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Conserved domains on  [gi|17975083|ref|NP_536597|]
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Soluble interferon-gamma receptor-like protein [Monkeypox virus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 135-244 2.79e-15

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam07140:

Pssm-ID: 480706  Cd Length: 133  Bit Score: 70.58  E-value: 2.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17975083   135 YKRGDMCDIYLLYTANFTFGDSEEPVTYDIDDYDCTSTGCSIDFATTEKVCVTAQGaTEGFLEKITPWSSEVCLTP--KK 212
Cdd:pfam07140   1 YGNGTTCDYTFGYTVYFLFNDSKEILEYSVDDRYCDEVQCRFNIESQENVCVSVVG-VYGNWYVRTEASKDVCVPElvPR 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 17975083   213 NVYTCAIRSKEDVPNFKDKIARVITRKFNKQS 244
Cdd:pfam07140  80 PVDPYYIKKRNDLKRVKIRLPNSLESVVKSAT 111
 
Name Accession Description Interval E-value
IFNGR1 pfam07140
Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral ...
 135-244 2.79e-15

Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.


Pssm-ID: 284538  Cd Length: 133  Bit Score: 70.58  E-value: 2.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17975083   135 YKRGDMCDIYLLYTANFTFGDSEEPVTYDIDDYDCTSTGCSIDFATTEKVCVTAQGaTEGFLEKITPWSSEVCLTP--KK 212
Cdd:pfam07140   1 YGNGTTCDYTFGYTVYFLFNDSKEILEYSVDDRYCDEVQCRFNIESQENVCVSVVG-VYGNWYVRTEASKDVCVPElvPR 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 17975083   213 NVYTCAIRSKEDVPNFKDKIARVITRKFNKQS 244
Cdd:pfam07140  80 PVDPYYIKKRNDLKRVKIRLPNSLESVVKSAT 111
 
Name Accession Description Interval E-value
IFNGR1 pfam07140
Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral ...
 135-244 2.79e-15

Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.


Pssm-ID: 284538  Cd Length: 133  Bit Score: 70.58  E-value: 2.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17975083   135 YKRGDMCDIYLLYTANFTFGDSEEPVTYDIDDYDCTSTGCSIDFATTEKVCVTAQGaTEGFLEKITPWSSEVCLTP--KK 212
Cdd:pfam07140   1 YGNGTTCDYTFGYTVYFLFNDSKEILEYSVDDRYCDEVQCRFNIESQENVCVSVVG-VYGNWYVRTEASKDVCVPElvPR 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 17975083   213 NVYTCAIRSKEDVPNFKDKIARVITRKFNKQS 244
Cdd:pfam07140  80 PVDPYYIKKRNDLKRVKIRLPNSLESVVKSAT 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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