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Conserved domains on  [gi|209954781|ref|NP_476432|]
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artemin isoform 1 preproprotein [Homo sapiens]

Protein Classification

TGF-beta family protein( domain architecture ID 14443713)

transforming growth factor-beta (TGF-beta) family protein may control proliferation, differentiation, and other functions in many cell types

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 122-219 1.80e-57

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


:

Pssm-ID: 381651  Cd Length: 98  Bit Score: 176.77  E-value: 1.80e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 122 GCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDV 201
Cdd:cd19381    1 GCRLRSLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGAIPPGPHERVSSQPCCRPTRYENVSFMDV 80

                         90
                 ....*....|....*...
gi 209954781 202 NSTWRTVDRLSATACGCL 219
Cdd:cd19381   81 QNVWQTVEKLSAAECSCV 98
 
Name Accession Description Interval E-value
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 122-219 1.80e-57

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 176.77  E-value: 1.80e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 122 GCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDV 201
Cdd:cd19381    1 GCRLRSLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGAIPPGPHERVSSQPCCRPTRYENVSFMDV 80

                         90
                 ....*....|....*...
gi 209954781 202 NSTWRTVDRLSATACGCL 219
Cdd:cd19381   81 QNVWQTVEKLSAAECSCV 98
TGF_beta pfam00019
Transforming growth factor beta like domain;
122-218 2.97e-17

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 73.90  E-value: 2.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781  122 GCRLRSQLVPVRALGLGHR--SDELVRFRFCSGSCR------RARSPHDLsLASLLGAgalrppPGSRPVSQPCCRPTRY 193
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDDWiiAPKGYNAYYCSGSCPshlnpqLSATNHAI-LQSLLHS------LKPANVPKPCCVPTKL 73

                          90       100
                  ....*....|....*....|....*....
gi 209954781  194 EAVSFMDVNS----TWRTVDRLSATACGC 218
Cdd:pfam00019  74 SPLSVLYYDDegnvVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 122-219 1.80e-57

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 176.77  E-value: 1.80e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 122 GCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDV 201
Cdd:cd19381    1 GCRLRSLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGAIPPGPHERVSSQPCCRPTRYENVSFMDV 80

                         90
                 ....*....|....*...
gi 209954781 202 NSTWRTVDRLSATACGCL 219
Cdd:cd19381   81 QNVWQTVEKLSAAECSCV 98
TGF_beta_GDNF_like cd13750
transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived ...
 122-218 5.72e-41

transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived neurotrophic factor (GDNF) family of ligands; GDNF family of ligands includes GDNF, Artemin, Neurturin, and Persephin. They plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis.


Pssm-ID: 381628  Cd Length: 95  Bit Score: 134.89  E-value: 5.72e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 122 GCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPpgsRPVSQPCCRPTRYE-AVSFMD 200
Cdd:cd13750    1 GCVLRELHLRVTDLGLGYASEEEVIFRYCAGSCEAARTNYDLILANLRGWRRLRSD---RKVGQPCCRPTAYDdDVSFLD 77

                         90
                 ....*....|....*...
gi 209954781 201 VNSTWRTVDRLSATACGC 218
Cdd:cd13750   78 DNSRYHILRKLSAKACGC 95
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 121-220 1.82e-33

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


Pssm-ID: 381652  Cd Length: 99  Bit Score: 115.64  E-value: 1.82e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 121 RGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALrPPPGSRPVSQPCCRPTRYEAVSFMD 200
Cdd:cd19382    1 RPCRLRSLLLRVGDLGLGYDSEETVLFKYCSGGCPRARTNHDLTLSRLLQKGDL-PSLGEKIFGGPCCRPTHYEDVAFLD 79

                         90       100
                 ....*....|....*....|
gi 209954781 201 VNSTWRTVDRLSATACGCLG 220
Cdd:cd19382   80 DNHRWHTVEKLSAAACACVG 99
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 117-218 9.49e-29

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 104.01  E-value: 9.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 117 AAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEA- 195
Cdd:cd19383    1 RRRSKPCSLRELEVTVSELGLGYESDETVLFRYCSGKCEAARRNYDLTLKHMRGKKSLKKGRKDKVRARPCCRPTAYEDd 80

                         90       100
                 ....*....|....*....|...
gi 209954781 196 VSFMDVNSTWRTVDRLSATACGC 218
Cdd:cd19383   81 VSFLDNNNRYHTIQELSAKECGC 103
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 121-218 3.12e-18

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 76.43  E-value: 3.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 121 RGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALrpppGSRPVSQPCCRPTRYE-AVSFM 199
Cdd:cd19380    2 RGCVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTRNKKL----VSDKVGQACCRPIAFDdDLSFL 77

                         90
                 ....*....|....*....
gi 209954781 200 DVNSTWRTVDRLSATACGC 218
Cdd:cd19380   78 DDNLVYHTLKKHSAKKCGC 96
TGF_beta pfam00019
Transforming growth factor beta like domain;
122-218 2.97e-17

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 73.90  E-value: 2.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781  122 GCRLRSQLVPVRALGLGHR--SDELVRFRFCSGSCR------RARSPHDLsLASLLGAgalrppPGSRPVSQPCCRPTRY 193
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDDWiiAPKGYNAYYCSGSCPshlnpqLSATNHAI-LQSLLHS------LKPANVPKPCCVPTKL 73

                          90       100
                  ....*....|....*....|....*....
gi 209954781  194 EAVSFMDVNS----TWRTVDRLSATACGC 218
Cdd:pfam00019  74 SPLSVLYYDDegnvVLKTYPDMVVESCGC 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 123-218 5.57e-09

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 51.93  E-value: 5.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 123 CRLRSQLVPVRALGLGHR--SDELVRFRFCSGSCRRARSPH-DLSLASLLGAgALRPPPGSRPVSQPCCRPTRYEAVSFM 199
Cdd:cd13756    1 CRRRPLYVDFSDLGWDDWiiAPKGYNANYCAGSCPFPLSSHaNATNHAILQA-LLHSLNPKKSVPKPCCVPTKYSPLSVL 79

                         90       100
                 ....*....|....*....|...
gi 209954781 200 ----DVNSTWRTVDRLSATACGC 218
Cdd:cd13756   80 yydeDGNVVLKTYPDMVVEECGC 102
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 123-218 1.66e-08

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 50.55  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209954781 123 CRLRSQLVPVRALGLGH--RSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPgsRPVSQPCCRPTRYEAVSFM- 199
Cdd:cd08698    1 CCKQPLYVNFKDLGGLNwiIAPSGFTANYCRGSCNSESSATTNHTKLLQWSRTRRHTP--REELKPCCVPTSYEPLSILy 78

                         90       100
                 ....*....|....*....|..
gi 209954781 200 ---DVNSTWRTVDRLSATACGC 218
Cdd:cd08698   79 ydnNGTVVETLLPNLIVTECGC 100
TGF_beta_DAF7 cd19378
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ...
 147-218 1.24e-04

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.


Pssm-ID: 381648  Cd Length: 100  Bit Score: 40.01  E-value: 1.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209954781 147 FRFCSGSCRrARSPHDLSLASLLGAGALRPPpgSRPVSQPCCRPTRYEAVSFMDVNS----TWRTVDRLSATACGC 218
Cdd:cd19378   28 ANMCRGDCK-SNHHHRPNSASILLNPITRSE--SKQEHGSCCHPTEYDPITVVYFNEdgqlKIKTINGMIAKKCSC 100
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 149-218 3.93e-03

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 35.71  E-value: 3.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 209954781 149 FCSGSC----RRARSPHDLSLASLLGAGalrpppGSRPVSQPCCRPTRYEAVS--FMDVNSTWRTVD--RLSATACGC 218
Cdd:cd13752   29 YCKGSCsgssSPFRSHHTTILQKYLSKN------KAKSELTPCCTPTKMSPLSllYYDSDGNIVKKDlpNMIVESCGC 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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