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Conserved domains on  [gi|15599443|ref|NP_252937|]
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50S ribosomal protein L18 [Pseudomonas aeruginosa PAO1]

Protein Classification

50S ribosomal protein L18( domain architecture ID 17565799)

50S ribosomal protein L18 is part of the 5S rRNA/L5/L18/L25 subcomplex; it contacts 5S and 23S rRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 21-116 9.20e-54

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


:

Pssm-ID: 440026  Cd Length: 119  Bit Score: 163.73  E-value: 9.20e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443  21 ELETVRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRE--GATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKY 98
Cdd:COG0256  22 TSERPRLVVFRSNKHIYAQIIDDTGGKTLASASTLEKELRKklGSGGNTEAAYLVGKLIAERAKAKGIEEVVFDRGGYLY 101

                        90
                ....*....|....*...
gi 15599443  99 HGRVKALADAAREGGLEF 116
Cdd:COG0256 102 HGRVKALADGAREAGLKF 119
 
Name Accession Description Interval E-value
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 21-116 9.20e-54

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440026  Cd Length: 119  Bit Score: 163.73  E-value: 9.20e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443  21 ELETVRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRE--GATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKY 98
Cdd:COG0256  22 TSERPRLVVFRSNKHIYAQIIDDTGGKTLASASTLEKELRKklGSGGNTEAAYLVGKLIAERAKAKGIEEVVFDRGGYLY 101

                        90
                ....*....|....*...
gi 15599443  99 HGRVKALADAAREGGLEF 116
Cdd:COG0256 102 HGRVKALADGAREAGLKF 119
Ribosomal_L18p pfam00861
Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large ...
 23-116 7.52e-44

Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large subunit ribosomal proteins from bacteria, archaea, the mitochondria and the chloroplast. It does not include the 60S L18 or L5 proteins from Metazoa.


Pssm-ID: 395691  Cd Length: 116  Bit Score: 138.65  E-value: 7.52e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443    23 ETVRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLREGATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRV 102
Cdd:pfam00861  23 ERPRLVVFRSNRHIYAQVIDDVKGHTLASASTLEKDLKGLSGGNQDAAKKVGELIAERAKAKGITAVVFDRGGYKYHGRV 102

                          90
                  ....*....|....
gi 15599443   103 KALADAAREGGLEF 116
Cdd:pfam00861 103 AALADAAREAGLNF 116
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
 26-114 5.35e-39

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 126.12  E-value: 5.35e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443  26 RLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRE--GATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVK 103
Cdd:cd00432  13 RLVVRKSNKHIYAQIIDDSGDKTLVSASTLELAIKGvlGSGNNVEAAYLVGRLLAKRALEKGIKKVVFDRGGYRYHGRVK 92

                        90
                ....*....|.
gi 15599443 104 ALADAAREGGL 114
Cdd:cd00432  93 ALAKGAREGGL 103
rpl18 CHL00139
ribosomal protein L18; Validated
 26-116 3.67e-37

ribosomal protein L18; Validated


Pssm-ID: 214373  Cd Length: 109  Bit Score: 121.67  E-value: 3.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443   26 RLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRE--GATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVK 103
Cdd:CHL00139  17 RLSVFRSNKHIYAQIIDDTNGKTLVACSTLEPDVKSslSSTSTCDASKLVGQKLAKKSLKKGITKVVFDRGGKLYHGRIK 96

                         90
                 ....*....|...
gi 15599443  104 ALADAAREGGLEF 116
Cdd:CHL00139  97 ALAEAAREAGLQF 109
L18_bact TIGR00060
ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not ...
 25-116 7.18e-36

ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not detectable under this model. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 272881  Cd Length: 114  Bit Score: 118.39  E-value: 7.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443    25 VRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRegATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVKA 104
Cdd:TIGR00060  25 PRLVVFRSNRHIYAQVIDDVKGVTLASASTLEKKLK--STGNKDAAKKVGKLVAERLKEKGIKDVVFDRGGYKYHGRVAA 102

                          90
                  ....*....|..
gi 15599443   105 LADAAREGGLEF 116
Cdd:TIGR00060 103 LAEAAREAGLNF 114
 
Name Accession Description Interval E-value
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 21-116 9.20e-54

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440026  Cd Length: 119  Bit Score: 163.73  E-value: 9.20e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443  21 ELETVRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRE--GATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKY 98
Cdd:COG0256  22 TSERPRLVVFRSNKHIYAQIIDDTGGKTLASASTLEKELRKklGSGGNTEAAYLVGKLIAERAKAKGIEEVVFDRGGYLY 101

                        90
                ....*....|....*...
gi 15599443  99 HGRVKALADAAREGGLEF 116
Cdd:COG0256 102 HGRVKALADGAREAGLKF 119
Ribosomal_L18p pfam00861
Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large ...
 23-116 7.52e-44

Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large subunit ribosomal proteins from bacteria, archaea, the mitochondria and the chloroplast. It does not include the 60S L18 or L5 proteins from Metazoa.


Pssm-ID: 395691  Cd Length: 116  Bit Score: 138.65  E-value: 7.52e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443    23 ETVRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLREGATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRV 102
Cdd:pfam00861  23 ERPRLVVFRSNRHIYAQVIDDVKGHTLASASTLEKDLKGLSGGNQDAAKKVGELIAERAKAKGITAVVFDRGGYKYHGRV 102

                          90
                  ....*....|....
gi 15599443   103 KALADAAREGGLEF 116
Cdd:pfam00861 103 AALADAAREAGLNF 116
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
 26-114 5.35e-39

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 126.12  E-value: 5.35e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443  26 RLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRE--GATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVK 103
Cdd:cd00432  13 RLVVRKSNKHIYAQIIDDSGDKTLVSASTLELAIKGvlGSGNNVEAAYLVGRLLAKRALEKGIKKVVFDRGGYRYHGRVK 92

                        90
                ....*....|.
gi 15599443 104 ALADAAREGGL 114
Cdd:cd00432  93 ALAKGAREGGL 103
rpl18 CHL00139
ribosomal protein L18; Validated
 26-116 3.67e-37

ribosomal protein L18; Validated


Pssm-ID: 214373  Cd Length: 109  Bit Score: 121.67  E-value: 3.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443   26 RLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRE--GATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVK 103
Cdd:CHL00139  17 RLSVFRSNKHIYAQIIDDTNGKTLVACSTLEPDVKSslSSTSTCDASKLVGQKLAKKSLKKGITKVVFDRGGKLYHGRIK 96

                         90
                 ....*....|...
gi 15599443  104 ALADAAREGGLEF 116
Cdd:CHL00139  97 ALAEAAREAGLQF 109
L18_bact TIGR00060
ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not ...
 25-116 7.18e-36

ribosomal protein L18, bacterial type; The archaeal and eukaryotic type rpL18 is not detectable under this model. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 272881  Cd Length: 114  Bit Score: 118.39  E-value: 7.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443    25 VRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLRegATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVKA 104
Cdd:TIGR00060  25 PRLVVFRSNRHIYAQVIDDVKGVTLASASTLEKKLK--STGNKDAAKKVGKLVAERLKEKGIKDVVFDRGGYKYHGRVAA 102

                          90
                  ....*....|..
gi 15599443   105 LADAAREGGLEF 116
Cdd:TIGR00060 103 LAEAAREAGLNF 114
PTZ00032 PTZ00032
60S ribosomal protein L18; Provisional
 26-116 1.01e-15

60S ribosomal protein L18; Provisional


Pssm-ID: 240235  Cd Length: 211  Bit Score: 69.51  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443   26 RLCVYRSSQHIYAQVIAADGGKVLASASTLDKDL-------REGAT-------GNIDAAKKVGQLVAERAKAAGVTQVAF 91
Cdd:PTZ00032 107 RLTLKNTNNQMYATIVDDYTRHVLCFSCTNFKYLshifgtyPTKTTnrvrnngGTIKAAYELGKLIGRKALSKGISKVRF 186

                         90       100
                 ....*....|....*....|....*
gi 15599443   92 DRSGFKYHGRVKALADAAREGGLEF 116
Cdd:PTZ00032 187 DRAHYKYAGKVEALAEGARAVGLQF 211
rpl18p PRK08569
50S ribosomal protein L18P; Reviewed
 26-115 2.51e-07

50S ribosomal protein L18P; Reviewed


Pssm-ID: 236294 [Multi-domain]  Cd Length: 193  Bit Score: 46.85  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15599443   26 RLCVYRSSQHIYAQVIAAD--GGKVLASASTldKDLR----EGATGNIDAAKKVGQLVAERAKAAGVTQVAFD--RSGFK 97
Cdd:PRK08569  34 RLVVRKTNKHVIAQIVKYDpkGDRTLASAHS--RELAkygwKGDTGNTPAAYLTGLLAGKKALKAGVEEAVLDigLHRPT 111

                         90
                 ....*....|....*...
gi 15599443   98 YHGRVKALADAAREGGLE 115
Cdd:PRK08569 112 KGSRVFAALKGAIDAGLE 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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