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Conserved domains on  [gi|19882203|ref|NP_598864|]
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interleukin-1 receptor accessory protein isoform b precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 243-349 1.11e-78

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


:

Pssm-ID: 409525  Cd Length: 107  Bit Score: 236.46  E-value: 1.11e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 243 PQIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSIKKVT 322
Cdd:cd20931   1 PQIYSPNDRVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDVTIDVTINESISYSSTEDETRTQILSIKKVT 80

                        90       100
                ....*....|....*....|....*..
gi 19882203 323 PEDLRRNYVCHARNTKGEAEQAAKVKQ 349
Cdd:cd20931  81 PEDLKRNYVCHARNAKGEVEKAAKVKQ 107
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 5.18e-76

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


:

Pssm-ID: 409584  Cd Length: 108  Bit Score: 229.43  E-value: 5.18e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  25 DDWGLDTMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPT 104
Cdd:cd20992   1 DDWGLDTMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPDNRISKEKDVLWFRPT 80

                        90       100
                ....*....|....*....|....*...
gi 19882203 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd20992  81 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 108
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 145-235 1.46e-43

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20993:

Pssm-ID: 472250  Cd Length: 93  Bit Score: 145.81  E-value: 1.46e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 145 PVHKMYIEHGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMNLSFFIPLVSNNGNYTCVVTYPENGRLFH 224
Cdd:cd20993   3 TPVIAYIEYGGRTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYETKGRTIK 82

                        90
                ....*....|.
gi 19882203 225 LTRTVTVKVVG 235
Cdd:cd20993  83 LTRTVNVKVVG 93
 
Name Accession Description Interval E-value
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 243-349 1.11e-78

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


Pssm-ID: 409525  Cd Length: 107  Bit Score: 236.46  E-value: 1.11e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 243 PQIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSIKKVT 322
Cdd:cd20931   1 PQIYSPNDRVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDVTIDVTINESISYSSTEDETRTQILSIKKVT 80

                        90       100
                ....*....|....*....|....*..
gi 19882203 323 PEDLRRNYVCHARNTKGEAEQAAKVKQ 349
Cdd:cd20931  81 PEDLKRNYVCHARNAKGEVEKAAKVKQ 107
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 5.18e-76

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409584  Cd Length: 108  Bit Score: 229.43  E-value: 5.18e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  25 DDWGLDTMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPT 104
Cdd:cd20992   1 DDWGLDTMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPDNRISKEKDVLWFRPT 80

                        90       100
                ....*....|....*....|....*...
gi 19882203 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd20992  81 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 108
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 145-235 1.46e-43

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409585  Cd Length: 93  Bit Score: 145.81  E-value: 1.46e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 145 PVHKMYIEHGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMNLSFFIPLVSNNGNYTCVVTYPENGRLFH 224
Cdd:cd20993   3 TPVIAYIEYGGRTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYETKGRTIK 82

                        90
                ....*....|.
gi 19882203 225 LTRTVTVKVVG 235
Cdd:cd20993  83 LTRTVNVKVVG 93
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 3-325 2.84e-12

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 66.96  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203    3 LLWYLMSLSFYG-ILQSHASERCDDWGLdTMRQIQVFEDEPARIKCPlfehflKYNYSTAHSSGLTLIWYWTRQDRDLEE 81
Cdd:PHA02785   4 LPVIFLPIFFYSsFVQTFNAPECIDKGQ-YFASFMELENEPVILPCP------QINTLSSGYNILDILWEKRGADNDRII 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203   82 PINfrlpenrisKEKDVLWFRPTLlNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSAMRFPvhKMYIEHGIHKITCP 161
Cdd:PHA02785  77 PID---------NGSNMLILNPTQ-SDSGIYICITKNETYCDMMSLNLTIVSVSESNIDLISYP--QIVNERSTGEMVCP 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  162 NVDGYFPSSVKPSVTWyKGCTEIVDfhNVLPEGMNLSFFIPLVSNN--GNYTCVVTYPENGRLFHLTRTVTVKVvgspKD 239
Cdd:PHA02785 145 NINAFIASNVNADIIW-SGHRRLRN--KRLKQRTPGIITIEDVRKNdaGYYTCVLKYIYGDKTYNVTRIVKLEV----RD 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  240 AL-PPQIYSPNDRVVyekEPGEELVIPCKVYFSfIMDSHNEVWWTIDGK--KPDDVTVD--ITINESVsYSSTEDETRTQ 314
Cdd:PHA02785 218 RIiPPTMQLPEGVVT---SIGSNLTIACRVSLR-PPTTDADVFWISNGMyyEEDDEDGDgrISVANKI-YTTDKRRVITS 292

                        330
                 ....*....|.
gi 19882203  315 ILSIKKVTPED 325
Cdd:PHA02785 293 RLNINPVKEED 303
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 168-233 2.80e-07

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 47.77  E-value: 2.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19882203   168 PSSVKPSVTWYKGCTEIvdfhnvlPEGMNLSFFIPLVSNNGNYTCVVTypeNGRLFHLTRTVTVKV 233
Cdd:pfam13895  24 PGNPPPSYTWYKDGSAI-------SSSPNFFTLSVSAEDSGTYTCVAR---NGRGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 253-348 5.24e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.11  E-value: 5.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203    253 VYEKEPGEELVIPCKVYFSfimdSHNEVWWTIDGKKPddvtvditINESVSYSSTEDETrTQILSIKKVTPEDlRRNYVC 332
Cdd:smart00410   3 SVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKL--------LAESGRFSVSRSGS-TSTLTISNVTPED-SGTYTC 68

                           90
                   ....*....|....*.
gi 19882203    333 HARNTKGEAEQAAKVK 348
Cdd:smart00410  69 AATNSSGSASSGTTLT 84
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 70-141 6.48e-07

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 47.80  E-value: 6.48e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19882203    70 WYWTRQDRDLEEPINFRLPEnrISKEKDVLWFRPTLLNDTGNYTCMLRNTTY-----CSKVAfpLEVVQKD--SCFNSA 141
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPH--IIQEGNALWFLPVGVNDSGSYICRPRIRSPqdeacCLKII--LEVQPKTnaSCSGSV 122
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 242-336 7.48e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 46.40  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203   242 PPQIYSPNDRVVYEkePGEELVIPCKVYFSfimdSHNEVWWTIDGKKPDdvtvditineSVSYSSTEDETRTQILSIKKV 321
Cdd:pfam13927   1 KPVITVSPSSVTVR--EGETVTLTCEATGS----PPPTITWYKNGEPIS----------SGSTRSRSLSGSNSTLTISNV 64

                          90
                  ....*....|....*
gi 19882203   322 TPEDlRRNYVCHARN 336
Cdd:pfam13927  65 TRSD-AGTYTCVASN 78
 
Name Accession Description Interval E-value
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 243-349 1.11e-78

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


Pssm-ID: 409525  Cd Length: 107  Bit Score: 236.46  E-value: 1.11e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 243 PQIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSIKKVT 322
Cdd:cd20931   1 PQIYSPNDRVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDVTIDVTINESISYSSTEDETRTQILSIKKVT 80

                        90       100
                ....*....|....*....|....*..
gi 19882203 323 PEDLRRNYVCHARNTKGEAEQAAKVKQ 349
Cdd:cd20931  81 PEDLKRNYVCHARNAKGEVEKAAKVKQ 107
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 5.18e-76

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409584  Cd Length: 108  Bit Score: 229.43  E-value: 5.18e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  25 DDWGLDTMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPT 104
Cdd:cd20992   1 DDWGLDTMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPDNRISKEKDVLWFRPT 80

                        90       100
                ....*....|....*....|....*...
gi 19882203 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd20992  81 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 108
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 3.13e-46

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 152.96  E-value: 3.13e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  25 DDWGLDtMRQIQVFEDEPARIKCPLFEHFLkynystAHSSGLTLIWYWTrqdrDLEEPINFRlPENRISKEKDVLWFRPT 104
Cdd:cd05756   1 DEWGED-IKILVVLEGEPDVIKCPLFPNFL------AQSAGLNLTWYKN----DSETPISFE-PDSRIHQEKDKLWFVPA 68

                        90       100
                ....*....|....*....|....*...
gi 19882203 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd05756  69 LLEDSGNYYCVVRNSTYCSKVSISLEVV 96
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 145-235 1.46e-43

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409585  Cd Length: 93  Bit Score: 145.81  E-value: 1.46e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 145 PVHKMYIEHGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMNLSFFIPLVSNNGNYTCVVTYPENGRLFH 224
Cdd:cd20993   3 TPVIAYIEYGGRTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYETKGRTIK 82

                        90
                ....*....|.
gi 19882203 225 LTRTVTVKVVG 235
Cdd:cd20993  83 LTRTVNVKVVG 93
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 26-131 1.45e-33

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


Pssm-ID: 409477  Cd Length: 105  Bit Score: 120.05  E-value: 1.45e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  26 DWGLDtMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFrlPENRISKEKDVLWFRPTL 105
Cdd:cd05896   2 DWSVD-LKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIF--DGVRMSKEEDSIWFRPAE 78

                        90       100
                ....*....|....*....|....*.
gi 19882203 106 LNDTGNYTCMLRNTTYCSKVAFPLEV 131
Cdd:cd05896  79 LQDSGLYTCVLRNSTYCMKVSMSLTV 104
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 144-235 1.23e-25

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 98.55  E-value: 1.23e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 144 FPVHKMYIEhGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMNLSFFIPLVSNNGNYTCVVTYPENGRLF 223
Cdd:cd05757   2 RYKQKLPIT-KGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHNGKQY 80

                        90
                ....*....|..
gi 19882203 224 HLTRTVTVKVVG 235
Cdd:cd05757  81 NVTRTISLTVTE 92
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 3-325 2.84e-12

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 66.96  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203    3 LLWYLMSLSFYG-ILQSHASERCDDWGLdTMRQIQVFEDEPARIKCPlfehflKYNYSTAHSSGLTLIWYWTRQDRDLEE 81
Cdd:PHA02785   4 LPVIFLPIFFYSsFVQTFNAPECIDKGQ-YFASFMELENEPVILPCP------QINTLSSGYNILDILWEKRGADNDRII 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203   82 PINfrlpenrisKEKDVLWFRPTLlNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSAMRFPvhKMYIEHGIHKITCP 161
Cdd:PHA02785  77 PID---------NGSNMLILNPTQ-SDSGIYICITKNETYCDMMSLNLTIVSVSESNIDLISYP--QIVNERSTGEMVCP 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  162 NVDGYFPSSVKPSVTWyKGCTEIVDfhNVLPEGMNLSFFIPLVSNN--GNYTCVVTYPENGRLFHLTRTVTVKVvgspKD 239
Cdd:PHA02785 145 NINAFIASNVNADIIW-SGHRRLRN--KRLKQRTPGIITIEDVRKNdaGYYTCVLKYIYGDKTYNVTRIVKLEV----RD 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  240 AL-PPQIYSPNDRVVyekEPGEELVIPCKVYFSfIMDSHNEVWWTIDGK--KPDDVTVD--ITINESVsYSSTEDETRTQ 314
Cdd:PHA02785 218 RIiPPTMQLPEGVVT---SIGSNLTIACRVSLR-PPTTDADVFWISNGMyyEEDDEDGDgrISVANKI-YTTDKRRVITS 292

                        330
                 ....*....|.
gi 19882203  315 ILSIKKVTPED 325
Cdd:PHA02785 293 RLNINPVKEED 303
Ig1_IL1R_like cd20991
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 37-132 1.50e-10

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. IL-1 receptor antagonist (IL-1RA), a naturally occurring cytokine, is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409583  Cd Length: 91  Bit Score: 57.30  E-value: 1.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203  37 VFEDEPARIKCPLfehflkynysTAHSSGLTLIWYwtrqDRDLEEPINFRlPENRISKEKDVLWFRPTLLNDTGNYTCML 116
Cdd:cd20991  11 SSANEIDVRSCPL----------NPNESKGTITWY----KNDSKTPISME-QDSRIHQYKEKLWFVPAKVEDSGHYYCVV 75

                        90
                ....*....|....*.
gi 19882203 117 RNTTYCSKVAFPLEVV 132
Cdd:cd20991  76 RNSTYCLKIKITAKFV 91
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 168-233 2.80e-07

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 47.77  E-value: 2.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19882203   168 PSSVKPSVTWYKGCTEIvdfhnvlPEGMNLSFFIPLVSNNGNYTCVVTypeNGRLFHLTRTVTVKV 233
Cdd:pfam13895  24 PGNPPPSYTWYKDGSAI-------SSSPNFFTLSVSAEDSGTYTCVAR---NGRGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 253-348 5.24e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.11  E-value: 5.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203    253 VYEKEPGEELVIPCKVYFSfimdSHNEVWWTIDGKKPddvtvditINESVSYSSTEDETrTQILSIKKVTPEDlRRNYVC 332
Cdd:smart00410   3 SVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKL--------LAESGRFSVSRSGS-TSTLTISNVTPED-SGTYTC 68

                           90
                   ....*....|....*.
gi 19882203    333 HARNTKGEAEQAAKVK 348
Cdd:smart00410  69 AATNSSGSASSGTTLT 84
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 70-141 6.48e-07

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 47.80  E-value: 6.48e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19882203    70 WYWTRQDRDLEEPINFRLPEnrISKEKDVLWFRPTLLNDTGNYTCMLRNTTY-----CSKVAfpLEVVQKD--SCFNSA 141
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPH--IIQEGNALWFLPVGVNDSGSYICRPRIRSPqdeacCLKII--LEVQPKTnaSCSGSV 122
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 242-336 7.48e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 46.40  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203   242 PPQIYSPNDRVVYEkePGEELVIPCKVYFSfimdSHNEVWWTIDGKKPDdvtvditineSVSYSSTEDETRTQILSIKKV 321
Cdd:pfam13927   1 KPVITVSPSSVTVR--EGETVTLTCEATGS----PPPTITWYKNGEPIS----------SGSTRSRSLSGSNSTLTISNV 64

                          90
                  ....*....|....*
gi 19882203   322 TPEDlRRNYVCHARN 336
Cdd:pfam13927  65 TRSD-AGTYTCVASN 78
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 157-235 9.12e-05

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 40.91  E-value: 9.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 157 KITCPNVDgYF--PSSVKPSVTWYKGCT--EIVDFHNVLPEGMNLSFFIPLVsNNGNYTCVVTYPENGRLFHLTRTVTVK 232
Cdd:cd20994  14 RIVCPHLD-FFkdENNNLPKVQWYKDCKplLLDDKRFAGLESDLLIFNVTVQ-DQGNYTCHTSYTYMGKQYNISRTISLI 91


                ...
gi 19882203 233 VVG 235
Cdd:cd20994  92 VLE 94
I-set pfam07679
Immunoglobulin I-set domain;
172-215 3.73e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.08  E-value: 3.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 19882203   172 KPSVTWYKGCTEIV--DFHNVLPEGMNLSFFIPLV--SNNGNYTCVVT 215
Cdd:pfam07679  29 DPEVSWFKDGQPLRssDRFKVTYEGGTYTLTISNVqpDDSGKYTCVAT 76
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 262-344 5.39e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.38  E-value: 5.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882203 262 LVIPCKVYFsfimDSHNEVWWTIDGKKPDDVTVDITINESVSYSstedetrtqiLSIKKVTPEDlRRNYVCHARNTKGEA 341
Cdd:cd00096   1 VTLTCSASG----NPPPTITWYKNGKPLPPSSRDSRRSELGNGT----------LTISNVTLED-SGTYTCVASNSAGGS 65


                ...
gi 19882203 342 EQA 344
Cdd:cd00096  66 ASA 68
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 158-221 6.49e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.00  E-value: 6.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19882203 158 ITCPnvdgyFPSSVKPSVTWYKGCTEIV--DFHNVLPEGMNLSFFIPLV--SNNGNYTCVVTYPENGR 221
Cdd:cd00096   3 LTCS-----ASGNPPPTITWYKNGKPLPpsSRDSRRSELGNGTLTISNVtlEDSGTYTCVASNSAGGS 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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