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Conserved domains on  [gi|161333813|ref|NP_598834|]
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BTB/POZ domain-containing protein KCTD9 isoform b [Mus musculus]

Protein Classification

BTB/POZ domain-containing protein KCTD9( domain architecture ID 13018758)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein KCTD9 acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KCTD9 cd18368
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-188 5.33e-69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.


:

Pssm-ID: 349677 [Multi-domain]  Cd Length: 100  Bit Score: 210.58  E-value: 5.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18368    1 DWIKLNVGGRIFTTTRSTLVKKEPDSMLARMFSDDSTWPSSRDENGAYLIDRSPEYFEPILNYLRHGQLILNDGLNPLGV 80

                         90       100
                 ....*....|....*....|
gi 161333813 169 LEEARFFGIDSLIEHLEVAI 188
Cdd:cd18368   81 LEEAKFFGIQSLIEILEQLI 100
KHA cd17073
KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found ...
 2-66 7.67e-32

KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found in potassium channel tetramerization domain containing 9 (KCTD9) and similar proteins; This family corresponds to KHA, the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins, mainly found in vertebrates KCTD9 and plants AKT proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus. KHA shows high sequence similarity with doublecortin-like domain, which has a stable ubiquitin-like tertiary fold. KCTD9, also termed BTB/POZ domain-containing protein 9, belongs to the KCTD protein family, which corresponds to potassium channel tetramerization domain proteins, a class of BTB-domain-containing proteins. It is involved in potassium channel formation. Moreover, KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus (HBV)-induced acute-on-chronic liver failure. AKT proteins play crucial roles in K+ uptake and translocation in plant cells.


:

Pssm-ID: 340593  Cd Length: 65  Bit Score: 113.85  E-value: 7.67e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161333813   2 RRVTLFLNGSPSNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCE 66
Cdd:cd17073    1 KRVTVFVNGSSSGGKVIALPSTLSELLKIASEKLGIPAKRLYTGSGGEIDDIALIRDDDVLYVSE 65
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
223-327 1.28e-23

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


:

Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 95.78  E-value: 1.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDPSGlkANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLEN 302
Cdd:COG1357   64 ANLSGADLSGANLTGADLSGANLANLSG--ANLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSG 141

                         90       100
                 ....*....|....*....|....*
gi 161333813 303 CDLSGCDLQEANLRGSNVKGAIFEE 327
Cdd:COG1357  142 ANLSGADLSGADLSGANLSGANLSG 166
 
Name Accession Description Interval E-value
BTB_POZ_KCTD9 cd18368
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-188 5.33e-69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.


Pssm-ID: 349677 [Multi-domain]  Cd Length: 100  Bit Score: 210.58  E-value: 5.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18368    1 DWIKLNVGGRIFTTTRSTLVKKEPDSMLARMFSDDSTWPSSRDENGAYLIDRSPEYFEPILNYLRHGQLILNDGLNPLGV 80

                         90       100
                 ....*....|....*....|
gi 161333813 169 LEEARFFGIDSLIEHLEVAI 188
Cdd:cd18368   81 LEEAKFFGIQSLIEILEQLI 100
KHA cd17073
KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found ...
 2-66 7.67e-32

KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found in potassium channel tetramerization domain containing 9 (KCTD9) and similar proteins; This family corresponds to KHA, the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins, mainly found in vertebrates KCTD9 and plants AKT proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus. KHA shows high sequence similarity with doublecortin-like domain, which has a stable ubiquitin-like tertiary fold. KCTD9, also termed BTB/POZ domain-containing protein 9, belongs to the KCTD protein family, which corresponds to potassium channel tetramerization domain proteins, a class of BTB-domain-containing proteins. It is involved in potassium channel formation. Moreover, KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus (HBV)-induced acute-on-chronic liver failure. AKT proteins play crucial roles in K+ uptake and translocation in plant cells.


Pssm-ID: 340593  Cd Length: 65  Bit Score: 113.85  E-value: 7.67e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161333813   2 RRVTLFLNGSPSNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCE 66
Cdd:cd17073    1 KRVTVFVNGSSSGGKVIALPSTLSELLKIASEKLGIPAKRLYTGSGGEIDDIALIRDDDVLYVSE 65
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 91-181 1.04e-23

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 93.04  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813   91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKDKGvwGNKQDHRGAFLIDRSPEYFEPILNYLRH-GQLIVNDGINLLGVL 169
Cdd:pfam02214   1 VKLNVGGTRFETLKSTL-TRFPDTRLGRLLELEC--DDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFL 77

                          90
                  ....*....|..
gi 161333813  170 EEARFFGIDSLI 181
Cdd:pfam02214  78 EEAEFYGLDELA 89
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
223-327 1.28e-23

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 95.78  E-value: 1.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDPSGlkANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLEN 302
Cdd:COG1357   64 ANLSGADLSGANLTGADLSGANLANLSG--ANLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSG 141

                         90       100
                 ....*....|....*....|....*
gi 161333813 303 CDLSGCDLQEANLRGSNVKGAIFEE 327
Cdd:COG1357  142 ANLSGADLSGADLSGANLSGANLSG 166
KHA pfam11834
KHA, dimerization domain of potassium ion channel; KHA is the tetramerization domain of ...
 2-64 3.52e-22

KHA, dimerization domain of potassium ion channel; KHA is the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus.


Pssm-ID: 463367  Cd Length: 65  Bit Score: 88.28  E-value: 3.52e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161333813    2 RRVTLFLN--GSPSNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFV 64
Cdd:pfam11834   1 KRVTIFPNhdGKRRNGKLIWLPDSLEELLKIASEKFGISATKILTEDGAEIDDIDVIRDGDHLYL 65
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 90-191 2.52e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 76.19  E-value: 2.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813    90 WLTLNVGGRYFTTTRSTLvNKEPDSMLAhMFKDKGVwgnKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGiNLLGVL 169
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVL-AAHSPYFKA-LFSSDFK---ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVEELL 74

                           90       100
                   ....*....|....*....|..
gi 161333813   170 EEARFFGIDSLIEHLEVAIKNS 191
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKL 96
PRK15197 PRK15197
type III secretion system effector PipB;
224-323 4.29e-11

type III secretion system effector PipB;


Pssm-ID: 185119 [Multi-domain]  Cd Length: 291  Bit Score: 62.64  E-value: 4.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 224 NLQGVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENC 303
Cdd:PRK15197 165 DFQGEDLSDIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDLTDT 244

                         90       100
                 ....*....|....*....|....*.
gi 161333813 304 DLSGCDLQEA------NLRGSNVKGA 323
Cdd:PRK15197 245 KLNGAKLDKIaltlakALTGADLTGS 270
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 288-326 8.80e-10

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 53.50  E-value: 8.80e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 161333813  288 CNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFE 326
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSGADLSGANLS 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 15-68 2.83e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 2.83e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 161333813  15 GKVVAVYGTLSDLLSVASSKLGIKA--TSVYNGKGGLIDDIALIRDDDVLFVCEGE 68
Cdd:PLN03192 764 GKLINLPPSLEELKAIAGEKLGFDArkAMVTNEEGAEIDSIEVIRDNDKLFVVEDE 819
 
Name Accession Description Interval E-value
BTB_POZ_KCTD9 cd18368
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-188 5.33e-69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.


Pssm-ID: 349677 [Multi-domain]  Cd Length: 100  Bit Score: 210.58  E-value: 5.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18368    1 DWIKLNVGGRIFTTTRSTLVKKEPDSMLARMFSDDSTWPSSRDENGAYLIDRSPEYFEPILNYLRHGQLILNDGLNPLGV 80

                         90       100
                 ....*....|....*....|
gi 161333813 169 LEEARFFGIDSLIEHLEVAI 188
Cdd:cd18368   81 LEEAKFFGIQSLIEILEQLI 100
KHA cd17073
KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found ...
 2-66 7.67e-32

KHA, dimerization domain of potassium ion channel, similar to doublecortin-like domain, found in potassium channel tetramerization domain containing 9 (KCTD9) and similar proteins; This family corresponds to KHA, the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins, mainly found in vertebrates KCTD9 and plants AKT proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus. KHA shows high sequence similarity with doublecortin-like domain, which has a stable ubiquitin-like tertiary fold. KCTD9, also termed BTB/POZ domain-containing protein 9, belongs to the KCTD protein family, which corresponds to potassium channel tetramerization domain proteins, a class of BTB-domain-containing proteins. It is involved in potassium channel formation. Moreover, KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus (HBV)-induced acute-on-chronic liver failure. AKT proteins play crucial roles in K+ uptake and translocation in plant cells.


Pssm-ID: 340593  Cd Length: 65  Bit Score: 113.85  E-value: 7.67e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161333813   2 RRVTLFLNGSPSNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCE 66
Cdd:cd17073    1 KRVTVFVNGSSSGGKVIALPSTLSELLKIASEKLGIPAKRLYTGSGGEIDDIALIRDDDVLYVSE 65
BTB_POZ_KCTD2-like cd18362
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-175 1.17e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.


Pssm-ID: 349671 [Multi-domain]  Cd Length: 85  Bit Score: 111.31  E-value: 1.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  90 WLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL 169
Cdd:cd18362    1 WVKLNVGGTYFLTTRTTLC-RDPKSFLCRLCQEDPDLPSDKDETGAYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEGVL 79


                 ....*.
gi 161333813 170 EEARFF 175
Cdd:cd18362   80 EEAEFY 85
BTB_POZ_KCTD2 cd18389
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-192 1.73e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.


Pssm-ID: 349697 [Multi-domain]  Cd Length: 105  Bit Score: 106.22  E-value: 1.73e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  90 WLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL 169
Cdd:cd18389    2 WVRLNVGGTYFVSTKQTLC-RDPKSFLYRLCQEDPDLDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL 80

                         90       100
                 ....*....|....*....|...
gi 161333813 170 EEARFFGIDSLIEHLEVAIKNSQ 192
Cdd:cd18389   81 EEAEFYNIASLVRLVKERIRDNE 103
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-175 6.64e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 104.18  E-value: 6.64e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQL-IVNDGINLLGVL 169
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLL-KDPDSLLAALFS--GRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLpLPSDFVELEELL 77


                 ....*.
gi 161333813 170 EEARFF 175
Cdd:cd18316   78 AEAEFY 83
BTB_POZ_KCTD5 cd18390
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-189 3.70e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.


Pssm-ID: 349698 [Multi-domain]  Cd Length: 112  Bit Score: 100.45  E-value: 3.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  85 GSHTDWLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGIN 164
Cdd:cd18390    1 GGVSKWVRLNVGGTYFLTTRQTLC-RDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLA 79

                         90       100
                 ....*....|....*....|....*
gi 161333813 165 LLGVLEEARFFGIDSLIEHLEVAIK 189
Cdd:cd18390   80 EEGVLEEAEFYNITSLIKLVKDKIR 104
BTB_POZ_KCTD17 cd18391
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-182 8.83e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.


Pssm-ID: 349699  Cd Length: 101  Bit Score: 93.90  E-value: 8.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  90 WLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVWGNKqDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL 169
Cdd:cd18391    2 WVRLNVGGTVFLTTRQTLC-REQKSFLSRLCQGEELQSDR-DETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL 79

                         90
                 ....*....|...
gi 161333813 170 EEARFFGIDSLIE 182
Cdd:cd18391   80 EEAEFYNIGPLIR 92
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 91-181 1.04e-23

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 93.04  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813   91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKDKGvwGNKQDHRGAFLIDRSPEYFEPILNYLRH-GQLIVNDGINLLGVL 169
Cdd:pfam02214   1 VKLNVGGTRFETLKSTL-TRFPDTRLGRLLELEC--DDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFL 77

                          90
                  ....*....|..
gi 161333813  170 EEARFFGIDSLI 181
Cdd:pfam02214  78 EEAEFYGLDELA 89
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
223-327 1.28e-23

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 95.78  E-value: 1.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDPSGlkANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLEN 302
Cdd:COG1357   64 ANLSGADLSGANLTGADLSGANLANLSG--ANLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSG 141

                         90       100
                 ....*....|....*....|....*
gi 161333813 303 CDLSGCDLQEANLRGSNVKGAIFEE 327
Cdd:COG1357  142 ANLSGADLSGADLSGANLSGANLSG 166
KHA pfam11834
KHA, dimerization domain of potassium ion channel; KHA is the tetramerization domain of ...
 2-64 3.52e-22

KHA, dimerization domain of potassium ion channel; KHA is the tetramerization domain of eukaryotic voltage-dependent potassium ion-channel proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus.


Pssm-ID: 463367  Cd Length: 65  Bit Score: 88.28  E-value: 3.52e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161333813    2 RRVTLFLN--GSPSNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFV 64
Cdd:pfam11834   1 KRVTIFPNhdGKRRNGKLIWLPDSLEELLKIASEKFGISATKILTEDGAEIDDIDVIRDGDHLYL 65
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
223-327 3.80e-22

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 91.54  E-value: 3.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDpsglkANLEGANLKGVDMEGSQMTGINLRVATLknAKLKNCNLRGATLAGTDLEN 302
Cdd:COG1357   34 ANLSGANLSGANLTGANLSGADLSG-----ADLSGANLSGADLSGANLTGADLSGANL--ANLSGANLSGANLSGANLRG 106

                         90       100
                 ....*....|....*....|....*
gi 161333813 303 CDLSGCDLQEANLRGSNVKGAIFEE 327
Cdd:COG1357  107 ANLSGANLSGADLSGADLSGANLSG 131
BTB_POZ_KCTD7 cd18366
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-182 1.29e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349675  Cd Length: 92  Bit Score: 87.75  E-value: 1.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDgiNLLGVLE 170
Cdd:cd18366    6 VPLNVGGMHFTTRLSTLR-KYEDSMLAAMFS--GRHHIPKDSEGRYFIDRDGSYFGYILNFLRDGDLPPRE--RARAVYK 80

                         90
                 ....*....|..
gi 161333813 171 EARFFGIDSLIE 182
Cdd:cd18366   81 EAQYYGIGPLIE 92
BTB_POZ_FIP2-like cd18376
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-180 5.30e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349685  Cd Length: 89  Bit Score: 85.76  E-value: 5.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQL-IVNDGINLLG-V 168
Cdd:cd18376    1 VKLNVGGQKFTTTLDTL-TKDPDSMLAAMFS--GRHSLKKDEDGSYFIDRDGTHFRHILNYLRDGEVkIPTEDRSVLKeL 77

                         90
                 ....*....|..
gi 161333813 169 LEEARFFGIDSL 180
Cdd:cd18376   78 LEEAEYYQLRGL 89
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-175 1.32e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 84.45  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLT-RHPDTLLGRMFK-PGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLRE 78


                 ....*
gi 161333813 171 EARFF 175
Cdd:cd18187   79 ECDFY 83
BTB_POZ_KCTD6_like cd18365
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-184 6.48e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349674 [Multi-domain]  Cd Length: 94  Bit Score: 80.52  E-value: 6.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18365    1 DIVNLNVGGVHYTTTLATL-TRFPDSMLGAMFS--GSMPTTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDL 77

                         90
                 ....*....|....*..
gi 161333813 169 LE-EARFFGIDSLIEHL 184
Cdd:cd18365   78 LLrEADFYQIEPLIEAL 94
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
223-325 4.19e-18

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 80.76  E-value: 4.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLcsNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGsqmtginlrvATLKNAKLKNCNLRGATLAGTDLEN 302
Cdd:COG1357   79 ADLSGANLA--NLSGANLSGANLSGANLRGANLSGANLSGADLSG----------ADLSGANLSGADLSGANLSGANLSG 146

                         90       100
                 ....*....|....*....|...
gi 161333813 303 CDLSGCDLQEANLRGSNVKGAIF 325
Cdd:COG1357  147 ADLSGADLSGANLSGANLSGANL 169
BTB_POZ_KCTD21 cd18395
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-185 9.94e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349703 [Multi-domain]  Cd Length: 98  Bit Score: 77.29  E-value: 9.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18395    1 DPITLNVGGKLYTTSLATLT-RYPDSMLGAMFS--GKFPTKKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGL 77

                         90
                 ....*....|....*...
gi 161333813 169 LE-EARFFGIDSLIEHLE 185
Cdd:cd18395   78 LKrEADFYQIQPLIEALQ 95
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 90-191 2.52e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 76.19  E-value: 2.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813    90 WLTLNVGGRYFTTTRSTLvNKEPDSMLAhMFKDKGVwgnKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGiNLLGVL 169
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVL-AAHSPYFKA-LFSSDFK---ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVEELL 74

                           90       100
                   ....*....|....*....|..
gi 161333813   170 EEARFFGIDSLIEHLEVAIKNS 191
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKL 96
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
236-319 2.03e-16

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 76.13  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 236 EGASLRLCNFEDpsglkANLEGANLKGVDMEGS----QMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQ 311
Cdd:COG1357    3 SGADLSGADLSG-----ADLSGADLSGANLSGAlsgaNLSGANLSGANLTGANLSGADLSGADLSGANLSGADLSGANLT 77


                 ....*...
gi 161333813 312 EANLRGSN 319
Cdd:COG1357   78 GADLSGAN 85
BTB_POZ_KCTD6 cd18394
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-184 2.65e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349702 [Multi-domain]  Cd Length: 104  Bit Score: 73.45  E-value: 2.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  88 TDWLTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLG 167
Cdd:cd18394    2 TDPVTLNVGGHLYTTSLSTL-TRYPDSMLGAMFR--GDFPTARDSQGNYFIDRDGPLFRYILNFLRTSELTLPVDFKEFD 78

                         90
                 ....*....|....*...
gi 161333813 168 VL-EEARFFGIDSLIEHL 184
Cdd:cd18394   79 LLrKEADFYQIEPLIQCL 96
BTB_POZ_KCTD8-like cd18367
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-184 4.18e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349676  Cd Length: 100  Bit Score: 72.71  E-value: 4.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE-E 171
Cdd:cd18367    7 LNVGGQVYTTSLSTLI-KDPDSLLGRMFSGKNRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERERLKrE 85

                         90
                 ....*....|...
gi 161333813 172 ARFFGIDSLIEHL 184
Cdd:cd18367   86 AEYFQLPELVKAL 98
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
224-327 9.12e-16

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 74.21  E-value: 9.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 224 NLQGVKMLCSNAEGASLRLCNFEdpsglKANLEGAnLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENC 303
Cdd:COG1357    1 DLSGADLSGADLSGADLSGADLS-----GANLSGA-LSGANLSGANLSGANLTGANLSGADLSGADLSGANLSGADLSGA 74

                         90       100
                 ....*....|....*....|....*..
gi 161333813 304 DLSGCDLQEANL---RGSNVKGAIFEE 327
Cdd:COG1357   75 NLTGADLSGANLanlSGANLSGANLSG 101
BTB_POZ_SHKBP1 cd18393
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-186 2.28e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349701  Cd Length: 103  Bit Score: 71.12  E-value: 2.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNdGINLLGV 168
Cdd:cd18393    2 EVIHLNVGGKRFSTSRQTLT-WIPDSFFSSLLS--GRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPR-GIHVSLL 77

                         90
                 ....*....|....*...
gi 161333813 169 LEEARFFGIDSLIEHLEV 186
Cdd:cd18393   78 LHEAQFYGITPLVRRLQL 95
BTB_POZ_KCTD4 cd18364
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-177 6.35e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349673 [Multi-domain]  Cd Length: 86  Bit Score: 69.32  E-value: 6.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKDKGVwgNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18364    2 VTLNVGGYLYITQRQTLT-KYPDSFLEGMVNGKIQ--CTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLA 78


                 ....*...
gi 161333813 171 -EARFFGI 177
Cdd:cd18364   79 lEADFYQL 86
BTB_POZ_KCTD3 cd18392
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-177 9.91e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349700  Cd Length: 88  Bit Score: 68.74  E-value: 9.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVnDGINLLGV 168
Cdd:cd18392    2 EIIQLNVGGTRFSTSRQTLM-WIPDSFFSSLLS--GRISSLKDETGAIFIDRDPTAFVPILNFLRTKELDL-RGVNINVL 77


                 ....*....
gi 161333813 169 LEEARFFGI 177
Cdd:cd18392   78 RHEAEFYGI 86
BTB_POZ_KCTD3-like cd18363
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-177 3.39e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349672  Cd Length: 86  Bit Score: 67.01  E-value: 3.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVNKePDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNdGINLLGV 168
Cdd:cd18363    2 DIINLNVGGKRFSTSRQTLTWI-PDSFFTSLLS--GRISSLKDETGAIFIDRDPKLFSIILNYLRTKEIDLR-NVDISSL 77


                 ....*....
gi 161333813 169 LEEARFFGI 177
Cdd:cd18363   78 RHEAEFYGI 86
BTB_POZ_KCTD14 cd18371
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-185 6.73e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349680  Cd Length: 99  Bit Score: 66.70  E-value: 6.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNdgiNLLGVLEEA 172
Cdd:cd18371    6 LNVGGHIYTTTLSTL-RKFPGSKLAELFN--GQPKLRTDSEGRYFIDRDGTYFRYILEYLRTNQVPTQ---HIQEVYKEA 79

                         90
                 ....*....|...
gi 161333813 173 RFFGIDSLIEHLE 185
Cdd:cd18371   80 LFYDIEPLVKLLE 92
BTB_POZ_KCTD18 cd18372
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-184 9.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349681  Cd Length: 101  Bit Score: 66.37  E-value: 9.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLrHGQL-IVNDGINLLG 167
Cdd:cd18372    1 DVLRLNVGGCIYTARRESLC-RFKDSMLSSMFS--GRFPLKLDESGACVIDRDGRLFKYLLDYL-HGELqIPEDEQTRLA 76

                         90       100
                 ....*....|....*....|
gi 161333813 168 VLEEARFFGID---SLIEHL 184
Cdd:cd18372   77 LQEEADYFGIPypySLTDHL 96
BTB_POZ_KCTD11 cd18370
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-175 2.77e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.


Pssm-ID: 349679  Cd Length: 88  Bit Score: 64.64  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFK--DKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18370    1 VTLNVGGTLYSTTLETL-TRFPDSMLGAMFRagTPIPPNLNMQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETAL 79


                 ....*...
gi 161333813 169 LE-EARFF 175
Cdd:cd18370   80 LRaEADFY 87
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-157 5.52e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 63.78  E-value: 5.52e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKDKGVWGNKQDHrgaFLIDRSPEYFEPILNYLRHGQL 157
Cdd:cd18317    1 VVLNVGGTRFELSRSTL-LRFPDTRLGKLAKESHAYDESTNE---YFFDRNPEVFEAILDYYRTGEL 63
BTB_POZ_KCTD13_BACURD1 cd18400
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-189 1.69e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13); KCTD13, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BACURD1), or TNFAIP1-like protein, is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD13 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349708  Cd Length: 103  Bit Score: 63.03  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  88 TDWLTLNVGGRYFTTTRSTLVNKepDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLG 167
Cdd:cd18400    1 SKYVKLNVGGSLHYTTVQTLTKQ--DTMLKAMFS--GRVEVLTDSEGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELE 76

                         90       100
                 ....*....|....*....|...
gi 161333813 168 -VLEEARFFGIDSLIEHLEVAIK 189
Cdd:cd18400   77 eLLGEARYYLVQGLVEDCQLALQ 99
BTB_POZ_KCNRG cd18375
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-185 1.94e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349684  Cd Length: 97  Bit Score: 62.44  E-value: 1.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkgvwGNKQDHR---GAFLIDRSPEYFEPILNYLRHGQLIVNDGI-N 164
Cdd:cd18375    1 ELVTLNVGGKKFTTRPSTL-RRFPDSRLARMLD-----GKDQDFKvvnGQFFVDRDGSLFSYILDYLRTGQLTLPTEFsD 74

                         90       100
                 ....*....|....*....|.
gi 161333813 165 LLGVLEEARFFGIDSLIEHLE 185
Cdd:cd18375   75 YNRLAREAEFYGLYSLADLLS 95
BTB_POZ_KCTD1-like cd18361
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-185 3.30e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349670  Cd Length: 94  Bit Score: 62.01  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLVnKEPDSMLAHMFKdkgvwGN--------KQdHrgaFLIDRSPEYFEPILNYLRHGQLIVNDGIN 164
Cdd:cd18361    3 IDVGGHIYTSSLETLT-KYPESRLGKLFN-----GSipivldslKQ-H---YFIDRDGKMFRHILNFLRTSKLLLPDDFT 72

                         90       100
                 ....*....|....*....|..
gi 161333813 165 LL-GVLEEARFFGIDSLIEHLE 185
Cdd:cd18361   73 EFdLLYEEARYYELQPMVKQLE 94
BTB_POZ_KCTD12_Pfetin cd18397
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-184 1.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349705 [Multi-domain]  Cd Length: 100  Bit Score: 60.67  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  89 DWLTLNVGGRYFTTTRSTLVNKePDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGV 168
Cdd:cd18397    3 EIVELNVGGQVYVTRHTTLVSV-PDSLLWHMFSQQKPGELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSR 81

                         90
                 ....*....|....*..
gi 161333813 169 LE-EARFFGIDSLIEHL 184
Cdd:cd18397   82 LQrEAEFFQLPELVKRL 98
BTB_POZ_KCTD10-like_BACURD cd18369
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-182 1.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349678 [Multi-domain]  Cd Length: 91  Bit Score: 60.10  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLVNKepDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLG-VLEE 171
Cdd:cd18369    3 LNVGGSLHYTTIGTLTKQ--DTMLRAMFS--GRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAeLLAE 78

                         90
                 ....*....|.
gi 161333813 172 ARFFGIDSLIE 182
Cdd:cd18369   79 AKYYLVQGLVE 89
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
223-306 2.48e-11

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 61.50  E-value: 2.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDpsglkANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAgtDLEN 302
Cdd:COG1357  102 ANLRGANLSGANLSGADLSGADLSG-----ANLSGADLSGANLSGANLSGADLSGADLSGANLSGANLSGANLA--NLEG 174


                 ....
gi 161333813 303 CDLS 306
Cdd:COG1357  175 ADLK 178
PRK15197 PRK15197
type III secretion system effector PipB;
224-323 4.29e-11

type III secretion system effector PipB;


Pssm-ID: 185119 [Multi-domain]  Cd Length: 291  Bit Score: 62.64  E-value: 4.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 224 NLQGVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENC 303
Cdd:PRK15197 165 DFQGEDLSDIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDLTDT 244

                         90       100
                 ....*....|....*....|....*.
gi 161333813 304 DLSGCDLQEA------NLRGSNVKGA 323
Cdd:PRK15197 245 KLNGAKLDKIaltlakALTGADLTGS 270
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-177 5.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 58.53  E-value: 5.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLA----HMFKDkgvwgnkqDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLL 166
Cdd:cd18380    2 IVINVSGRRFETWKNTL-EKYPDTLLGstekEFFYD--------DDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECIS 72

                         90
                 ....*....|.
gi 161333813 167 GVLEEARFFGI 177
Cdd:cd18380   73 AYDDELAFFGI 83
BTB_POZ_KCTD8 cd18396
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-184 6.46e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349704 [Multi-domain]  Cd Length: 103  Bit Score: 58.66  E-value: 6.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLVNKePDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGI-NLLGVLEE 171
Cdd:cd18396    8 LNVGGQVYVTKHSTLLSV-PDSTLASMFSRRAARELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALPDHFpEKERLLRE 86

                         90
                 ....*....|...
gi 161333813 172 ARFFGIDSLIEHL 184
Cdd:cd18396   87 AEYFQLGDLVKLL 99
PRK15196 PRK15196
type III secretion system effector PipB2;
223-330 1.59e-10

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 61.56  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLEn 302
Cdd:PRK15196 227 ANLTGANLQHASLLGCSMIECNCSGANMDHTNLSGATLIRADMSGATLQGATIMAAIMEGAVLTRANLRKASFISTNLD- 305

                         90       100
                 ....*....|....*....|....*...
gi 161333813 303 cdlsGCDLQEANLRGSNVKGAIFEEMLT 330
Cdd:PRK15196 306 ----GADLAEANLNNTCFKDCTLTHLRT 329
BTB_POZ_KCTD16 cd18398
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-184 6.98e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349706 [Multi-domain]  Cd Length: 103  Bit Score: 55.69  E-value: 6.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLVNKePDSMLAHMFKDKGVWGNK--QDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18398    7 LNVGGQVYFTRHATLVSI-PHSLLWKMFSPKRDTANDlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRLK 85

                         90
                 ....*....|....*
gi 161333813 171 -EARFFGIDSLIEHL 184
Cdd:cd18398   86 rEAEYFQLPDLVKLL 100
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 288-326 8.80e-10

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 53.50  E-value: 8.80e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 161333813  288 CNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFE 326
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSGADLSGANLS 39
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 283-322 1.45e-09

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 52.73  E-value: 1.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 161333813  283 AKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKG 322
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSGADLSGANLSG 40
PRK15196 PRK15196
type III secretion system effector PipB2;
223-325 1.82e-09

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 58.09  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKN-----AKLKNCNLRGATLAG 297
Cdd:PRK15196 157 AVLTGANLTAENLCDADLSGANLEGAVLFMADCEGANFKGANLSGTSLGDSNFKNACLEDsimcgATLDHANLTGANLQH 236

                         90       100
                 ....*....|....*....|....*...
gi 161333813 298 TDLENCDLSGCDLQEANLRGSNVKGAIF 325
Cdd:PRK15196 237 ASLLGCSMIECNCSGANMDHTNLSGATL 264
BTB_POZ_KCTD10_BACURD3 cd18399
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-195 4.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349707  Cd Length: 110  Bit Score: 53.53  E-value: 4.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  88 TDWLTLNVGGRYFTTTRSTLVNKepDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQL-IVNDGINLL 166
Cdd:cd18399    6 SKYVKLNVGGALYYTTMQTLTKQ--DTMLKAMFS--GRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVpLPESRREIE 81

                         90       100
                 ....*....|....*....|....*....
gi 161333813 167 GVLEEARFFGIDSLIEHLEVAIKNSQPPE 195
Cdd:cd18399   82 ELLAEAKYYLVQGLVEECQAALQNKDTYE 110
PRK15196 PRK15196
type III secretion system effector PipB2;
221-312 6.86e-09

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 56.55  E-value: 6.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 221 QCANLQGVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDL 300
Cdd:PRK15196 235 QHASLLGCSMIECNCSGANMDHTNLSGATLIRADMSGATLQGATIMAAIMEGAVLTRANLRKASFISTNLDGADLAEANL 314

                         90
                 ....*....|..
gi 161333813 301 ENCDLSGCDLQE 312
Cdd:PRK15196 315 NNTCFKDCTLTH 326
PRK15196 PRK15196
type III secretion system effector PipB2;
223-326 7.51e-09

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 56.55  E-value: 7.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 223 ANLQGVKMLCSNAEGASLRLCNFEDPSGLKANLEGANLK-----GVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAG 297
Cdd:PRK15196 177 ANLEGAVLFMADCEGANFKGANLSGTSLGDSNFKNACLEdsimcGATLDHANLTGANLQHASLLGCSMIECNCSGANMDH 256

                         90       100
                 ....*....|....*....|....*....
gi 161333813 298 TDLENCDLSGCDLQEANLRGSNVKGAIFE 326
Cdd:PRK15196 257 TNLSGATLIRADMSGATLQGATIMAAIME 285
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-179 7.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 52.78  E-value: 7.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLVNKePDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLivNDGINLLGVL- 169
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNL-PDTRLAWLTETEASAFDYDPVTGEFFFDRHPGVFAQILNYYRTGKL--HCPADVCGPLf 77

                         90
                 ....*....|.
gi 161333813 170 -EEARFFGIDS 179
Cdd:cd18379   78 eEELAFWGIDE 88
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 280-317 1.18e-08

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 50.03  E-value: 1.18e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 161333813  280 LKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRG 317
Cdd:pfam00805   3 LSGANLSGANLSGANLSGANLTGANLSGADLSGANLSG 40
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 2-65 1.74e-08

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 50.69  E-value: 1.74e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161333813   2 RRVTLFLNGSPSNGKVVAV-----YGTLSDLLSVASSKLGI---KATSVYNGKGGLIDDIALIRDDDVLFVC 65
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLvkprrFRTFDQLLDELTEKLGLptgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72
BTB_POZ_TNFAIP1_BACURD2 cd18401
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-192 2.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349709  Cd Length: 104  Bit Score: 51.42  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  90 WLTLNVGGRYFTTTRSTLVNKepDSMLAHMFKdkGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIV-NDGINLLGV 168
Cdd:cd18401    4 YVRLNVGGSLYYTTVQVLTRH--DTMLKAMFS--GRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALpKSRQEIKEL 79

                         90       100
                 ....*....|....*....|....
gi 161333813 169 LEEARFFGIDSLIEHLEVAIKNSQ 192
Cdd:cd18401   80 MAEAKYYLIQGLVDMCQAALQDKK 103
PRK15196 PRK15196
type III secretion system effector PipB2;
220-327 2.55e-08

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 54.63  E-value: 2.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 220 CQCANLQGvkmlcSNAEGASLRLCNF-----EDPSGLKANLEGANLKGVDME---------------GSQMTGINLRVAT 279
Cdd:PRK15196 189 CEGANFKG-----ANLSGTSLGDSNFknaclEDSIMCGATLDHANLTGANLQhasllgcsmiecncsGANMDHTNLSGAT 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 161333813 280 LKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEE 327
Cdd:PRK15196 264 LIRADMSGATLQGATIMAAIMEGAVLTRANLRKASFISTNLDGADLAE 311
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-177 6.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 51.00  E-value: 6.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLA----HMFKDkgvwgnkqDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLL 166
Cdd:cd18420   38 LIINVSGRRFETWRNTL-EKYPDTLLGsnerEFFYD--------EETKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLT 108

                         90
                 ....*....|.
gi 161333813 167 GVLEEARFFGI 177
Cdd:cd18420  109 AYDEELAFFGI 119
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 274-311 7.32e-08

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 48.11  E-value: 7.32e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 161333813  274 NLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQ 311
Cdd:pfam00805   2 NLSGANLSGANLSGANLSGANLTGANLSGADLSGANLS 39
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 253-292 9.18e-08

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 47.72  E-value: 9.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 161333813  253 ANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRG 292
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSGADLSGANLSG 40
BTB_POZ_KCTD15 cd18388
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-185 1.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.


Pssm-ID: 349696  Cd Length: 99  Bit Score: 49.22  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLVnKEPDSMLAHMFK--DKGVWGNKQDHrgaFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL- 169
Cdd:cd18388    6 IDVGGHMYTSSLATLT-KYPDSRISRLFNgtEPIVLDSLKQH---YFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLLy 81

                         90
                 ....*....|....*.
gi 161333813 170 EEARFFGIDSLIEHLE 185
Cdd:cd18388   82 EEAKYYQLQPMVKELE 97
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-177 2.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 49.57  E-value: 2.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  74 QTDARPPGGLLGSHTDWLTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKDkgvWGNKQDhRGAFLIDRSPEYFEPILNYLR 153
Cdd:cd18417   20 KPMPKPPSDKKRRNDEILVVNVSGRRFQTWKNTL-DRYPDTLLGSSEKE---FFYNED-TQEYFFDRDPEMFRHILNFYR 94

                         90       100
                 ....*....|....*....|....
gi 161333813 154 HGQLIVNDGINLLGVLEEARFFGI 177
Cdd:cd18417   95 TGRLHYPRHECIQAFDEELSFYGI 118
PRK15196 PRK15196
type III secretion system effector PipB2;
234-323 2.30e-07

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 51.93  E-value: 2.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 234 NAEGASLRLCNFEDPSGLKANLEGANLKG-----VDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGC 308
Cdd:PRK15196 153 NLKGAVLTGANLTAENLCDADLSGANLEGavlfmADCEGANFKGANLSGTSLGDSNFKNACLEDSIMCGATLDHANLTGA 232

                         90       100
                 ....*....|....*....|
gi 161333813 309 DLQEANLRG-----SNVKGA 323
Cdd:PRK15196 233 NLQHASLLGcsmieCNCSGA 252
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-177 3.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 48.82  E-value: 3.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHmfKDKGVWGNKQDHRgaFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18419   37 IVLNVSGRRFQTWRTTL-ERYPDTLLGS--TEKEFFFNEDTKE--YFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDE 111


                 ....*..
gi 161333813 171 EARFFGI 177
Cdd:cd18419  112 ELAFYGI 118
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-177 6.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 47.26  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKDkgVWGNKQDhrGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLE 170
Cdd:cd18418    2 IVLNVSGTRFQTWRNTL-ERYPDTLLGSSERD--FFYHEET--QEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDE 76


                 ....*..
gi 161333813 171 EARFFGI 177
Cdd:cd18418   77 ELAFFGI 83
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
263-326 7.99e-07

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 46.11  E-value: 7.99e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161333813  263 VDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLR-----GSNVKGAIFE 326
Cdd:pfam13599   1 ADFTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKnaqfsGCNLKNSNFS 69
PRK15197 PRK15197
type III secretion system effector PipB;
254-333 1.46e-06

type III secretion system effector PipB;


Pssm-ID: 185119 [Multi-domain]  Cd Length: 291  Bit Score: 49.16  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813 254 NLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAI-FEEML--T 330
Cdd:PRK15197 165 DFQGEDLSDIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAIlFGSDLtdT 244


                 ...
gi 161333813 331 PLH 333
Cdd:PRK15197 245 KLN 247
BTB_POZ_KCTD1 cd18387
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-185 1.60e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349695  Cd Length: 105  Bit Score: 46.15  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLVnKEPDSMLAHMF--KDKGVWGNKQDHrgaFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVL- 169
Cdd:cd18387    7 IDVGGHMYTSSLATLT-KYPESRIGRLFdgTEPIVLDSLKQH---YFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSLLy 82

                         90
                 ....*....|....*.
gi 161333813 170 EEARFFGIDSLIEHLE 185
Cdd:cd18387   83 EEAKYFQLQPMLLELE 98
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-180 1.91e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 45.96  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLVN-----------KEPDSMLaHMFKDKGVWGNKqdhrgaFLIDRSPEYFEPILNYLRHGQLIV 159
Cdd:cd18424    1 FTINVGGSRFVLSQQVLSShpetrlgklavSVRDSVL-ELCDDANFVDNE------YFFDRSSQAFKYIMNYYKTGHLHV 73

                         90       100
                 ....*....|....*....|.
gi 161333813 160 NDGINLLGVLEEARFFGIDSL 180
Cdd:cd18424   74 MEELCAISFLQEIEYWGIDEL 94
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 85-191 1.30e-05

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 43.40  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813   85 GSHTDwLTLNVGGRYFTTTRSTLVNKEP--DSMLAHMFKDKgvwgNKQDHRgafLIDRSPEYFEPILNYLRHGQLIvnDG 162
Cdd:pfam00651   8 GELCD-VTLVVGDKEFRAHKAVLAACSPyfKALFSGQESES----SVSEIT---LDDVSPEDFEALLEFMYTGKLI--SE 77

                          90       100
                  ....*....|....*....|....*....
gi 161333813  163 INLLGVLEEARFFGIDSLIEHLEVAIKNS 191
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB_Shaw-like cd18416
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-179 2.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349723 [Multi-domain]  Cd Length: 112  Bit Score: 43.03  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  91 LTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKdkgVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLivNDGINLLGVL- 169
Cdd:cd18416    4 VVLNVGGIRHETYKATL-KKIPATRLSRLTE---ALANYDPVLNEYFFDRHPGVFAQILNYYRTGKL--HYPTDVCGPLf 77

                         90
                 ....*....|.
gi 161333813 170 -EEARFFGIDS 179
Cdd:cd18416   78 eEELEFWGLDA 88
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 15-68 2.83e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 2.83e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 161333813  15 GKVVAVYGTLSDLLSVASSKLGIKA--TSVYNGKGGLIDDIALIRDDDVLFVCEGE 68
Cdd:PLN03192 764 GKLINLPPSLEELKAIAGEKLGFDArkAMVTNEEGAEIDSIEVIRDNDKLFVVEDE 819
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
255-325 2.94e-05

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 41.88  E-value: 2.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161333813  255 LEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIF 325
Cdd:pfam13599   8 FEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLKGADF 78
PRK15196 PRK15196
type III secretion system effector PipB2;
262-327 3.32e-05

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 45.00  E-value: 3.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161333813 262 GVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEE 327
Cdd:PRK15196 151 GMNLKGAVLTGANLTAENLCDADLSGANLEGAVLFMADCEGANFKGANLSGTSLGDSNFKNACLED 216
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
278-328 3.99e-05

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 41.49  E-value: 3.99e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 161333813  278 ATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEM 328
Cdd:pfam13599   1 ADFTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEA 51
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-178 5.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 42.25  E-value: 5.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  88 TDWLTLNVGGRYFTTTRSTLvNKEPDSMLAHMFKDKGVWGNKQDHR-GAFLIDRSPEYFEPILNYLRHGQLivNDGINLL 166
Cdd:cd18414    2 SDRIVINVGGTRHETYRSTL-RTLPGTRLAWLAEPDAHSNFDYDPRaDEFFFDRHPGVFAHILNYYRTGKL--HCPADVC 78

                         90
                 ....*....|....
gi 161333813 167 GVL--EEARFFGID 178
Cdd:cd18414   79 GPLyeEELAFWGID 92
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
243-315 5.35e-05

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 41.11  E-value: 5.35e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161333813  243 CNFEdpsglKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANL 315
Cdd:pfam13599  11 CKLS-----GTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLKGADF 78
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 2-72 5.87e-05

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 40.74  E-value: 5.87e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161333813   2 RRVTLFLNGSPSNGKVVAVYGTLSDLLSVASSKLGIK--ATSVYNGKGGLIDDIALIRDDDVLFVCEGEPFID 72
Cdd:cd17159    1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRkpAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
BTB_POZ_Kv6_KCNG cd18382
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-185 1.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349691 [Multi-domain]  Cd Length: 109  Bit Score: 40.88  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLvNKEPDSMLAHMFKDKG------VWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLL 166
Cdd:cd18382    3 INVGGARYSLPWSTL-DRFPLTRLSRLKACRSeddilrVCDDYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCAL 81

                         90
                 ....*....|....*....
gi 161333813 167 GVLEEARFFGIDSliEHLE 185
Cdd:cd18382   82 SFQEELAYWGIEE--AHLE 98
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
219-295 3.19e-04

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 38.79  E-value: 3.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161333813  219 RCQCANLQgvkmlCSNAE--GASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATL 295
Cdd:pfam13599   5 RCSFEGCK-----LSGTEfyHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLKGADF 78
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 92-175 4.80e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 38.42  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  92 TLNVGGRYFTttrstlVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDR-SPEYFEPILNYLRHGQLIVNDGiNLLGVLE 170
Cdd:cd01165    2 VLVVEGEKFH------VNKELLAQSSEYFRALFRGGFRESGQAEINLRDiSPEDFRALLEFLYGGKRDLDAS-NLLELLE 74


                 ....*
gi 161333813 171 EARFF 175
Cdd:cd01165   75 AANFL 79
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 238-276 4.80e-04

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 37.32  E-value: 4.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 161333813  238 ASLRLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLR 276
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSGADLSGANLS 39
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 298-327 8.01e-04

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 36.55  E-value: 8.01e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 161333813  298 TDLENCDLSGCDLQEANLRGSNVKGAIFEE 327
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSG 30
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 223-272 9.47e-04

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 36.16  E-value: 9.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 161333813  223 ANLQGVkmlcsNAEGASLRLCNFEDpsglkANLEGANLKGVDMEGSQMTG 272
Cdd:pfam00805   1 ANLSGA-----NLSGANLSGANLSG-----ANLTGANLSGADLSGANLSG 40
BTB_POZ_Kv2_KCNB cd18378
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-180 2.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349687 [Multi-domain]  Cd Length: 109  Bit Score: 37.37  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLvNKEPDSMLAHMFKDKGV--WGNKQD----HRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLL 166
Cdd:cd18378    6 LNVGGVRHEVLWRTL-DRLPRTRLGRLRECNTHesLLELCDdydlEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMCVL 84

                         90
                 ....*....|....
gi 161333813 167 GVLEEARFFGIDSL 180
Cdd:cd18378   85 SFSQELEYWGIDEI 98
BTB_KCNC2_4 cd18415
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-178 5.76e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349722 [Multi-domain]  Cd Length: 124  Bit Score: 36.29  E-value: 5.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333813  93 LNVGGRYFTTTRSTLvNKEPDSMLAHM---------FKDKGVWGNKQDHRGA---FLIDRSPEYFEPILNYLRHGQLivN 160
Cdd:cd18415    6 LNVGGTRHETYRSTL-KTLPGTRLALLassdpqgdcLTQCSQVGGSDGSPGGgneFFFDRHPGVFAYVLNYYRTGKL--H 82

                         90       100
                 ....*....|....*....|
gi 161333813 161 DGINLLGVL--EEARFFGID 178
Cdd:cd18415   83 CPADVCGPLfeEELAFWGID 102
BTB_POZ_KCNV2 cd18425
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 132-192 7.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349732  Cd Length: 108  Bit Score: 35.90  E-value: 7.31e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161333813 132 HRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLEEARFFGidsliehleVAIKNSQ 192
Cdd:cd18425   47 QNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCPRNFLEEINYWG---------VRIKNTP 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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