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Conserved domains on  [gi|23618848|ref|NP_291020|]
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protein SYS1 homolog isoform a [Homo sapiens]

Protein Classification

protein SYS1( domain architecture ID 10561183)

protein SYS1 is involved in protein trafficking and may serve as a receptor for ARFRP1

Gene Ontology:  GO:0000139|GO:0005802|GO:0034067|GO:0043001|GO:0006895

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SYS1 pfam09801
Integral membrane protein S linking to the trans Golgi network; Members of this family are ...
 5-148 7.42e-64

Integral membrane protein S linking to the trans Golgi network; Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1). Sys1p is a small integral membrane protein with four predicted transmembrane domains that localizes to the Trans Golgi network TGN in yeast and human cells.


:

Pssm-ID: 370705  Cd Length: 144  Bit Score: 192.07  E-value: 7.42e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618848     5 FRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTCALGLLYF 84
Cdd:pfam09801   1 FRQTVWDPLLILSQIVLLQCFYYLTAGVLFYLTALLAGYSFSLDLIFSWHSLDFDTTSGWLLGLAWLLNSLVGVLFLTLI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23618848    85 IRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPL 148
Cdd:pfam09801  81 VGRSKLCLDFALTIHFIHLIVCWLYTRSFPTSFAWWLLQVISSAIMAVLGEWLCRWRELRDIPF 144
 
Name Accession Description Interval E-value
SYS1 pfam09801
Integral membrane protein S linking to the trans Golgi network; Members of this family are ...
 5-148 7.42e-64

Integral membrane protein S linking to the trans Golgi network; Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1). Sys1p is a small integral membrane protein with four predicted transmembrane domains that localizes to the Trans Golgi network TGN in yeast and human cells.


Pssm-ID: 370705  Cd Length: 144  Bit Score: 192.07  E-value: 7.42e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618848     5 FRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTCALGLLYF 84
Cdd:pfam09801   1 FRQTVWDPLLILSQIVLLQCFYYLTAGVLFYLTALLAGYSFSLDLIFSWHSLDFDTTSGWLLGLAWLLNSLVGVLFLTLI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23618848    85 IRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPL 148
Cdd:pfam09801  81 VGRSKLCLDFALTIHFIHLIVCWLYTRSFPTSFAWWLLQVISSAIMAVLGEWLCRWRELRDIPF 144
 
Name Accession Description Interval E-value
SYS1 pfam09801
Integral membrane protein S linking to the trans Golgi network; Members of this family are ...
 5-148 7.42e-64

Integral membrane protein S linking to the trans Golgi network; Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1). Sys1p is a small integral membrane protein with four predicted transmembrane domains that localizes to the Trans Golgi network TGN in yeast and human cells.


Pssm-ID: 370705  Cd Length: 144  Bit Score: 192.07  E-value: 7.42e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618848     5 FRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALTCALGLLYF 84
Cdd:pfam09801   1 FRQTVWDPLLILSQIVLLQCFYYLTAGVLFYLTALLAGYSFSLDLIFSWHSLDFDTTSGWLLGLAWLLNSLVGVLFLTLI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23618848    85 IRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPL 148
Cdd:pfam09801  81 VGRSKLCLDFALTIHFIHLIVCWLYTRSFPTSFAWWLLQVISSAIMAVLGEWLCRWRELRDIPF 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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