NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1654220559|ref|NP_598837|]
View 

(Lyso)-N-acylphosphatidylethanolamine lipase isoform 1 [Mus musculus]

Protein Classification

alpha/beta hydrolase domain-containing protein( domain architecture ID 1005082)

alpha/beta hydrolase (abhydrolase) domain-containing protein

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02894 super family cl30398
hydrolase, alpha/beta fold family protein
 11-338 1.73e-67

hydrolase, alpha/beta fold family protein


The actual alignment was detected with superfamily member PLN02894:

Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 217.09  E-value: 1.73e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  11 GWLSSWLpTWRPTSMSQLKNVEARILQCLQNKFLARYVSL----PNQNKIWTVTVSPE-----------QKDRTPLVMVH 75
Cdd:PLN02894   34 SLWPSPL-RWIPTSTDHIIAAEKRLLSLVKTPYVQEQVNIgsgpPGSKVRWFRSASNEprfintvtfdsKEDAPTLVMVH 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  76 GFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFP-RDPEGAEDEFVASIETWRETMGIPTMILLGHSLGGFLATS 154
Cdd:PLN02894  113 GYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAK 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 155 YSIKYPERVKHLILVDPWGFPLRPTDPSE--IRAPPTWVKAVASVLGRSN--PLAVLRVAGPWGPGLVQRFRpdfKRKFA 230
Cdd:PLN02894  193 YALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRGLGPWGPNLVRRYT---TARFG 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 231 DFFEDDTISE--------YIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRkdVPITMIYGANTWIDTSTGKKV- 301
Cdd:PLN02894  270 AHSTGDILSEeesklltdYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--VPTTFIYGRHDWMNYEGAVEAr 347

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1654220559 302 -KMQRPDSYVRdmeIEGASHHVYADQPHIFNAVVEEIC 338
Cdd:PLN02894  348 kRMKVPCEIIR---VPQGGHFVFLDNPSGFHSAVLYAC 382
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 11-338 1.73e-67

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 217.09  E-value: 1.73e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  11 GWLSSWLpTWRPTSMSQLKNVEARILQCLQNKFLARYVSL----PNQNKIWTVTVSPE-----------QKDRTPLVMVH 75
Cdd:PLN02894   34 SLWPSPL-RWIPTSTDHIIAAEKRLLSLVKTPYVQEQVNIgsgpPGSKVRWFRSASNEprfintvtfdsKEDAPTLVMVH 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  76 GFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFP-RDPEGAEDEFVASIETWRETMGIPTMILLGHSLGGFLATS 154
Cdd:PLN02894  113 GYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAK 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 155 YSIKYPERVKHLILVDPWGFPLRPTDPSE--IRAPPTWVKAVASVLGRSN--PLAVLRVAGPWGPGLVQRFRpdfKRKFA 230
Cdd:PLN02894  193 YALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRGLGPWGPNLVRRYT---TARFG 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 231 DFFEDDTISE--------YIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRkdVPITMIYGANTWIDTSTGKKV- 301
Cdd:PLN02894  270 AHSTGDILSEeesklltdYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--VPTTFIYGRHDWMNYEGAVEAr 347

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1654220559 302 -KMQRPDSYVRdmeIEGASHHVYADQPHIFNAVVEEIC 338
Cdd:PLN02894  348 kRMKVPCEIIR---VPQGGHFVFLDNPSGFHSAVLYAC 382
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 67-336 8.83e-28

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 108.16  E-value: 8.83e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  67 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDPegaeDEFVASIETWRETMGIPTMILLGHS 146
Cdd:COG0596    22 DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTL----DDLADDLAALLDALGLERVVLVGHS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 147 LGGFLATSYSIKYPERVKHLILVDpwgfplrptdpseirapptwvkavasvlgrsnplavlrvagpwgpglvqrfrpDFK 226
Cdd:COG0596    98 MGGMVALELAARHPERVAGLVLVD-----------------------------------------------------EVL 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 227 RKFADFFEDDtiseyiyhcnaqnPSGETAFKAMMESF-GWARRPMLERIhlirkDVPITMIYGAN-TWIDTSTGKKVKMQ 304
Cdd:COG0596   125 AALAEPLRRP-------------GLAPEALAALLRALaRTDLRERLARI-----TVPTLVIWGEKdPIVPPALARRLAEL 186

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1654220559 305 RPDSYVRdmEIEGASHHVYADQPHIFNAVVEE 336
Cdd:COG0596   187 LPNAELV--VLPGAGHFPPLEQPEAFAAALRD 216
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 69-327 4.31e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.73  E-value: 4.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  69 TPLVMVHGFGGGVGLWILNMDSLS-ARRTLHTFDLLGFGRSSRPtfPRDPEGAEDEFVASIETWRETMGIPTMILLGHSL 147
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRP--KAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 148 GGFLATSYSIKYPERVKHLILVDP--WGFPLRPTDPSEIRAPPTWVKAVASVLGR--SNPLAVLRVAGPWGPGLVQRFRP 223
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAPnpLGRLVAKLLALLLLRLRLLKALP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 224 DFKRKFADFFEDDTISEYIYHCNAQNpsgetafkammesfGWARRPMLERIHliRKDVPITMIYGANTWIDTSTGkKVKM 303
Cdd:pfam00561 159 LLNKRFPSGDYALAKSLVTGALLFIE--------------TWSTELRAKFLG--RLDEPTLIIWGDQDPLVPPQA-LEKL 221

                         250       260
                  ....*....|....*....|....
gi 1654220559 304 QRPDSYVRDMEIEGASHHVYADQP 327
Cdd:pfam00561 222 AQLFPNARLVVIPDAGHFAFLEGP 245
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 141-211 5.09e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 41.46  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 141 ILLGHSLGGFLATSYSIKYPERVKHLILVDPWGFPLRPTDPSEIRAP------------PTWVKAVASVlgrSNPLAVLR 208
Cdd:cd12808   191 IVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPDPAEAAPLADVPhllvwgdyidadPRWPRYRATV---DAYAAALR 267


                  ...
gi 1654220559 209 VAG 211
Cdd:cd12808   268 AAG 270
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 11-338 1.73e-67

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 217.09  E-value: 1.73e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  11 GWLSSWLpTWRPTSMSQLKNVEARILQCLQNKFLARYVSL----PNQNKIWTVTVSPE-----------QKDRTPLVMVH 75
Cdd:PLN02894   34 SLWPSPL-RWIPTSTDHIIAAEKRLLSLVKTPYVQEQVNIgsgpPGSKVRWFRSASNEprfintvtfdsKEDAPTLVMVH 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  76 GFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFP-RDPEGAEDEFVASIETWRETMGIPTMILLGHSLGGFLATS 154
Cdd:PLN02894  113 GYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTcKSTEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAK 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 155 YSIKYPERVKHLILVDPWGFPLRPTDPSE--IRAPPTWVKAVASVLGRSN--PLAVLRVAGPWGPGLVQRFRpdfKRKFA 230
Cdd:PLN02894  193 YALKHPEHVQHLILVGPAGFSSESDDKSEwlTKFRATWKGAVLNHLWESNftPQKIIRGLGPWGPNLVRRYT---TARFG 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 231 DFFEDDTISE--------YIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRkdVPITMIYGANTWIDTSTGKKV- 301
Cdd:PLN02894  270 AHSTGDILSEeesklltdYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEWK--VPTTFIYGRHDWMNYEGAVEAr 347

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1654220559 302 -KMQRPDSYVRdmeIEGASHHVYADQPHIFNAVVEEIC 338
Cdd:PLN02894  348 kRMKVPCEIIR---VPQGGHFVFLDNPSGFHSAVLYAC 382
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 67-336 8.83e-28

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 108.16  E-value: 8.83e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  67 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDPegaeDEFVASIETWRETMGIPTMILLGHS 146
Cdd:COG0596    22 DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTL----DDLADDLAALLDALGLERVVLVGHS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 147 LGGFLATSYSIKYPERVKHLILVDpwgfplrptdpseirapptwvkavasvlgrsnplavlrvagpwgpglvqrfrpDFK 226
Cdd:COG0596    98 MGGMVALELAARHPERVAGLVLVD-----------------------------------------------------EVL 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 227 RKFADFFEDDtiseyiyhcnaqnPSGETAFKAMMESF-GWARRPMLERIhlirkDVPITMIYGAN-TWIDTSTGKKVKMQ 304
Cdd:COG0596   125 AALAEPLRRP-------------GLAPEALAALLRALaRTDLRERLARI-----TVPTLVIWGEKdPIVPPALARRLAEL 186

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1654220559 305 RPDSYVRdmEIEGASHHVYADQPHIFNAVVEE 336
Cdd:COG0596   187 LPNAELV--VLPGAGHFPPLEQPEAFAAALRD 216
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 69-327 4.31e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.73  E-value: 4.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  69 TPLVMVHGFGGGVGLWILNMDSLS-ARRTLHTFDLLGFGRSSRPtfPRDPEGAEDEFVASIETWRETMGIPTMILLGHSL 147
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSRP--KAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 148 GGFLATSYSIKYPERVKHLILVDP--WGFPLRPTDPSEIRAPPTWVKAVASVLGR--SNPLAVLRVAGPWGPGLVQRFRP 223
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAPnpLGRLVAKLLALLLLRLRLLKALP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 224 DFKRKFADFFEDDTISEYIYHCNAQNpsgetafkammesfGWARRPMLERIHliRKDVPITMIYGANTWIDTSTGkKVKM 303
Cdd:pfam00561 159 LLNKRFPSGDYALAKSLVTGALLFIE--------------TWSTELRAKFLG--RLDEPTLIIWGDQDPLVPPQA-LEKL 221

                         250       260
                  ....*....|....*....|....
gi 1654220559 304 QRPDSYVRDMEIEGASHHVYADQP 327
Cdd:pfam00561 222 AQLFPNARLVVIPDAGHFAFLEGP 245
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 67-174 4.23e-18

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 84.23  E-value: 4.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  67 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSrptfPRDPEGAEDEFVASIETWRETMGIPTMILLGHS 146
Cdd:PRK14875  130 DGTPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASS----KAVGAGSLDELAAAVLAFLDALGIERAHLVGHS 205

                          90       100
                  ....*....|....*....|....*...
gi 1654220559 147 LGGFLATSYSIKYPERVKHLILVDPWGF 174
Cdd:PRK14875  206 MGGAVALRLAARAPQRVASLTLIAPAGL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
63-172 3.62e-17

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 79.28  E-value: 3.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  63 PEQKDRTPLVMVHGFGGGVGLWILNMDSLSARR-TLHTFDLLGFGRSSRPT-FPRDPEGAEDEFVASIETWRETMGIPTm 140
Cdd:COG2267    23 PAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGyAVLAFDLRGHGRSDGPRgHVDSFDDYVDDLRAALDALRARPGLPV- 101

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1654220559 141 ILLGHSLGGFLATSYSIKYPERVKHLILVDPW 172
Cdd:COG2267   102 VLLGHSMGGLIALLYAARYPDRVAGLVLLAPA 133
PLN02578 PLN02578
hydrolase
 64-184 1.02e-12

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 68.33  E-value: 1.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  64 EQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVASIetwRETMGIPTmILL 143
Cdd:PLN02578   82 VQGEGLPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDKALIEYDAMVWRDQVADFV---KEVVKEPA-VLV 157

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1654220559 144 GHSLGGFLATSYSIKYPERVKHLILVDP---WGFPLRPTDPSEI 184
Cdd:PLN02578  158 GNSLGGFTALSTAVGYPELVAGVALLNSagqFGSESREKEEAIV 201
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 71-333 9.58e-12

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 63.65  E-value: 9.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  71 LVMVHGFGGGVGLWIlnmDSLSARRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVASIETWRETmgiptmILLGHSLGGF 150
Cdd:pfam12697   1 VVLVHGAGLSAAPLA---ALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAARPV------VLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 151 LATSYsikYPERVKHLILVDPWGFPLRPTDPseirapptwvkavasvlgrsnplAVLRVAGPWGPGLVQRFRPDFKRkfA 230
Cdd:pfam12697  72 VALAA---AAAALVVGVLVAPLAAPPGLLAA-----------------------LLALLARLGAALAAPAWLAAESL--A 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 231 DFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPmlerihlirkdVPITMIYGANTWIDTSTGKKVKMQRPDSYV 310
Cdd:pfam12697 124 RGFLDDLPADAEWAAALARLAALLAALALLPLAAWRDLP-----------VPVLVLAEEDRLVPELAQRLLAALAGARLV 192

                         250       260
                  ....*....|....*....|...
gi 1654220559 311 rdmEIEGASHHVYaDQPHIFNAV 333
Cdd:pfam12697 193 ---VLPGAGHLPL-DDPEEVAEA 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 71-230 8.16e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 61.08  E-value: 8.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  71 LVMVHGFGGGVGLWILNMDSLSAR-RTLHTFDLLGFGRSS-RPTFPRDPEGAEDEFVASIETWRETMGIPTMILLGHSLG 148
Cdd:pfam12146   7 VVLVHGLGEHSGRYAHLADALAAQgFAVYAYDHRGHGRSDgKRGHVPSFDDYVDDLDTFVDKIREEHPGLPLFLLGHSMG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 149 GFLATSYSIKYPERVKHLILVDPWgfpLRPTDPSeiraPPTWVKAVASVLGRSNPLavLRVAGPWGPGLVQRfRPDFKRK 228
Cdd:pfam12146  87 GLIAALYALRYPDKVDGLILSAPA---LKIKPYL----APPILKLLAKLLGKLFPR--LRVPNNLLPDSLSR-DPEVVAA 156


                  ..
gi 1654220559 229 FA 230
Cdd:pfam12146 157 YA 158
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 65-171 3.00e-10

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 56.76  E-value: 3.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  65 QKDRTPLVMVHGFGGGVGLWILNMDSLSAR-RTLHTFDLlgfgrssrPTFPRDPEGAEDEFVASIETWRETMGIPTMILL 143
Cdd:COG1075     2 AATRYPVVLVHGLGGSAASWAPLAPRLRAAgYPVYALNY--------PSTNGSIEDSAEQLAAFVDAVLAATGAEKVDLV 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1654220559 144 GHSLGGFLATSY--SIKYPERVKHLILVDP 171
Cdd:COG1075    74 GHSMGGLVARYYlkRLGGAAKVARVVTLGT 103
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 69-171 3.93e-10

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 59.75  E-value: 3.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  69 TPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPtfprDPEGAEDEFVASIETW--------RETMGIPTM 140
Cdd:PLN02824   30 PALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKP----NPRSAPPNSFYTFETWgeqlndfcSDVVGDPAF 105

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1654220559 141 ILLgHSLGGFLATSYSIKYPERVKHLILVDP 171
Cdd:PLN02824  106 VIC-NSVGGVVGLQAAVDAPELVRGVMLINI 135
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 57-170 4.76e-10

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 60.24  E-value: 4.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  57 WTVTVSPEQKDRTP-LVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTfprdpegaedEFVASIETW---- 131
Cdd:PLN02679   76 YLVKGSPEVTSSGPpVLLVHGFGASIPHWRRNIGVLAKNYTVYAIDLLGFGASDKPP----------GFSYTMETWaeli 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1654220559 132 ----RETMGIPTmILLGHSLGGF---LATSYSikYPERVKHLILVD 170
Cdd:PLN02679  146 ldflEEVVQKPT-VLIGNSVGSLacvIAASES--TRDLVRGLVLLN 188
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 63-195 3.67e-09

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 57.90  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  63 PEQKDRTPLVMVHGFGGGVGLWILNM-----DSLSARRTLHTFDLLGFGRSSRPTfprDPEGAEDEFVASIE-TWRETMG 136
Cdd:PLN03087  196 KDNKAKEDVLFIHGFISSSAFWTETLfpnfsDAAKSTYRLFAVDLLGFGRSPKPA---DSLYTLREHLEMIErSVLERYK 272

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1654220559 137 IPTMILLGHSLGGFLATSYSIKYPERVKHLILVDPWGFPLrptdPSEIRAPPTWVKAVA 195
Cdd:PLN03087  273 VKSFHIVAHSLGCILALALAVKHPGAVKSLTLLAPPYYPV----PKGVQATQYVMRKVA 327
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
54-169 8.88e-08

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 52.71  E-value: 8.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  54 NKIWTVTVSpeqKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSrptfprdpeGAEDEFVASIETWRE 133
Cdd:PRK10349    2 NNIWWQTKG---QGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSR---------GFGALSLADMAEAVL 69

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1654220559 134 TMGIPTMILLGHSLGGFLATSYSIKYPERVKHLILV 169
Cdd:PRK10349   70 QQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTV 105
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
72-335 5.27e-06

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 46.86  E-value: 5.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  72 VMVHGFGGG---VGLWilnmdslsARR------TLHTFDLLGFGRSSRPTFPRDPE----GAEDEFVASIETWRETmgip 138
Cdd:COG1647    19 LLLHGFTGSpaeMRPL--------AEAlakagyTVYAPRLPGHGTSPEDLLKTTWEdwleDVEEAYEILKAGYDKV---- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 139 tmILLGHSLGGFLATSYSIKYPErVKHLILVDPwgfPLRPTDPSEIRAPptwvkavasvlgrsnplaVLRVAGPWgpglv 218
Cdd:COG1647    87 --IVIGLSMGGLLALLLAARYPD-VAGLVLLSP---ALKIDDPSAPLLP------------------LLKYLARS----- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 219 qrfrpdfKRKFADFFEDDTISEYIYHCNAQNpsgetAFKAMMESFGWARRPmLERIHlirkdVPITMIYGAN-TWIDTST 297
Cdd:COG1647   138 -------LRGIGSDIEDPEVAEYAYDRTPLR-----ALAELQRLIREVRRD-LPKIT-----APTLIIQSRKdEVVPPES 199

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1654220559 298 GKKVKMQRPDSYVRDMEIEGASH--HVYADQPHIFNAVVE 335
Cdd:COG1647   200 ARYIYERLGSPDKELVWLEDSGHviTLDKDREEVAEEILD 239
PRK10673 PRK10673
esterase;
62-208 1.18e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 46.26  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  62 SPEQ-KDRTPLVMVHG-FGGGVGLWILNMDsLSARRTLHTFDLLGFGRSsrptfPRDPEGAEDEFVASIETWRETMGIPT 139
Cdd:PRK10673    9 TAQNpHNNSPIVLVHGlFGSLDNLGVLARD-LVNDHDIIQVDMRNHGLS-----PRDPVMNYPAMAQDLLDTLDALQIEK 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1654220559 140 MILLGHSLGGFLATSYSIKYPERVKHLILVD--PWGFPLRPTDpsEIRAPPTWVKAvASVLGRSNPLAVLR 208
Cdd:PRK10673   83 ATFIGHSMGGKAVMALTALAPDRIDKLVAIDiaPVDYHVRRHD--EIFAAINAVSE-AGATTRQQAAAIMR 150
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 64-180 4.84e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 44.60  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  64 EQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPtfprDPEGAEDEFVASIETWRETMGIPTMILL 143
Cdd:PRK03592   23 ETGEGDPIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKP----DIDYTFADHARYLDAWFDALGLDDVVLV 98

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1654220559 144 GHSLGGFLATSYSIKYPERVKHLILVDPWgfpLRPTD 180
Cdd:PRK03592   99 GHDWGSALGFDWAARHPDRVRGIAFMEAI---VRPMT 132
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 71-172 5.61e-05

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 44.14  E-value: 5.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  71 LVMVHGFGGGVGLWILNMDSLsARRTLHT--FDLLGFGRSS-RPTFPRDPEgAEDeFVASIETWRETMGIPT--MILLGH 145
Cdd:COG1073    40 VVVAHGNGGVKEQRALYAQRL-AELGFNVlaFDYRGYGESEgEPREEGSPE-RRD-ARAAVDYLRTLPGVDPerIGLLGI 116

                          90       100
                  ....*....|....*....|....*..
gi 1654220559 146 SLGGFLATSYSIKYPeRVKHLILVDPW 172
Cdd:COG1073   117 SLGGGYALNAAATDP-RVKAVILDSPF 142
YpfH COG0400
Predicted esterase [General function prediction only];
64-168 4.11e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 41.05  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  64 EQKDRTPLVMVHGFGG----GVGLWilnmDSLSARRTLH-----TFDLLGFGRS----SRPTFPRDPEGAE---DEFVAS 127
Cdd:COG0400     1 GGPAAPLVVLLHGYGGdeedLLPLA----PELALPGAAVlapraPVPEGPGGRAwfdlSFLEGREDEEGLAaaaEALAAF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1654220559 128 IETWRETMGIPT--MILLGHSLGGFLATSYSIKYPERVKHLIL 168
Cdd:COG0400    77 IDELEARYGIDPerIVLAGFSQGAAMALSLALRRPELLAGVVA 119
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 141-211 5.09e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 41.46  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559 141 ILLGHSLGGFLATSYSIKYPERVKHLILVDPWGFPLRPTDPSEIRAP------------PTWVKAVASVlgrSNPLAVLR 208
Cdd:cd12808   191 IVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPDPAEAAPLADVPhllvwgdyidadPRWPRYRATV---DAYAAALR 267


                  ...
gi 1654220559 209 VAG 211
Cdd:cd12808   268 AAG 270
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
55-171 7.11e-04

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 40.39  E-value: 7.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  55 KIWTVTVSPEQKDRTPLVM-VHGFGGGVGL-WILNMDSLSAR--RTLhTFDLLGFGRSSRPTfprdPEGAEDEFVASIET 130
Cdd:COG1506     9 TLPGWLYLPADGKKYPVVVyVHGGPGSRDDsFLPLAQALASRgyAVL-APDYRGYGESAGDW----GGDEVDDVLAAIDY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1654220559 131 WRETMGIPT--MILLGHSLGGFLATSYSIKYPERVKHLILVDP 171
Cdd:COG1506    84 LAARPYVDPdrIGIYGHSYGGYMALLAAARHPDRFKAAVALAG 126
EntF2 COG3319
Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...
 67-208 3.23e-03

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442548 [Multi-domain]  Cd Length: 855  Bit Score: 39.30  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  67 DRTPLVMVHGFGGGV----GLwilnMDSLSARRTLHTFDLLGFGRSSRPtfPRDPEGAEDEFVASIETWRetmgiPT--M 140
Cdd:COG3319   600 SGPPLFCVHPAGGNVlcyrPL----ARALGPDRPVYGLQAPGLDGGEPP--PASVEEMAARYVEAIRAVQ-----PEgpY 668

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1654220559 141 ILLGHSLGGFLAtsysikYP---------ERVKHLILVDPWGfPLRPTDPSEirapPTWVKAVASVLGRSNPLAVLR 208
Cdd:COG3319   669 HLLGWSFGGLVA------YEmarqleaqgEEVALLVLLDSYA-PGALARLDE----AELLAALLRDLARGVDLPLDA 734
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 67-171 3.66e-03

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 38.71  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220559  67 DRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVASIETWRETMGIPTMILLGHS 146
Cdd:PLN03084  126 NNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEYVSSLESLIDELKSDKVSLVVQG 205

                          90       100
                  ....*....|....*....|....*
gi 1654220559 147 LGGFLATSYSIKYPERVKHLILVDP 171
Cdd:PLN03084  206 YFSPPVVKYASAHPDKIKKLILLNP 230
MET2 COG2021
Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine ...
 110-173 5.92e-03

Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine O-acetyltransferase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 441624 [Multi-domain]  Cd Length: 355  Bit Score: 38.15  E-value: 5.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1654220559 110 RPTFP----RDpegaedeFVASIETWRETMGIPT-MILLGHSLGGFLATSYSIKYPERVKHLILV------DPWG 173
Cdd:COG2021   102 GLDFPvvtiRD-------MVRAQKRLLDHLGIERlAAVIGGSMGGMQALEWAVSYPDRVRRAIVIataarlSAQN 169
PAF-AH_p_II pfam03403
Platelet-activating factor acetylhydrolase, isoform II; Platelet-activating factor ...
 141-187 8.52e-03

Platelet-activating factor acetylhydrolase, isoform II; Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.


Pssm-ID: 397462 [Multi-domain]  Cd Length: 372  Bit Score: 37.81  E-value: 8.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1654220559 141 ILLGHSLGGflATSY-SIKYPERVKHLILVDPWGFPLRPTDPSEIRAP 187
Cdd:pfam03403 224 AVIGHSFGG--ATVIqSLSEDTRFRCGIALDAWMFPVGDDVYSKARQP 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH