NCBI Conserved Domain Search

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 112.06 E-value: 1.51e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560    411 TYDVVISYVENgPYLFWVHLKSSDHDLSTMMGQIERTK--LKALAQAPELGTACVARFSEDGHLYRAMV-CAVYAQRYRV 487
Cdd:pfam00567    2 TIDVVVSHIES-PSTFYIQPKSDSKKLEKLTEELQEYYasKPPESLPPAVGDGCVAAFSEDGKWYRAKItESLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 17136560    488 VYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAG 524
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 109.37 E-value: 1.17e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560    595 NDDAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRV--PDQLILGAPCIVKCDQEWYRAEIL--RVDDSVIV 670
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPEslPPAVGDGCVAAFSEDGKWYRAKITesLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 17136560    671 RHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKG 707
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 109.37 E-value: 1.20e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560   2347 ELHNCVVVQFDGPMSFYVQMESDVPALEQMTDKLLDAEQDLPA-FSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEV 2425
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPeSLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 17136560   2426 HFIDFGNNAV--TQQFRQLPEELAKPARYSRHCEL 2458
Cdd:pfam00567   81 LFIDYGNTETvpLSDLRPLPPELESLPPQAIKCQL 115

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 109.37 E-value: 1.32e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560   1016 SKEAASLSWWLSPFQFYIVPKSVSAKYDNIMRDMREFYRQKQHQPLQLKVGSTVVVRQRKDNAILRATVTaCNHMMRKYR 1095
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKIT-ESLDDGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 17136560   1096 VFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCSFH 1132
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 106.67 E-value: 1.27e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560   1795 SGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKDTLKPLEGF--EKGLIVAALFEDDELWYRAQLQKELPDSRYEV 1872
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLppAVGDGCVAAFSEDGKWYRAKITESLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 17136560   1873 LFIDYGNTST--TSKCLMLSEEIASLPSLSKKCSLQ 1906
Cdd:pfam00567   81 LFIDYGNTETvpLSDLRPLPPELESLPPQAIKCQLA 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 103.97 E-value: 9.00e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560   2163 ENSECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYSQEDACYYRCSIKSVLDpSQGFE 2242
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLD-DGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 17136560   2243 VFLLDYGNTLVVP--EVWQLPQEIEPIPSLALHCQLS 2277
Cdd:pfam00567   80 VLFIDYGNTETVPlsDLRPLPPELESLPPQAIKCQLA 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 102.82 E-value: 2.62e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560   1309 SSFQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKKFDVGQIC-AVRSSDGNWYRARISGKDSNaACFE 1387
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCvAAFSEDGKWYRAKITESLDD-GLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 17136560   1388 VFYIDYGNTEEIKRDDIKALDaKFYEHASGFAVEINLP 1425
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLP-PELESLPPQAIKCQLA 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 101.28 E-value: 7.91e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560   1980 TTKAIITHVENTSRIYLQFSEKDSLMDIICEKLN--GSKLQPKTEKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVI 2057
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQeyYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVL 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 17136560   2058 LIDYGNTTVV--DKLYELPQEFTLIKPVAEICSM 2089
Cdd:pfam00567   82 FIDYGNTETVplSDLRPLPPELESLPPQAIKCQL 115

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 98.97 E-value: 6.32e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560   1620 CVVLSHCDNPAQFYVHPIDQLSKLNQLHENLQIVSPSLPQLMNVVN-GADCVSMYSVDKCWYRAKI---IDAELMVLLFI 1695
Cdd:pfam00567    4 DVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAvGDGCVAAFSEDGKWYRAKItesLDDGLVEVLFI 83

                           90       100       110
                   ....*....|....*....|....*....|....
gi 17136560   1696 DYGNTDCVsDATDIKE--SMWSHIEPFCLPCALP 1727
Cdd:pfam00567   84 DYGNTETV-PLSDLRPlpPELESLPPQAIKCQLA 116

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 87.51 E-value: 5.46e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1797 CSCYISHVNGICDFFIQLERDSKALELIELYLRKKDTLK-PLEG--FEKGLIVAALFEDDELWYRAQLQKELPDSRYEVL 1873
Cdd:cd20425    2 TEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDeEVECesLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQ 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17136560 1874 FIDYGNTST--TSKCLMLSEEIASLPSLSKKCSL 1905
Cdd:cd20425   82 FIDYGNTSVvqPSKIHRLPKELLSIPALSIHCFL 115

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 82.54 E-value: 3.96e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  401 FRTTSLTVGLTYDVVISYVeNGPYLFWVHLKSSDHDLSTMMGQIERTKLKALAQAPELGTACVARFSEDGHLYRAMVCA- 479
Cdd:cd20439    1 YKEYLFKPGSVVDVKCSYV-NSPGDFWCQLQTKSSELKSLMKQIQSYYLIHNDPYKHGQIACVAKYSKDGKWYRAAVLKq 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 17136560  480 VYAQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFAL 522
Cdd:cd20439   80 VSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSL 122

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 76.70 E-value: 3.11e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2359 PMSFYVQMESDVPALEQMTDKL---LDAEQDLPAfSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAV 2435
Cdd:cd20441    2 PSRFFIQLSEDEKVILQLAEELnetSEKSRENAA-VKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAV 80

                         90       100
                 ....*....|....*....|....*.
gi 17136560 2436 --TQQFRQLPEE-LAKPaRYSRHCEL 2458
Cdd:cd20441   81 vdKSNIYTLQEKfLSLP-RLSIPCSL 105

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 76.32 E-value: 4.12e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1810 FFIQLERDSKAL-----ELIELylRKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTST-- 1882
Cdd:cd20441    5 FFIQLSEDEKVIlqlaeELNET--SEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVvd 82

                         90       100
                 ....*....|....*....|...
gi 17136560 1883 TSKCLMLSEEIASLPSLSKKCSL 1905
Cdd:cd20441   83 KSNIYTLQEKFLSLPRLSIPCSL 105

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 77.15 E-value: 5.15e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  604 IDSPSNFYVQ-KVANIGKFEQLMDEMFSYYNANQRVPDQLILGAPCIVKC--DQEWYRAEILRV-DDSVIVRHVDFGYEQ 679
Cdd:cd20426    8 VDSPEYFWCQfATEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYseDNHWYRALVTKInDNLVSVRFVDYGNEE 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17136560  680 NVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSE--LSEDKITDQFEMLAEE 728
Cdd:cd20426   88 DVVREQVRALPSELLKIPVQAFPCCLSGFNLSEglWSDEANDYFYEIVTED 138

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 73.46 E-value: 9.13e-16

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560    1354 KKFDVGQICAVRSSDGNWYRARISGKDSNAACfEVFYIDYGNTEEIKRDDIKALDAKF 1411
Cdd:smart00333    1 PTFKVGDKVAARWEDGEWYRARIVKVDGEQLY-EVFFIDYGNEEVVPPSDLRQLPEEL 57

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 74.08 E-value: 5.53e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  412 YDVVISYVENgPYLFWVHLKSSDHDLSTMMGQIERT-----KLKALAQAPELGTACVARFSEDGHlYRAMVCAVYAQRYR 486
Cdd:cd20422    2 YDAQVEFVKD-PSEFWIRLGEHAVPFSKLMRSMTAFysqasKLDGVVLKPQPGQLCCAKWKEDRY-YRAIVTAVKGKMVE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 17136560  487 VVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAgtkEIEPI 531
Cdd:cd20422   80 VFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLA---DICPL 121

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 71.18 E-value: 1.09e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2369 DVPALEQMTDKL---LDAEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAVTQ--QFRQLP 2443
Cdd:cd20433    1 TGPQLEKLMEKLrfeIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPstRLAALP 80


                 ....
gi 17136560 2444 EELA 2447
Cdd:cd20433   81 PAFS 84

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 70.92 E-value: 2.94e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1990 NTSRIYLQFSEKDSLMDIICEKLNGSKLQPKTEKAA---VDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTV 2066
Cdd:cd20441    1 SPSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVklkVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAV 80

                         90
                 ....*....|...
gi 17136560 2067 VD--KLYELPQEF 2077
Cdd:cd20441   81 VDksNIYTLQEKF 93

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 70.56 E-value: 4.74e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1981 TKAIITHVENTSRIYLQFSEKDSLMDIICEKLNGSKLQPKT---EKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVI 2057
Cdd:cd20425    2 TEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEvecESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQ 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17136560 2058 LIDYGNTTVVD--KLYELPQEFTLIKPVAEICSM 2089
Cdd:cd20425   82 FIDYGNTSVVQpsKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 66.38 E-value: 2.01e-13

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17136560 1358 VGQICAVRSS-DGNWYRARISGKDSNAaCFEVFYIDYGNTEEIKRDDIKAL 1407
Cdd:cd20379    1 VGDLCAAKYEeDGKWYRARVLEVLSND-KVEVFFVDYGNTETVPLSDLRPL 50

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 66.74 E-value: 4.55e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17136560  461 ACVARFSEDGHLYRAMVCAVYA--QRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGTKEIE 529
Cdd:cd20423    8 VCLAKYSEDGKWCRALIDNVYEpvEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPS 78

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 66.68 E-value: 1.70e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1314 LVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAK---GDSLKKFDVGQICAVRSSDGNWYRARISGKDSNAACFEVFY 1390
Cdd:cd20421   16 VVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRvgsGYETRPEKLGSPCAARGSDGRWYRAVLQQVFSANRVVEVLH 95

                         90       100
                 ....*....|....*....|..
gi 17136560 1391 IDYGNTEEIKRDDIKALDAKFY 1412
Cdd:cd20421   96 VDYGRKEVVSVSNLRYLAPEYF 117

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 66.73 E-value: 2.18e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  406 LTVGLTYDVVISYVENgPYLFWVHLKSSDHDLSTMMGQIERTKLKA-----LAQAPELGTACVARFSEDGHLYRAMVCAV 480
Cdd:cd20438    1 MEVDAAYVAFVEYVLN-PSNFWIRTDEYNNEFQALMKNIADIYNLCgndeeLLKKPEPGLLCCARYSKDRHYYRAVITEV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17136560  481 YAQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAgtkEIEPIDD 533
Cdd:cd20438   80 LDLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLA---HVFPVEE 129

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 63.83 E-value: 2.41e-12

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560     454 QAPELGTACVARFsEDGHLYRAMVCAVY-AQRYRVVYVDYGNSELLSASDLFQIPPEL 510
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDgEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 63.45 E-value: 2.65e-12

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560    2391 SDLKEGALCVAQFpEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAV--TQQFRQLPEEL 2446
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVvpPSDLRQLPEEL 57

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 62.86 E-value: 8.71e-12

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560  456 PELGTACVARFSEDGHLYRAMVCAVYAQ-RYRVVYVDYGNSELLSASDLFQIPPELL 511
Cdd:cd20409   26 PAVGEVCCAQFTEDNQWYRASVLAYSSEdSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 64.83 E-value: 9.61e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  421 NGPYLFWVHLKSSDHDLSTM----MGQIERTKLKALAqAPELGTACVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSE 496
Cdd:cd20426    9 DSPEYFWCQFATEKIQCLAVkvqeAGEQVADRGNFIP-SIYVGDPCIVKYSEDNHWYRALVTKINDNLVSVRFVDYGNEE 87

                         90       100
                 ....*....|....*....|....*...
gi 17136560  497 LLSASDLFQIPPELLEIKPFAFRFALAG 524
Cdd:cd20426   88 DVVREQVRALPSELLKIPVQAFPCCLSG 115

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 64.31 E-value: 1.17e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  456 PELGTACVARFSEDGHLYRAMVCAVYAQR--YRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGtkeIEPIDD 533
Cdd:cd20408   47 PEVGEVCVAKYSEDQNWYRALVQTVDVQQkkAGVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLAN---VKPPSG 123


                 .
gi 17136560  534 S 534
Cdd:cd20408  124 S 124

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 60.99 E-value: 1.78e-11

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 17136560 2026 VDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVV--DKLYEL 2073
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVplSDLRPL 50

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 62.86 E-value: 2.13e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2165 SECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVC-YSQEDACYYRCSIKSVLdPSQGFEV 2243
Cdd:cd20425    2 TEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICaEYPEDGLWYRAVVKEKI-PNNLVSV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 17136560 2244 FLLDYGNTLVVP--EVWQLPQEIEPIPSLALHCQL 2276
Cdd:cd20425   81 QFIDYGNTSVVQpsKIHRLPKELLSIPALSIHCFL 115

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 62.85 E-value: 2.32e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  456 PELGTACVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDLFQIPPELLEIkPFA-FRFALAG 524
Cdd:cd20411   48 PRIGDACCARFTGDKNWYRAVVLETSDSEVKVLYADYGNTETLPLSRILPITKSHLEL-PFQiIRCSLAG 116

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 60.22 E-value: 3.04e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17136560 1842 KGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSK 1885
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPL 44

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 61.16 E-value: 3.58e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1817 DSKALELIELYLRKKDTLKP-LEG-FE--KGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKClmlseE 1892
Cdd:cd20433    1 TGPQLEKLMEKLRFEIASNPpLPGsYTprKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPST-----R 75


                 ....*.
gi 17136560 1893 IASLPS 1898
Cdd:cd20433   76 LAALPP 81

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 60.05 E-value: 4.59e-11

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17136560  454 QAPELGTACVARFSEDGHLYRAMVCAVYAQ-RYRVVYVDYGNSELLSASDLFQIPPELL 511
Cdd:cd20410    1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGgAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 62.08 E-value: 4.94e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  606 SPSNFYVQKVA---NIGKFEQLMDEMFSYYNAnQRVPDQLI--LGAPCIVK--CDQEWYRAEILRVDDS-VIVRHVDFGY 677
Cdd:cd20411    8 SPDLFYALPKTgqvNVEKLKALMTELAEYCSK-QSVPQQFRprIGDACCARftGDKNWYRAVVLETSDSeVKVLYADYGN 86

                         90       100       110
                 ....*....|....*....|....*....|
gi 17136560  678 EQNVKRHLIGHIAEKHLEMPRQAIKCCLKG 707
Cdd:cd20411   87 TETLPLSRILPITKSHLELPFQIIRCSLAG 116

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 59.45 E-value: 6.46e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 17136560 2395 EGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAV 2435
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTET 41

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 62.00 E-value: 8.01e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1321 PYRVYVQPQA--IVPSMQTLLDNMYEHYkAKGDSLKKF--DVGQICAVR-SSDGNWYRARISGKDSNAACFEVFYIDYGN 1395
Cdd:cd20408    9 PGEFYIQIYTleVLESLVKLTSQLKKTY-ASVNNHKEYipEVGEVCVAKySEDQNWYRALVQTVDVQQKKAGVFYIDYGN 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 17136560 1396 TEEIKRDDIKALDAKFyEHASGFAVEINLPIGRPSND 1432
Cdd:cd20408   88 EETVPLNRIQPLKKDI-ELFPPCAIKCCLANVKPPSG 123

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 60.54 E-value: 1.59e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  604 IDSPSNFYVQKVANIG--KFEQLMDEMFSYYNANQ-----RVPDQLIL-GAPCIVKC--DQEWYRAEILRVDDS--VIVR 671
Cdd:cd20419    5 IESPSQFYVRFYSKDTseMLEDMMIEMRRCYSNEHvseryVMPEAFIQpGQVCCVRIpeDVWWYRVIIHQVLNKqeVEVF 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17136560  672 HVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCL 705
Cdd:cd20419   85 YPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 59.75 E-value: 2.21e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2174 SPKSFYVQMKHN-SADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYSQEDACYYRCSIKSVLdPSQGFEVFLLDYGNTL 2252
Cdd:cd20441    1 SPSRFFIQLSEDeKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVL-PGKSFKVEFIDYGNTA 79

                         90       100
                 ....*....|....*....|....*....
gi 17136560 2253 VV--PEVWQLPQEIEPIPSLALHCQLSKI 2279
Cdd:cd20441   80 VVdkSNIYTLQEKFLSLPRLSIPCSLSGV 108

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 60.13 E-value: 3.17e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  406 LTVGLTYDVVISYVENgPYLFWVHLKSSDHD---LSTMMGQI--ERTKLKALAQAPELGTACVARfSEDGHLYRAMVCAV 480
Cdd:cd20421    7 LQVGVTETVVVTEVTD-PHRIFCQLRSLSQElkrLSESMHQYyeGRVGSGYETRPEKLGSPCAAR-GSDGRWYRAVLQQV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 17136560  481 YAQRY--RVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAG 524
Cdd:cd20421   85 FSANRvvEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 59.79 E-value: 3.39e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1810 FFIQLERDSKaLELIELYLRK---KDTLKPLEGF--EKGLIVAALFEDDELWYRAQL------QKELPDSRYEVLFIDYG 1878
Cdd:cd20443    4 FYVQVVSDQR-LSSIQQQLEGlslKDKANPPGGFnpKKGELVLAQFSADNSWNRAMVvnaprqGTQSPKDEYEVFYIDYG 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 17136560 1879 NTSTT--SKCLMLSEEIASLPSLSKKCSLqlpdAYI 1912
Cdd:cd20443   83 NQETVplSALRPLDPSVSSAPGLAQLCSL----AHI 114

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 57.67 E-value: 3.55e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 17136560    2028 DMCVVQFaDDLEFYRSRILEVLEDDQYKVILIDYGNTTVVDK--LYELPQEF 2077
Cdd:smart00333    7 DKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPsdLRQLPEEL 57

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 58.47 E-value: 3.58e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17136560  437 LSTMMGQ----IERTKLKALAQAPELGTACVARFSEDGHLYRAMVCAVYAQ-RYRVVYVDYGNSELLSASDLFQIPPEL 510
Cdd:cd20433    5 LEKLMEKlrfeIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDkKVHVLYIDYGNREVLPSTRLAALPPAF 83

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 57.14 E-value: 3.94e-10

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 17136560  458 LGTACVARFSEDGHLYRAMVCAVYA-QRYRVVYVDYGNSELLSASDLFQI 506
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSnDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 59.83 E-value: 4.14e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  599 VEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVpDQLIL----GAPCIVKC-DQEWYRAEILRVDD-SVIVRH 672
Cdd:cd20422    4 AQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKL-DGVVLkpqpGQLCCAKWkEDRYYRAIVTAVKGkMVEVFL 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17136560  673 VDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCL 705
Cdd:cd20422   83 VDRGNTEMVDWYDVKKLLPQFRELPALALKCCL 115

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 58.97 E-value: 6.27e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  408 VGLTYDVVISyVENGPYLFWVHLKSSDHDLSTMMGQI----ERTKLKALAQAPELGTACVARfSEDGHLYRAMV-CAVYA 482
Cdd:cd20437    1 VGTTEKVKIT-AAVSPSKFYCQLLSWEPELSKLTTQMtlhyESVSKELNPSCENFGLLCAAK-GKDGQWHRGFLqQLLPP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 17136560  483 QRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALA 523
Cdd:cd20437   79 SQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 58.66 E-value: 9.97e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  599 VEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYN--ANQRVPDQLilgaPCIVKC--DQEWYRAEILRVDDS--VIVRH 672
Cdd:cd20439   14 VKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLihNDPYKHGQI----ACVAKYskDGKWYRAAVLKQVSAkeVDVIF 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 17136560  673 VDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGF 708
Cdd:cd20439   90 VDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 58.54 E-value: 1.05e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  604 IDSPSNFYVQ----KVA-NIGKFEQLMDEmfSYYNANQRVPDQLILGAPCIVK--CDQEWYRAEILRVDDSVIVRHV--- 673
Cdd:cd20408    6 FKNPGEFYIQiytlEVLeSLVKLTSQLKK--TYASVNNHKEYIPEVGEVCVAKysEDQNWYRALVQTVDVQQKKAGVfyi 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17136560  674 DFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKG 707
Cdd:cd20408   84 DYGNEETVPLNRIQPLKKDIELFPPCAIKCCLAN 117

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 56.92 E-value: 1.25e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1332 VPSMQTLLDNMYEHYKAKGDSLKKFDV--GQICAVR-SSDGNWYRARISgKDSNAACFEVFYIDYGNTEEIKRDDIKALD 1408
Cdd:cd20433    2 GPQLEKLMEKLRFEIASNPPLPGSYTPrkGDLCAAKfVEDGEWYRAKVE-KVEGDKKVHVLYIDYGNREVLPSTRLAALP 80


                 ...
gi 17136560 1409 AKF 1411
Cdd:cd20433   81 PAF 83

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 57.08 E-value: 2.35e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2359 PMSFYVQMESDVPALEQMTDKLlDAEQDLPAFSD---LKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAV 2435
Cdd:cd20425   12 PSDFYVQLAQDEDELSMISEKL-NASKANDEEVEcesLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFIDYGNTSV 90

                         90       100
                 ....*....|....*....|....*
gi 17136560 2436 TQ--QFRQLPEELAKPARYSRHCEL 2458
Cdd:cd20425   91 VQpsKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 56.71 E-value: 3.45e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  433 SDHDLSTMMGQIERTKLKALAQ-----APELGTACVARFSEDGHLYRAMVCAVYAQ-------RYRVVYVDYGNSELLSA 500
Cdd:cd20443   10 SDQRLSSIQQQLEGLSLKDKANppggfNPKKGELVLAQFSADNSWNRAMVVNAPRQgtqspkdEYEVFYIDYGNQETVPL 89

                         90       100
                 ....*....|....*....|....*.
gi 17136560  501 SDLFQIPPELLEIKPFAFRFALAGTK 526
Cdd:cd20443   90 SALRPLDPSVSSAPGLAQLCSLAHIK 115

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 54.20 E-value: 6.00e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 17136560    1840 FEKGLIVAALFeDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKCLMLSEE 1892
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLP 54

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 54.20 E-value: 6.12e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 17136560     644 LGAPCIVKC-DQEWYRAEILRVD--DSVIVRHVDFGYEQNVKRHLIGHIAEKH 693
Cdd:smart00333    5 VGDKVAARWeDGEWYRARIVKVDgeQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 55.52 E-value: 6.91e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  423 PYLFWVHLKSSDHDLSTMMGQIERTKLKALAQA---PELGTACVARFSEDGHLYRAMVCAVYAQ-RYRVVYVDYGNSELL 498
Cdd:cd20441    2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAavkLKVGDLVAAEYDEDLALYRAVITAVLPGkSFKVEFIDYGNTAVV 81

                         90       100
                 ....*....|....*....|....*.
gi 17136560  499 SASDLFQIPPELLEIKPFAFRFALAG 524
Cdd:cd20441   82 DKSNIYTLQEKFLSLPRLSIPCSLSG 107

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 54.39 E-value: 2.02e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1621 VVLSHCDNPAQFYVHPIDQLSKLNQLHENL--------QIVSPSLpQLMNVVngadCvSMYSVDKCWYRAKI---IDAEL 1689
Cdd:cd20425    4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLnaskandeEVECESL-QLGDLI----C-AEYPEDGLWYRAVVkekIPNNL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 17136560 1690 MVLLFIDYGNTDCVsDATDI----KESMwsHIEPFCLPCAL 1726
Cdd:cd20425   78 VSVQFIDYGNTSVV-QPSKIhrlpKELL--SIPALSIHCFL 115

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 54.01 E-value: 2.72e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1323 RVYVQpqaiVPSMQTL--LDNMYEHYKAKGDSL-------KKFDVgqICAVRSSDGNWYRARISGKDSNAAC-----FEV 1388
Cdd:cd20443    3 RFYVQ----VVSDQRLssIQQQLEGLSLKDKANppggfnpKKGEL--VLAQFSADNSWNRAMVVNAPRQGTQspkdeYEV 76

                         90       100
                 ....*....|....*....|
gi 17136560 1389 FYIDYGNTEEIKRDDIKALD 1408
Cdd:cd20443   77 FYIDYGNQETVPLSALRPLD 96

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 54.43 E-value: 3.34e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2357 DGPMSFYVQMESD-VPALEQMTDKLLDAEQDLPAF-SDLKEGALCVAQFPEDEVFYRAQIRKVLDDgKCEVHFIDFGN-- 2432
Cdd:cd20426    9 DSPEYFWCQFATEkIQCLAVKVQEAGEQVADRGNFiPSIYVGDPCIVKYSEDNHWYRALVTKINDN-LVSVRFVDYGNee 87

                         90
                 ....*....|....*.
gi 17136560 2433 NAVTQQFRQLPEELAK 2448
Cdd:cd20426   88 DVVREQVRALPSELLK 103

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 53.18 E-value: 4.38e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  645 GAPCIVK-CDQEWYRAEILRVDD----SVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFE--NSELSEDK 717
Cdd:cd20418    7 EMPCLAEySDGKWYRAKLLSILEfnpvKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKppLNDSETER 86


                 .
gi 17136560  718 I 718
Cdd:cd20418   87 I 87

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 53.91 E-value: 4.44e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1809 DFFIQLErDSKALE-LIELYLRKKDTLKPLEGF-----EKGLIVAALFEDDELWYRAQLQKELPDSRY-EVLFIDYGNTS 1881
Cdd:cd20408   11 EFYIQIY-TLEVLEsLVKLTSQLKKTYASVNNHkeyipEVGEVCVAKYSEDQNWYRALVQTVDVQQKKaGVFYIDYGNEE 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 17136560 1882 TTS--KCLMLSEEIASLPSLSKKCSL-QLPDAYISWSPEA 1918
Cdd:cd20408   90 TVPlnRIQPLKKDIELFPPCAIKCCLaNVKPPSGSWSEEC 129

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 53.91 E-value: 5.28e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1628 NPAQFYVHPIDQ--LSKLNQLHENLQ--IVSPSLPQLMNVVNGADCVSMYSVDKCWYRAKI----IDAELMVLLFIDYGN 1699
Cdd:cd20408    8 NPGEFYIQIYTLevLESLVKLTSQLKktYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVqtvdVQQKKAGVFYIDYGN 87

                         90       100
                 ....*....|....*....|....*..
gi 17136560 1700 TDCVSdATDIKEsMWSHIEPFClPCAL 1726
Cdd:cd20408   88 EETVP-LNRIQP-LKKDIELFP-PCAI 111

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 51.12 E-value: 5.60e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560    2210 PTTNSNGVCYSQ-EDACYYRCSIKSVlDPSQGFEVFLLDYGNTLVVP--EVWQLPQEI 2264
Cdd:smart00333    1 PTFKVGDKVAARwEDGEWYRARIVKV-DGEQLYEVFFIDYGNEEVVPpsDLRQLPEEL 57

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 53.23 E-value: 6.06e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  414 VVISYVeNGPYLFWVHLkSSDHDLSTMMGQiertKLKALAQAPE--------LGTACVARFSEDGHLYRAMVCAVYAQR- 484
Cdd:cd20425    4 VYVSHV-NSPSDFYVQL-AQDEDELSMISE----KLNASKANDEeveceslqLGDLICAEYPEDGLWYRAVVKEKIPNNl 77

                         90       100
                 ....*....|....*....|....*....
gi 17136560  485 YRVVYVDYGNSELLSASDLFQIPPELLEI 513
Cdd:cd20425   78 VSVQFIDYGNTSVVQPSKIHRLPKELLSI 106

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 51.92 E-value: 6.84e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17136560 2028 DMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGN--TTVVDKLYELPQEFT 2078
Cdd:cd20433   32 DLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNreVLPSTRLAALPPAFS 84

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 53.41 E-value: 7.06e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 2026 VDDMCVVQFADDLeFYRSRILEVLEDD------QYKVILIDYGNTT--VVDKLYELPQEFTLIKPVA-EI--CSMEP 2091
Cdd:cd20435   52 VGDLCAVEDENNL-YHRVKVLEITEKDdktkprEVLVKFIDEGRVEtvVVSQLLELPEELKSLPPQAvEVflCNVKP 127

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 51.52 E-value: 7.82e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136560 1650 LQIVSPSLPQL-----MNVVNGAdcvsMYSVDKCWYRAK---IIDAELMVLLFIDYGNTDCVS 1704
Cdd:cd20430    5 LAEVCPTAPPLfgtpdPNKIYGG----KFSEDNCWYRCKvksILSDEKCTVQYIDYGNTETVS 63

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 51.14 E-value: 1.22e-07

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 17136560 1363 AVRSSDGNWYRARISGKDSNAACfEVFYIDYGNTEEIKRDDI 1404
Cdd:cd20430   27 GKFSEDNCWYRCKVKSILSDEKC-TVQYIDYGNTETVSRSSI 67

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 52.37 E-value: 1.63e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2352 VVVQFDGPMSFYVQMESD--VPALEQMTDKLLDAEQDLPAFSDLK--EGALCVAQFPEDEVFYRAQIRKV-LDDGKCEVH 2426
Cdd:cd20408    2 TVTEFKNPGEFYIQIYTLevLESLVKLTSQLKKTYASVNNHKEYIpeVGEVCVAKYSEDQNWYRALVQTVdVQQKKAGVF 81


                 ....*.
gi 17136560 2427 FIDFGN 2432
Cdd:cd20408   82 YIDYGN 87

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 50.03 E-value: 1.74e-07

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 17136560 2396 GALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNN 2433
Cdd:cd20410    6 GEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNV 43

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 51.64 E-value: 1.78e-07

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560  462 CVARFSeDGHLYRAMVCAV---YAQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGTK 526
Cdd:cd20418   10 CLAEYS-DGKWYRAKLLSIlefNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFK 76

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 52.12 E-value: 1.87e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  401 FRTTSLTVGLTYDVVISYVENgPYLFWVHLKSSDHDLSTMMGQIER--TKLKALAQAPELGTACVARFSeDGHLYRAMVC 478
Cdd:cd20424    3 YSMHDIKIGSEEEVYITYVND-PWTFYCQLARNAGVLDQLASAISRlsSEIRKLELSVNPGTLCLAKYS-DQHWYRGIII 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 17136560  479 AVyAQRYRVVYVDYGNSELLSASDLFQIPPELLEI 513
Cdd:cd20424   81 TN-KNSTEVFFVDYGNTEKVEKEDMLPIPSDAYEL 114

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 52.07 E-value: 2.05e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1985 ITHVENTSRIYLQFSEKDSLMDIICEKLNGSKLQPKTEKAAVDD--MCVVQFADDLEFYRSRILEVLEDDQYKVILIDYG 2062
Cdd:cd20440   16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILDNCKtrLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDYG 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 17136560 2063 NTTVVDK--LYELPQEFT--LIKPVAEI-CSM 2089
Cdd:cd20440   96 NKQIVEKneVLPIPDTAVdlLLTPMQAIkCCL 127

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 52.09 E-value: 2.53e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1309 SSFQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDS---LKKFDVGQICAVR-SSDGNWYRARISgkDSNAA 1384
Cdd:cd20438    5 AAYVAFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDeelLKKPEPGLLCCARySKDRHYYRAVIT--EVLDL 82

                         90       100
                 ....*....|....*....|....*....
gi 17136560 1385 CFEVFYIDYGNTEEIKRDDIKALDAKFYE 1413
Cdd:cd20438   83 KVSVYFLDFGNTDTVPFYDVKTLLPEFSE 111

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 51.26 E-value: 2.87e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1321 PYRVYVQPQAIVPSMQTLLDNMYEHYKAK----GDSLKKFDVgqICAVRSSDGNWYRARISGKDSNAAcFEVFYIDYGNT 1396
Cdd:cd20437   15 PSKFYCQLLSWEPELSKLTTQMTLHYESVskelNPSCENFGL--LCAAKGKDGQWHRGFLQQLLPPSQ-VKVWFIDYGNS 91

                         90
                 ....*....|....*
gi 17136560 1397 EEIKRDDIKALDAKF 1411
Cdd:cd20437   92 EAVSSHSVLKLPPDF 106

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 51.35 E-value: 3.12e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1800 YISHVNGICDFFIQLERDSKALELIELYL-RKKDTLKPLE-GFEKGLIVAALFEDDElWYRAQLQKELPDSryEVLFIDY 1877
Cdd:cd20424   17 YITYVNDPWTFYCQLARNAGVLDQLASAIsRLSSEIRKLElSVNPGTLCLAKYSDQH-WYRGIIITNKNST--EVFFVDY 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17136560 1878 GNTSTTSKCLML-----SEEIASLPSLSKKCSL 1905
Cdd:cd20424   94 GNTEKVEKEDMLpipsdAYELLLLPMQAIKCSL 126

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 51.35 E-value: 3.15e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  595 NDDAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLILGAPCIVK-CDQEWYRAEILRVDDSVIVRHV 673
Cdd:cd20424   12 SEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLELSVNPGTLCLAKySDQHWYRGIIITNKNSTEVFFV 91

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 17136560  674 DFGYEQNV-KRHL--IGHIAEKHLEMPRQAIKCCL 705
Cdd:cd20424   92 DYGNTEKVeKEDMlpIPSDAYELLLLPMQAIKCSL 126

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 49.60 E-value: 3.53e-07

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 17136560 2401 AQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAVTQQ--FRQLPEELA 2447
Cdd:cd20430   27 GKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRssIVELPPDLQ 75

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 50.37 E-value: 3.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1337 TLLDNMYEHYKAK--GDSLKKFDVGQICA-VRSSDGNWYRARISG--KDSNAacfEVFYIDYGNTEEIKRDDIKALDAKF 1411
Cdd:cd20412    8 KLVQEMTQYYESEenRHTLLTVQVGDIVAaPFRHDGSWYRARVLGflENGNL---DLYFVDYGDSGYVPLEDLRALRSDF 84

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 51.27 E-value: 4.14e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  592 QLENDDAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQ---LILGAPCIVK-CDQEWYRA---EILRV 664
Cdd:cd20421    8 QVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYEtrpEKLGSPCAARgSDGRWYRAvlqQVFSA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 17136560  665 DDSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKG 707
Cdd:cd20421   88 NRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 50.08 E-value: 4.52e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1986 THVENTSRIYLQFSEKDSlMDIICE---KLNGSKLQPKTEKAAVDDMCVVQFADDLE--FYRSRILEVLEDDQyKVILID 2060
Cdd:cd20431    1 TEVVEVGHFWGYRIDENS-SEILQQltaEINQRQLVPLTTKPVPNLLCLAPFTDADMkkYYRAKILYVSGSSA-EVFFVD 78

                         90
                 ....*....|....*....
gi 17136560 2061 YGNTTVVDK--LYELPQEF 2077
Cdd:cd20431   79 YGNTSQVPSslLREIPETL 97

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 48.81 E-value: 4.74e-07

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560    1062 QLKVGSTVVVRQrKDNAILRATVTACNHMmRKYRVFCVDTGSLITVTSEDIWQLEQRF 1119
Cdd:smart00333    2 TFKVGDKVAARW-EDGEWYRARIVKVDGE-QLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 48.28 E-value: 5.86e-07

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 17136560 1669 CVSMYSVDKCWYRAKIID---AELMVLLFIDYGNTDCVSdATDIKE 1711
Cdd:cd20379    5 CAAKYEEDGKWYRARVLEvlsNDKVEVFFVDYGNTETVP-LSDLRP 49

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 49.69 E-value: 6.24e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  426 FWVH---LKSSdHDLSTMMGQIERTKLKALAQAPELGTACVARFSE--DGHLYRAMVCAVYAQRYRVVYVDYGNSELLSA 500
Cdd:cd20431    9 FWGYridENSS-EILQQLTAEINQRQLVPLTTKPVPNLLCLAPFTDadMKKYYRAKILYVSGSSAEVFFVDYGNTSQVPS 87

                         90
                 ....*....|...
gi 17136560  501 SDLFQIPPELLEI 513
Cdd:cd20431   88 SLLREIPETLLTL 100

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 48.83 E-value: 7.50e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17136560 1845 IVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKclmlsEEIASLP 1897
Cdd:cd20430   24 IYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSR-----SSIVELP 71

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 50.15 E-value: 8.34e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  599 VEIRFIDSPSNFYVQKVANIGKFEQLMD---EMFSYYNANQRVPDQLILgapCIVK--CDQEWYRAEILRVDDS--VIVR 671
Cdd:cd20440   14 VYITHVYSPAKFYCQLDRNTEILEALMEkiaEISKLFNSQILDNCKTRL---CLAKyfEDGQWYRALAHPVESSshLSVY 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 17136560  672 HVDFGYEQNVKRHLIGHIAEKHLEM---PRQAIKCCL 705
Cdd:cd20440   91 FVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 48.45 E-value: 1.05e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136560 1638 DQLSKL-NQLHENLQiVSPSLPQLMNVVNGADCVSMYSVDKCWYRAKII----DAELMVlLFIDYGNTDCVS 1704
Cdd:cd20433    3 PQLEKLmEKLRFEIA-SNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEkvegDKKVHV-LYIDYGNREVLP 72

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 47.72 E-value: 1.14e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17136560 1362 CAVRSSDGNWYRARIsgKDS-NAACFEVFYIDYGNTEEIKRDDIKALDAKF 1411
Cdd:cd20410   10 CAFFSGDGNWYRAMV--KEIlPGGAVKVHFVDYGNVEEVTLDKLRKITSTF 58

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 49.76 E-value: 1.30e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  408 VGLTYDVVISYVENgPYLFWVHLKSSDHDLSTMMGQIerTKLKALAQAPELGTA----CVARFSEDGHLYRAMVCAVYA- 482
Cdd:cd20440    8 VGSEEEVYITHVYS-PAKFYCQLDRNTEILEALMEKI--AEISKLFNSQILDNCktrlCLAKYFEDGQWYRALAHPVESs 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 17136560  483 QRYRVVYVDYGNSELLSASDLFQIP---PELLEIKPFAFRFAL 522
Cdd:cd20440   85 SHLSVYFVDYGNKQIVEKNEVLPIPdtaVDLLLTPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 48.58 E-value: 1.52e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1335 MQTLLDNMYEHYKAKGDSLKKF---DVGQICAVRSSDGNWYRARISGKDSNAAcFEVFYIDYGNTEEIKRDDIKALDAKF 1411
Cdd:cd20415    1 FLILTKKIQEFYKEGDDGGLEIlcpVQGQACVALFEDGAWYRARIIGLPGHRE-VEVKYVDFGNTATVTIKHVRKIKDDF 79

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 47.34 E-value: 1.66e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 2023 KAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVV--DKLYELPQEF 2077
Cdd:cd20410    2 KPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVtlDKLRKITSTF 58

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 49.38 E-value: 1.70e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2166 ECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPttNSNGVCYSQ--EDACYYRCSIKSVlDPSQGFEV 2243
Cdd:cd20440   13 EVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILDN--CKTRLCLAKyfEDGQWYRALAHPV-ESSSHLSV 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 17136560 2244 FLLDYGNTLVVPEvwqlpQEIEPIPSLALhcQLSKIPM 2281
Cdd:cd20440   90 YFVDYGNKQIVEK-----NEVLPIPDTAV--DLLLTPM 120

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 49.43 E-value: 1.85e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17136560 2218 CYSQEDACYYRCSIKSVLDpsQGFEVFLLDYGNTLVVP--EVWQLPQEIEPIPSLALHCQLSKI 2279
Cdd:cd20422   57 CAKWKEDRYYRAIVTAVKG--KMVEVFLVDRGNTEMVDwyDVKKLLPQFRELPALALKCCLADI 118

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 46.88 E-value: 1.98e-06

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560    1666 GADCVSMYSvDKCWYRAKII---DAELMVLLFIDYGNTDCVSdatdiKESMWSHIEPF 1720
Cdd:smart00333    6 GDKVAARWE-DGEWYRARIVkvdGEQLYEVFFIDYGNEEVVP-----PSDLRQLPEEL 57

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 47.81 E-value: 2.50e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17136560 1340 DNMYEHYK--AKGDSLKKFDVGQICAVRSSDGNWYRARISGKDSNAacFEVFYIDYGNTEEIKRDDIKALDAKFY 1412
Cdd:cd20427    5 DEMKEFYSksSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEEDK--VKVYYVDHGFSEVVERSKLFKLNKQFY 77

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 48.57 E-value: 2.61e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  606 SPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLI--LGAPCIVKC-DQEWYRAEILRV--DDSVIVRHVDFGYEQN 680
Cdd:cd20437   14 SPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELNPSCenFGLLCAAKGkDGQWHRGFLQQLlpPSQVKVWFIDYGNSEA 93

                         90       100
                 ....*....|....*....|....*.
gi 17136560  681 VKRHLIGHIAEKHLEMPRQAIKCCLK 706
Cdd:cd20437   94 VSSHSVLKLPPDFFSLPLMSFPCSLS 119

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 49.34 E-value: 2.63e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2025 AVDDMCVVQFADDLEFYRSRILEVlEDDQYKVILIDYGNTTVVDK--LYELPQEFTLIKPVAEIC---SMEPsaIFEKNK 2099
Cdd:cd20436   48 GVGEFCLVEDTTSGEWYRGRVLEK-IDEKYEVFLIDRGEVLNVHAtnMASASGELFQLPPKAVCGifaNILP--IGEKWS 124

                         90
                 ....*....|...
gi 17136560 2100 ALTLTTFDALLDS 2112
Cdd:cd20436  125 STAVNYFSSLIGS 137

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 46.35 E-value: 2.90e-06

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 17136560 2217 VCYSQEDACYYRCSIKSVLDPSQgFEVFLLDYGNTLVVP 2255
Cdd:cd20379    6 AAKYEEDGKWYRARVLEVLSNDK-VEVFFVDYGNTETVP 43

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 48.23 E-value: 3.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2361 SFYVQMESD--VPALEQMTDKLLDAEQDLPAFSDL-KEGALCVAQFPEDEVFYRAQIRKVLDDG------KCEVHFIDFG 2431
Cdd:cd20443    3 RFYVQVVSDqrLSSIQQQLEGLSLKDKANPPGGFNpKKGELVLAQFSADNSWNRAMVVNAPRQGtqspkdEYEVFYIDYG 82

                         90       100
                 ....*....|....*....|....*....
gi 17136560 2432 NNAVT--QQFRQLPEELAKPARYSRHCEL 2458
Cdd:cd20443   83 NQETVplSALRPLDPSVSSAPGLAQLCSL 111

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 48.27 E-value: 3.63e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 17136560 1359 GQICAVRSSDGNWYRARISGKDSNAacfEVFYIDYGNTEEIKRDDIKALDAKFYE 1413
Cdd:cd20424   62 GTLCLAKYSDQHWYRGIIITNKNST---EVFFVDYGNTEKVEKEDMLPIPSDAYE 113

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 45.97 E-value: 3.64e-06

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 17136560  644 LGAPCIVKC--DQEWYRAEILRV--DDSVIVRHVDFGYEQNVKRH 684
Cdd:cd20379    1 VGDLCAAKYeeDGKWYRARVLEVlsNDKVEVFFVDYGNTETVPLS 45

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 46.68 E-value: 4.34e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17136560 1334 SMQTLLDNMYEHYKAKG-DSLKKFDVGQICAVR-SSDGNWYRARISGKdSNAACFEVFYIDYGNTEEIK 1400
Cdd:cd20409    3 QLAELQESLSAYCKVAPaSSDFSPAVGEVCCAQfTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVA 70

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 45.80 E-value: 5.27e-06

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 17136560 2393 LKEGALCVAQFPEDEVFYRAQIRKVLDDGK-CEVHFIDFGN 2432
Cdd:cd20413    1 WKPGDECLAKYWEDNKFYRAEVTAVHPSGKtAVVKFMEYGN 41

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 47.04 E-value: 5.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  622 EQLMDEMFSYYNANqrvPDQLILGAPCI-----VKCDQE-WYRAEILRV-DDSVIVRHVDFGYEQNVKRHLIGHIAEKHL 694
Cdd:cd20427    1 EQMEDEMKEFYSKS---STAMCLRSPSVgqlvaVKAEEDaWLRAQVIEVeEDKVKVYYVDHGFSEVVERSKLFKLNKQFY 77

                         90
                 ....*....|....*
gi 17136560  695 EMPRQAIKCCLKGFE 709
Cdd:cd20427   78 SLPFQATKCKLAGLE 92

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 46.13 E-value: 5.81e-06

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 17136560  464 ARFSEDGHLYRAMVCAVYAQ-RYRVVYVDYGNSELLSASDLFQIPPEL 510
Cdd:cd20430   27 GKFSEDNCWYRCKVKSILSDeKCTVQYIDYGNTETVSRSSIVELPPDL 74

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 46.61 E-value: 7.19e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17136560 2398 LCVAQFPE--DEVFYRAQIRKVLDDgKCEVHFIDFGNNAVTQ--QFRQLPEEL 2446
Cdd:cd20431   46 LCLAPFTDadMKKYYRAKILYVSGS-SAEVFFVDYGNTSQVPssLLREIPETL 97

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 44.93 E-value: 7.62e-06

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 17136560  459 GTACVARFSEDGHLYRAMVCAVYAQ--RYRVVYVDYGNSELLSASDL 503
Cdd:cd21182    1 GDKCLAPYSDDGKYYEATIEEITEEsdTATVVFDGYGNSEEVPLSDL 47

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 47.36 E-value: 9.42e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2173 NSPKSFYVQMkHNSADLDLIVK-TLQSLKKEKLKKLIDPTTNSNG-VC---YSQeDACYYRCSIKSVlDPSQGF-EVFLL 2246
Cdd:cd20408    7 KNPGEFYIQI-YTLEVLESLVKlTSQLKKTYASVNNHKEYIPEVGeVCvakYSE-DQNWYRALVQTV-DVQQKKaGVFYI 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 17136560 2247 DYGNTLVVPEVW--QLPQEIEPIPSLALHCQLSKIP 2280
Cdd:cd20408   84 DYGNEETVPLNRiqPLKKDIELFPPCAIKCCLANVK 119

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 44.95 E-value: 1.05e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 17136560 1358 VGQIC-AVRSSDGNWYRARI-SGKDSNAACFeVFYIDYGNTEEIKRDDIK 1405
Cdd:cd20398    3 VGDKCrAVYSEDGIIYEATIvSIDAERGTCV-VRYTGYGNEEEQNLSDLL 51

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 47.25 E-value: 1.09e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 1342 MYEHYKAKGD--SLKKFDVGQICAVRSSDGNWYRARI-----SGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKF 1411
Cdd:cd20435   34 LNMYYSDPSNriLHGKVKVGDLCAVEDENNLYHRVKVleiteKDDKTKPREVLVKFIDEGRVETVVVSQLLELPEEL 110

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 46.64 E-value: 1.33e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2358 GPMSFYVQMESDVPALEQMTDKL---LDAEQDLPAFSDLKEGALCVAQfPEDEVFYRAQIRKVLDDGKCEVHFIDFGN-N 2433
Cdd:cd20437   14 SPSKFYCQLLSWEPELSKLTTQMtlhYESVSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWFIDYGNsE 92

                         90
                 ....*....|...
gi 17136560 2434 AVTQQF-RQLPEE 2445
Cdd:cd20437   93 AVSSHSvLKLPPD 105

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 46.64 E-value: 1.38e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 1831 KDTLKPLEGFekGLIVAALfEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSK--CLMLSEEIASLPSLSKKCSL 1905
Cdd:cd20437   45 KELNPSCENF--GLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWFIDYGNSEAVSShsVLKLPPDFFSLPLMSFPCSL 118

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 47.11 E-value: 1.42e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 1344 EHYKAKGDSLKKFDVGQICAVR-SSDGNWYRARISGKDSNAacFEVFYIDYGNTEEIKRDDIKALDA 1409
Cdd:cd20426   35 EQVADRGNFIPSIYVGDPCIVKySEDNHWYRALVTKINDNL--VSVRFVDYGNEEDVVREQVRALPS 99

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 45.16 E-value: 1.47e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17136560  647 PCIVKC--DQEWYRAEILRVD---DSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCL 705
Cdd:cd20423    8 VCLAKYseDGKWCRALIDNVYepvEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 46.26 E-value: 1.63e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2169 ISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYS-QEDACYYRCSIKSVLDPSQgFEVFLLD 2247
Cdd:cd20437    9 ITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELNPSCENFGLLCAAkGKDGQWHRGFLQQLLPPSQ-VKVWFID 87

                         90       100       110
                 ....*....|....*....|....*....|..
gi 17136560 2248 YGNTLVVPE--VWQLPQEIEPIPSLALHCQLS 2277
Cdd:cd20437   88 YGNSEAVSShsVLKLPPDFFSLPLMSFPCSLS 119

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 46.72 E-value: 1.65e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1797 CSCYISHVNGICDFFIQL---ERDSKALELIELYLRKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQKeLPDSRYEVL 1873
Cdd:cd20426    1 IEAYATAVDSPEYFWCQFateKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTK-INDNLVSVR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136560 1874 FIDYGNTSTTSKCLM--LSEEIASLPSLSKKCSL---QLPDAyiSWSPEAEAKFAELTGEGEL 1931
Cdd:cd20426   80 FVDYGNEEDVVREQVraLPSELLKIPVQAFPCCLsgfNLSEG--LWSDEANDYFYEIVTEDLL 140

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 46.33 E-value: 1.76e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1317 YTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKkfdVGQI-CAVR-SSDGNWYRARISGKDSnAACFEVFYIDYG 1394
Cdd:cd20439   18 YVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHNDPYK---HGQIaCVAKySKDGKWYRAAVLKQVS-AKEVDVIFVDYG 93

                         90
                 ....*....|....*..
gi 17136560 1395 NTEEIKRDDIKALDAKF 1411
Cdd:cd20439   94 NQERVLISDLRAIKPQF 110

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 46.96 E-value: 2.15e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2361 SFYVQMESDVP---ALEQMTDKLLDaEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVL-DDGKCEVHFIDFGNNAVT 2436
Cdd:cd20442   16 TFYVRLLRNSEqltDLESLIAKEAK-KCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYpETEKMLVFFVDHGITEVV 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17136560 2437 --QQFRQLPEELAKPARYSRHCELDA--STISKCDAALLQSFIDT-------RFSETFQ---VEIL 2488
Cdd:cd20442   95 smGNIKQLSNDLLQIPRQAVLCRWNWpeSSKELSFEILWKSLAGKevkllflSYSEADQlweVEIL 160

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 45.12 E-value: 2.29e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136560  456 PELGTACVARFsEDGHLYRAMVCAVY-AQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGTK 526
Cdd:cd20415   25 PVQGQACVALF-EDGAWYRARIIGLPgHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIE 95

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 43.75 E-value: 2.38e-05

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 17136560 2390 FSDLKEGALCVAQFpEDEVFYRAQIRKVLDDGKCEVHF 2427
Cdd:cd20384    2 FSSLKEGSRCLAKY-DDGLWYPATVTDIDEDGKYTVKF 38

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 44.78 E-value: 2.43e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 17136560 1361 IC-AVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYE 1413
Cdd:cd20423    8 VClAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLK 61

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 45.57 E-value: 3.06e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2169 ISYGNSPKSFYVQMKHNSADLDLIvkTLQSLKKEKLKKLIDPTTNSNGVCYSQ-EDACYYRCSIKSVLDPSqgfEVFLLD 2247
Cdd:cd20424   18 ITYVNDPWTFYCQLARNAGVLDQL--ASAISRLSSEIRKLELSVNPGTLCLAKySDQHWYRGIIITNKNST---EVFFVD 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17136560 2248 YGNTLVVPEvwqlpQEIEPIPSLAlhCQLSKIPM 2281
Cdd:cd20424   93 YGNTEKVEK-----EDMLPIPSDA--YELLLLPM 119

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 46.57 E-value: 3.09e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1808 CDFFIQLERDSKALELIELYL---RKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQKELPDS-RYEVLFIDYGNTSTT 1883
Cdd:cd20442   15 GTFYVRLLRNSEQLTDLESLIakeAKKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETeKMLVFFVDHGITEVV 94

                         90       100
                 ....*....|....*....|..
gi 17136560 1884 SKCLM--LSEEIASLPSLSKKC 1903
Cdd:cd20442   95 SMGNIkqLSNDLLQIPRQAVLC 116

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 44.20 E-value: 3.26e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 17136560 2034 FADDLEFYRSRILEVLEDDQYKVILIDYGNTTVVDKLY--ELPQEFT 2078
Cdd:cd20430   29 FSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSivELPPDLQ 75

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 45.57 E-value: 3.61e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1621 VVLSHCDNPAQFYVhpidQLSK----LNQLHENLQIVSPSLPQLMNVVN-GADCVSMYSvDKCWYRAKIID-AELMVLLF 1694
Cdd:cd20424   16 VYITYVNDPWTFYC----QLARnagvLDQLASAISRLSSEIRKLELSVNpGTLCLAKYS-DQHWYRGIIITnKNSTEVFF 90

                         90       100
                 ....*....|....*....|....
gi 17136560 1695 IDYGNTDCV---------SDATDI 1709
Cdd:cd20424   91 VDYGNTEKVekedmlpipSDAYEL 114

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 44.59 E-value: 3.64e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 1818 SKALELIEL------YLRKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYG 1878
Cdd:cd20412    1 SRSLQLDKLvqemtqYYESEENRHTLLTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYG 67

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 43.45 E-value: 3.72e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560  456 PELGTACVARFseDGHLYRAMV--CAVYAQRYRVVYVDYGNSELLSASDLFQIPPEL 510
Cdd:cd20444    1 PTPGQMVIAKF--DGNHYRAIVlrVLNPDLKILVRFVDFGNVEVMKLENLYECPEYL 55

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 44.73 E-value: 4.11e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  606 SPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLILGAPCIV---KCDQEWYRAEILRV--DDSVIVRHVDFGYEQN 680
Cdd:cd20441    1 SPSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAaeyDEDLALYRAVITAVlpGKSFKVEFIDYGNTAV 80

                         90       100
                 ....*....|....*....|....*..
gi 17136560  681 VKRHLIGHIAEKHLEMPRQAIKCCLKG 707
Cdd:cd20441   81 VDKSNIYTLQEKFLSLPRLSIPCSLSG 107

Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.

Pssm-ID: 428716 [Multi-domain] Cd Length: 264 Bit Score: 47.30 E-value: 5.25e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560    457 ELGTACVARFSEDGHLYRAMVCAVYAQRYR--VVYVDYGNSELLSASDLFQIPPELLE 512
Cdd:pfam06003   70 KVGDSCNAFWSEDGNLYPATITSIDQKKGTcvVFYTGYGNEEEQNLADLLTPPPDMDE 127

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 45.05 E-value: 6.05e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1985 ITHVENTSRIYLQ---------FSEKDSLMDIICEKLNGSKLQpkteKAAVDDMCVVQFADDLEFYRSRILEVLEDDQY- 2054
Cdd:cd20408    3 VTEFKNPGEFYIQiytlevlesLVKLTSQLKKTYASVNNHKEY----IPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKa 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 17136560 2055 KVILIDYGNTTVV--DKLYELPQEFTLIKPVAEICS 2088
Cdd:cd20408   79 GVFYIDYGNEETVplNRIQPLKKDIELFPPCAIKCC 114

Survival motor neuron protein (SMN); This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.

Pssm-ID: 428716 [Multi-domain] Cd Length: 264 Bit Score: 47.30 E-value: 6.34e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 17136560   1353 LKKFDVGQIC-AVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEE 1398
Cdd:pfam06003   66 LKEWKVGDSCnAFWSEDGNLYPATITSIDQKKGTCVVFYTGYGNEEE 112

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 44.37 E-value: 6.41e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17136560 1361 ICAVRSSDGNWYRARISGKDSNAAcFEVFYIDYGNTEEIKRDDIKALDAKFYE 1413
Cdd:cd20425   54 ICAEYPEDGLWYRAVVKEKIPNNL-VSVQFIDYGNTSVVQPSKIHRLPKELLS 105

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 45.42 E-value: 6.42e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  592 QLENddaVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLIL-GAPCIVKC--DQEWYRAEILRV---D 665
Cdd:cd20442    2 QIEK---GTLLSVSKNGTFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDIKeGLECLAKSkkNLKWYRAVVEHLypeT 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17136560  666 DSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSELSEDKI 718
Cdd:cd20442   79 EKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRWNWPESSKELSFEI 131

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 44.36 E-value: 7.21e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560 1358 VGQICAVR-SSDGNWYRARISGKDSNAAcfEVFYIDYGNTEEIKRDDIKALDAKFYEH 1414
Cdd:cd20411   50 IGDACCARfTGDKNWYRAVVLETSDSEV--KVLYADYGNTETLPLSRILPITKSHLEL 105

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 43.96 E-value: 7.35e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136560  463 VARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDLFQIPPELLEIkPF-AFRFALAGtkeIEPIDD 533
Cdd:cd20427   29 VAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSL-PFqATKCKLAG---LEPFSD 96

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 44.36 E-value: 7.67e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1314 LVVYTAKPYRVYVQP--QAIVPSMQTLLDNMYEHYKAKGDSLK------KFDVGQICAVR-SSDGNWYRARISgKDSNAA 1384
Cdd:cd20419    1 FVEYIESPSQFYVRFysKDTSEMLEDMMIEMRRCYSNEHVSERyvmpeaFIQPGQVCCVRiPEDVWWYRVIIH-QVLNKQ 79

                         90       100
                 ....*....|....*....|....*..
gi 17136560 1385 CFEVFYIDYGNTEEIKRDDIKALDAKF 1411
Cdd:cd20419   80 EVEVFYPDFGDIGTVQKSRLRFLKCCY 106

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 44.81 E-value: 7.95e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1982 KAIITHVENTSRIYLQFSEKDS----LMDIICE------KLNGSKLQPKTekaavDDMCVVQFADDlEFYRSRILEVLeD 2051
Cdd:cd20422    3 DAQVEFVKDPSEFWIRLGEHAVpfskLMRSMTAfysqasKLDGVVLKPQP-----GQLCCAKWKED-RYYRAIVTAVK-G 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 17136560 2052 DQYKVILIDYGNTTVVD--KLYELPQEFTLIKPVAEICSM 2089
Cdd:cd20422   76 KMVEVFLVDRGNTEMVDwyDVKKLLPQFRELPALALKCCL 115

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 43.24 E-value: 8.76e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136560 2030 CVVQFADDLEFYRSRILEVLED-DQYKVILIDYGNTTVVD--KLYELPQEFTLIKPVAEICSM 2089
Cdd:cd20423    9 CLAKYSEDGKWCRALIDNVYEPvEMVEVTYVDYGNKELVSlkNLRSISEEFLKLKAQAFRCSL 71

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 42.26 E-value: 9.64e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 17136560  459 GTACVARFSEDGHLYRAMVCAVYAQRYR--VVYVDYGNSELLSASDLfqIPP 508
Cdd:cd20398    4 GDKCRAVYSEDGIIYEATIVSIDAERGTcvVRYTGYGNEEEQNLSDL--LPP 53

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 43.98 E-value: 1.13e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1800 YISHVNGICDFFIQLERDSKALELIELYLRKKDTLKP---LEGFEKGLIVAALFEDDeLWYRAQLQKELPDSRYEVLFID 1876
Cdd:cd20440   15 YITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNsqiLDNCKTRLCLAKYFEDG-QWYRALAHPVESSSHLSVYFVD 93

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17136560 1877 YGNTSTTSKCLML-----SEEIASLPSLSKKCSL 1905
Cdd:cd20440   94 YGNKQIVEKNEVLpipdtAVDLLLTPMQAIKCCL 127

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 42.67 E-value: 1.22e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136560  620 KFEQLMDEMFSYYNANQRVPD--QLILGAPCIVK--CDQEWYRAEILRV--DDSVIVRHVDFG 676
Cdd:cd20433    4 QLEKLMEKLRFEIASNPPLPGsyTPRKGDLCAAKfvEDGEWYRAKVEKVegDKKVHVLYIDYG 66

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 44.16 E-value: 1.23e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1034 VPKSVSAKYDNIMRDMREFYRQKQHQPL--QLKVGSTVVVrQRKDNAILRATV---TACNHMM--RKYRVFCVDTGSLIT 1106
Cdd:cd20435   19 VTKSMSSTYLKLSMKLNMYYSDPSNRILhgKVKVGDLCAV-EDENNLYHRVKVleiTEKDDKTkpREVLVKFIDEGRVET 97

                         90       100
                 ....*....|....*....|
gi 17136560 1107 VTSEDIWQLEQRFADPPCMA 1126
Cdd:cd20435   98 VVVSQLLELPEELKSLPPQA 117

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 44.00 E-value: 1.45e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2359 PMSFYVQMESDVPALEQMTDKLLD----AEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDgKCEVHFIDFGNNA 2434
Cdd:cd20438   17 PSNFWIRTDEYNNEFQALMKNIADiynlCGNDEELLKKPEPGLLCCARYSKDRHYYRAVITEVLDL-KVSVYFLDFGNTD 95

                         90       100
                 ....*....|....*....|....*..
gi 17136560 2435 VTQQFR---QLPEELAKPArYSRHCEL 2458
Cdd:cd20438   96 TVPFYDvktLLPEFSELPA-LAMCCSL 121

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 42.44 E-value: 1.53e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 17136560 2388 PAFSDlKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGN 2432
Cdd:cd20409   22 SDFSP-AVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGN 65

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 41.56 E-value: 1.72e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 17136560 1841 EKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNT 1880
Cdd:cd20410    4 IVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNV 43

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 43.18 E-value: 1.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1979 VTTKAIITHVENTSRIYLQF--SEKD-----SLMDIICEKLNGsKLQPKTEKaaVDDMCVVQFADDLeFYRSRILEVLED 2051
Cdd:cd20437    3 TTEKVKITAAVSPSKFYCQLlsWEPElskltTQMTLHYESVSK-ELNPSCEN--FGLLCAAKGKDGQ-WHRGFLQQLLPP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 17136560 2052 DQYKVILIDYGNTTVV--DKLYELPQEFTLIKPVAEICSM 2089
Cdd:cd20437   79 SQVKVWFIDYGNSEAVssHSVLKLPPDFFSLPLMSFPCSL 118

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 44.00 E-value: 1.85e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 2219 YSQeDACYYRCSIKSVLDPSqgFEVFLLDYGNTLVVP--EVWQLPQEIEPIPSLALHCQLSKI-PMD 2282
Cdd:cd20438   65 YSK-DRHYYRAVITEVLDLK--VSVYFLDFGNTDTVPfyDVKTLLPEFSELPALAMCCSLAHVfPVE 128

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 43.20 E-value: 2.03e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17136560 1843 GLIVAALFEDDELWYRAqLQKELPDSRYEVLFIDYGNTSTT--SKCLMLSEEIASLPSLSKKCSL 1905
Cdd:cd20411   51 GDACCARFTGDKNWYRA-VVLETSDSEVKVLYADYGNTETLplSRILPITKSHLELPFQIIRCSL 114

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 40.65 E-value: 2.19e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 17136560 1359 GQICAVRSS-DGNWYRARISGKDSNAAcFEVFYiDYGNTEEIKRDDIK 1405
Cdd:cd04508    1 GDRVEAKWSdDGQWYPATVVAVNDDGK-YTVLF-DDGNEEEVSEDDIR 46

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 42.82 E-value: 2.52e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2353 VVQFDGPMSFYVQM--ESDVPALEQMTDKL-------LDAEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKC 2423
Cdd:cd20419    2 VEYIESPSQFYVRFysKDTSEMLEDMMIEMrrcysneHVSERYVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQEV 81

                         90
                 ....*....|....*..
gi 17136560 2424 EVHFIDFGNNAVTQQFR 2440
Cdd:cd20419   82 EVFYPDFGDIGTVQKSR 98

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 42.88 E-value: 2.79e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2353 VVQFDGPMSFYVQMESDVPALEQMTDKLLDAEQDLPAF-SDLKEGALCVAQFpEDEVFYRAQIRKVLDdgKCEVHFIDFG 2431
Cdd:cd20424   18 ITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLeLSVNPGTLCLAKY-SDQHWYRGIIITNKN--STEVFFVDYG 94

                         90
                 ....*....|..
gi 17136560 2432 NNAVTQQFRQLP 2443
Cdd:cd20424   95 NTEKVEKEDMLP 106

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 40.75 E-value: 3.10e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17136560 2394 KEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAVTQ 2437
Cdd:cd20399    2 KVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTP 45

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 41.12 E-value: 3.39e-04

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 17136560 2216 GVCYSqEDACYYRCSIKSVLDPSQgFEVFLLDYGNTLVV 2254
Cdd:cd20430   26 GGKFS-EDNCWYRCKVKSILSDEK-CTVQYIDYGNTETV 62

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 40.31 E-value: 3.55e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 17136560 1359 GQIC-AVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKAL 1407
Cdd:cd21182    1 GDKClAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 41.29 E-value: 4.41e-04

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 17136560 1843 GLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGN 1879
Cdd:cd20409   29 GEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGN 65

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 41.65 E-value: 4.58e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  621 FEQLMDEMFSYYNANQRVPDQL---ILGAPCIVKC-DQEWYRAEILRVDDS--VIVRHVDFGYEQNVKRHLIGHIAEKHL 694
Cdd:cd20415    1 FLILTKKIQEFYKEGDDGGLEIlcpVQGQACVALFeDGAWYRARIIGLPGHreVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                         90
                 ....*....|.
gi 17136560  695 EMPRQAIKCCL 705
Cdd:cd20415   81 SLPEKARECRL 91

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 40.02 E-value: 4.84e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17136560 1356 FDVGQIC-AVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKAL 1407
Cdd:cd20413    1 WKPGDEClAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 42.50 E-value: 5.02e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1834 LKPlegfEKGLIVAALFEDDElWYRAQLQKeLPDSRYEVLFIDYGNTSTTS--KCLMLSEEIASLPSLSKKCSLQlpDAY 1911
Cdd:cd20422   48 LKP----QPGQLCCAKWKEDR-YYRAIVTA-VKGKMVEVFLVDRGNTEMVDwyDVKKLLPQFRELPALALKCCLA--DIC 119

                         90
                 ....*....|....
gi 17136560 1912 ---ISWSPEAEAKF 1922
Cdd:cd20422  120 plgERWSPEAISAF 133

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 42.09 E-value: 5.21e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1802 SHVNGICDFFIQLERDSKALELI-----ELYLRKKDTLKPLEgfekgLIVAALFEDDELWYRAQLQKELPDSRYEVLFID 1876
Cdd:cd20439   17 SYVNSPGDFWCQLQTKSSELKSLmkqiqSYYLIHNDPYKHGQ-----IACVAKYSKDGKWYRAAVLKQVSAKEVDVIFVD 91


                 ....
gi 17136560 1877 YGNT 1880
Cdd:cd20439   92 YGNQ 95

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 41.60 E-value: 5.22e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  606 SPSNFYVQKVA--NIGKFEQLMDE--MFSYYNANQR-VPDQLILgAPCIVKCDQEWYRAEILRV-DDSVIVRHVDFGYEQ 679
Cdd:cd20431    5 EVGHFWGYRIDenSSEILQQLTAEinQRQLVPLTTKpVPNLLCL-APFTDADMKKYYRAKILYVsGSSAEVFFVDYGNTS 83

                         90
                 ....*....|....*...
gi 17136560  680 NVKRHLIGHIAEKHLEMP 697
Cdd:cd20431   84 QVPSSLLREIPETLLTLP 101

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 42.46 E-value: 5.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  597 DAVEIRFID---SPSNFYVQKVANIGKFEQLMDEMFSYYnaNQRVPDQLILGAP-----CIVKC--DQEWYRAEILRV-D 665
Cdd:cd20438    4 DAAYVAFVEyvlNPSNFWIRTDEYNNEFQALMKNIADIY--NLCGNDEELLKKPepgllCCARYskDRHYYRAVITEVlD 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 17136560  666 DSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCL 705
Cdd:cd20438   82 LKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 42.06 E-value: 5.61e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17136560 2359 PMSFYVQMESDVPALEQMTDKLLDaEQDLPAFS--DLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGN 2432
Cdd:cd20440   22 PAKFYCQLDRNTEILEALMEKIAE-ISKLFNSQilDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDYGN 96

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 39.49 E-value: 6.80e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 17136560  459 GTACVARFSEDGHLYRAMVCAVY-AQRYRVVYvDYGNSELLSASDL 503
Cdd:cd04508    1 GDRVEAKWSDDGQWYPATVVAVNdDGKYTVLF-DDGNEEEVSEDDI 45

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 42.08 E-value: 6.97e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17136560 1841 EKGLIVAALFEDDELWYRAQLqKELPDSRYEVLFIDYGNTSTTS----KCLMlsEEIASLPSLSKKCSL 1905
Cdd:cd20438   56 EPGLLCCARYSKDRHYYRAVI-TEVLDLKVSVYFLDFGNTDTVPfydvKTLL--PEFSELPALAMCCSL 121

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 42.05 E-value: 7.99e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  620 KFEQLMDEMFSYYNANQRVPDQLI----LGAPCIVKCDQEWYRAEILRVDDS--VIVRHVDFGYEQNVKRHLIGHIAEKH 693
Cdd:cd20428   26 KLNEILDKIEYYFHSRQMTSEYFVslpfCGKICLARYKGKWARVEITNVHSSraLDVHFLDTGTVASVKVSELREIPPPF 105

                         90
                 ....*....|....*.
gi 17136560  694 LE----MPRQAIKCCL 705
Cdd:cd20428  106 LRelisIPPQALKCCL 121

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 40.52 E-value: 8.09e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17136560 2024 AAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVV 2067
Cdd:cd20409   26 PAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEV 69

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 41.30 E-value: 8.90e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1992 SRIYLQfSEKDSLMDIICEKLNGSKLQPKTEKAAV-----DDMCVVQFADDLEFYRSRILEV------LEDDQYKVILID 2060
Cdd:cd20443    2 GRFYVQ-VVSDQRLSSIQQQLEGLSLKDKANPPGGfnpkkGELVLAQFSADNSWNRAMVVNAprqgtqSPKDEYEVFYID 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 17136560 2061 YGN--TTVVDKLYELPQEFTLIKPVAEICSM 2089
Cdd:cd20443   81 YGNqeTVPLSALRPLDPSVSSAPGLAQLCSL 111

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 40.36 E-value: 9.55e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  620 KFEQLMDEMFSYYN--ANQRVPDQLILG----APciVKCDQEWYRAEILRV--DDSVIVRHVDFGYEQNVKRHLIGHIAE 691
Cdd:cd20412    5 QLDKLVQEMTQYYEseENRHTLLTVQVGdivaAP--FRHDGSWYRARVLGFleNGNLDLYFVDYGDSGYVPLEDLRALRS 82

                         90
                 ....*....|..
gi 17136560  692 KHLEMPRQAIKC 703
Cdd:cd20412   83 DFLSLPFQAIEC 94

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 41.72 E-value: 1.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1666 GADCVSMYSVDKCWYRAKI--IDAELMVLLFIDYGNTDCVSdatdiKESMWS------HIEPFCLPCALPIRPKGTADWV 1737
Cdd:cd20426   50 GDPCIVKYSEDNHWYRALVtkINDNLVSVRFVDYGNEEDVV-----REQVRAlpsellKIPVQAFPCCLSGFNLSEGLWS 124


                 ....*....
gi 17136560 1738 DAANGIFNE 1746
Cdd:cd20426  125 DEANDYFYE 133

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 39.75 E-value: 1.16e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 17136560 1666 GADCVSMYSVDKCWYRAKIID---AELMVLLFIDYGNTDCVS 1704
Cdd:cd20409   29 GEVCCAQFTEDNQWYRASVLAyssEDSVLVGYIDFGNSEEVA 70

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 41.29 E-value: 1.18e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 17136560 1368 DGNWYRARISGKDSNAAcFEVFYIDYGNTEEIKRDDIKALDAKFYE 1413
Cdd:cd20440   70 DGQWYRALAHPVESSSH-LSVYFVDYGNKQIVEKNEVLPIPDTAVD 114

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 40.95 E-value: 1.19e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1985 ITHVENTSRIYLQFSEKDSLMDIICEKLN--GSKLQPKTEKAAVDDMCVVQFADDlEFYRSRILEVLEDDqyKVILIDYG 2062
Cdd:cd20424   18 ITYVNDPWTFYCQLARNAGVLDQLASAISrlSSEIRKLELSVNPGTLCLAKYSDQ-HWYRGIIITNKNST--EVFFVDYG 94

                         90
                 ....*....|..
gi 17136560 2063 NTTVVDKLYELP 2074
Cdd:cd20424   95 NTEKVEKEDMLP 106

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 41.20 E-value: 1.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1026 LSPFQFYI---VPKSVSAKYdNIMRDMREFYRQ-KQHQPLQLKVGSTVVVRQRKDNAILRATVTACNHMMRKYRVFCVDT 1101
Cdd:cd20408    7 KNPGEFYIqiyTLEVLESLV-KLTSQLKKTYASvNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGVFYIDY 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17136560 1102 GSLITVTSEDIWQLEQRFADPPCMAHRCSFHSVV 1135
Cdd:cd20408   86 GNEETVPLNRIQPLKKDIELFPPCAIKCCLANVK 119

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 40.11 E-value: 1.31e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136560 1847 AALFEDDElWYRAQLQKELPDSRYEVLFIDYGNTS--TTSKCLMLSEEIASLPSLSKKCSLQL 1907
Cdd:cd20415   32 VALFEDGA-WYRARIIGLPGHREVEVKYVDFGNTAtvTIKHVRKIKDDFLSLPEKARECRLAF 93

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 38.72 E-value: 1.33e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 17136560 1843 GLIVAALFEDDELWYRAQLQKELPDSRYEVLFiDYGNTSTTSK 1885
Cdd:cd04508    1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSE 42

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 41.34 E-value: 1.33e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 2396 GALCVAQFPEDEvFYRAQIRKVLDDGkCEVHFIDFGNNAVTQ---------QFRQLP 2443
Cdd:cd20422   53 GQLCCAKWKEDR-YYRAIVTAVKGKM-VEVFLVDRGNTEMVDwydvkkllpQFRELP 107

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 41.31 E-value: 1.33e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 2027 DDMCVVQFADDLEFYRSRILEVLeDDQYKVILIDYGNTTVVDkLYE----LPqEFTLIKPVAEICSM 2089
Cdd:cd20438   58 GLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVP-FYDvktlLP-EFSELPALAMCCSL 121

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 40.10 E-value: 1.66e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1046 MRD-MREFYRQKQH-QPLQ-LKVGSTVVVRQRKDnAILRATVtaCNHMMRKYRVFCVDTGSLITVTSEDIWQLEQRFADP 1122
Cdd:cd20427    3 MEDeMKEFYSKSSTaMCLRsPSVGQLVAVKAEED-AWLRAQV--IEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSL 79


                 ....*..
gi 17136560 1123 PCMAHRC 1129
Cdd:cd20427   80 PFQATKC 86

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 40.95 E-value: 1.73e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2173 NSPKSFYVQMKHNSAD-LDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYSQEDACYYRCSIKSVLDpsQGFEVFLLDYGN- 2250
Cdd:cd20426    9 DSPEYFWCQFATEKIQcLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIND--NLVSVRFVDYGNe 86

                         90       100
                 ....*....|....*....|....*...
gi 17136560 2251 -TLVVPEVWQLPQEIEPIPSLALHCQLS 2277
Cdd:cd20426   87 eDVVREQVRALPSELLKIPVQAFPCCLS 114

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 39.11 E-value: 1.84e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560  452 LAQAPELGTACVARFseDGHLYRAMVCAVYAQRYRVV--YVDYGNSELLSASDLFQIPPELLEIkPF 516
Cdd:cd20407    1 LPEPIEVGVICAAPV--MNAWYRAQVVGVFEETDEVEikYLDYGGYERVPVDDLRQIRSDFMTL-PF 64

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 40.48 E-value: 1.93e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 1853 DELWYRAQLQKELPDSR-YEVLFIDYGNTSTTSKCLM--LSEEIASLPSLSKKCSLQ 1906
Cdd:cd20421   73 DGRWYRAVLQQVFSANRvVEVLHVDYGRKEVVSVSNLryLAPEYFRMPVVTYPCALF 129

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 39.73 E-value: 1.96e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136560 2395 EGALCVAQFpEDEVFYRAQIRKVLDDGKCEVHFIDFGNNA-VT-QQFRQLPEE-LAKPARySRHCEL 2458
Cdd:cd20415   27 QGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTAtVTiKHVRKIKDDfLSLPEK-ARECRL 91

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 40.57 E-value: 2.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1311 FQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYK--AKGDS-LKKFDVGQICAVRSSDGNWYRARISGKDSNAAcfE 1387
Cdd:cd20422    2 YDAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSqaSKLDGvVLKPQPGQLCCAKWKEDRYYRAIVTAVKGKMV--E 79

                         90       100
                 ....*....|....*....|....*.
gi 17136560 1388 VFYIDYGNTEEIKRDDIKALDAKFYE 1413
Cdd:cd20422   80 VFLVDRGNTEMVDWYDVKKLLPQFRE 105

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 38.05 E-value: 2.50e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 17136560 2396 GALCVAQFpeDEVFYRAQIRKVLD-DGKCEVHFIDFGNNAVTQ--QFRQLPEEL 2446
Cdd:cd20444    4 GQMVIAKF--DGNHYRAIVLRVLNpDLKILVRFVDFGNVEVMKleNLYECPEYL 55

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 37.88 E-value: 2.58e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17136560 1065 VGSTVVVRQRKDNAILRATVTACNHMmRKYRVFCVDTGSLITVTSEDIWQL 1115
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSN-DKVEVFFVDYGNTETVPLSDLRPL 50

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 40.31 E-value: 2.71e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  456 PELGTACVARfsEDGHLY-RAMVCAVY-------AQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGtke 527
Cdd:cd20435   50 VKVGDLCAVE--DENNLYhRVKVLEITekddktkPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCN--- 124


                 ....*.
gi 17136560  528 IEPIDD 533
Cdd:cd20435  125 VKPVDN 130

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 40.48 E-value: 3.02e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560  426 FWVHLKS-SDHDLSTMMGQI-ERTKLKALAQAPELgtaCVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDL 503
Cdd:cd20436   18 FQGQYNSiCELDYHILQNEIqNATKSKSSWGVGEF---CLVEDTTSGEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNM 94

                         90       100
                 ....*....|....*....|....*...
gi 17136560  504 FQIPPELLEIKPFAFRFALAGtkeIEPI 531
Cdd:cd20436   95 ASASGELFQLPPKAVCGIFAN---ILPI 119

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 40.19 E-value: 3.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1028 PFQFYIVPKSVSAKYDNIMRDMREFYRQKQHQP---LQLKVGSTVVVRQrKDNAILRATVTACNHMMrkYRVFCVDTGSL 1104
Cdd:cd20422   12 PSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDgvvLKPQPGQLCCAKW-KEDRYYRAIVTAVKGKM--VEVFLVDRGNT 88

                         90       100
                 ....*....|....*....|....*.
gi 17136560 1105 ITVTSEDIWQLEQRFADPPCMAHRCS 1130
Cdd:cd20422   89 EMVDWYDVKKLLPQFRELPALALKCC 114

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410491 Cd Length: 132 Bit Score: 40.10 E-value: 3.07e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17136560 2014 GSKLQPKTEKAAVDDMCVVQFadDLEFYRSRILEVlEDDQYKVILIDYGNTTVVDKLY--ELPQEFTLIKPVAEIC 2087
Cdd:cd20420   53 GCGAGDGGAEPSVGDLCLVEV--GGLWHRCRVVSR-QGDDYRVFLLDEGRTVVARAKSlaRGRKDFFSLPPEVLGC 125

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 37.71 E-value: 3.83e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 17136560  459 GTACVARFSEDGHLYRAMVCAVYAQRYR--VVYVDYGNSELLSASDLFQI 506
Cdd:cd20413    4 GDECLAKYWEDNKFYRAEVTAVHPSGKTavVKFMEYGNYEEVLLSDIKPI 53

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 39.76 E-value: 4.31e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1628 NPAQFYVHPIDQLSKLNQLHENL-QIVSPSLPQLMNVVN---GADCVSMYSVDKCWYRA---KIIDAELMVLlFIDYGNT 1700
Cdd:cd20438   16 NPSNFWIRTDEYNNEFQALMKNIaDIYNLCGNDEELLKKpepGLLCCARYSKDRHYYRAvitEVLDLKVSVY-FLDFGNT 94

                         90
                 ....*....|
gi 17136560 1701 DCVsDATDIK 1710
Cdd:cd20438   95 DTV-PFYDVK 103

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 38.82 E-value: 4.37e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 17136560 2026 VDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVV--DKLYELPQEF 2077
Cdd:cd20412   31 VGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVplEDLRALRSDF 84

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 39.35 E-value: 4.53e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1026 LSPFQFYIVP--KSVSAKYDNIMRDMREFYRQKQHQ------PLQLKVGSTVVVRQRKD--------NAILRATVTacnh 1089
Cdd:cd20419    6 ESPSQFYVRFysKDTSEMLEDMMIEMRRCYSNEHVSeryvmpEAFIQPGQVCCVRIPEDvwwyrviiHQVLNKQEV---- 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 17136560 1090 mmrkyRVFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCS 1130
Cdd:cd20419   82 -----EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPAS 117

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 37.96 E-value: 4.78e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136560  645 GAPCIVKCDQEWYRAEILRVD---DSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFE 709
Cdd:cd20407    8 GVICAAPVMNAWYRAQVVGVFeetDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIE 75

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 39.01 E-value: 5.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2166 ECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLkkliDPTTNSNGVCYSQ--EDACYYRCSIKSVLDpSQGFEV 2243
Cdd:cd20439   13 DVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHN----DPYKHGQIACVAKysKDGKWYRAAVLKQVS-AKEVDV 87


                 ....*...
gi 17136560 2244 FLLDYGNT 2251
Cdd:cd20439   88 IFVDYGNQ 95

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 39.64 E-value: 6.48e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 17136560 1359 GQICAVRSSDGN-WYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKAL 1407
Cdd:cd20442   53 GLECLAKSKKNLkWYRAVVEHLYPETEKMLVFFVDHGITEVVSMGNIKQL 102

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 37.19 E-value: 8.28e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 17136560 1357 DVGQICAVRSSDGnWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKF 1411
Cdd:cd20407    6 EVGVICAAPVMNA-WYRAQVVGVFEETDEVEIKYLDYGGYERVPVDDLRQIRSDF 59

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 38.14 E-value: 8.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 1810 FFIQLErDSKALELIELYLRKKDTLKPLEGFEKGLIVAALFEDDEL--WYRAQLQKELPDSrYEVLFIDYGNTSTT-SKC 1886
Cdd:cd20431   12 YRIDEN-SSEILQQLTAEINQRQLVPLTTKPVPNLLCLAPFTDADMkkYYRAKILYVSGSS-AEVFFVDYGNTSQVpSSL 89

                         90
                 ....*....|..
gi 17136560 1887 LM-LSEEIASLP 1897
Cdd:cd20431   90 LReIPETLLTLP 101

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 37.03 E-value: 8.64e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 17136560 1359 GQICAVRSSDGNWYRARIsgKDSNAACFEVFYIDYGNTEEI 1399
Cdd:cd20417    4 GEGCVVRGSDTLWYRGKV--LEVIGGMVRVQYVDQGYIEKI 42

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 39.25 E-value: 8.76e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136560 2220 SQEDACYYRCSIKSVLDPSQGFEVFLLDYGNTLVVP--EVWQLPQEIEPIPSLALHCQLS 2277
Cdd:cd20442   60 SKKNLKWYRAVVEHLYPETEKMLVFFVDHGITEVVSmgNIKQLSNDLLQIPRQAVLCRWN 119