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Conserved domains on  [gi|19743848|ref|NP_598011|]
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decorin isoform b precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-196 2.50e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.50e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  83 ENGAFQGMKKLSYIRIADTNITSIPQGLP--PSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNSISAVDNgSLANTP 160
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLT 182

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 19743848 161 HLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 196
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-77 1.08e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 1.08e-05
                           10        20
                   ....*....|....*....|....
gi 19743848     54 CPFRCQCHLRVVQCSDLELGTNPL 77
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPL 25
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-196 2.50e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.50e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  83 ENGAFQGMKKLSYIRIADTNITSIPQGLP--PSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNSISAVDNgSLANTP 160
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLT 182

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 19743848 161 HLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 196
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218
LRR_8 pfam13855
Leucine rich repeat;
112-172 2.46e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 2.46e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19743848   112 PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-198 1.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848 113 SLTELHLDGNKISRVDAasLKGLNNLAKLGLSFNSISAVDNgsLANTPHLRELHLDNNKLTRVPgGLAEHKYIQVVYLHN 192
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77


                ....*.
gi 19743848 193 NNISVV 198
Cdd:cd21340  78 NRISVV 83
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-196 4.40e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 4.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848   70 LELGTNPLkSSGIENGAFQGMKKLSYIRIADTNIT-SIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 148
Cdd:PLN00113  98 INLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVL 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 19743848  149 SAVDNGSLANTPHLRELHLDNNKLT-RVPGGLAEHKYIQVVYLHNNNIS 196
Cdd:PLN00113 177 VGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLS 225
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-77 1.08e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 1.08e-05
                           10        20
                   ....*....|....*....|....
gi 19743848     54 CPFRCQCHLRVVQCSDLELGTNPL 77
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPL 25
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-77 1.68e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 1.68e-05
                          10        20
                  ....*....|....*....|....
gi 19743848    54 CPFRCQCHLRVVQCSDLELGTNPL 77
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPR 25
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-196 2.50e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.50e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  83 ENGAFQGMKKLSYIRIADTNITSIPQGLP--PSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNSISAVDNgSLANTP 160
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLT 182

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 19743848 161 HLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 196
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-196 7.20e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 7.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  70 LELGTNPLKSSGIEngaFQGMKKLSYIRIADTNITSIPQGLP--PSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNS 147
Cdd:COG4886 118 LDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 19743848 148 ISAVDNgSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 196
Cdd:COG4886 194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-196 4.23e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 4.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  70 LELGTNPLKSSGIEngaFQGMKKLSYIRIADTNITSIPQGLP--PSLTELHLDGNKISRVdAASLKGLNNLAKLGLSFNS 147
Cdd:COG4886 141 LDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 19743848 148 ISAVDNgSLANTPHLRELHLDNNKLTRVPgGLAEHKYIQVVYLHNNNIS 196
Cdd:COG4886 217 LTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263
LRR_8 pfam13855
Leucine rich repeat;
112-172 2.46e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 2.46e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19743848   112 PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
112-201 3.30e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 3.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848 112 PSLTELHLDGNKisrvdaaSLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 191
Cdd:COG4886  96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLS 167

                        90
                ....*....|
gi 19743848 192 NNNISVVGSS 201
Cdd:COG4886 168 NNQLTDLPEE 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-198 1.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848 113 SLTELHLDGNKISRVDAasLKGLNNLAKLGLSFNSISAVDNgsLANTPHLRELHLDNNKLTRVPgGLAEHKYIQVVYLHN 192
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77


                ....*.
gi 19743848 193 NNISVV 198
Cdd:cd21340  78 NRISVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-177 1.04e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 1.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  90 MKKLSYIRIADTNITSIP-QGLPPSLTELHLDGNKISRVDaaSLKGLNNLAKLGLSFNSISAVDNgsLANTPHLRELHLD 168
Cdd:cd21340   1 LKRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76


                ....*....
gi 19743848 169 NNKLTRVPG 177
Cdd:cd21340  77 GNRISVVEG 85
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-195 1.92e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  70 LELGTNPLKSsgiENGAFQGMKKLSYIRIADTNITSIPQ-GLPPSLTELHLDGNKISRVDaaSLKGLNNLAKLGLSFNSI 148
Cdd:COG4886 210 LDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPElGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 19743848 149 SAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNI 195
Cdd:COG4886 285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR_8 pfam13855
Leucine rich repeat;
137-195 1.63e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848   137 NLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNI 195
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-196 4.40e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 4.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848   70 LELGTNPLkSSGIENGAFQGMKKLSYIRIADTNIT-SIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 148
Cdd:PLN00113  98 INLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVL 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 19743848  149 SAVDNGSLANTPHLRELHLDNNKLT-RVPGGLAEHKYIQVVYLHNNNIS 196
Cdd:PLN00113 177 VGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLS 225
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-173 7.69e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 7.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  70 LELGTNPLKSSGIENgAFQGMKKLSYIRIADTNITSI-PQGL---------PPSLTELHLDGNKISRVDAASL-----KG 134
Cdd:cd00116 170 LNLANNGIGDAGIRA-LAEGLKANCNLEVLDLNNNGLtDEGAsalaetlasLKSLEVLNLGDNNLTDAGAAALasallSP 248

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 19743848 135 LNNLAKLGLSFNSISAVDNGSLA----NTPHLRELHLDNNKLT 173
Cdd:cd00116 249 NISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFG 291
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-77 1.08e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 1.08e-05
                           10        20
                   ....*....|....*....|....
gi 19743848     54 CPFRCQCHLRVVQCSDLELGTNPL 77
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPL 25
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-77 1.68e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 1.68e-05
                          10        20
                  ....*....|....*....|....
gi 19743848    54 CPFRCQCHLRVVQCSDLELGTNPL 77
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPR 25
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
66-213 2.94e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848   66 QCSDLELGTNPLKSSGiENgaFQGMKKLSYIRiaDTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAklgLSF 145
Cdd:PRK15370 200 QITTLILDNNELKSLP-EN--LQGNIKTLYAN--SNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLD---LFH 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19743848  146 NSISAVDNgslaNTPH-LRELHLDNNKLTRVPgglaEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKA 213
Cdd:PRK15370 272 NKISCLPE----NLPEeLRYLSVYDNSIRTLP----AHLPSGITHLNVQSNSLTALPETLPPGLKTLEA 332
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-203 4.67e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 4.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848   90 MKKLSYIRIADTNIT-SIPQGLP--PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELH 166
Cdd:PLN00113 307 LQNLEILHLFSNNFTgKIPVALTslPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 19743848  167 LDNNKL-TRVPGGLAEHKYIQVVYLHNNNISVVGSSDF 203
Cdd:PLN00113 387 LFSNSLeGEIPKSLGACRSLRRVRLQDNSFSGELPSEF 424
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
93-189 5.01e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.30  E-value: 5.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848   93 LSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI-----SAVDNGSLANT-------- 159
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNqitvlpet 364

                         90       100       110
                 ....*....|....*....|....*....|...
gi 19743848  160 --PHLRELHLDNNKLTRVPGGL-AEHKYIQVVY 189
Cdd:PRK15370 365 lpPTITTLDVSRNALTNLPENLpAALQIMQASR 397
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-176 7.43e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 7.43e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19743848 108 QGLPPSLTELHLDGNKISrvDAASLKGLNNLAKLGLSFNSISAVDN--GSLANTPHLRELHLDNNKLTRVP 176
Cdd:cd21340 116 AALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 102-196 1.61e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848 102 NITSIP--QGLPpSLTELHLDGNKISRVdaaslKGLNNLAKL--------------GLSFNSISAVdngSLANTphLREL 165
Cdd:cd21340  57 QIEKIEnlENLV-NLKKLYLGGNRISVV-----EGLENLTNLeelhienqrlppgeKLTFDPRSLA---ALSNS--LRVL 125

                        90       100       110
                ....*....|....*....|....*....|.
gi 19743848 166 HLDNNKLTRVpGGLAEHKYIQVVYLHNNNIS 196
Cdd:cd21340 126 NISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-205 1.69e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848 110 LPPSLTELHLDGNKISRVDAASLKGL----NNLAKLGLSFNSISavDNG------SLANTPHLRELHLDNNKLTR----- 174
Cdd:cd00116 135 LPPALEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNGLTDegasa 212

                        90       100       110
                ....*....|....*....|....*....|.
gi 19743848 175 VPGGLAEHKYIQVVYLHNNNISVVGSSDFCP 205
Cdd:cd00116 213 LAETLASLKSLEVLNLGDNNLTDAGAAALAS 243
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-196 1.88e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848   72 LGTNPLkSSGIENgAFQGMKKLSYIRIADTNIT-SIPQGLPpSLTELH---LDGNKISRVDAASLKGLNNLAKLGLSFNS 147
Cdd:PLN00113 219 LGYNNL-SGEIPY-EIGGLTSLNHLDLVYNNLTgPIPSSLG-NLKNLQylfLYQNKLSGPIPPSIFSLQKLISLDLSDNS 295

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 19743848  148 ISAVDNGSLANTPHLRELHLDNNKLT-RVPGGLAEHKYIQVVYLHNNNIS 196
Cdd:PLN00113 296 LSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFS 345
LRR_8 pfam13855
Leucine rich repeat;
70-124 2.44e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19743848    70 LELGTNPLKSsgIENGAFQGMKKLSYIRIADTNITSIP----QGLpPSLTELHLDGNKI 124
Cdd:pfam13855   6 LDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGL-PSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-173 6.21e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 6.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848  70 LELGTNPLKSsgIENgaFQGMKKLSYIRIADTNITSIPQGLP-PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSI 148
Cdd:COG4886 233 LDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                        90       100
                ....*....|....*....|....*
gi 19743848 149 SAVDNGSLANTPHLRELHLDNNKLT 173
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGL 333
LRR_8 pfam13855
Leucine rich repeat;
160-203 1.55e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 1.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 19743848   160 PHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSDF 203
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAF 45
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-204 5.69e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.33  E-value: 5.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743848 112 PSLTELHLDGNKIS----RVDAASLKGLNNLAKLGLSFNSISavDNGS------LANTPHLRELHLDNNKLTRV------ 175
Cdd:cd00116 165 RDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLT--DEGAsalaetLASLKSLEVLNLGDNNLTDAgaaala 242

                        90       100
                ....*....|....*....|....*....
gi 19743848 176 PGGLAEHKYIQVVYLHNNNISVVGSSDFC 204
Cdd:cd00116 243 SALLSPNISLLTLSLSCNDITDDGAKDLA 271
PLN03150 PLN03150
hypothetical protein; Provisional
 114-179 6.80e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 37.49  E-value: 6.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19743848  114 LTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLT-RVPGGL 179
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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