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Conserved domains on  [gi|15610186|ref|NP_217565|]
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monooxygenase [Mycobacterium tuberculosis H37Rv]

Protein Classification

flavin-containing monooxygenase( domain architecture ID 11449697)

flavin-containing monooxygenase (FMO) catalyses the flavin-dependent oxidation of ketones and cyclic ketones to esters and lactones, by using molecular oxygen and NAD(P)H.

CATH:  3.50.50.60
Gene Ontology:  GO:0016709|GO:0004497|GO:0050660
PubMed:  20015679|33588053

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 17-464 4.61e-170

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 486.68  E-value: 4.61e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  17 NQPPVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWD 96
Cdd:COG2072   1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  97 EILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGREYVAQFLISGAGALHIPSFPEIAGRDEFAGPAFHS 176
Cdd:COG2072  81 EILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 177 AQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPPWVVPRTNeelpvslrralrtVPGLRAllRLGIYWA 256
Cdd:COG2072 161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRPN-------------YDPERG--RPANYLG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 257 QEALAYGMTKRpntlkiIEAYAKYNIRRSVKDRELrRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRIDRITHDGI 336
Cdd:COG2072 226 LEAPPALNRRD------ARAWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGV 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 337 VTADGTgrevFREADVIVYATGFHVTDSYTyvqikgrHGEDLVDRWNREGIGAHRGITVANMPNLFFlLGPNTGLGHNSV 416
Cdd:COG2072 299 VFADGT----EHEVDVIVWATGFRADLPWL-------APLDVRGRDGRSGPRAYLGVVVPGFPNLFF-LGPNSPSGHSSL 366

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 15610186 417 VFMIESQIHYVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSV 464
Cdd:COG2072 367 TLGAERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 17-464 4.61e-170

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 486.68  E-value: 4.61e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  17 NQPPVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWD 96
Cdd:COG2072   1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  97 EILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGREYVAQFLISGAGALHIPSFPEIAGRDEFAGPAFHS 176
Cdd:COG2072  81 EILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 177 AQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPPWVVPRTNeelpvslrralrtVPGLRAllRLGIYWA 256
Cdd:COG2072 161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRPN-------------YDPERG--RPANYLG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 257 QEALAYGMTKRpntlkiIEAYAKYNIRRSVKDRELrRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRIDRITHDGI 336
Cdd:COG2072 226 LEAPPALNRRD------ARAWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGV 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 337 VTADGTgrevFREADVIVYATGFHVTDSYTyvqikgrHGEDLVDRWNREGIGAHRGITVANMPNLFFlLGPNTGLGHNSV 416
Cdd:COG2072 299 VFADGT----EHEVDVIVWATGFRADLPWL-------APLDVRGRDGRSGPRAYLGVVVPGFPNLFF-LGPNSPSGHSSL 366

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 15610186 417 VFMIESQIHYVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSV 464
Cdd:COG2072 367 TLGAERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 24-359 5.39e-16

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 80.59  E-value: 5.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186    24 RAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWR--DNTYPGCACDIPS-------HLYSFSFEPKADWKHLFSY 94
Cdd:pfam00743   3 KVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRftENVEEGRASIYKSvitntskEMSCFSDFPFPEDYPNFMH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186    95 WDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDD---ECRWHVFT-ADGREYVAQF----LISGAGAL-HIP--SFPei 163
Cdd:pfam00743  83 NSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDfstSGQWEVVTeHEGKQESAVFdavmVCTGHHTNpHLPleSFP-- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   164 aGRDEFAGPAFHSAQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPPWVVPRTNEE-LPVSLRRALRTV 242
Cdd:pfam00743 161 -GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHgYPWDMLFSTRFT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   243 PGLRALLRLGIY-WAQEAlayGMTKRPNtlkiieaYAKYNIrrSVKDRELRRKLTpryrigCKRILNSSTYYPAVAdpkt 321
Cdd:pfam00743 240 SFLRNILPTSISnWLMEK---QMNRRFN-------HENYGL--KPKNRALSKEPV------VNDDLPNRILCGAVK---- 297

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 15610186   322 elITDRIDRITHDGIVTADGTgreVFREADVIVYATGF 359
Cdd:pfam00743 298 --VKPNVKEFTETSAIFEDGT---VEEDIDVVIFATGY 330
PRK07233 PRK07233
hypothetical protein; Provisional
 24-67 7.40e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 45.26  E-value: 7.40e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 15610186   24 RAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGG---TWRDNTYP 67
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGlaaSFEFGGLP 47
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 17-464 4.61e-170

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 486.68  E-value: 4.61e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  17 NQPPVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWD 96
Cdd:COG2072   1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  97 EILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGREYVAQFLISGAGALHIPSFPEIAGRDEFAGPAFHS 176
Cdd:COG2072  81 EILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 177 AQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPPWVVPRTNeelpvslrralrtVPGLRAllRLGIYWA 256
Cdd:COG2072 161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRPN-------------YDPERG--RPANYLG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 257 QEALAYGMTKRpntlkiIEAYAKYNIRRSVKDRELrRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRIDRITHDGI 336
Cdd:COG2072 226 LEAPPALNRRD------ARAWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGV 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 337 VTADGTgrevFREADVIVYATGFHVTDSYTyvqikgrHGEDLVDRWNREGIGAHRGITVANMPNLFFlLGPNTGLGHNSV 416
Cdd:COG2072 299 VFADGT----EHEVDVIVWATGFRADLPWL-------APLDVRGRDGRSGPRAYLGVVVPGFPNLFF-LGPNSPSGHSSL 366

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 15610186 417 VFMIESQIHYVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSV 464
Cdd:COG2072 367 TLGAERQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 24-359 5.39e-16

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 80.59  E-value: 5.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186    24 RAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWR--DNTYPGCACDIPS-------HLYSFSFEPKADWKHLFSY 94
Cdd:pfam00743   3 KVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRftENVEEGRASIYKSvitntskEMSCFSDFPFPEDYPNFMH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186    95 WDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDD---ECRWHVFT-ADGREYVAQF----LISGAGAL-HIP--SFPei 163
Cdd:pfam00743  83 NSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDfstSGQWEVVTeHEGKQESAVFdavmVCTGHHTNpHLPleSFP-- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   164 aGRDEFAGPAFHSAQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPPWVVPRTNEE-LPVSLRRALRTV 242
Cdd:pfam00743 161 -GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHgYPWDMLFSTRFT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   243 PGLRALLRLGIY-WAQEAlayGMTKRPNtlkiieaYAKYNIrrSVKDRELRRKLTpryrigCKRILNSSTYYPAVAdpkt 321
Cdd:pfam00743 240 SFLRNILPTSISnWLMEK---QMNRRFN-------HENYGL--KPKNRALSKEPV------VNDDLPNRILCGAVK---- 297

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 15610186   322 elITDRIDRITHDGIVTADGTgreVFREADVIVYATGF 359
Cdd:pfam00743 298 --VKPNVKEFTETSAIFEDGT---VEEDIDVVIFATGY 330
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
27-98 8.25e-13

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 63.32  E-value: 8.25e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15610186    27 IIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPkadwkHLFSYWDEI 98
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVPGYVFDYGAHIFHGSDEP-----NVRDLLDEL 67
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
34-231 2.00e-11

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 64.94  E-value: 2.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186    34 GLGMAIALQKQGV-DFVILEKADdVGGTWR---------DNTYPGCACDIPShLYSFSFEPKADWKHLFSYW--DEILGY 101
Cdd:pfam13738   3 GIGCAIALKKAGLeDYLILEKGN-IGNSFYrypthmtffSPSFTSNGFGIPD-LNAISPGTSPAFTFNREHPsgNEYAEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   102 LKGVTDKYGLRryIEFNSLV------DRGYwdddecrwhVFTADGREYVAQFLISGAGALHIPSFPEiagrdeFAGPAFH 175
Cdd:pfam13738  81 LRRVADHFELP--INLFEEVtsvkkeDDGF---------VVTTSKGTYQARYVIIATGEFDFPNKLG------VPELPKH 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15610186   176 SAQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPP----------WVVPRTNEEL 231
Cdd:pfam13738 144 YSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEwedrdsdpsySLSPDTLNRL 209
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 114-361 3.38e-06

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 49.12  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   114 YIEFNSLVDRGYWD--DDECRWHVFTAD----GREYVAQFLISGAGAlhIPSFPEIAGRDEfagPAFHSAQWDHSID--L 185
Cdd:pfam13434 111 RLRFGQEVESVEPDaeRGEPLLRVRVRDadgeETTFLARNLVLGTGG--EPYIPECARGGE---RVFHSSEYLERIDrlA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   186 TGKRVAIVGTGASAIQIVpeivgqvaeLQLYQRTPP----WVVPR-----------TNE-----------ELPVSLRRAL 239
Cdd:pfam13434 186 AKKRIAVVGSGQSAAEIF---------RDLLRRGPAyeltWVTRSpnffplddspfVNEifspeyvdyfySLPEDTRRAL 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   240 rtVPGLRALLRLGIywaqealaygmtkRPNTLKIIeayakYNI--RRSVkDRELRRKLTPRYRI-GCKRilnsstyypaV 316
Cdd:pfam13434 257 --LREQKGTNYDGI-------------DPSLIEEI-----YRLlyEQRV-DGDPRHRLLPNREVqSAER----------V 305

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 15610186   317 ADPKTELitdridrITHDGIvtadgTGREVFREADVIVYATGFHV 361
Cdd:pfam13434 306 GDGGVEL-------TLRDGE-----QGREETLETDVVVLATGYRR 338
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 22-59 4.05e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 49.06  E-value: 4.05e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15610186  22 RTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGG 59
Cdd:COG1232   1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGG 38
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
23-201 4.27e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 48.58  E-value: 4.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  23 TRAVIIGTGFSGLGMAIALQKQGVDFVILEKaDDVGG----TWRDNTYPGcacdIPshlysfsfepkadwkhlfsywDEI 98
Cdd:COG0492   1 YDVVIIGAGPAGLTAAIYAARAGLKTLVIEG-GEPGGqlatTKEIENYPG----FP---------------------EGI 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  99 LG-----YLKGVTDKYGLRRYIEF-NSLvdrgywDDDECRWHVFTADGREYVAQFLI--SGAGalhiPSFPEIAGRDEFA 170
Cdd:COG0492  55 SGpelaeRLREQAERFGAEILLEEvTSV------DKDDGPFRVTTDDGTEYEAKAVIiaTGAG----PRKLGLPGEEEFE 124

                       170       180       190
                ....*....|....*....|....*....|..
gi 15610186 171 GP-AFHSAQWDHSiDLTGKRVAIVGTGASAIQ 201
Cdd:COG0492 125 GRgVSYCATCDGF-FFRGKDVVVVGGGDSALE 155
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 26-200 4.65e-06

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 48.47  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186    26 VIIGTGFSGLGMAIALQKQGVDFVILEkaddVGGTWrdnTYPGCacdIPSHLYSFSFEPkadwKHLFSYWDEILGYLKGV 105
Cdd:pfam07992   4 VVIGGGPAGLAAALTLAQLGGKVTLIE----DEGTC---PYGGC---VLSKALLGAAEA----PEIASLWADLYKRKEEV 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   106 TDKYGLRryIEFNSLVDRGYWDDDECR---WHVFTADGREYVAQFLI--SGAGAlHIPSFPEIAGRDEFAGPAFHSAQwD 180
Cdd:pfam07992  70 VKKLNNG--IEVLLGTEVVSIDPGAKKvvlEELVDGDGETITYDRLViaTGARP-RLPPIPGVELNVGFLVRTLDSAE-A 145

                         170       180
                  ....*....|....*....|
gi 15610186   181 HSIDLTGKRVAIVGTGASAI 200
Cdd:pfam07992 146 LRLKLLPKRVVVVGGGYIGV 165
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
1-71 3.79e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 46.39  E-value: 3.79e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15610186   1 MSIAdtAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWR--DNTYPGCAC 71
Cdd:COG1148 121 MAVA--KAKLLEPLEPIKVPVNKRALVIGGGIAGMTAALELAEQGYEVYLVEKEPELGGRAAqlHKTFPGLDC 191
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 22-145 5.61e-05

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 45.61  E-value: 5.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  22 RTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGG---TWRdntYPGCACDIPSHLYSfsfepkadwkhLFSYWDEI 98
Cdd:COG1233   3 MYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGrarTFE---RPGFRFDVGPSVLT-----------MPGVLERL 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15610186  99 LGYLkgvtdkyGLRRYIEFNSLvdrgywdddECRWHVFTADGREYVA 145
Cdd:COG1233  69 FREL-------GLEDYLELVPL---------DPAYRVPFPDGRALDL 99
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
22-359 6.19e-05

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 45.33  E-value: 6.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  22 RTRAVIIGTGFSGLGMAIAL---QKQGVDFVILEKADDVG-GTWRDNTYPGCACDIPSHLYSFSFEPKADwkhlFSYW-- 95
Cdd:COG4529   5 RKRIAIIGGGASGTALAIHLlrrAPEPLRITLFEPRPELGrGVAYSTDSPEHLLNVPAGRMSAFPDDPDH----FLRWlr 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186  96 DEILGYLKGVTDK-------YGlrRYIE--FNSLVDRGYWDD--------------DECRWHVFTADGREYVAQFLI--S 150
Cdd:COG4529  81 ENGARAAPAIDPDafvprrlFG--EYLRerLAEALARAPAGVrlrhiraevvdlerDDGGYRVTLADGETLRADAVVlaT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 151 GAGAlhipsfPEIAGRDEFAGPAFHSAQWDHSIDLT---GKRVAIVGTGASAIQIV---------PEIV-----GQVAEL 213
Cdd:COG4529 159 GHPP------PAPPPGLAAGSPRYIADPWPPGALARippDARVLIIGTGLTAIDVVlslaarghrGPITalsrrGLLPRA 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 214 QLYQRTPPWVV--PRTNEELPVSL--RRALRTVPGLRALLR----LGIYWaqEALAYGMtkRPNTLKIIEayakyniRRS 285
Cdd:COG4529 233 HPPGAPLPLKFltPEALEELPLFFaaRTARDLLRALRADLAeaeaGGVDW--RAVIDAL--RPVLQALWA-------ALS 301

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186 286 VKDRE-LRRKLTP-----RYRIG---CKRILNsstyypAVADPKTELITDRIDRIT-HDGIVTADGTGREVFREADVIVY 355
Cdd:COG4529 302 AEERRrFLRHLRPywdvhRHRMPpesAARLLA------LIAAGRLEVLAGRLEDIEaAEGGFVVTGAGDGETLEVDVVIN 375


                ....
gi 15610186 356 ATGF 359
Cdd:COG4529 376 ATGP 379
PRK07233 PRK07233
hypothetical protein; Provisional
 24-67 7.40e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 45.26  E-value: 7.40e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 15610186   24 RAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGG---TWRDNTYP 67
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGlaaSFEFGGLP 47
PRK07208 PRK07208
hypothetical protein; Provisional
 20-99 1.68e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 44.11  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610186   20 PVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWRDNTYPGCACDIPSHLYsFSFEPKA-DWkhlfsyWDEI 98
Cdd:PRK07208   2 TNKKSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGISRTVTYKGNRFDIGGHRF-FSKSPEVmDL------WNEI 74


                 .
gi 15610186   99 L 99
Cdd:PRK07208  75 L 75
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 22-58 4.72e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 42.23  E-value: 4.72e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 15610186  22 RTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVG 58
Cdd:COG0654   3 RTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPR 39
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
22-59 7.54e-04

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 41.79  E-value: 7.54e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15610186  22 RTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGG 59
Cdd:COG3380   3 MPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGG 40
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 24-91 1.72e-03

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 40.84  E-value: 1.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15610186    24 RAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVG-GTWRDNT---YPGCACDIPSHLYSFSFEPKADWKHL 91
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGsGASGRNAgliHPGLRYLEPSELARLALEALDLWEEL 72
PLN02676 PLN02676
polyamine oxidase
 20-68 2.56e-03

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 40.47  E-value: 2.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 15610186   20 PVRTRAVIIGTGFSGLGMAIALQKQGV-DFVILEKADDVGGTWRDNTYPG 68
Cdd:PLN02676  24 KPSPSVIIVGAGMSGISAAKTLSEAGIeDILILEATDRIGGRMRKANFAG 73
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
22-59 2.72e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 40.29  E-value: 2.72e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15610186  22 RTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGG 59
Cdd:COG1231   7 GKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGG 44
PRK08243 PRK08243
4-hydroxybenzoate 3-monooxygenase; Validated
 21-62 2.73e-03

4-hydroxybenzoate 3-monooxygenase; Validated


Pssm-ID: 236198 [Multi-domain]  Cd Length: 392  Bit Score: 40.17  E-value: 2.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 15610186   21 VRTRAVIIGTGFSGLGMAIALQKQGVDFVILEK--ADDVGGTWR 62
Cdd:PRK08243   1 MRTQVAIIGAGPAGLLLGQLLHLAGIDSVVLERrsREYVEGRIR 44
PRK08132 PRK08132
FAD-dependent oxidoreductase; Provisional
 13-58 2.99e-03

FAD-dependent oxidoreductase; Provisional


Pssm-ID: 236158 [Multi-domain]  Cd Length: 547  Bit Score: 40.24  E-value: 2.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 15610186   13 PSPANQPPVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVG 58
Cdd:PRK08132  14 ADQDADDPARHPVVVVGAGPVGLALAIDLAQQGVPVVLLDDDDTLS 59
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 22-63 3.84e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 39.84  E-value: 3.84e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15610186  22 RTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGG---TWRD 63
Cdd:COG3349   3 PPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGGrarSFPD 47
PRK12842 PRK12842
putative succinate dehydrogenase; Reviewed
 26-60 4.22e-03

putative succinate dehydrogenase; Reviewed


Pssm-ID: 237224 [Multi-domain]  Cd Length: 574  Bit Score: 39.68  E-value: 4.22e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 15610186   26 VIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGT 60
Cdd:PRK12842  13 LVIGSGAGGLSAAITARKLGLDVVVLEKEPVFGGT 47
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
21-62 5.14e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 39.12  E-value: 5.14e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15610186  21 VRTRAVIIGTGFSGLGMAIALQKQGVDFVILEkADDVGG--TWR 62
Cdd:COG0665   1 ATADVVVIGGGIAGLSTAYHLARRGLDVTVLE-RGRPGSgaSGR 43
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 24-59 7.38e-03

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 38.68  E-value: 7.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 15610186   24 RAVIIGTGFSGLGMAIALQKQG--VDFVILEKADDVGG 59
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKKGpdADITLLEASDRLGG 39
PRK12844 PRK12844
3-ketosteroid-delta-1-dehydrogenase; Reviewed
 26-60 9.41e-03

3-ketosteroid-delta-1-dehydrogenase; Reviewed


Pssm-ID: 183787 [Multi-domain]  Cd Length: 557  Bit Score: 38.58  E-value: 9.41e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 15610186   26 VIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGT 60
Cdd:PRK12844  10 VVVGSGGGGMCAALAAADSGLEPLIVEKQDKVGGS 44
PRK06847 PRK06847
hypothetical protein; Provisional
 24-62 9.44e-03

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 38.32  E-value: 9.44e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 15610186   24 RAVIIGTGFSGLGMAIALQKQGVDFVILEKADDvggtWR 62
Cdd:PRK06847   6 KVLIVGGGIGGLSAAIALRRAGIAVDLVEIDPE----WR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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