDILMEFghlfppptPIFAGG 162
Cdd:PTZ00420 147 DSFVNIWDIEnekrafQINMPKKLSSLKWNI-------KGNLLSGTCVGKHMHIIDPRKQEIASSF--------HIHDGG 211

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 20143912  163 AN------------DRWVRSVSFSHDGLHVASLADDK 187
Cdd:PTZ00420 212 KNtkniwidglggdDNYILSTGFSKNNMREMKLWDLK 248
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 239-274 4.40e-08

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 48.31  E-value: 4.40e-08
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 20143912 239 PSLQHLCRMSIRRVmpTQEVQELPIPSKLLEFLS-YR 274
Cdd:cd03736   4 PSLQHLCRITINKC--TRQIQELPLPTRLKDYLTeYT 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-138 7.83e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 7.83e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 20143912    103 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 138
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-138 1.03e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 20143912   103 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 138
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 236-273 4.94e-07

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 45.47  E-value: 4.94e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 20143912 236 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSY 273
Cdd:cd03741   1 KNVQSLQHLCRFVIRKLVRRDHIPALPLPRRLIDYLRE 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-96 6.92e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 6.92e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 20143912     57 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 96
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-53 1.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.22e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 20143912     14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWD 53
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
14-53 1.73e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 1.73e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 20143912    14 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWD 53
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
58-96 8.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 8.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 20143912    58 GNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 96
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 237-271 1.65e-05

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 41.25  E-value: 1.65e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 20143912 237 QVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFL 271
Cdd:cd03740   2 QVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 109-138 1.89e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.45  E-value: 1.89e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 20143912   109 HHHDVVAC-DFSPDGALLATASYDTRVYIWD 138
Cdd:pfam20426 122 QHKDVVSCvAVTSDGSILATGSYDTTVMVWE 152
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 238-271 2.64e-05

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 40.72  E-value: 2.64e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 20143912 238 VPSLQHLCRMSIRRVmpTQEVQELPIPSKLLEFL 271
Cdd:cd03734   3 ARSLQHLCRLVINRL--VTDVDCLPLPRRMADYL 34
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 240-274 1.23e-04

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 38.82  E-value: 1.23e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 20143912 240 SLQHLCRMSIRRVM---PTQEVQELPIPSKLLEFLSYR 274
Cdd:cd03718   5 PLMDLCRRRVRVALgrdRLEEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 234-271 1.55e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 38.58  E-value: 1.55e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 20143912 234 TPRqvpSLQHLCRMSIRRVMPTQ---EVQELPIPSKLLEFL 271
Cdd:cd03723   2 TPR---SLQHLCRCAIRKLLGSRchkLVPQLSLPTSLKNYL 39
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 234-274 2.58e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 37.84  E-value: 2.58e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 20143912 234 TPRqvpSLQHLCRMSIRRVMPTQEVQ---ELPIPSKLLEFLSYR 274
Cdd:cd03729   2 TPL---SLQQLCRINLRKALGTRALEkiaKLNIPNRIIDYLSYN 42
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 238-273 3.14e-04

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 37.85  E-value: 3.14e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 20143912 238 VPSLQHLCRMSIRRVMPTQE------VQELPIPSKLLEFLSY 273
Cdd:cd03722   3 VPSLTHLCRLEIRSSLKSERlrsdsfICQLPLPRSLQDYLLY 44
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 49-232 4.98e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912   49 LRV-WDLKDdGNMMKvlrgHQNWVYSCAFSPDSSMLCSVGASKAVFLW--------NMDKYTMIRKLEGHHHDVVACDFS 119
Cdd:PLN00181 468 LRVkADLKQ-GDLLN----SSNLVCAIGFDRDGEFFATAGVNKKIKIFecesiikdGRDIHYPVVELASRSKLSGICWNS 542

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  120 PDGALLATASYDTRVYIWDPHNGDILMEFGHlfppptpifaggaNDRWVRSVSFSH-DGLHVASLADDKMVRFWRIDEDY 198
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARSQLVTEMKE-------------HEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGV 609

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 20143912  199 PVQVAPLSNGLCCA-FSTD-GSVLAAGTHDGSVYFW 232
Cdd:PLN00181 610 SIGTIKTKANICCVqFPSEsGRSLAFGSADHKVYYY 645
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 19-138 5.62e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.66  E-value: 5.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  19 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML---CSVGASKAVFLW 95
Cdd:COG0823  25 RLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLafvSRSDGRFDIYVL 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 20143912  96 NMDKYTMIRKLEGHHHDVvacdFSPDGALLATASY---DTRVYIWD 138
Cdd:COG0823 105 DLDGGAPRRLTDGPGSPS----WSPDGRRIVFSSDrggRPDLYVVD 146
PTZ00421 PTZ00421
coronin; Provisional
 17-109 1.32e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912   17 LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 96
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV-ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196

                         90
                 ....*....|...
gi 20143912   97 MDKYTMIRKLEGH 109
Cdd:PTZ00421 197 PRDGTIVSSVEAH 209
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 240-274 1.46e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 35.96  E-value: 1.46e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 20143912 240 SLQHLCRMSIRRVMPTQEVQE------LPIPSKLLEFLSYR 274
Cdd:cd03731   5 PLKHLCRLKIRKLMGLQKLQQpssmkkLPLPPALKRYILYK 45
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 76-152 1.50e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.79  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912    76 FSPDSSMLCSVG---ASKAVFLWNMDKYTMIRKLEghHHDVVACDFSPDGALLATAS------YDTRVYIWDpHNGDILM 146
Cdd:pfam08662 108 WSPFGRLVLLAGfgnLAGDIEFWDVVNKKKIATAE--ASNATLCEWSPDGRYFLTATtaprlrVDNGFKIWH-YNGALVY 184


                  ....*...
gi 20143912   147 E--FGHLF 152
Cdd:pfam08662 185 KydFDELY 192
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
28-142 3.48e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 3.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  28 RDLTFAPDGSLILVSASRDKTLRVWDLKDdgnmMKVLR----GhqNWVYSCAFSPDSSML--CSVGA---SKAVFLWNMD 98
Cdd:COG3391 113 RGLAVDPDGGRLYVADSGNGRVSVIDTAT----GKVVAtipvG--AGPHGIAVDPDGKRLyvANSGSntvSVIVSVIDTA 186

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 20143912  99 KYTMIRKLEGHHHdVVACDFSPDGALLATASYDT--------RVYIWDPHNG 142
Cdd:COG3391 187 TGKVVATIPVGGG-PVGVAVSPDGRRLYVANRGSntsnggsnTVSVIDLATL 237
SOCS_SOCS5 cd03739
SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the ...
 240-271 3.58e-03

SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting IL-4 signaling. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239708  Cd Length: 57  Bit Score: 34.97  E-value: 3.58e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 20143912 240 SLQHLCRMSIRRVMPTQEVQELPIPSKLLEFL 271
Cdd:cd03739   5 SLQYICRAVICRCTTYDGIDALPLPSMLQDFL 36
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 163-192 5.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 5.50e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 20143912    163 ANDRWVRSVSFSHDGLHVASLADDKMVRFW 192
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-232 5.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 5.78e-03
                           10        20
                   ....*....|....*....|....
gi 20143912    209 LCCAFSTDGSVLAAGTHDGSVYFW 232
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 39-181 6.11e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 36.57  E-value: 6.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912  39 ILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML--CSV-GASKAVFLWNMDKYTMIRKLEGHHHDvVA 115
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIafTSDrGGGPQIYVVDADGGEPRRLTFGGGYN-AS 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20143912 116 CDFSPDGALLATASYDT---RVYIWDPHNGDilmefghlfppPTPIFAGGAndrwvrSVSFSHDGLHVA 181
Cdd:COG0823  80 PSWSPDGKRLAFVSRSDgrfDIYVLDLDGGA-----------PRRLTDGPG------SPSWSPDGRRIV 131
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 179-256 7.71e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 37.36  E-value: 7.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20143912   179 HVASLADDKMVRFWRIDEDYpvqVAplsnglCCAFSTDGSVLAAGTHDGSVYFWATPRQvpslqhlcRMSIRRVMPTQ 256
Cdd:pfam20426 107 QVISLNDGRMVQSIRQHKDV---VS------CVAVTSDGSILATGSYDTTVMVWEVLRG--------RSSEKRSRNTQ 167
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 233-274 8.26e-03

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 33.70  E-value: 8.26e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 20143912 233 ATPRqvpSLQHLCRMSIRRVMPTQE---VQELPIPSKLLEFLSYR 274
Cdd:cd03724   1 ATPS---SLCQLCRLCIRNYIGRSRlhlIPQLQLPTLLKNFLQYR 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 240-274 9.61e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 33.67  E-value: 9.61e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 20143912 240 SLQHLCRMSIRRVMPTQEVQE------LPIPSKLLEFLSYR 274
Cdd:cd03730   5 SLKHLCRLKIRACMGRLRLRCpvfmsfLPLPNRLKAYILYK 45
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 27-142 9.67e-03

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 37.05  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912    27 VRDLTFAPDGSLILVSASRDKTLRVWDLKD-DGNMM--KVLRGHQNW---------VYSCAFSPDSSMLCSVG--ASKAV 92
Cdd:pfam16529  67 VLDLAFAHTDCVILACVDDVGNLFVYKVDQiEGKILcnLLLHIEDPIgtypseyhrVIWCPYIPEDDETESDDddESKLL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143912    93 FLWNMDK-----YTMIRKLEG-----------------HHHDVVACDFSPDGALLATASYDT-----RVYI--------- 136
Cdd:pfam16529 147 VLLRGDKaeiwnVDMIVSEHGsgplqpaalesgyieieEHSLLVDAAFSPDGTALATASLDGevkffQIYLfdnrnprcl 226


                  ....*...
gi 20143912   137 --WDPHNG 142
Cdd:pfam16529 227 heWKPHDG 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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