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Conserved domains on  [gi|17974922|ref|NP_536436|]
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Interleukin-18-binding protein [Monkeypox virus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pox_vIL-18BP super family cl23951
Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory ...
 1-126 4.78e-84

Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.


The actual alignment was detected with superfamily member pfam05566:

Pssm-ID: 305108  Cd Length: 126  Bit Score: 241.10  E-value: 4.78e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17974922     1 MRILFLIAFMYGCVHSYVNAVETKCPNLAIVTSSGEFHCSGCVERMPGFSYMYWLANDMKSDEDTKFIEHLGDGIKEDET 80
Cdd:pfam05566   1 MRILFLIAFMYGCVHPYVNADEIKCPNLDIVTSSGEFRCSGCVEFMPKFSYMYWLAKDMKSDEDAKFIEHLGDGIKEDET 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 17974922    81 VRTTDGGITTLRKVLHVTDTNKFAHYRFTCVLITLDGVSKKNIWLK 126
Cdd:pfam05566  81 IRTIDGGITTLQKVLHVTDTNKFAHYRFTCVLTTIDGVSKKNIWLK 126
 
Name Accession Description Interval E-value
Pox_vIL-18BP pfam05566
Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory ...
 1-126 4.78e-84

Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.


Pssm-ID: 283269  Cd Length: 126  Bit Score: 241.10  E-value: 4.78e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17974922     1 MRILFLIAFMYGCVHSYVNAVETKCPNLAIVTSSGEFHCSGCVERMPGFSYMYWLANDMKSDEDTKFIEHLGDGIKEDET 80
Cdd:pfam05566   1 MRILFLIAFMYGCVHPYVNADEIKCPNLDIVTSSGEFRCSGCVEFMPKFSYMYWLAKDMKSDEDAKFIEHLGDGIKEDET 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 17974922    81 VRTTDGGITTLRKVLHVTDTNKFAHYRFTCVLITLDGVSKKNIWLK 126
Cdd:pfam05566  81 IRTIDGGITTLQKVLHVTDTNKFAHYRFTCVLTTIDGVSKKNIWLK 126
PHA03112 PHA03112
IL-18 binding protein; Provisional
 1-126 5.08e-46

IL-18 binding protein; Provisional


Pssm-ID: 222990  Cd Length: 141  Bit Score: 145.62  E-value: 5.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17974922    1 MRILFLIAFMYgCVHSYVNAVETKCPNLAIVTSSGE---FHCSGCvERMPGFSYMYWLANDMKSDEDTKFIEHLGDGIKE 77
Cdd:PHA03112   5 MIILFLIIYIY-SVDSYVDCVKTRDVNIYIPTKETEkvvLECRGC-SYFPKFSYVYWLIGNNKSDVDQKPIEHYGEGIYE 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 17974922   78 DETVRTTDGGITTLRKVLHVTDTNKFAhyRFTCVLITLDGVSKKNIWLK 126
Cdd:PHA03112  83 SEKPRTCDNEPRTDLIVYNVTDEMKFT--KLTCVLMDLDGPIKKSIILN 129
 
Name Accession Description Interval E-value
Pox_vIL-18BP pfam05566
Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory ...
 1-126 4.78e-84

Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.


Pssm-ID: 283269  Cd Length: 126  Bit Score: 241.10  E-value: 4.78e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17974922     1 MRILFLIAFMYGCVHSYVNAVETKCPNLAIVTSSGEFHCSGCVERMPGFSYMYWLANDMKSDEDTKFIEHLGDGIKEDET 80
Cdd:pfam05566   1 MRILFLIAFMYGCVHPYVNADEIKCPNLDIVTSSGEFRCSGCVEFMPKFSYMYWLAKDMKSDEDAKFIEHLGDGIKEDET 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 17974922    81 VRTTDGGITTLRKVLHVTDTNKFAHYRFTCVLITLDGVSKKNIWLK 126
Cdd:pfam05566  81 IRTIDGGITTLQKVLHVTDTNKFAHYRFTCVLTTIDGVSKKNIWLK 126
PHA03112 PHA03112
IL-18 binding protein; Provisional
 1-126 5.08e-46

IL-18 binding protein; Provisional


Pssm-ID: 222990  Cd Length: 141  Bit Score: 145.62  E-value: 5.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17974922    1 MRILFLIAFMYgCVHSYVNAVETKCPNLAIVTSSGE---FHCSGCvERMPGFSYMYWLANDMKSDEDTKFIEHLGDGIKE 77
Cdd:PHA03112   5 MIILFLIIYIY-SVDSYVDCVKTRDVNIYIPTKETEkvvLECRGC-SYFPKFSYVYWLIGNNKSDVDQKPIEHYGEGIYE 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 17974922   78 DETVRTTDGGITTLRKVLHVTDTNKFAhyRFTCVLITLDGVSKKNIWLK 126
Cdd:PHA03112  83 SEKPRTCDNEPRTDLIVYNVTDEMKFT--KLTCVLMDLDGPIKKSIILN 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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