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Conserved domains on  [gi|16757994|ref|NP_445749|]
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pyruvate kinase PKM [Rattus norvegicus]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 42-530 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 823.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  42 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpilyRPVAVALDTKGPEIRT 121
Cdd:cd00288   1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 122 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADY-LVTEVENG 200
Cdd:cd00288  75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 201 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 280
Cdd:cd00288 152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 281 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 360
Cdd:cd00288 232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 361 LSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQ 440
Cdd:cd00288 312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 441 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDaWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSG 520
Cdd:cd00288 392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                       490
                ....*....|
gi 16757994 521 FTNTMRVVPV 530
Cdd:cd00288 471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 42-530 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 823.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  42 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpilyRPVAVALDTKGPEIRT 121
Cdd:cd00288   1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 122 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADY-LVTEVENG 200
Cdd:cd00288  75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 201 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 280
Cdd:cd00288 152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 281 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 360
Cdd:cd00288 232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 361 LSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQ 440
Cdd:cd00288 312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 441 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDaWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSG 520
Cdd:cd00288 392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                       490
                ....*....|
gi 16757994 521 FTNTMRVVPV 530
Cdd:cd00288 471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 43-527 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 756.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994    43 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpilyRPVAVALDTKGPEIRTG 122
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   123 LIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGS 202
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   203 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 281
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   282 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   362 SGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQV 441
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   442 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavldaWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG-WRPGSG 520
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 16757994   521 FTNTMRV 527
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 43-530 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 672.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  43 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATEsfasdpILYRPVAVALDTKGPEIRTG 122
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAK------ELGRPVAILLDLQGPKIRTG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 123 LIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGS 202
Cdd:COG0469  77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 203 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 282
Cdd:COG0469 151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 283 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 362
Cdd:COG0469 231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 363 GETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDplEAMAMGSVEASYKCLAAALIVLTESGRSAHQVA 442
Cdd:COG0469 311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 443 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavldawAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPG-SGF 521
Cdd:COG0469 389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                ....*....
gi 16757994 522 TNTMRVVPV 530
Cdd:COG0469 463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 42-395 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 622.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994    42 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDpilyrpVAVALDTKGPEIRT 121
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   122 GLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGAD-YLVTEVENG 200
Cdd:pfam00224  75 GNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   201 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 280
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   281 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 360
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 16757994   361 LSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLF 395
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 43-514 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 577.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   43 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESfasdpiLYRPVAVALDTKGPEIRTG 122
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  123 LIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGS 202
Cdd:PRK05826  78 KFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  203 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 281
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  282 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  362 SGETAKGDYPLEAVRMQHLIAREAEAavfHRLLFEELARASSQSTDPLEAMAMGSVEASYK-CLAAALIVLTESGRSAHQ 440
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16757994  441 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLC-KDAVLDAWAEDvdlrvnlAMNVGKARGFFKKGDVVIVLTG 514
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFdSAADTDDAAEE-------ALRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 42-530 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 823.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  42 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpilyRPVAVALDTKGPEIRT 121
Cdd:cd00288   1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 122 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADY-LVTEVENG 200
Cdd:cd00288  75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 201 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 280
Cdd:cd00288 152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 281 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 360
Cdd:cd00288 232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 361 LSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQ 440
Cdd:cd00288 312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 441 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDaWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSG 520
Cdd:cd00288 392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                       490
                ....*....|
gi 16757994 521 FTNTMRVVPV 530
Cdd:cd00288 471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 43-527 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 756.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994    43 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpilyRPVAVALDTKGPEIRTG 122
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   123 LIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGS 202
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   203 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 281
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   282 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   362 SGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQV 441
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   442 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavldaWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTG-WRPGSG 520
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 16757994   521 FTNTMRV 527
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 43-530 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 672.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  43 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATEsfasdpILYRPVAVALDTKGPEIRTG 122
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAK------ELGRPVAILLDLQGPKIRTG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 123 LIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGS 202
Cdd:COG0469  77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 203 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 282
Cdd:COG0469 151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 283 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 362
Cdd:COG0469 231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 363 GETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDplEAMAMGSVEASYKCLAAALIVLTESGRSAHQVA 442
Cdd:COG0469 311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 443 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavldawAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPG-SGF 521
Cdd:COG0469 389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                ....*....
gi 16757994 522 TNTMRVVPV 530
Cdd:COG0469 463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 42-395 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 622.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994    42 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDpilyrpVAVALDTKGPEIRT 121
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   122 GLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGAD-YLVTEVENG 200
Cdd:pfam00224  75 GNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   201 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 280
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   281 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 360
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 16757994   361 LSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLF 395
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 43-514 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 577.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   43 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESfasdpiLYRPVAVALDTKGPEIRTG 122
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  123 LIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGS 202
Cdd:PRK05826  78 KFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  203 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 281
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  282 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361
Cdd:PRK05826 233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  362 SGETAKGDYPLEAVRMQHLIAREAEAavfHRLLFEELARASSQSTDPLEAMAMGSVEASYK-CLAAALIVLTESGRSAHQ 440
Cdd:PRK05826 313 SGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16757994  441 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLC-KDAVLDAWAEDvdlrvnlAMNVGKARGFFKKGDVVIVLTG 514
Cdd:PRK05826 390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFdSAADTDDAAEE-------ALRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 45-512 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 547.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   45 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATesfASDPILyrpVAVALDTKGPEIRTGLI 124
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAM---ANTGIL---CAVMLDTKGPEIRTGFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  125 KGSGTaeVELKKGATLKITLDnaYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQV----KEKGadyLVT-EVEN 199
Cdd:PLN02461  97 KDGKP--VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlscdVEAG---TVRcRCEN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  200 GGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVR 278
Cdd:PLN02461 170 SAMLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLD 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  279 RFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADC 358
Cdd:PLN02461 250 NFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDC 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  359 IMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSA 438
Cdd:PLN02461 330 VMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTA 409

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  439 HQVARYRPRAPIIAV-------------TRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKK 505
Cdd:PLN02461 410 RLVAKYRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKP 489


                 ....*..
gi 16757994  506 GDVVIVL 512
Cdd:PLN02461 490 GDSVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
43-527 0e+00

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 541.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   43 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpilyRPVAVALDTKGPEIRTg 122
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTG------KKAAILLDTKGPEIRT- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  123 lIKGSGTAEVELKKGATLKITLDNAYMEkcDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGS 202
Cdd:PRK09206  75 -MKLEGGNDVSLKAGQTFTFTTDKSVVG--NKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  203 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGE-KGKNIKIISKIENHEGVRRFD 281
Cdd:PRK09206 152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  282 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361
Cdd:PRK09206 232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  362 SGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFeelaRASSQSTDPLEAMAMGSVEASYKcLAAALIVL-TESGRSAHQ 440
Cdd:PRK09206 312 SGESAKGKYPLEAVSIMATICERTDRVMNSRLES----NNDNRKLRITEAVCRGAVETAEK-LDAPLIVVaTQGGKSARS 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  441 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKD-AVLDAWaedvdlrVNLAMNVGKARGFFKKGDVVIVLTGWRPGS 519
Cdd:PRK09206 387 VRKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEiASTDDF-------YRLGKELALQSGLAQKGDVVVMVSGALVPS 459


                 ....*...
gi 16757994  520 GFTNTMRV 527
Cdd:PRK09206 460 GTTNTASV 467
PRK06354 PRK06354
pyruvate kinase; Provisional
 30-527 4.59e-180

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 519.10  E-value: 4.59e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   30 MCRLDidsapiTARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATEsfasdpILYRPVA 109
Cdd:PRK06354   1 MSLRD------LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASK------KLGKTVG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  110 VALDTKGPEIRTGLIKGSGtaeVELKKGATLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKE-- 187
Cdd:PRK06354  69 ILQDLQGPKIRLGRFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEvd 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  188 KGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIK 266
Cdd:PRK06354 143 KADGELHCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIP 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  267 IISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGS 346
Cdd:PRK06354 223 IIAKIEKQEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEAS 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  347 DVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAmAMGSVEASYKclAA 426
Cdd:PRK06354 303 DVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQ-AVSHIALQLD--AA 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  427 ALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavldawAEDVDLRVNLAMNVGKARGFFKKG 506
Cdd:PRK06354 380 AIVTLTKSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLD------APSTDETFDAAINVAQESGLLKQG 453

                        490       500
                 ....*....|....*....|..
gi 16757994  507 DVVIVLTGWRPG-SGFTNTMRV 527
Cdd:PRK06354 454 DLVVITAGTLVGeSGSTDLMKV 475
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 8-531 2.17e-174

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 501.60  E-value: 2.17e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994    8 AGTAFIQTQQLHAAmADTFLEHMCRlDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAET 87
Cdd:PTZ00066   5 ASTSSVMGCSLGKA-TNISLDKILE-PISDNDLRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   88 IKNVRAATESfasdpilyRP---VAVALDTKGPEIRTGLIKGSgtAEVELKKGATLKITLDnaYMEKCDENILWLDYKNI 164
Cdd:PTZ00066  83 LNNVREAAKA--------RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTD--YTFLGDETCISCSYKKL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  165 CKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFAS 243
Cdd:PTZ00066 151 PQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALS 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  244 FIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKP 323
Cdd:PTZ00066 231 FVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKP 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  324 VICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASS 403
Cdd:PTZ00066 311 VITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVP 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  404 QSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIfpvlcKDAVLDAWa 483
Cdd:PTZ00066 391 TPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGV-----TTYVVNSF- 464

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 16757994  484 EDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVVPVP 531
Cdd:PTZ00066 465 QGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKIP 513
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 69-530 3.55e-173

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 496.50  E-value: 3.55e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   69 MNVARLNFSHGTHEYHAETIKNVRAATESFASDpilyrpVAVALDTKGPEIRTGLIKGSGTAeveLKKGATLKITLDNAY 148
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGGEAV---MERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  149 MEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADY-LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQ 227
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  228 DLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVF 307
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  308 LAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEA 387
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  388 AVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYR 467
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16757994  468 GIFPVLCkDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 530
Cdd:PTZ00300 392 GVESVFF-DAERLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PRK06247 PRK06247
pyruvate kinase; Provisional
 42-527 2.36e-155

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 451.69  E-value: 2.36e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   42 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESfasdpiLYRPVAVALDTKGPEIRT 121
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDE------TGRPIGILADLQGPKLRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  122 GLIKGSgtaEVELKKGATLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGG 201
Cdd:PRK06247  78 GRFADG---KVQLANGQTFRLDVDDA---PGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  202 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKgknIKIISKIENHEGVRRFD 281
Cdd:PRK06247 152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  282 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361
Cdd:PRK06247 229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  362 SGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFeELARASSQSTDPlEAMAMGSVEASYKCLAAALIVLTESGRSAHQV 441
Cdd:PRK06247 309 SAETASGKYPVEAVRTMARIIRQVERDPTYPPLI-HAQRPQPEATKR-DAISYAARDIAERLDLAALVAYTSSGDTALRA 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  442 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavldawAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPG-SG 520
Cdd:PRK06247 387 ARERPPLPILALTPNPETARRLALTWGVHCVVVDD------ARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPG 460


                 ....*..
gi 16757994  521 FTNTMRV 527
Cdd:PRK06247 461 STNMLRI 467
PLN02765 PLN02765
pyruvate kinase
 45-511 5.46e-121

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 365.92  E-value: 5.46e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   45 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESfasdpiLYRPVAVALDTKGPEIRtglI 124
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPELQ---V 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  125 KGSGTAEVELKKGATLKITLDNayMEKCDENILWLDYKNICKVVEVGSKIYVDDGLIS--------LQVKEKGADYLVTE 196
Cdd:PLN02765 101 INKTEKPISLKAGNTVTLTPDQ--SKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  197 VENGGSL-GSKKGVNLPGAAVDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIEN 273
Cdd:PLN02765 179 VKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIEN 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  274 HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVIcATQMLESMIKKPRPTRAEGSDVANAVL 353
Cdd:PLN02765 259 VEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVL 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  354 DGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTE 433
Cdd:PLN02765 338 DGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVIIVFTS 417

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  434 SGRSAHQVARYRPRAPIIAV-----TRNP--------QTARQAHLYRGIFPVLCK---DAVLDAWAEDVDLRVnlAMNVG 497
Cdd:PLN02765 418 SGRAARLIAKYRPTMPVLSVviprlKTNQlkwsftgaFQARQCLIVRGLFPMLADprhSAESTSATNESVLKV--ALDHG 495

                        490
                 ....*....|....
gi 16757994  498 KARGFFKKGDVVIV 511
Cdd:PLN02765 496 KAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 37-517 2.44e-112

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 345.37  E-value: 2.44e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   37 SAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIlyrpvAVALDTKG 116
Cdd:PLN02623 104 SKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNVI-----AIMLDTKG 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  117 PEIRTGLIKgsgtAEVELKKGATLKITLDNAY-MEKCdeniLWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVT 195
Cdd:PLN02623 179 PEVRSGDLP----QPIMLEEGQEFTFTIKRGVsTEDC----VSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKC 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  196 EVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHE 275
Cdd:PLN02623 251 EVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESAD 330

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  276 GVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDG 355
Cdd:PLN02623 331 SIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREG 410

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  356 ADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPL---EAMAMGSVeasykcLAAALIVLT 432
Cdd:PLN02623 411 ADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMfafHATMMANT------LGTSIIVFT 484

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  433 ESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKdavldaWAEDVDLRVNLAMNVGKARGFFKKGD-VVIV 511
Cdd:PLN02623 485 RTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQ------FSDDAEETFARALSLLLNKGMVKEGEeVALV 558


                 ....*.
gi 16757994  512 LTGWRP 517
Cdd:PLN02623 559 QSGRQP 564
PRK06739 PRK06739
pyruvate kinase; Validated
 48-386 7.09e-102

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 310.72  E-value: 7.09e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   48 ICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESfasdpilyrpVAVALDTKGPEIRTGLIKGS 127
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKGE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  128 gtaEVELKKGATLKITLDNAYMEKCDENIlwlDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKK 207
Cdd:PRK06739  76 ---QITLQAGDSFILHTQPVTGSSTEASV---DYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  208 GVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNI-KIISKIENHEGVRRFDEILEA 286
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  287 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETA 366
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 16757994  367 KGDYPLEAVRMQHLIAREAE 386
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 42-531 3.52e-88

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 280.48  E-value: 3.52e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   42 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATES--FAsdpilyrpVAVALDTKGPEI 119
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEkgFA--------VAVMMDTEGSEI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  120 RTGLIKGSGTAEVElkKGATLKITLdNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEK-GADYLVTEVE 198
Cdd:PLN02762  96 HMGDLGGASSAKAE--DGEEWTFTV-RKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKiGPDVKCKCTD 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  199 NG-------------GSLGSKKGVNlpgaavdLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKN- 264
Cdd:PLN02762 173 PGlllpranltfwrdGSLVRERNAM-------LPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDs 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  265 -IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 343
Cdd:PLN02762 246 dIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRA 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  344 EGSDVANAVLDGADCIMLSGETAKGDYPLEAV--------RMQHLIAREAEAAVFHRllfEELARASSQSTDplEAMAMG 415
Cdd:PLN02762 326 EVADVSEAVRQRADALMLSGESAMGLYPEKALsvlrsvslRMELWSREEKRHEALEL---PQLSSSLSDRIS--EEICNS 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  416 SVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCkdavldAWAEDVDLRVNLAMN 495
Cdd:PLN02762 401 AAKMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSDDMESNLNKTFS 474

                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 16757994  496 VGKARGFFKKGDVVIVLTGWRPgSGFTNTMRVVPVP 531
Cdd:PLN02762 475 LLKARGMIKSGDLVIAVSDLTP-SSMLQSIQVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 38-378 1.69e-50

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 180.21  E-value: 1.69e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   38 APITARNTGIICTI-GPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFAsdpilyRPVAVALDTKG 116
Cdd:PRK08187 128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATG------RRCKILMDLAG 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  117 PEIRTGLIKGsGTAEVELKKGATLKITLDNAyMEKCDENILWLDykniCKV------VEVGSKIYVDDGLISLQVKEKGA 190
Cdd:PRK08187 202 PKIRTGAVAG-PLGKTRLYTGDRLALVAQGP-PRRIDEEHFQVT----CTLpeilarLAVGARVWIDDGKLGARVERVGP 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  191 DYLVTEV----ENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQdVDMVFASFIRKAADVHEVRKVLGEKGKN-- 264
Cdd:PRK08187 276 GGALLEVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALAARRPDdw 354

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  265 --IKIISKIENHEGVRRFDEILEASDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKK 337
Cdd:PRK08187 355 rkLGLVLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKK 434

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 16757994  338 PRPTRAEGSDVANAvlDGADCIMLSgetaKGDYPLEAV--------RMQ 378
Cdd:PRK08187 435 GLPSRAEMTDAAMA--ARAECVMLN----KGPYLVEAVtflddllaRMD 477
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
316-530 2.00e-42

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 153.90  E-value: 2.00e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 316 RCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLF 395
Cdd:COG3848   1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994 396 eeLARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCK 475
Cdd:COG3848  81 --VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVE 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 16757994 476 DavldawAEDVDLRVNLAMNVGKARGFFKKGDVVI----VLTGwrpGSGFTNTMRVVPV 530
Cdd:COG3848 159 E------SASTDEMFAVAVALALEAGLVKDGDLVVitagVPVG---VSGTTNLLKVHVV 208
PRK14725 PRK14725
pyruvate kinase; Provisional
 168-377 9.09e-41

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 155.49  E-value: 9.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  168 VEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSK----KGVNLPGAAVDLPAVSEKDIQDLKFGVEQdVDMVFAS 243
Cdd:PRK14725 373 ARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALS 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  244 FIRKAADVHEVRKVLGE-KGKNIKIISKIENHEGVRRFDEI-LEA----SDGIMVARGDLGIEIPAEKVFLAQKMMIGRC 317
Cdd:PRK14725 452 FVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRIlLEAmrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLC 531

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994  318 NRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLdgADCIMLSgetaKGDYPLEAVRM 377
Cdd:PRK14725 532 EAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRV 585
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 410-528 5.03e-40

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 140.69  E-value: 5.03e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16757994   410 EAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavldawAEDVDLR 489
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 16757994   490 VNLAMNVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVV 528
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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