NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17975597|ref|NP_536355|]
View 

selenoprotein M precursor [Homo sapiens]

Protein Classification

Sep15_SelM domain-containing protein( domain architecture ID 10555966)

Sep15_SelM domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sep15_SelM pfam08806
Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a ...
 40-114 9.51e-35

Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.


:

Pssm-ID: 462607  Cd Length: 75  Bit Score: 115.74  E-value: 9.51e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17975597    40 ARVETCGGUQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTREEINALVQELGF 114
Cdd:pfam08806   1 AAVLEVCGCKLNRYPEVKAFVKSDIPKFPNLEVKYVRGAPPELVLLDDDGEEVERISIEKWDTDEINEFLKEKGF 75
 
Name Accession Description Interval E-value
Sep15_SelM pfam08806
Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a ...
 40-114 9.51e-35

Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.


Pssm-ID: 462607  Cd Length: 75  Bit Score: 115.74  E-value: 9.51e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17975597    40 ARVETCGGUQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTREEINALVQELGF 114
Cdd:pfam08806   1 AAVLEVCGCKLNRYPEVKAFVKSDIPKFPNLEVKYVRGAPPELVLLDDDGEEVERISIEKWDTDEINEFLKEKGF 75
 
Name Accession Description Interval E-value
Sep15_SelM pfam08806
Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a ...
 40-114 9.51e-35

Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.


Pssm-ID: 462607  Cd Length: 75  Bit Score: 115.74  E-value: 9.51e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17975597    40 ARVETCGGUQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRYEELERIPLSEMTREEINALVQELGF 114
Cdd:pfam08806   1 AAVLEVCGCKLNRYPEVKAFVKSDIPKFPNLEVKYVRGAPPELVLLDDDGEEVERISIEKWDTDEINEFLKEKGF 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH