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Conserved domains on  [gi|15812201|ref|NP_258441|]
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F-box only protein 9 isoform 2 [Homo sapiens]

Protein Classification

F-box only protein 9( domain architecture ID 17802991)

F-box only protein 9 (FBXO9) is the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling

CATH:  1.20.1280.50
Gene Symbol:  FBXO9
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  27197753|31898225|11178263|35025031
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 176-229 2.10e-27

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438861  Cd Length: 53  Bit Score: 103.46  E-value: 2.10e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15812201 176 IHISVLPMEVLMYIFRWVVSsDLDLRSLEQLSLVCRGFYICARDPEIWRLACLK 229
Cdd:cd22089   1 THISALPSEILLYILRWVVS-DLDLRSLEQLSLVCRKFYLLARDPSIWRLACER 53
FBO_C super family cl44705
F-box only protein C-terminal region; This entry represents the C-terminal region of several ...
 243-335 6.32e-25

F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.


The actual alignment was detected with superfamily member pfam19270:

Pssm-ID: 466021  Cd Length: 211  Bit Score: 101.62  E-value: 6.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812201   243 SWREMFLERPRVRFDGVYISKTTYIRQGeqsldgfYRAW------HQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRT 316
Cdd:pfam19270  11 SWRKMFLERPRLRTDGLYVSRNTYIRAG-------VAEWtvtnpvHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKSMNF 83

                          90       100
                  ....*....|....*....|
gi 15812201   317 RNTRTDA-ILLGHYRLSQDT 335
Cdd:pfam19270  84 RASKADQcVFSGRYTLTGDR 103
MIT super family cl45962
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 82-113 8.04e-03

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


The actual alignment was detected with superfamily member pfam04212:

Pssm-ID: 461228  Cd Length: 66  Bit Score: 34.82  E-value: 8.04e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15812201    82 EKARELFLKAVEEEQNGALYEAIKFYRRAMQL 113
Cdd:pfam04212   2 SKALELVKKAVEEDNAGNYEEALELYKEALDY 33
 
Name Accession Description Interval E-value
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 176-229 2.10e-27

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 103.46  E-value: 2.10e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15812201 176 IHISVLPMEVLMYIFRWVVSsDLDLRSLEQLSLVCRGFYICARDPEIWRLACLK 229
Cdd:cd22089   1 THISALPSEILLYILRWVVS-DLDLRSLEQLSLVCRKFYLLARDPSIWRLACER 53
FBO_C pfam19270
F-box only protein C-terminal region; This entry represents the C-terminal region of several ...
 243-335 6.32e-25

F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.


Pssm-ID: 466021  Cd Length: 211  Bit Score: 101.62  E-value: 6.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812201   243 SWREMFLERPRVRFDGVYISKTTYIRQGeqsldgfYRAW------HQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRT 316
Cdd:pfam19270  11 SWRKMFLERPRLRTDGLYVSRNTYIRAG-------VAEWtvtnpvHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKSMNF 83

                          90       100
                  ....*....|....*....|
gi 15812201   317 RNTRTDA-ILLGHYRLSQDT 335
Cdd:pfam19270  84 RASKADQcVFSGRYTLTGDR 103
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 178-224 2.96e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 2.96e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 15812201   178 ISVLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWR 224
Cdd:pfam12937   1 LSSLPDEILLQIFSY-----LDPKDLLRLALVCRRWRELASDDSLWR 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
181-224 5.59e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 34.72  E-value: 5.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 15812201    181 LPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWR 224
Cdd:smart00256   1 LPDEILEEILSK-----LDPKDLLRLRKVSRKWRSLIDSHDFWF 39
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 82-113 8.04e-03

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 34.82  E-value: 8.04e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15812201    82 EKARELFLKAVEEEQNGALYEAIKFYRRAMQL 113
Cdd:pfam04212   2 SKALELVKKAVEEDNAGNYEEALELYKEALDY 33
 
Name Accession Description Interval E-value
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 176-229 2.10e-27

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 103.46  E-value: 2.10e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15812201 176 IHISVLPMEVLMYIFRWVVSsDLDLRSLEQLSLVCRGFYICARDPEIWRLACLK 229
Cdd:cd22089   1 THISALPSEILLYILRWVVS-DLDLRSLEQLSLVCRKFYLLARDPSIWRLACER 53
FBO_C pfam19270
F-box only protein C-terminal region; This entry represents the C-terminal region of several ...
 243-335 6.32e-25

F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.


Pssm-ID: 466021  Cd Length: 211  Bit Score: 101.62  E-value: 6.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812201   243 SWREMFLERPRVRFDGVYISKTTYIRQGeqsldgfYRAW------HQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRT 316
Cdd:pfam19270  11 SWRKMFLERPRLRTDGLYVSRNTYIRAG-------VAEWtvtnpvHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKSMNF 83

                          90       100
                  ....*....|....*....|
gi 15812201   317 RNTRTDA-ILLGHYRLSQDT 335
Cdd:pfam19270  84 RASKADQcVFSGRYTLTGDR 103
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 178-224 2.96e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 2.96e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 15812201   178 ISVLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWR 224
Cdd:pfam12937   1 LSSLPDEILLQIFSY-----LDPKDLLRLALVCRRWRELASDDSLWR 42
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 180-227 3.91e-07

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 46.52  E-value: 3.91e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 15812201 180 VLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWRLAC 227
Cdd:cd22087   3 ALPPEIKLRILSL-----LDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
 178-224 5.30e-07

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 46.09  E-value: 5.30e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15812201 178 ISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWR 224
Cdd:cd22119   1 GQRLPPEILVKIFQFAVATEGAVPLLCRLSRVCRLWREVALDPSLWT 47
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 178-225 1.64e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.76  E-value: 1.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 15812201   178 ISVLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWRL 225
Cdd:pfam00646   1 LLDLPDDLLLEILSR-----LDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 178-224 3.24e-05

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 41.07  E-value: 3.24e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15812201 178 ISVLPMEVLMYIFrwvvsSDLDLRSLEQLSLVCRGFYICARDPEIWR 224
Cdd:cd22117   1 FDLLPYELIQLIL-----SYLDLPSLCRLSQTCKLFRKHCYDPLLWK 42
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 178-227 3.25e-05

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 41.15  E-value: 3.25e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15812201 178 ISVLPMEVLMYIFrwvvsSDLDLRSLEQLSLVCRGFY-ICARDPEIWRLAC 227
Cdd:cd22113   1 IELLPPEMSLRIF-----SQLDVQSLCRASQTCKTWNdLIENSDYLWRPHC 46
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 179-218 9.22e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 39.35  E-value: 9.22e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15812201 179 SVLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICAR 218
Cdd:cd09917   1 SDLPDEILLKILSY-----LDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 178-224 1.10e-04

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 39.54  E-value: 1.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15812201 178 ISVLPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWR 224
Cdd:cd22093   1 IERLPSEILLKILSY-----LDASSLLCISCVNKLFYQLANDNALWR 42
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 181-231 1.38e-04

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 39.16  E-value: 1.38e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 15812201 181 LPMEVLMYIFrwvvsSDLDLRSLEQLSLVCRGFY-ICARDPeIWRLACLKVW 231
Cdd:cd22084   4 LPSDPLLNIL-----SFLDYRDLISCSQVCRRLNqLCSHDP-LWKRLCKKYW 49
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 178-227 2.64e-04

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 38.45  E-value: 2.64e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 15812201 178 ISVLPMEVLMYIFrwvvsSDLDLRSLEQLSLVCRGFYICARDPEIWRLAC 227
Cdd:cd22147   2 LSALPVELSLKIL-----SYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 181-227 2.82e-04

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 38.38  E-value: 2.82e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15812201 181 LPMEVLMYIFrwvvsSDLDLRSLEQLSLVCRGFYICARDPEIWRLAC 227
Cdd:cd22139   4 LPDELWLHIF-----SFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45
F-box_FBXW9 cd22135
F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, ...
 181-225 1.86e-03

F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438907  Cd Length: 45  Bit Score: 36.10  E-value: 1.86e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15812201 181 LPMEVLMYIFrwvvsSDLDLRS-LEQLSLVCRGFYICARDPEIWRL 225
Cdd:cd22135   4 LPPELLLHIC-----SYLDARFvLHVLPLVCKTFRDILSDETTWRI 44
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 177-222 2.71e-03

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 35.71  E-value: 2.71e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15812201 177 HISVLPMEVLMYIFRWVVSSDLdlrsLEQLSLVCRGFYICARDPEI 222
Cdd:cd22095   1 HIQQLPEELLRNIFAFLPAEDL----YQNISLVCRHWRDIVSDPLF 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
181-224 5.59e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 34.72  E-value: 5.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 15812201    181 LPMEVLMYIFRWvvssdLDLRSLEQLSLVCRGFYICARDPEIWR 224
Cdd:smart00256   1 LPDEILEEILSK-----LDPKDLLRLRKVSRKWRSLIDSHDFWF 39
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 82-113 8.04e-03

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 34.82  E-value: 8.04e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15812201    82 EKARELFLKAVEEEQNGALYEAIKFYRRAMQL 113
Cdd:pfam04212   2 SKALELVKKAVEEDNAGNYEEALELYKEALDY 33
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
 181-225 9.29e-03

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438868  Cd Length: 48  Bit Score: 34.20  E-value: 9.29e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15812201 181 LPMEVLMYIFRwvvSSDLDLRSLEQLSLVCRGFYICARDPEIWRL 225
Cdd:cd22096   4 LPDELLEYILC---SDNLDHHDIIRLSCTCRRLREVCQSGKVWRE 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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