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Conserved domains on  [gi|16306487|ref|NP_387450|]
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cadherin-7 isoform 1 preproprotein [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-258 5.46e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 5.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 157 PYTAGVPEMSPVGTSVVQVTATDADDptyGNSARVVYSILQGQP--YFSVEPKTGVIKTALPnMDREAKDQYLLVIQAKD 234
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16306487 235 MVGQngGLSGTTSVTVTLTDVNDN 258
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 382-478 9.79e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 9.79e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 382 YPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYSIDRNTDlERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNP 460
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 16306487 461 SQVGRGYVAITILDINDN 478
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 718-777 2.27e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 99.53  E-value: 2.27e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   718 ADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-373 5.02e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 5.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 266 SYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKIsvDKETqeGIITIQKELDFEAKTSYTLRIEAAN 345
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 16306487 346 KDADPRflslgpfSDTTTVKIIVEDVDE 373
Cdd:cd11304  77 GGGPPL-------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 486-584 1.45e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 1.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 486 YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYfSLTTDATNNHnFSLkdnKDNTASILTRRnGFRRQEQSVYYLPIFIV 565
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY-SIVSGNEDGL-FSI---DPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                        90
                ....*....|....*....
gi 16306487 566 DSGSPSLSSTNTLTIRVCD 584
Cdd:cd11304  76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-151 8.19e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 8.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487     73 SDVDKGD-GSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRlTNKPVEPESEFVIKIQDINDNEP 151
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG-GGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-258 5.46e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 5.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 157 PYTAGVPEMSPVGTSVVQVTATDADDptyGNSARVVYSILQGQP--YFSVEPKTGVIKTALPnMDREAKDQYLLVIQAKD 234
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16306487 235 MVGQngGLSGTTSVTVTLTDVNDN 258
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 382-478 9.79e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 9.79e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 382 YPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYSIDRNTDlERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNP 460
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 16306487 461 SQVGRGYVAITILDINDN 478
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 718-777 2.27e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 99.53  E-value: 2.27e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   718 ADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-373 5.02e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 5.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 266 SYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKIsvDKETqeGIITIQKELDFEAKTSYTLRIEAAN 345
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 16306487 346 KDADPRflslgpfSDTTTVKIIVEDVDE 373
Cdd:cd11304  77 GGGPPL-------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 401-480 5.34e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 5.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    401 AHDPDS-SNSPVRYSIDRNTDlERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNA 479
Cdd:smart00112   2 ATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 16306487    480 P 480
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 176-260 7.23e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 7.23e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    176 TATDADDptyGNSARVVYSILQG--QPYFSVEPKTGVIKTALPnMDREAKDQYLLVIQAKDMVGQNggLSGTTSVTVTLT 253
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITVL 74


                   ....*..
gi 16306487    254 DVNDNPP 260
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
158-253 4.46e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 4.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   158 YTAGVPEMSPVGTSVVQVTATDADDPTygnSARVVYSILQGQPY--FSVEPKTGVIKTALPnMDREAKDQYLLVIQAKDM 235
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 16306487   236 VGQngGLSGTTSVTVTLT 253
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
382-473 6.65e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 6.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   382 YPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYSIdRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNP 460
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 16306487   461 SQVGRGYVAITIL 473
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 486-584 1.45e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 1.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 486 YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYfSLTTDATNNHnFSLkdnKDNTASILTRRnGFRRQEQSVYYLPIFIV 565
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY-SIVSGNEDGL-FSI---DPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                        90
                ....*....|....*....
gi 16306487 566 DSGSPSLSSTNTLTIRVCD 584
Cdd:cd11304  76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-151 8.19e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 8.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487     73 SDVDKGD-GSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRlTNKPVEPESEFVIKIQDINDNEP 151
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG-GGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-375 1.15e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 1.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    285 KAADADIGANAEMEYKIVDGDGLGIFKIsvDKETqeGIITIQKELDFEAKTSYTLRIEAANKDADPRflslgpfSDTTTV 364
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATV 69

                           90
                   ....*....|..
gi 16306487    365 KIIVEDV-DEPP 375
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 68-149 4.40e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 4.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487  68 VGKLH-SDVDKGD-GSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNkPVEPESEFVIKIQD 145
Cdd:cd11304  16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTATVTITVLD 94


                ....
gi 16306487 146 INDN 149
Cdd:cd11304  95 VNDN 98
Cadherin pfam00028
Cadherin domain;
267-369 4.07e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   267 YQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKIsvDKETqeGIITIQKELDFEAKTSYTLRIEAANK 346
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI--DPDT--GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 16306487   347 DADPRflslgpfSDTTTVKIIVE 369
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
486-583 4.33e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   486 YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDAtnNHNFSLkdNKDnTASILTRRNgFRRQEQSVYYLPIFIV 565
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRI--DPD-TGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 16306487   566 DSGSPSLSSTNTLTIRVC 583
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
74-144 3.46e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 3.46e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16306487    74 DVDKGD-GSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTnKPVEPESEFVIKIQ 144
Cdd:pfam00028  22 DPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 504-586 4.79e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 4.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    504 SAVDKDEPSNGhQFYFSLTTDATNNHnFSLKDNKDntasILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVC 583
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDGL-FSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 16306487    584 DCD 586
Cdd:smart00112  75 DVN 77
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-258 5.46e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 5.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 157 PYTAGVPEMSPVGTSVVQVTATDADDptyGNSARVVYSILQGQP--YFSVEPKTGVIKTALPnMDREAKDQYLLVIQAKD 234
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16306487 235 MVGQngGLSGTTSVTVTLTDVNDN 258
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 382-478 9.79e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 9.79e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 382 YPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYSIDRNTDlERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNP 460
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 16306487 461 SQVGRGYVAITILDINDN 478
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 718-777 2.27e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 99.53  E-value: 2.27e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   718 ADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYG 777
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-373 5.02e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 5.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 266 SYQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKIsvDKETqeGIITIQKELDFEAKTSYTLRIEAAN 345
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 16306487 346 KDADPRflslgpfSDTTTVKIIVEDVDE 373
Cdd:cd11304  77 GGGPPL-------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 401-480 5.34e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 5.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    401 AHDPDS-SNSPVRYSIDRNTDlERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNA 479
Cdd:smart00112   2 ATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 16306487    480 P 480
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 176-260 7.23e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 7.23e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    176 TATDADDptyGNSARVVYSILQG--QPYFSVEPKTGVIKTALPnMDREAKDQYLLVIQAKDMVGQNggLSGTTSVTVTLT 253
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITVL 74


                   ....*..
gi 16306487    254 DVNDNPP 260
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
158-253 4.46e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 4.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   158 YTAGVPEMSPVGTSVVQVTATDADDPTygnSARVVYSILQGQPY--FSVEPKTGVIKTALPnMDREAKDQYLLVIQAKDM 235
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 16306487   236 VGQngGLSGTTSVTVTLT 253
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
382-473 6.65e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 6.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   382 YPMEVSEATQVGNIIGTVAAHDPDS-SNSPVRYSIdRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNP 460
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 16306487   461 SQVGRGYVAITIL 473
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 486-584 1.45e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 1.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487 486 YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYfSLTTDATNNHnFSLkdnKDNTASILTRRnGFRRQEQSVYYLPIFIV 565
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTY-SIVSGNEDGL-FSI---DPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                        90
                ....*....|....*....
gi 16306487 566 DSGSPSLSSTNTLTIRVCD 584
Cdd:cd11304  76 DGGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-151 8.19e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 8.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487     73 SDVDKGD-GSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRlTNKPVEPESEFVIKIQDINDNEP 151
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG-GGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-375 1.15e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 1.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    285 KAADADIGANAEMEYKIVDGDGLGIFKIsvDKETqeGIITIQKELDFEAKTSYTLRIEAANKDADPRflslgpfSDTTTV 364
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATV 69

                           90
                   ....*....|..
gi 16306487    365 KIIVEDV-DEPP 375
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 68-149 4.40e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 4.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487  68 VGKLH-SDVDKGD-GSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNkPVEPESEFVIKIQD 145
Cdd:cd11304  16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTATVTITVLD 94


                ....
gi 16306487 146 INDN 149
Cdd:cd11304  95 VNDN 98
Cadherin pfam00028
Cadherin domain;
267-369 4.07e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   267 YQYNVPESLPVASVVARIKAADADIGANAEMEYKIVDGDGLGIFKIsvDKETqeGIITIQKELDFEAKTSYTLRIEAANK 346
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI--DPDT--GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 16306487   347 DADPRflslgpfSDTTTVKIIVE 369
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
486-583 4.33e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487   486 YETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDAtnNHNFSLkdNKDnTASILTRRNgFRRQEQSVYYLPIFIV 565
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRI--DPD-TGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 16306487   566 DSGSPSLSSTNTLTIRVC 583
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
74-144 3.46e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 3.46e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16306487    74 DVDKGD-GSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTnKPVEPESEFVIKIQ 144
Cdd:pfam00028  22 DPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 504-586 4.79e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 4.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487    504 SAVDKDEPSNGhQFYFSLTTDATNNHnFSLKDNKDntasILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVC 583
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDGL-FSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 16306487    584 DCD 586
Cdd:smart00112  75 DVN 77
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 63-149 2.99e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.96  E-value: 2.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306487  63 SDPLYVGKLHSDVDKGDGSIKYILS--GEGASSIFIIDENTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPeSEFV 140
Cdd:cd00031  11 SRGSFRVSIPTDLIASSGEIIKISAagKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTS-SVFS 89


                ....*....
gi 16306487 141 IKIQDINDN 149
Cdd:cd00031  90 IEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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