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Conserved domains on  [gi|15607429|ref|NP_214802|]
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ESAT-6-like protein EsxH [Mycobacterium tuberculosis H37Rv]

Protein Classification

WXG100 family type VII secretion target( domain architecture ID 10024144)

WXG100 family type VII secretion target similar to mycobacterial ESAT-6-like protein EsxB, also called CFP-10, which is a secreted protein that acts as a strong host T-cell antigen and is involved in the translocation of bacteria from the host phagolysosome to the host cytoplasm

CATH:  1.10.287.1060
Gene Ontology:  GO:0005576
PubMed:  24586681|11973144

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WXG100_ESAT6 TIGR03930
WXG100 family type VII secretion target; Members of this protein family include secretion ...
 3-92 7.70e-14

WXG100 family type VII secretion target; Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.


:

Pssm-ID: 274862 [Multi-domain]  Cd Length: 90  Bit Score: 61.08  E-value: 7.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607429    3 QIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMA 82
Cdd:TIGR03930  1 QIKVDPEELRQAAARFGKTAQELQQLLQRLRSEIDALQGTWEGAAADAFQAEFQQWDPAAERLINALQEISEALRQAADK 80

                         90
                 ....*....|
gi 15607429   83 MMARDTAEAA 92
Cdd:TIGR03930 81 FEQADQEAAS 90
 
Name Accession Description Interval E-value
WXG100_ESAT6 TIGR03930
WXG100 family type VII secretion target; Members of this protein family include secretion ...
 3-92 7.70e-14

WXG100 family type VII secretion target; Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.


Pssm-ID: 274862 [Multi-domain]  Cd Length: 90  Bit Score: 61.08  E-value: 7.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607429    3 QIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMA 82
Cdd:TIGR03930  1 QIKVDPEELRQAAARFGKTAQELQQLLQRLRSEIDALQGTWEGAAADAFQAEFQQWDPAAERLINALQEISEALRQAADK 80

                         90
                 ....*....|
gi 15607429   83 MMARDTAEAA 92
Cdd:TIGR03930 81 FEQADQEAAS 90
EsxA COG4842
Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];
4-96 1.74e-12

Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];


Pssm-ID: 443870  Cd Length: 93  Bit Score: 57.70  E-value: 1.74e-12
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607429  4 IMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAM 83
Cdd:COG4842  1 IRVDPEALRAAAGRFGAAAGELQALLDDLRSQLAALQSSWEGDAATAFQAAQAQWDQAATKLNQALEDIAQALRQAADAY 80

                       90
               ....*....|...
gi 15607429 84 MARDTAEAAKWGG 96
Cdd:COG4842 81 EEAEQANAALFGG 93
WXG100 pfam06013
Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental ...
 3-87 3.23e-12

Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.


Pssm-ID: 428722  Cd Length: 85  Bit Score: 56.89  E-value: 3.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607429    3 QIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMA 82
Cdd:pfam06013  1 QIKVDPEELRQAAARFQKSAEEIEDELQRLKSTVAALGGGWSGAAADAFQAEFDEWKPAAQKLVDALEEISEALKQAANA 80


                 ....*
gi 15607429   83 MMARD 87
Cdd:pfam06013 81 YEDAD 85
 
Name Accession Description Interval E-value
WXG100_ESAT6 TIGR03930
WXG100 family type VII secretion target; Members of this protein family include secretion ...
 3-92 7.70e-14

WXG100 family type VII secretion target; Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.


Pssm-ID: 274862 [Multi-domain]  Cd Length: 90  Bit Score: 61.08  E-value: 7.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607429    3 QIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMA 82
Cdd:TIGR03930  1 QIKVDPEELRQAAARFGKTAQELQQLLQRLRSEIDALQGTWEGAAADAFQAEFQQWDPAAERLINALQEISEALRQAADK 80

                         90
                 ....*....|
gi 15607429   83 MMARDTAEAA 92
Cdd:TIGR03930 81 FEQADQEAAS 90
EsxA COG4842
Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];
4-96 1.74e-12

Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms];


Pssm-ID: 443870  Cd Length: 93  Bit Score: 57.70  E-value: 1.74e-12
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607429  4 IMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAM 83
Cdd:COG4842  1 IRVDPEALRAAAGRFGAAAGELQALLDDLRSQLAALQSSWEGDAATAFQAAQAQWDQAATKLNQALEDIAQALRQAADAY 80

                       90
               ....*....|...
gi 15607429 84 MARDTAEAAKWGG 96
Cdd:COG4842 81 EEAEQANAALFGG 93
WXG100 pfam06013
Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental ...
 3-87 3.23e-12

Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.


Pssm-ID: 428722  Cd Length: 85  Bit Score: 56.89  E-value: 3.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15607429    3 QIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMA 82
Cdd:pfam06013  1 QIKVDPEELRQAAARFQKSAEEIEDELQRLKSTVAALGGGWSGAAADAFQAEFDEWKPAAQKLVDALEEISEALKQAANA 80


                 ....*
gi 15607429   83 MMARD 87
Cdd:pfam06013 81 YEDAD 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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