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Conserved domains on  [gi|16716433|ref|NP_444363|]
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protocadherin beta-8 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 1.38e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.44  E-value: 1.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    30 AISYSMPEETESGYLVANLAQDLGLRVGELTTRGARIHHNGNKELLQLDAERGNLLLKEKPDREALCGATEPCVLHFQII 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 16716433   110 LEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-342 7.55e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 7.55e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 247 YAVEVPENSPLNALVVTVSARDLDAGIHGNVAYSLfQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGG- 325
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                        90
                ....*....|....*...
gi 16716433 326 -LSGKCTVAIQVLDVNDN 342
Cdd:cd11304  81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 454-556 2.42e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.42e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 454 SYTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQqlglaSLISINSDNGQLFALRALDYEALQAFEFHVGAT 533
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 16716433 534 DRGSPALSSEALVRVVVLDDNDN 556
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-446 2.00e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 2.00e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 354 SIPENAPE-AVVAVFSVSDPDSGDNGRMVCSIQNGLP---FLLKPtfkNFYTLVTERPLDRESNAEYNITITVSDLGTPR 429
Cdd:cd11304   5 SVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 16716433 430 LTTQHTITVQVSDINDN 446
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 2.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 140 LKIQEIAQPGTVFPLKAAQDPDIGSNAVQNYTVS---PNLHFHVvtlsrsdDRKYPELVLDRALDREEQPELTLILTALD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 16716433 217 GGAPPKSGTTTVRIEVVDINDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-663 2.40e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 575 LPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSAS 654
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 16716433 655 VMLQVLVVD 663
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-766 4.76e-19

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 82.19  E-value: 4.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   685 MLTLYLVIALASVSSLFLLSVLLFVGVKLCKKAREASLAD----CSIPEGHFPSHlvdvSGAGTLSQSYHYEVCLTEDSG 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*.
gi 16716433   761 TSDFKF 766
Cdd:pfam16492  77 KSEFKF 82
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 1.38e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.44  E-value: 1.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    30 AISYSMPEETESGYLVANLAQDLGLRVGELTTRGARIHHNGNKELLQLDAERGNLLLKEKPDREALCGATEPCVLHFQII 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 16716433   110 LEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-342 7.55e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 7.55e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 247 YAVEVPENSPLNALVVTVSARDLDAGIHGNVAYSLfQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGG- 325
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                        90
                ....*....|....*...
gi 16716433 326 -LSGKCTVAIQVLDVNDN 342
Cdd:cd11304  81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 454-556 2.42e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.42e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 454 SYTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQqlglaSLISINSDNGQLFALRALDYEALQAFEFHVGAT 533
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 16716433 534 DRGSPALSSEALVRVVVLDDNDN 556
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-446 2.00e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 2.00e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 354 SIPENAPE-AVVAVFSVSDPDSGDNGRMVCSIQNGLP---FLLKPtfkNFYTLVTERPLDRESNAEYNITITVSDLGTPR 429
Cdd:cd11304   5 SVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 16716433 430 LTTQHTITVQVSDINDN 446
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-344 5.70e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 5.70e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    265 SARDLDAGIHGNVAYSLfQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGG--LSGKCTVAIQVLDVNDN 342
Cdd:smart00112   1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 16716433    343 AP 344
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-558 7.87e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 7.87e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    473 SATDSDSGSNGLIIYSLLPPHDqqlglASLISINSDNGQLFALRALDYEALQAFEFHVGATDRGSPALSSEALVRVVVLD 552
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 16716433    553 DNDNAP 558
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 2.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 140 LKIQEIAQPGTVFPLKAAQDPDIGSNAVQNYTVS---PNLHFHVvtlsrsdDRKYPELVLDRALDREEQPELTLILTALD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 16716433 217 GGAPPKSGTTTVRIEVVDINDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-337 4.16e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 4.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   247 YAVEVPENSPLNALVVTVSARDLDAGIHGNVAYSLfQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSG-- 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgp 79

                          90
                  ....*....|...
gi 16716433   325 GLSGKCTVAIQVL 337
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 4.88e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 4.88e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    157 AQDPDIGSNAVQNYTVSPNLHFHVVTLSRSDDrkypELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRIEVVDIN 236
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 16716433    237 DNAP 240
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-663 2.40e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 575 LPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSAS 654
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 16716433 655 VMLQVLVVD 663
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 368-448 2.72e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 2.72e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    368 SVSDPDSGDNGRMVCSIQNGLPFLLkptFK---NFYTLVTERPLDRESNAEYNITITVSDLGTPRLTTQHTITVQVSDIN 444
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL---FSidpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 16716433    445 DNAP 448
Cdd:smart00112  78 DNAP 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-766 4.76e-19

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 82.19  E-value: 4.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   685 MLTLYLVIALASVSSLFLLSVLLFVGVKLCKKAREASLAD----CSIPEGHFPSHlvdvSGAGTLSQSYHYEVCLTEDSG 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*.
gi 16716433   761 TSDFKF 766
Cdd:pfam16492  77 KSEFKF 82
Cadherin pfam00028
Cadherin domain;
455-551 1.58e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   455 YTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQQLglaslISINSDNGQLFALRALDYEALQAFEFHVGATD 534
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 16716433   535 RGSPALSSEALVRVVVL 551
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-129 1.75e-15

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 72.76  E-value: 1.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433  31 ISYSMPEETESGYLVANLAQDLGlrvgELTTRGARIHHNGNK---ELLQLDAERGNLLLKEKPDREALcgatepCVLHFQ 107
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYIS 71

                        90       100
                ....*....|....*....|....*..
gi 16716433 108 IIL-----ENPVQFFQTDLQFTDINDH 129
Cdd:cd00031  72 VSAaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
354-440 2.61e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 2.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   354 SIPENAPE-AVVAVFSVSDPDSGDNGRMVCSIQNGlpfllkPTFKNFY------TLVTERPLDRESNAEYNITITVSDLG 426
Cdd:pfam00028   4 SVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGG------GPGGNFRidpdtgDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 16716433   427 TPRLTTQHTITVQV 440
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-663 1.81e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.81e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16716433    589 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSASVMLQVLVVD 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
142-232 1.18e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   142 IQEIAQPGTVFPLKAAQDPDIGSNAVQNYTVS---PNLHFHVVTLSRsddrkypELVLDRALDREEQPELTLILTALDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 16716433   219 APPKSGTTTVRIEV 232
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
575-661 5.58e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 5.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   575 LPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSAS 654
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 16716433   655 VMLQVLV 661
Cdd:pfam00028  85 ATVTITV 91
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 208-558 3.26e-05

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 47.73  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   208 LTLILTALDGgaPPKSGTTTVRIEVVDINdNAPQFLQSLYAvEVPENSP--LNAlvvtvSARDLDAGIhgnVAYSLFQGG 285
Cdd:NF038112 1254 LTFQLVVSDG--TKTSAPDTVTVLVRNVN-RAPVAVAGAPA-TVDERSTvtLDG-----SGTDADGDA---LTYAWTQTS 1321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   286 G---------GPQP-FVIDEITGEIRLkgaldfeatsyyTMEIVATDsGGLSGKCTVAIQVLDVNdNAPkltISSLTSSI 355
Cdd:NF038112 1322 GpavtltgatTATAtFTAPEVTADTQL------------TFTLTVSD-GTASATDTVTVTVRNVN-RAP---VANAGADQ 1384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   356 PENAPEAVVAVFSVSDPDsGDNGRMVCSIQNGLPFLLkpTFKNFYTLVTERPlDRESNAEYNITITVSDLGTprLTTQHT 435
Cdd:NF038112 1385 TVDERSTVTLSGSATDPD-GDALTYAWTQTAGPTVTL--TGADTATASFTAP-EVAADTELTFQLTVSADGQ--ASADVT 1458

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   436 ITVQVSDINDNAPAFTQTSYTlfVHENNSPALhigTISATDSDSGSngliiyslLPPHDQQLGLASlISINSDNGQLFAL 515
Cdd:NF038112 1459 VTVTVRNVNRAPVAHAGESIT--VDEGSTVTL---DASATDPDGDT--------LTYAWTQVAGPS-VTLTGADSAKLTF 1524

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 16716433   516 RALDYEALQAFEFHVGATDrgSPALSSEALVRVVVLDDNDNAP 558
Cdd:NF038112 1525 TAPEVSADTTLTFSLTVTD--GSGSSGPVVVTVTVKNVNRAPD 1565
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 1.38e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.44  E-value: 1.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    30 AISYSMPEETESGYLVANLAQDLGLRVGELTTRGARIHHNGNKELLQLDAERGNLLLKEKPDREALCGATEPCVLHFQII 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 16716433   110 LEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-342 7.55e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 7.55e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 247 YAVEVPENSPLNALVVTVSARDLDAGIHGNVAYSLfQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGG- 325
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                        90
                ....*....|....*...
gi 16716433 326 -LSGKCTVAIQVLDVNDN 342
Cdd:cd11304  81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 454-556 2.42e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.42e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 454 SYTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQqlglaSLISINSDNGQLFALRALDYEALQAFEFHVGAT 533
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 16716433 534 DRGSPALSSEALVRVVVLDDNDN 556
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-446 2.00e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 2.00e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 354 SIPENAPE-AVVAVFSVSDPDSGDNGRMVCSIQNGLP---FLLKPtfkNFYTLVTERPLDRESNAEYNITITVSDLGTPR 429
Cdd:cd11304   5 SVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 16716433 430 LTTQHTITVQVSDINDN 446
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-344 5.70e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 5.70e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    265 SARDLDAGIHGNVAYSLfQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGG--LSGKCTVAIQVLDVNDN 342
Cdd:smart00112   1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 16716433    343 AP 344
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-558 7.87e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 7.87e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    473 SATDSDSGSNGLIIYSLLPPHDqqlglASLISINSDNGQLFALRALDYEALQAFEFHVGATDRGSPALSSEALVRVVVLD 552
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 16716433    553 DNDNAP 558
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 2.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 140 LKIQEIAQPGTVFPLKAAQDPDIGSNAVQNYTVS---PNLHFHVvtlsrsdDRKYPELVLDRALDREEQPELTLILTALD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 16716433 217 GGAPPKSGTTTVRIEVVDINDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-337 4.16e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 4.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   247 YAVEVPENSPLNALVVTVSARDLDAGIHGNVAYSLfQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSG-- 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgp 79

                          90
                  ....*....|...
gi 16716433   325 GLSGKCTVAIQVL 337
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 4.88e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 4.88e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    157 AQDPDIGSNAVQNYTVSPNLHFHVVTLSRSDDrkypELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRIEVVDIN 236
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 16716433    237 DNAP 240
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-663 2.40e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 2.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433 575 LPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSAS 654
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 16716433 655 VMLQVLVVD 663
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 368-448 2.72e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 2.72e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433    368 SVSDPDSGDNGRMVCSIQNGLPFLLkptFK---NFYTLVTERPLDRESNAEYNITITVSDLGTPRLTTQHTITVQVSDIN 444
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL---FSidpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 16716433    445 DNAP 448
Cdd:smart00112  78 DNAP 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 685-766 4.76e-19

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 82.19  E-value: 4.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   685 MLTLYLVIALASVSSLFLLSVLLFVGVKLCKKAREASLAD----CSIPEGHFPSHlvdvSGAGTLSQSYHYEVCLTEDSG 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSG 76


                  ....*.
gi 16716433   761 TSDFKF 766
Cdd:pfam16492  77 KSEFKF 82
Cadherin pfam00028
Cadherin domain;
455-551 1.58e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   455 YTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQQLglaslISINSDNGQLFALRALDYEALQAFEFHVGATD 534
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 16716433   535 RGSPALSSEALVRVVVL 551
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-129 1.75e-15

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 72.76  E-value: 1.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433  31 ISYSMPEETESGYLVANLAQDLGlrvgELTTRGARIHHNGNK---ELLQLDAERGNLLLKEKPDREALcgatepCVLHFQ 107
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYIS 71

                        90       100
                ....*....|....*....|....*..
gi 16716433 108 IIL-----ENPVQFFQTDLQFTDINDH 129
Cdd:cd00031  72 VSAaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
354-440 2.61e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 2.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   354 SIPENAPE-AVVAVFSVSDPDSGDNGRMVCSIQNGlpfllkPTFKNFY------TLVTERPLDRESNAEYNITITVSDLG 426
Cdd:pfam00028   4 SVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGG------GPGGNFRidpdtgDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 16716433   427 TPRLTTQHTITVQV 440
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-663 1.81e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.81e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16716433    589 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSASVMLQVLVVD 663
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
142-232 1.18e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   142 IQEIAQPGTVFPLKAAQDPDIGSNAVQNYTVS---PNLHFHVVTLSRsddrkypELVLDRALDREEQPELTLILTALDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 16716433   219 APPKSGTTTVRIEV 232
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
575-661 5.58e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 5.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   575 LPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSAS 654
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 16716433   655 VMLQVLV 661
Cdd:pfam00028  85 ATVTITV 91
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 208-558 3.26e-05

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 47.73  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   208 LTLILTALDGgaPPKSGTTTVRIEVVDINdNAPQFLQSLYAvEVPENSP--LNAlvvtvSARDLDAGIhgnVAYSLFQGG 285
Cdd:NF038112 1254 LTFQLVVSDG--TKTSAPDTVTVLVRNVN-RAPVAVAGAPA-TVDERSTvtLDG-----SGTDADGDA---LTYAWTQTS 1321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   286 G---------GPQP-FVIDEITGEIRLkgaldfeatsyyTMEIVATDsGGLSGKCTVAIQVLDVNdNAPkltISSLTSSI 355
Cdd:NF038112 1322 GpavtltgatTATAtFTAPEVTADTQL------------TFTLTVSD-GTASATDTVTVTVRNVN-RAP---VANAGADQ 1384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   356 PENAPEAVVAVFSVSDPDsGDNGRMVCSIQNGLPFLLkpTFKNFYTLVTERPlDRESNAEYNITITVSDLGTprLTTQHT 435
Cdd:NF038112 1385 TVDERSTVTLSGSATDPD-GDALTYAWTQTAGPTVTL--TGADTATASFTAP-EVAADTELTFQLTVSADGQ--ASADVT 1458

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16716433   436 ITVQVSDINDNAPAFTQTSYTlfVHENNSPALhigTISATDSDSGSngliiyslLPPHDQQLGLASlISINSDNGQLFAL 515
Cdd:NF038112 1459 VTVTVRNVNRAPVAHAGESIT--VDEGSTVTL---DASATDPDGDT--------LTYAWTQVAGPS-VTLTGADSAKLTF 1524

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 16716433   516 RALDYEALQAFEFHVGATDrgSPALSSEALVRVVVLDDNDNAP 558
Cdd:NF038112 1525 TAPEVSADTTLTFSLTVTD--GSGSSGPVVVTVTVKNVNRAPD 1565
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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