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Conserved domains on  [gi|16078694|ref|NP_389513|]
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flagellar motor switching and energizing component [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

flagellar motor switch protein FliM( domain architecture ID 11482383)

flagellar motor switch protein FliM is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring) located at the base of the basal body

CATH:  3.40.1550.10
Gene Ontology:  GO:0003774|GO:0006935|GO:0071973
PubMed:  19081534

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
fliM PRK06666
flagellar motor switch protein FliM; Validated
 1-330 1.31e-162

flagellar motor switch protein FliM; Validated


:

Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 456.99  E-value: 1.31e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    1 MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIH 80
Cdd:PRK06666   1 MMDDILSQEEIDALLSGVSDGEVDDEELKEEGDEKKVRPYDFKRQERFSRERLRSLEIINERFARLLRIGLSNLLRRSVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   81 ISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKV-DSLTEIETKIISNLFE 159
Cdd:PRK06666  81 ISVGSVDQQPYGEFIRSLPVPTSLNLVHMKPLRGTALIEFDPSLVFIMVDNLFGGDGRFHTKVgREFTETEQRIIDRILK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  160 NALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKLSVHYWMqSD 239
Cdd:PRK06666 161 LAFENLKEAWSSVVPIEPEYVRSEVNPQFANIVSPNEIVVVVSFHIEIGGGGGMMNICIPYSMIEPIREKLSSPYWM-SD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  240 RNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQ 319
Cdd:PRK06666 240 SRDKDKRWRKELEQQVQQAEVELVAELGEIKLTLSEILNLKVGDVIPLEKPADDPLIVYVDGKPKFLCQYGKSNGRKALQ 319

                        330
                 ....*....|.
gi 16078694  320 IlDHDIRGEQD 330
Cdd:PRK06666 320 I-EELIERELN 329
 
Name Accession Description Interval E-value
fliM PRK06666
flagellar motor switch protein FliM; Validated
 1-330 1.31e-162

flagellar motor switch protein FliM; Validated


Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 456.99  E-value: 1.31e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    1 MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIH 80
Cdd:PRK06666   1 MMDDILSQEEIDALLSGVSDGEVDDEELKEEGDEKKVRPYDFKRQERFSRERLRSLEIINERFARLLRIGLSNLLRRSVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   81 ISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKV-DSLTEIETKIISNLFE 159
Cdd:PRK06666  81 ISVGSVDQQPYGEFIRSLPVPTSLNLVHMKPLRGTALIEFDPSLVFIMVDNLFGGDGRFHTKVgREFTETEQRIIDRILK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  160 NALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKLSVHYWMqSD 239
Cdd:PRK06666 161 LAFENLKEAWSSVVPIEPEYVRSEVNPQFANIVSPNEIVVVVSFHIEIGGGGGMMNICIPYSMIEPIREKLSSPYWM-SD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  240 RNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQ 319
Cdd:PRK06666 240 SRDKDKRWRKELEQQVQQAEVELVAELGEIKLTLSEILNLKVGDVIPLEKPADDPLIVYVDGKPKFLCQYGKSNGRKALQ 319

                        330
                 ....*....|.
gi 16078694  320 IlDHDIRGEQD 330
Cdd:PRK06666 320 I-EELIERELN 329
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
1-330 2.34e-145

Flagellar motor switch protein FliM [Cell motility];


Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 412.63  E-value: 2.34e-145
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   1 MSgEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKvYDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIH 80
Cdd:COG1868   1 MS-DVLSQEEIDALLSAVSSGEVDAEEKEEEEEKKVKP-YDFRRPDRFSKERLPTLEIIHERFARLLRTSLSNLLRRNVE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  81 ISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHN-KVDSLTEIETKIISNLFE 159
Cdd:COG1868  79 ISVASVEQLTYGEFIRSLPVPTSLNIFRLEPLRGSALLEIDPSLVFALVDRLLGGDGRPHAiEGREFTEIEQRIIERLLE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 160 NALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKLSVHYWMqsD 239
Cdd:COG1868 159 LLLEDLEEAWAPVYPLEPELERSETNPQFAQIVSPNEVVVVVTFEVEIGDRSGMINICIPYSTLEPIRDKLSSRFQS--D 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 240 RNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQ 319
Cdd:COG1868 237 RKERDERWRERLREELEEAEVELSAELGETEITLRELLNLKVGDVIPLDKKVDDPLTVYVGGVPKFEGKPGVSNGRLAVK 316

                       330
                ....*....|.
gi 16078694 320 ILDHdIRGEQD 330
Cdd:COG1868 317 ITEI-IEEEEE 326
fliM_switch TIGR01397
flagellar motor switch protein FliM; Members of this family are the flagellar motor switch ...
 4-322 1.75e-117

flagellar motor switch protein FliM; Members of this family are the flagellar motor switch protein FliM. The family excludes FliM homologs that lack an N-terminal region critical to interaction with phosphorylated CheY. One set lacking this N-terminal region is found in Rhizobium meliloti, in which the direction of flagellar rotation is not reversible (i.e. the FliM homolog does not act to reverse the motor direction), and in related species. Another is found in Buchnera, an obligate intracellular endosymbiont with genes for many of the components of the flagellar apparatus, but not, apparently, for flagellin iself. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 130464 [Multi-domain]  Cd Length: 320  Bit Score: 341.99  E-value: 1.75e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694     4 EVLSQNEIDALLSAISTGEmDAEELKKEEKEKKVKVYDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISV 83
Cdd:TIGR01397   1 DILSQDEIDALLGGLSEGD-DSDEPSAVEDEKKVKPYDFKRPDRVSKEQLRTLEIINERFARLLRTSLSNMLRRFVEVSV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    84 SSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFENALG 163
Cdd:TIGR01397  80 ASVDQLTYGEFLRSLPVPTSLNVFRMEPLRGTALIEIDPSLIYTMVDRLFGGQGRSVPEGREFTEIERRVIDRILDRVLE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   164 NYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKLSVHYwMQSDRNEP 243
Cdd:TIGR01397 160 DLKEAWSPVMPLEPELDRSETNPQFAQIVPPNEIVVLVSFSVEVGETEGMINICLPYSTLEPIRSKLSQRF-MQSEKVER 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16078694   244 KPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILD 322
Cdd:TIGR01397 239 DSSWRDALERELSTVPVDMRAVLGEVEVSLRQLLNLQVGDVIPLNTDMPEEVSLRVGGRPKFRAQPGVRGGKLAVQITR 317
FliM pfam02154
Flagellar motor switch protein FliM;
40-230 2.33e-101

Flagellar motor switch protein FliM;


Pssm-ID: 111086  Cd Length: 192  Bit Score: 296.21  E-value: 2.33e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    40 YDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMME 119
Cdd:pfam02154   1 YDFKRPDRVSKEQLRTLEIIHERFARLMTTSLSNLLRSMVEVSVASVDQMTYGEFIRSIPVPTILNVFRMKPLKGTGLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   120 VNPTIAYTMMDRVMGGIGISHNK-VDSLTEIETKIISNLFENALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETV 198
Cdd:pfam02154  81 VDPSIAFIIVDRLFGGDGRFHAKeGREFTDIERRVIQRMLKRVLENYKEAWSPVVDLEPEYDRSEVNPQFAQIVSPNEIV 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 16078694   199 VVISLNTQIGEISGVINLCIPHIVLEPLIPKL 230
Cdd:pfam02154 161 VLVSLEIEIGERGGMMNLCLPYITIEPIRSKL 192
FliM cd17908
flagellar protein FliM; This family contains bacterial flagellar protein FliM which is ...
 50-229 3.83e-75

flagellar protein FliM; This family contains bacterial flagellar protein FliM which is localized in the flagellar switch complex along with FliG and FliY; all are present in many copies, and together they correspond structurally to the C-ring of the flagellar basal body. FliM does not contain the CheC consensus sequence of the phosphatase active site ([DS]xxxExxNx(22)P) and is not a CheY-P phosphatase. FliM sits in the center of the rotor with the N-terminal region interacting with the signaling protein, phosphorylated CheY (CheY-P). The activated form of CheY destabilizes the parallel arrangement of FliM molecules, and perturbs FliG alignment in a process that may reflect the onset of rotation switching. This suggests a model of C-ring assembly in which intermolecular contacts among FliG domains provide a template for FliM assembly. Recent data show that binding of FliM to spermine synthase, SpeE, contributes to flagellar motility, an association that is unique to Helicobacter species.


Pssm-ID: 381736  Cd Length: 181  Bit Score: 228.94  E-value: 3.83e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  50 KDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMM 129
Cdd:cd17908   1 REQLRTLEVIHERFARLLSTSLSALLRTPVEVSLESVEQLTYGEFLASLPNPTSLAVFSLEPLKGRALLEIDPSLVFALV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 130 DRVMGGIGISHNKVD-SLTEIETKIISNLFENALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIG 208
Cdd:cd17908  81 DRLLGGSGEAPKIEGrEFTEIELRLLRRLLERLLEDLEEAWSPVLPLEFELERIETNPQFAQIAPPNEPVVVVTFEVKIG 160

                       170       180
                ....*....|....*....|.
gi 16078694 209 EISGVINLCIPHIVLEPLIPK 229
Cdd:cd17908 161 EREGTINLCIPYSALEPILEK 181
 
Name Accession Description Interval E-value
fliM PRK06666
flagellar motor switch protein FliM; Validated
 1-330 1.31e-162

flagellar motor switch protein FliM; Validated


Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 456.99  E-value: 1.31e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    1 MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIH 80
Cdd:PRK06666   1 MMDDILSQEEIDALLSGVSDGEVDDEELKEEGDEKKVRPYDFKRQERFSRERLRSLEIINERFARLLRIGLSNLLRRSVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   81 ISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKV-DSLTEIETKIISNLFE 159
Cdd:PRK06666  81 ISVGSVDQQPYGEFIRSLPVPTSLNLVHMKPLRGTALIEFDPSLVFIMVDNLFGGDGRFHTKVgREFTETEQRIIDRILK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  160 NALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKLSVHYWMqSD 239
Cdd:PRK06666 161 LAFENLKEAWSSVVPIEPEYVRSEVNPQFANIVSPNEIVVVVSFHIEIGGGGGMMNICIPYSMIEPIREKLSSPYWM-SD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  240 RNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQ 319
Cdd:PRK06666 240 SRDKDKRWRKELEQQVQQAEVELVAELGEIKLTLSEILNLKVGDVIPLEKPADDPLIVYVDGKPKFLCQYGKSNGRKALQ 319

                        330
                 ....*....|.
gi 16078694  320 IlDHDIRGEQD 330
Cdd:PRK06666 320 I-EELIERELN 329
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
1-330 2.34e-145

Flagellar motor switch protein FliM [Cell motility];


Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 412.63  E-value: 2.34e-145
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   1 MSgEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKvYDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIH 80
Cdd:COG1868   1 MS-DVLSQEEIDALLSAVSSGEVDAEEKEEEEEKKVKP-YDFRRPDRFSKERLPTLEIIHERFARLLRTSLSNLLRRNVE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  81 ISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHN-KVDSLTEIETKIISNLFE 159
Cdd:COG1868  79 ISVASVEQLTYGEFIRSLPVPTSLNIFRLEPLRGSALLEIDPSLVFALVDRLLGGDGRPHAiEGREFTEIEQRIIERLLE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 160 NALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKLSVHYWMqsD 239
Cdd:COG1868 159 LLLEDLEEAWAPVYPLEPELERSETNPQFAQIVSPNEVVVVVTFEVEIGDRSGMINICIPYSTLEPIRDKLSSRFQS--D 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 240 RNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQ 319
Cdd:COG1868 237 RKERDERWRERLREELEEAEVELSAELGETEITLRELLNLKVGDVIPLDKKVDDPLTVYVGGVPKFEGKPGVSNGRLAVK 316

                       330
                ....*....|.
gi 16078694 320 ILDHdIRGEQD 330
Cdd:COG1868 317 ITEI-IEEEEE 326
fliM_switch TIGR01397
flagellar motor switch protein FliM; Members of this family are the flagellar motor switch ...
 4-322 1.75e-117

flagellar motor switch protein FliM; Members of this family are the flagellar motor switch protein FliM. The family excludes FliM homologs that lack an N-terminal region critical to interaction with phosphorylated CheY. One set lacking this N-terminal region is found in Rhizobium meliloti, in which the direction of flagellar rotation is not reversible (i.e. the FliM homolog does not act to reverse the motor direction), and in related species. Another is found in Buchnera, an obligate intracellular endosymbiont with genes for many of the components of the flagellar apparatus, but not, apparently, for flagellin iself. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 130464 [Multi-domain]  Cd Length: 320  Bit Score: 341.99  E-value: 1.75e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694     4 EVLSQNEIDALLSAISTGEmDAEELKKEEKEKKVKVYDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISV 83
Cdd:TIGR01397   1 DILSQDEIDALLGGLSEGD-DSDEPSAVEDEKKVKPYDFKRPDRVSKEQLRTLEIINERFARLLRTSLSNMLRRFVEVSV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    84 SSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFENALG 163
Cdd:TIGR01397  80 ASVDQLTYGEFLRSLPVPTSLNVFRMEPLRGTALIEIDPSLIYTMVDRLFGGQGRSVPEGREFTEIERRVIDRILDRVLE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   164 NYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKLSVHYwMQSDRNEP 243
Cdd:TIGR01397 160 DLKEAWSPVMPLEPELDRSETNPQFAQIVPPNEIVVLVSFSVEVGETEGMINICLPYSTLEPIRSKLSQRF-MQSEKVER 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16078694   244 KPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILD 322
Cdd:TIGR01397 239 DSSWRDALERELSTVPVDMRAVLGEVEVSLRQLLNLQVGDVIPLNTDMPEEVSLRVGGRPKFRAQPGVRGGKLAVQITR 317
FliM pfam02154
Flagellar motor switch protein FliM;
40-230 2.33e-101

Flagellar motor switch protein FliM;


Pssm-ID: 111086  Cd Length: 192  Bit Score: 296.21  E-value: 2.33e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    40 YDFKRALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMME 119
Cdd:pfam02154   1 YDFKRPDRVSKEQLRTLEIIHERFARLMTTSLSNLLRSMVEVSVASVDQMTYGEFIRSIPVPTILNVFRMKPLKGTGLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   120 VNPTIAYTMMDRVMGGIGISHNK-VDSLTEIETKIISNLFENALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETV 198
Cdd:pfam02154  81 VDPSIAFIIVDRLFGGDGRFHAKeGREFTDIERRVIQRMLKRVLENYKEAWSPVVDLEPEYDRSEVNPQFAQIVSPNEIV 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 16078694   199 VVISLNTQIGEISGVINLCIPHIVLEPLIPKL 230
Cdd:pfam02154 161 VLVSLEIEIGERGGMMNLCLPYITIEPIRSKL 192
FliM cd17908
flagellar protein FliM; This family contains bacterial flagellar protein FliM which is ...
 50-229 3.83e-75

flagellar protein FliM; This family contains bacterial flagellar protein FliM which is localized in the flagellar switch complex along with FliG and FliY; all are present in many copies, and together they correspond structurally to the C-ring of the flagellar basal body. FliM does not contain the CheC consensus sequence of the phosphatase active site ([DS]xxxExxNx(22)P) and is not a CheY-P phosphatase. FliM sits in the center of the rotor with the N-terminal region interacting with the signaling protein, phosphorylated CheY (CheY-P). The activated form of CheY destabilizes the parallel arrangement of FliM molecules, and perturbs FliG alignment in a process that may reflect the onset of rotation switching. This suggests a model of C-ring assembly in which intermolecular contacts among FliG domains provide a template for FliM assembly. Recent data show that binding of FliM to spermine synthase, SpeE, contributes to flagellar motility, an association that is unique to Helicobacter species.


Pssm-ID: 381736  Cd Length: 181  Bit Score: 228.94  E-value: 3.83e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  50 KDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMM 129
Cdd:cd17908   1 REQLRTLEVIHERFARLLSTSLSALLRTPVEVSLESVEQLTYGEFLASLPNPTSLAVFSLEPLKGRALLEIDPSLVFALV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 130 DRVMGGIGISHNKVD-SLTEIETKIISNLFENALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIG 208
Cdd:cd17908  81 DRLLGGSGEAPKIEGrEFTEIELRLLRRLLERLLEDLEEAWSPVLPLEFELERIETNPQFAQIAPPNEPVVVVTFEVKIG 160

                       170       180
                ....*....|....*....|.
gi 16078694 209 EISGVINLCIPHIVLEPLIPK 229
Cdd:cd17908 161 EREGTINLCIPYSALEPILEK 181
fliM PRK12795
flagellar motor switch protein FliM; Reviewed
 2-320 9.86e-22

flagellar motor switch protein FliM; Reviewed


Pssm-ID: 237208 [Multi-domain]  Cd Length: 388  Bit Score: 94.75  E-value: 9.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694    2 SGEVLSQNEIDALLsAISTGEMDAEELKKEEKEKKVKVYDFKRalrfskdqIRSLTRIHDNFARLLTThfsaQLRTY--- 78
Cdd:PRK12795  54 SERVLNQDEIDSLL-GFSLGEDSADDRSGIRAIIDSALVSYER--------LPMLEIVFDRLVRLLTT----SLRNFtsd 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   79 -IHISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGI-GISHNKVDS--LTEIETKII 154
Cdd:PRK12795 121 nVEVSLDNITSVRFGDYLNSIPLPALLAVFKAEEWDNYGLLTVDSSLIYSIVDVLLGGRrGTAAMRIEGrpYTTIERNLV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  155 SNLFENALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPlIPKLSVHY 234
Cdd:PRK12795 201 ERLVEVVLADLETAFRPLSPVTFTIDRLETNPRFAAIARPANAAILVRLRIDMEDRGGRIELLLPYATLEP-IRDLLLQM 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  235 WMQSDRNEPKPEETKsLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNR 314
Cdd:PRK12795 280 FMGEKFGRDSIWEGH-LATEIWQTDVEVDAVLDEQTLPLKRVLNLKVGDTLMLDARPDALVTLRCGDVPLTEGRMGRVGD 358


                 ....*.
gi 16078694  315 KQAVQI 320
Cdd:PRK12795 359 RVAVRV 364
FliMN_C pfam01052
Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal ...
 260-322 1.52e-19

Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, pfam02154 and family FliN_N pfam16973.


Pssm-ID: 460043 [Multi-domain]  Cd Length: 66  Bit Score: 80.85  E-value: 1.52e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16078694   260 IPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILD 322
Cdd:pfam01052   1 VELSAELGRTTLTLRELLNLKVGDVIPLDKPADEPVDVLVNGKPKFRGELGVVGGNLAVRITE 63
CheC_CheX_FliY cd16353
CheC/CheX/FliY (CXY) family phosphatases; The CXY family includes CheY-P-hydrolyzing proteins ...
 58-219 2.27e-17

CheC/CheX/FliY (CXY) family phosphatases; The CXY family includes CheY-P-hydrolyzing proteins that function in bacterial chemotaxis, which involves cellular processes that control the movement of organisms toward favorable environments via rotating flagella, which in turn determines the sense of rotation by the intracellular response regulator CheY. When phosphorylated, CheY-P interacts directly with the flagellar motor, and this signal is terminated by the CXY family of phosphatases (Escherichia coli uses CheZ). CheC acts as a weak CheY-P phosphatase but increases activity in the presence of CheD. Bacillus subtilis has only CheC and FliY while many systems also have CheX. CheC and CheX appear to be primarily involved in restoring normal CheY-P levels, whereas FliY seems to act on CheY-P constitutively. Unlike CheC and CheX, FliY is localized in the flagellar switch complex, which also contains the stator-coupling protein FliG and the target of CheY-P, FliM. CheC, CheX, and FliY phosphatases share a consensus sequence ([DS]xxxExxNx(22)P) with four conserved residues thought to form the phosphatase active site. CheC class I and FliY each have two active sites, while CheC class II and III, and CheX have only one. This family also includes FliM, a component of the flagellar switch complex and a target of CheY, which lacks the phosphatase active site consensus sequence, and is not a CheY phosphatase.


Pssm-ID: 381732 [Multi-domain]  Cd Length: 162  Bit Score: 77.93  E-value: 2.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  58 RIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRS--IPNMTILNLFDVHpMEGRIMMEVNPTIAYTMMDRVMGG 135
Cdd:cd16353   2 EIGNIFGGAAATTLSGRLRTGIEPEVGSPDQVKYEEVIRDvmIPSVVVVVGITGG-IEGSAILEMRKDLAYKVLDI*MGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 136 IGISHNKvdsLTEIETKIISNLFENALGNYKEAWQSIA-DIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVI 214
Cdd:cd16353  81 PGEPNRP---LDEIELSAVGEEGNNMLGLLAQALSDFGqTFDISPPNVEIGPQFVIIDNPEEIVLLVPFSVSWEEFTSFF 157


                ....*
gi 16078694 215 NLCIP 219
Cdd:cd16353 158 YVCWS 162
FliN COG1886
Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular ...
 241-322 2.77e-08

Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441490 [Multi-domain]  Cd Length: 172  Bit Score: 52.70  E-value: 2.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694 241 NEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQI 320
Cdd:COG1886  88 DAPEAEEEPENLDLLLDVPVEVTVELGRTRLTLRELLKLGPGSVIELDRLAGEPVDILVNGRLIARGEVVVVDDRFGVRI 167


                ..
gi 16078694 321 LD 322
Cdd:COG1886 168 TE 169
fliN TIGR02480
flagellar motor switch protein FliN; Proteins that consist largely of the domain described by ...
 255-322 2.81e-07

flagellar motor switch protein FliN; Proteins that consist largely of the domain described by this model for this protein family can be designated flagellar motor switch protein FliN. Longer proteins in which this region is a C-terminal domain typically are designated FliY. More distantly related sequences, outside the scope of this family, are associated with type III secretion and include the surface presentation of antigens protein SpaO required or invasion of host cells by Salmonella enterica. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 131533 [Multi-domain]  Cd Length: 77  Bit Score: 47.21  E-value: 2.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16078694   255 IMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILD 322
Cdd:TIGR02480   5 ILDIPVELTVELGRTRITLGDLLKLGEGSVIELDKLAGEPLDILVNGRLIARGEVVVVEDKFGIRITE 72
PRK08432 PRK08432
flagellar motor switch protein FliY; Validated
 112-322 7.01e-05

flagellar motor switch protein FliY; Validated


Pssm-ID: 236264 [Multi-domain]  Cd Length: 283  Bit Score: 43.85  E-value: 7.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  112 MEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETK-IISNLF---ENALGNYKEAwqsiadiePEMtEFEV-NP 186
Cdd:PRK08432  55 ENGKIELLAPVVLVTALSDLMLGGEGISKEEMDDDDLDAAKeIASNIFgaiSTSLGAQKLL--------PKL-NFTIeNV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  187 QFVQ-MVSPNETVVVISLNTQIGEISGVINLCIPHIVLEPLIPKlsvHYWMQSDRNEPKPEETK-------SLEKR---- 254
Cdd:PRK08432 126 EFVDeNPDLSDYAKLFLFSFKIEDIKSQIILLMDEAFENIFEKK---PKEEGEETTDSASEEIKthkaslsNEEIKninm 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16078694  255 IMTAQIPVVAELGTSELTIEEFLSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILD 322
Cdd:PRK08432 203 ILDVKLPVRVRIGQKKMLLKDVLSMDIGSVVELNQLANDPLEILVDDKVIAKGEVVIVDGNFGIQITE 270
PRK06782 PRK06782
flagellar motor switch protein; Reviewed
 68-320 2.50e-04

flagellar motor switch protein; Reviewed


Pssm-ID: 235861 [Multi-domain]  Cd Length: 528  Bit Score: 42.52  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694   68 TTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMTILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDsLT 147
Cdd:PRK06782 245 STVLSTLLNQPVSISTPNVEAINVRHYDGVEVPFVILNVDFVEGLKNENVFVFTKDVALIMADLMMMGTGEVDEEKE-LT 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  148 EIETKIISNLFENALGN----YKEAWQSIADIEPEMTEF-EVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCIPHI- 221
Cdd:PRK06782 324 ELELSAIKEIMNQMMGHaataMSEMFQEKIDISPPTVKFvTLKEEMLGESIEVDELVQITFNLEVGDLLQTKMYQILPIs 403

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16078694  222 -----------VLEPLIPKLSVHYWMQSDRNEP--KPEETKSLEKR----IMTA---QIPVVAE--LGTSELTIEEFLSL 279
Cdd:PRK06782 404 eakemvrlllyPMVKEEEEIATEEIEPEKVVEPvvQPIEFKEVKQMepvyMDTSilqDVPMNVKvvFGSTKKTIQDILSL 483

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 16078694  280 EVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQI 320
Cdd:PRK06782 484 QENEVVVLDEDIDEPIRIYVNGVLVAYGELVNVDGFFGVKV 524
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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