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Conserved domains on  [gi|24640506|ref|NP_572441|]
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uncharacterized protein Dmel_CG2260 [Drosophila melanogaster]

Protein Classification

WDR46/Utp7 family WD40 repeat domain-containing protein( domain architecture ID 11457065)

WDR46/Utp7 family WD40 repeat domain-containing protein similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA, and Canis lupus familiaris WD repeat-containing protein 46, a scaffold component of the nucleolar structure

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 422-500 3.57e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 198101  Cd Length: 80  Bit Score: 160.08  E-value: 3.57e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506    422 PYIRQRCDAF-VHGLRFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLDP 500
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 COG2319
WD40 repeat [General function prediction only];
177-367 1.27e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 177 YRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEFNA-MESVEDVQWLHVPTMYAVAqkSW---VYFYDKKGTElhCIKR 252
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASG--SAdgtVRLWDLATGE--LLRT 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 253 L----NRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVRE 328
Cdd:COG2319 284 LtghsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 24640506 329 PLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIR 367
Cdd:COG2319 364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 422-500 3.57e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 160.08  E-value: 3.57e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506    422 PYIRQRCDAF-VHGLRFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLDP 500
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 422-499 7.11e-46

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 156.46  E-value: 7.11e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24640506   422 PYIRQRCDA-FVHGLRFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLD 499
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
177-367 1.27e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 177 YRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEFNA-MESVEDVQWLHVPTMYAVAqkSW---VYFYDKKGTElhCIKR 252
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASG--SAdgtVRLWDLATGE--LLRT 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 253 L----NRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVRE 328
Cdd:COG2319 284 LtghsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 24640506 329 PLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIR 367
Cdd:COG2319 364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-398 5.45e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 5.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 177 YRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEF-NAMESVEDVQWL-HVPTMYAVAQKSWVYFYDKKGTElhCIKRL- 253
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGE--CVRTLt 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 254 ---NRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPL 330
Cdd:cd00200  91 ghtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24640506 331 AKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIRMLVHDKPLT-HfqlRLPANELDVSQRGMLALS 398
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgH---ENGVNSVAFSPDGYLLAS 236
WD40 pfam00400
WD domain, G-beta repeat;
327-365 2.08e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24640506   327 REPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWD 365
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 327-365 7.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 7.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24640506    327 REPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWD 365
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 422-500 3.57e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 160.08  E-value: 3.57e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506    422 PYIRQRCDAF-VHGLRFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLDP 500
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 422-499 7.11e-46

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 156.46  E-value: 7.11e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24640506   422 PYIRQRCDA-FVHGLRFCPYEDVLGVSTAKGFQSLLVPGSGEPNFDAMEDNPYETSKQRREHEVHALLEKIPPELITLD 499
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
177-367 1.27e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 177 YRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEFNA-MESVEDVQWLHVPTMYAVAqkSW---VYFYDKKGTElhCIKR 252
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASG--SAdgtVRLWDLATGE--LLRT 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 253 L----NRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVRE 328
Cdd:COG2319 284 LtghsGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 24640506 329 PLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIR 367
Cdd:COG2319 364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-398 5.45e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 5.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 177 YRMRYTKNGRHLLLGGKRGHVAAFDWVTKRLHCEF-NAMESVEDVQWL-HVPTMYAVAQKSWVYFYDKKGTElhCIKRL- 253
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGE--CVRTLt 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 254 ---NRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPL 330
Cdd:cd00200  91 ghtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24640506 331 AKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIRMLVHDKPLT-HfqlRLPANELDVSQRGMLALS 398
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgH---ENGVNSVAFSPDGYLLAS 236
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 256-376 2.20e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 2.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 256 VNRLDFLPYHFLLAAGNSAGYAS-WlDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKLL 334
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKlW-DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24640506 335 CHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIRMLVHDKPLT 376
Cdd:cd00200 217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-365 9.24e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 9.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 186 RHLLLGGKRGHVAA-FDWVTKRLHCEFNA-MESVEDVQWLHVPTMYAVAqkSW---VYFYDkkGTELHCIKRL----NRV 256
Cdd:cd00200 105 GRILSSSSRDKTIKvWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASS--SQdgtIKLWD--LRTGKCVATLtghtGEV 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 257 NRLDFLP--YHFLLAAGNSAgyaSWL-DVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKL 333
Cdd:cd00200 181 NSVAFSPdgEKLLSSSSDGT---IKLwDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                       170       180       190
                ....*....|....*....|....*....|..
gi 24640506 334 LCHSTAMSALAVEPKGQYLVTAGLDRAVKVWD 365
Cdd:cd00200 258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
267-367 8.95e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 8.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 267 LLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKLLCHSTAMSALAVE 346
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                        90       100
                ....*....|....*....|.
gi 24640506 347 PKGQYLVTAGLDRAVKVWDIR 367
Cdd:COG2319 256 PDGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
254-367 9.60e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 9.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 254 NRVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKL 333
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110
                ....*....|....*....|....*....|....
gi 24640506 334 LCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIR 367
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
WD40 COG2319
WD40 repeat [General function prediction only];
255-367 1.13e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 1.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 255 RVNRLDFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKLL 334
Cdd:COG2319  38 AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT 117

                        90       100       110
                ....*....|....*....|....*....|...
gi 24640506 335 CHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIR 367
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 296-367 3.34e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 3.34e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24640506 296 GDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWDIR 367
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81
WD40 pfam00400
WD domain, G-beta repeat;
327-365 2.08e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24640506   327 REPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWD 365
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 327-365 7.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 7.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24640506    327 REPLAKLLCHSTAMSALAVEPKGQYLVTAGLDRAVKVWD 365
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
260-366 7.24e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 7.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640506 260 DFLPYHFLLAAGNSAGYASWLDVSIGELVGNFNTGLGDIRMLRHNPRNGVLCIGGGRGVVSMWSPKVREPLAKLLCHSTA 339
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100
                ....*....|....*....|....*..
gi 24640506 340 MSALAVEPKGQYLVTAGLDRAVKVWDI 366
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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