Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933774    88 SKTEGKPERGGRAEGEGEPdserepesegepesetraagkRPAEDDIPRKAKRKTNKG-LAQYLKQYKEAIHDMNFSNED 166
Cdd:pfam04538   6 QENEGKPEEQGKVENEEEP---------------------EDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEE 64

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 17933774   167 MIREFDNMARVEDKRRKSKQKLGAFLWMQRNLQDPFYPR 205
Cdd:pfam04538  65 MMREGDDMERFGEEMRELRQKLREQQWRQRPHRDHHYPF 103

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933774    88 SKTEGKPERGGRAEGEGEPdserepesegepesetraagkRPAEDDIPRKAKRKTNKG-LAQYLKQYKEAIHDMNFSNED 166
Cdd:pfam04538   6 QENEGKPEEQGKVENEEEP---------------------EDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEE 64

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 17933774   167 MIREFDNMARVEDKRRKSKQKLGAFLWMQRNLQDPFYPR 205
Cdd:pfam04538  65 MMREGDDMERFGEEMRELRQKLREQQWRQRPHRDHHYPF 103

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933774    88 SKTEGKPERGGRAEGEGEPdserepesegepesetraagkRPAEDDIPRKAKRKTNKG-LAQYLKQYKEAIHDMNFSNED 166
Cdd:pfam04538   6 QENEGKPEEQGKVENEEEP---------------------EDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEE 64

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 17933774   167 MIREFDNMARVEDKRRKSKQKLGAFLWMQRNLQDPFYPR 205
Cdd:pfam04538  65 MMREGDDMERFGEEMRELRQKLREQQWRQRPHRDHHYPF 103

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933774      7 ENEGMPSNQGKIDNEEQPPHEGKPEVACILEDKKLENEGNTENTGKRVEEplKDKEKPESAGKAKGEGKSERKgKSEMQG 86
Cdd:TIGR00927  692 EQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEV--EDEGEGEAEGKHEVETEGDRK-ETEHEG 768

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17933774     87 GSKTEGKPERGG---RAEGEGEPDSEREPESEGEPESETRAAGKRPAEDDIPRKAKRKTNKG 145
Cdd:TIGR00927  769 ETEAEGKEDEDEgeiQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKD 830