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Conserved domains on  [gi|91807117|ref|NP_510883|]
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TM2 domain-containing protein 3 isoform a precursor [Homo sapiens]

Protein Classification

TM2 domain-containing protein( domain architecture ID 10524121)

TM2 domain-containing protein similar to Homo sapiens TM2 domain-containing protein 1 (TM2D1) that may participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42

Gene Ontology:  GO:0097190|GO:0004930|GO:0001540

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 182-231 4.68e-17

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


:

Pssm-ID: 428337  Cd Length: 50  Bit Score: 72.52  E-value: 4.68e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 91807117   182 GGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVL 231
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 182-231 4.68e-17

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 72.52  E-value: 4.68e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 91807117   182 GGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVL 231
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 185-233 6.28e-10

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 54.15  E-value: 6.28e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 91807117 185 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSF--GGLGIWTLIDVLLI 233
Cdd:COG2314   9 SKLVAGLLAIFLGGFGIHRFYLGKTGTGIIYLLFFwtGIPGIIGLIDGILY 59
PHA01886 PHA01886
TM2 domain-containing protein
 185-233 2.97e-05

TM2 domain-containing protein


Pssm-ID: 222840  Cd Length: 78  Bit Score: 41.49  E-value: 2.97e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 91807117  185 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLI 233
Cdd:PHA01886   3 STAIAYVLWFFLGFFGIHRFYTGNIATGIIWLFTGGLFGIGWFIDLFLT 51
 
Name Accession Description Interval E-value
TM2 pfam05154
TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a ...
 182-231 4.68e-17

TM2 domain; This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.


Pssm-ID: 428337  Cd Length: 50  Bit Score: 72.52  E-value: 4.68e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 91807117   182 GGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVL 231
Cdd:pfam05154   1 SGKSKLIAYLLWLFLGGFGVHRFYLGKTGTGILYLLTFGGLGIWWLIDLI 50
TM2 COG2314
Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction ...
 185-233 6.28e-10

Uncharacterized membrane protein YozV, TM2 domain, contains pTyr [General function prediction only];


Pssm-ID: 441888  Cd Length: 79  Bit Score: 54.15  E-value: 6.28e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 91807117 185 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSF--GGLGIWTLIDVLLI 233
Cdd:COG2314   9 SKLVAGLLAIFLGGFGIHRFYLGKTGTGIIYLLFFwtGIPGIIGLIDGILY 59
PHA01886 PHA01886
TM2 domain-containing protein
 185-233 2.97e-05

TM2 domain-containing protein


Pssm-ID: 222840  Cd Length: 78  Bit Score: 41.49  E-value: 2.97e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 91807117  185 KWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLI 233
Cdd:PHA01886   3 STAIAYVLWFFLGFFGIHRFYTGNIATGIIWLFTGGLFGIGWFIDLFLT 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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