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Conserved domains on  [gi|15238665|ref|NP_197288|]
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calcium exchanger 7 [Arabidopsis thaliana]

Protein Classification

cation/calcium exchanger( domain architecture ID 1004073)

cation/calcium exchanger belonging to the Ca(2+):cation antiporter (CaCA) family, such as mitochondrial sodium/calcium exchanger protein, an antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion

Gene Ontology:  GO:0015368|GO:0016020|GO:0070588
PubMed:  23685453
SCOP:  3002205
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN03151 super family cl33648
cation/calcium exchanger; Provisional
30-566 9.17e-173

cation/calcium exchanger; Provisional


The actual alignment was detected with superfamily member PLN03151:

Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 504.30  E-value: 9.17e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   30 FASQTPPPSGSIQTLNSFAGGDSDSCSGgLASLDDHRSKCSYIRSQSKCGPQGYIDYLKIFFCIFGQSPVLGHLVLSAWL 109
Cdd:PLN03151  69 RLSDIDVNSSYFSDNSSLSGDSPVLCSG-LHEHEGYADQCEFLKAHPICSSGGFFDYLKFFYCSCEDFRILGYAVLGVWL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  110 FVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNGDFGLNSILGGAFFVSSFVVG 189
Cdd:PLN03151 148 VALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVG 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  190 TICVLIGSRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGKVTIWVALCYLSIYLLYVGFLSVSHFFDRKKR--------- 260
Cdd:PLN03151 228 IVSLCVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARrlkldvvtp 307
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  261 ---MSDQIL-RSREDLAEMGVSLLGYIAEEKLA-----LPE---------KTTQEFKIVFEDSPK-------------RH 309
Cdd:PLN03151 308 llpVQGSIFsPSVEEDESMYSPLLESDTESDVPrlqtsLPQwmwasnvaiYSNHFAKGSVHDEERppwgwtdegaeveSS 387
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  310 RSCFSVLVSIIGLPLYLPRRLTIPVVCEEKWSKPCAVVSTAIAPVLLTELYCSHYS-GSQRNLILYIISGSIGLIVGILA 388
Cdd:PLN03151 388 LFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSKTYAVASASLAPVLLAFLWSSQDDvSLQARIAAYFIGVAIGSTLGFLA 467
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  389 YLTTEKSHPPKKFSLVWLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGn 468
Cdd:PLN03151 468 YKYTEPDRPPRRFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGG- 546
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  469 DGAQIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLL 548
Cdd:PLN03151 547 DGVQIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLI 626
                        570
                 ....*....|....*...
gi 15238665  549 AIYLCFLSLRLARVFGVL 566
Cdd:PLN03151 627 ALYLIFLTFRVSTAMGFI 644
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
30-566 9.17e-173

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 504.30  E-value: 9.17e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   30 FASQTPPPSGSIQTLNSFAGGDSDSCSGgLASLDDHRSKCSYIRSQSKCGPQGYIDYLKIFFCIFGQSPVLGHLVLSAWL 109
Cdd:PLN03151  69 RLSDIDVNSSYFSDNSSLSGDSPVLCSG-LHEHEGYADQCEFLKAHPICSSGGFFDYLKFFYCSCEDFRILGYAVLGVWL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  110 FVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNGDFGLNSILGGAFFVSSFVVG 189
Cdd:PLN03151 148 VALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVG 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  190 TICVLIGSRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGKVTIWVALCYLSIYLLYVGFLSVSHFFDRKKR--------- 260
Cdd:PLN03151 228 IVSLCVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARrlkldvvtp 307
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  261 ---MSDQIL-RSREDLAEMGVSLLGYIAEEKLA-----LPE---------KTTQEFKIVFEDSPK-------------RH 309
Cdd:PLN03151 308 llpVQGSIFsPSVEEDESMYSPLLESDTESDVPrlqtsLPQwmwasnvaiYSNHFAKGSVHDEERppwgwtdegaeveSS 387
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  310 RSCFSVLVSIIGLPLYLPRRLTIPVVCEEKWSKPCAVVSTAIAPVLLTELYCSHYS-GSQRNLILYIISGSIGLIVGILA 388
Cdd:PLN03151 388 LFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSKTYAVASASLAPVLLAFLWSSQDDvSLQARIAAYFIGVAIGSTLGFLA 467
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  389 YLTTEKSHPPKKFSLVWLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGn 468
Cdd:PLN03151 468 YKYTEPDRPPRRFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGG- 546
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  469 DGAQIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLL 548
Cdd:PLN03151 547 DGVQIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLI 626
                        570
                 ....*....|....*...
gi 15238665  549 AIYLCFLSLRLARVFGVL 566
Cdd:PLN03151 627 ALYLIFLTFRVSTAMGFI 644
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
405-559 2.52e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 87.66  E-value: 2.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   405 WLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLF 484
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPD---LALGNVIGSNIF 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238665   485 NTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVImpkkKMRLDKLVGGGLLAIYLCFLSLRL 559
Cdd:pfam01699  78 NILLVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLVLLLLYIVYLVFQI 148
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
127-557 1.38e-17

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 83.26  E-value: 1.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 127 SLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSfTRSNNGDFGLNSILGGAFFVSSFVVGtICVLIgsRDVAIDRNS 206
Cdd:COG0530   7 GADALARRLGISPLVIGLTIVAFGTSLPELAVSVTA-ALDGSPDIAVGNVVGSNIANILLILG-LAALI--RPLAVDRRV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 207 FIRDVVFLLVALCCLGLIIFIGKVTIWVALCYLSIYLLYVGFLsvshffdrkkrmsdqILRSREDLAEMGVsllgyiaEE 286
Cdd:COG0530  83 LRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------IRRARKEPAWEEV-------EE 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 287 KLALPEKTtqefkivfedspkrhrscfsvlvsiiglplylprrltipvvceekwskpcavvstaiapvlltelycshysg 366
Cdd:COG0530 141 ELEEKPKM------------------------------------------------------------------------ 148
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 367 SQRNLILYIISGSIGLIVGilaylttekshppkkfslvwllggftmsvtwtymiAQELVSLLISLGNIFGISPSVLGLTV 446
Cdd:COG0530 149 SLWKALLLLVLGLALLVVG-----------------------------------ARLLVDGAVEIARALGVSELVIGLTI 193
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 447 LAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFNTVIGLGVPLVISSlaeypgvyiIPSDNSLLETLGFLMVGLL 526
Cdd:COG0530 194 VAIGTSLPELATSIVAARKGEDD---LAVGNIIGSNIFNILLVLGIGALITP---------IPVDPAVLSFDLPVMLAAT 261
                       410       420       430
                ....*....|....*....|....*....|.
gi 15238665 527 WALVIMPKKKMRLDKLVGGGLLAIYLCFLSL 557
Cdd:COG0530 262 LLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
399-570 1.78e-13

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 73.49  E-value: 1.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665    399 KKFSLVWLLGgftmSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGC 478
Cdd:TIGR00927  931 RKFFVITFLG----SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD---MAVSSS 1003
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665    479 YAGPLFNTVIGLGVPLVISSLAEypGVYIIP-SDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFLsl 557
Cdd:TIGR00927 1004 VGSNIFDITVGLPVPWLLFSLIN--GLQPVPvSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFL-- 1079
                          170
                   ....*....|...
gi 15238665    558 rlarVFGVLDTDR 570
Cdd:TIGR00927 1080 ----IISVMLEDR 1088
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
30-566 9.17e-173

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 504.30  E-value: 9.17e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   30 FASQTPPPSGSIQTLNSFAGGDSDSCSGgLASLDDHRSKCSYIRSQSKCGPQGYIDYLKIFFCIFGQSPVLGHLVLSAWL 109
Cdd:PLN03151  69 RLSDIDVNSSYFSDNSSLSGDSPVLCSG-LHEHEGYADQCEFLKAHPICSSGGFFDYLKFFYCSCEDFRILGYAVLGVWL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  110 FVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNGDFGLNSILGGAFFVSSFVVG 189
Cdd:PLN03151 148 VALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVG 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  190 TICVLIGSRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGKVTIWVALCYLSIYLLYVGFLSVSHFFDRKKR--------- 260
Cdd:PLN03151 228 IVSLCVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARrlkldvvtp 307
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  261 ---MSDQIL-RSREDLAEMGVSLLGYIAEEKLA-----LPE---------KTTQEFKIVFEDSPK-------------RH 309
Cdd:PLN03151 308 llpVQGSIFsPSVEEDESMYSPLLESDTESDVPrlqtsLPQwmwasnvaiYSNHFAKGSVHDEERppwgwtdegaeveSS 387
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  310 RSCFSVLVSIIGLPLYLPRRLTIPVVCEEKWSKPCAVVSTAIAPVLLTELYCSHYS-GSQRNLILYIISGSIGLIVGILA 388
Cdd:PLN03151 388 LFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSKTYAVASASLAPVLLAFLWSSQDDvSLQARIAAYFIGVAIGSTLGFLA 467
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  389 YLTTEKSHPPKKFSLVWLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGn 468
Cdd:PLN03151 468 YKYTEPDRPPRRFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGG- 546
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  469 DGAQIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLL 548
Cdd:PLN03151 547 DGVQIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLI 626
                        570
                 ....*....|....*...
gi 15238665  549 AIYLCFLSLRLARVFGVL 566
Cdd:PLN03151 627 ALYLIFLTFRVSTAMGFI 644
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
405-559 2.52e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 87.66  E-value: 2.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   405 WLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLF 484
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPD---LALGNVIGSNIF 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238665   485 NTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVImpkkKMRLDKLVGGGLLAIYLCFLSLRL 559
Cdd:pfam01699  78 NILLVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLVLLLLYIVYLVFQI 148
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
105-251 2.46e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 84.96  E-value: 2.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   105 LSAWLFVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFtRSNNGDFGLNSILGGAFFVS 184
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAA-LRGEPDLALGNVIGSNIFNI 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15238665   185 SFVVGTICVLIGsrdVAIDRNSFIRDV-VFLLVALCCLGL-----IIFIGKVTIWVALCYLSIYLLYVGFLSV 251
Cdd:pfam01699  80 LLVLGLSALIGP---VKVDSLLLKLDLgVLLLVALLLLLLlllllLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
127-557 1.38e-17

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 83.26  E-value: 1.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 127 SLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSfTRSNNGDFGLNSILGGAFFVSSFVVGtICVLIgsRDVAIDRNS 206
Cdd:COG0530   7 GADALARRLGISPLVIGLTIVAFGTSLPELAVSVTA-ALDGSPDIAVGNVVGSNIANILLILG-LAALI--RPLAVDRRV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 207 FIRDVVFLLVALCCLGLIIFIGKVTIWVALCYLSIYLLYVGFLsvshffdrkkrmsdqILRSREDLAEMGVsllgyiaEE 286
Cdd:COG0530  83 LRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------IRRARKEPAWEEV-------EE 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 287 KLALPEKTtqefkivfedspkrhrscfsvlvsiiglplylprrltipvvceekwskpcavvstaiapvlltelycshysg 366
Cdd:COG0530 141 ELEEKPKM------------------------------------------------------------------------ 148
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 367 SQRNLILYIISGSIGLIVGilaylttekshppkkfslvwllggftmsvtwtymiAQELVSLLISLGNIFGISPSVLGLTV 446
Cdd:COG0530 149 SLWKALLLLVLGLALLVVG-----------------------------------ARLLVDGAVEIARALGVSELVIGLTI 193
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 447 LAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFNTVIGLGVPLVISSlaeypgvyiIPSDNSLLETLGFLMVGLL 526
Cdd:COG0530 194 VAIGTSLPELATSIVAARKGEDD---LAVGNIIGSNIFNILLVLGIGALITP---------IPVDPAVLSFDLPVMLAAT 261
                       410       420       430
                ....*....|....*....|....*....|.
gi 15238665 527 WALVIMPKKKMRLDKLVGGGLLAIYLCFLSL 557
Cdd:COG0530 262 LLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
399-570 1.78e-13

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 73.49  E-value: 1.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665    399 KKFSLVWLLGgftmSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGC 478
Cdd:TIGR00927  931 RKFFVITFLG----SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD---MAVSSS 1003
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665    479 YAGPLFNTVIGLGVPLVISSLAEypGVYIIP-SDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFLsl 557
Cdd:TIGR00927 1004 VGSNIFDITVGLPVPWLLFSLIN--GLQPVPvSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFL-- 1079
                          170
                   ....*....|...
gi 15238665    558 rlarVFGVLDTDR 570
Cdd:TIGR00927 1080 ----IISVMLEDR 1088
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
96-246 1.55e-11

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 67.33  E-value: 1.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665     96 QSPVLGHLVLSAWLFVLFYLLGDtaaSYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNgDFGLNS 175
Cdd:TIGR00927  454 QGWVVLHIFGMMYVFVALAIVCD---EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHS-NVGIGT 529
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15238665    176 ILGGAFFVSSFVVGTiCVLIGSRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGKVTIWVALCYLSIYLLYV 246
Cdd:TIGR00927  530 IVGSAVFNILFVIGT-CALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYV 599
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
103-249 2.88e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 58.61  E-value: 2.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 103 LVLSAWLFVlfyllgdtaasyfcPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSfTRSNNGDFGLNSILGGAFF 182
Cdd:COG0530 164 LVVGARLLV--------------DGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVA-ARKGEDDLAVGNIIGSNIF 228
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238665 183 VSSFVVGtICVLIgsRDVAIDRNSFIRDVVFLL-VALCCLGLIIFIGKVTIWVALCYLSIYLLYVGFL 249
Cdd:COG0530 229 NILLVLG-IGALI--TPIPVDPAVLSFDLPVMLaATLLLLGLLRTGGRIGRWEGLLLLALYLAYLALL 293
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
401-554 5.23e-09

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 57.72  E-value: 5.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   401 FSLVWLLGGFTMSVTWTYMiaqeLVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYA 480
Cdd:TIGR00367 170 FSLVLLIIGLIGLVVGSRL----LVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGD---IAVGNVIG 242
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238665   481 GPLFNTVIGLGVPLVIsslaeypgvYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCF 554
Cdd:TIGR00367 243 SNIFNILVGLGVPSLF---------MPIPVEPLAYNLDAPVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
424-555 7.53e-08

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 53.98  E-value: 7.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665 424 LVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFNTVIGLGVPLVISSLAeyp 503
Cdd:COG0530   4 LVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPD---IAVGNVVGSNIANILLILGLAALIRPLA--- 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15238665 504 gvyiIPSDNSLLETLGFLMVGLLWALVIMPkkkMRLDKLVGGGLLAIYLCFL 555
Cdd:COG0530  78 ----VDRRVLRRDLPFLLLASLLLLALLLD---GTLSRIDGVILLLLYVLYL 122
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
431-557 1.84e-06

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 50.03  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665  431 LGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYiiPS 510
Cdd:PRK10734 200 LANYFAISELTIGLTVIAIGTSLPELATAIAGARKGEND---IAVGNIIGSNIFNIVIVLGLPALISPGEINPLAF--SR 274
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 15238665  511 DNSLLetlgfLMVGLLWALVIMpKKKMRLDKLVGGGLLAIYLCFLSL 557
Cdd:PRK10734 275 DYWVM-----LLVSVIFALLCW-RRKRRIGRGAGALLLGGFIVWLAM 315
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
406-555 6.12e-03

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 38.84  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   406 LLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFN 485
Cdd:TIGR00367   3 LIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPD---IGVGNVIGSNIFN 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238665   486 TVIGLGVPLVISSLaeypgvyIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFL 555
Cdd:TIGR00367  80 ILLILGLSAIFSPI-------IVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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