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Conserved domains on  [gi|15240644|ref|NP_196855|]
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Ribosomal protein L10 family protein [Arabidopsis thaliana]

Protein Classification

50S ribosomal protein L10( domain architecture ID 10146583)

50S ribosomal protein L10 binds and anchors the two L7/L12 dimers to the large ribosomal subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 44-201 6.91e-48

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


:

Pssm-ID: 240223  Cd Length: 157  Bit Score: 154.58  E-value: 6.91e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  44 SRNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWL 122
Cdd:cd05797   1 NREKKEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAgVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240644 123 FVQTDEIpSAIKPYRSFQKERKleNNDFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPAR 201
Cdd:cd05797  81 FSEEDPV-AAAKVLKDFAKENK--KLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPAS 156
 
Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 44-201 6.91e-48

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 154.58  E-value: 6.91e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  44 SRNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWL 122
Cdd:cd05797   1 NREKKEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAgVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240644 123 FVQTDEIpSAIKPYRSFQKERKleNNDFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPAR 201
Cdd:cd05797  81 FSEEDPV-AAAKVLKDFAKENK--KLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPAS 156
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 44-215 7.09e-42

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 139.82  E-value: 7.09e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  44 SRNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWL 122
Cdd:COG0244   2 TREEKKAVVAELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAgVEYKVVKNTLARIALEGTGFEGLDDLLKGPTAIA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644 123 FVQTDEIpSAIKPYRSFQKE-RKLEnndFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPAR 201
Cdd:COG0244  82 FSYEDPV-AAAKVLKDFAKEnEKLV---IKGGVLDGKVLDAEQVKALAKLPSREELLAKLLGLLQAPATKLVGVLNAPPR 157

                       170
                ....*....|....
gi 15240644 202 EVIMVLMAYIKKLE 215
Cdd:COG0244 158 KLARVLKAIAEKKE 171
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 45-215 5.18e-38

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 129.88  E-value: 5.18e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644   45 RNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWLF 123
Cdd:PRK00099   3 REEKKEIVAELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAgVEYKVVKNTLARRALEGTGFEGLDDLLKGPTAIAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  124 VqTDEIPSAIKPYRSFQKER-KLEnndFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPARE 202
Cdd:PRK00099  83 S-YEDPVAAAKVLKDFAKDNkKLE---IKGGAIEGKVLDAEEVKALAKLPSREELLAKLLGVLQAPATKLAGVLNAPPSK 158

                        170
                 ....*....|...
gi 15240644  203 VIMVLMAYIKKLE 215
Cdd:PRK00099 159 LARVLKALAEKKE 171
Ribosomal_L10 pfam00466
Ribosomal protein L10;
45-141 3.07e-18

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 76.43  E-value: 3.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644    45 RNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTL-PDTTKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWLF 123
Cdd:pfam00466   3 REKKEELVEELKELLKEYKSVVVVDYRGLTVAQLTELRKKLrENGAELKVGKNTLMRRALEETGEEKLEDYLKGPTALLF 82

                          90
                  ....*....|....*...
gi 15240644   124 VqTDEIPSAIKPYRSFQK 141
Cdd:pfam00466  83 T-NEDPVAVAKVLEDFAK 99
 
Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 44-201 6.91e-48

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 154.58  E-value: 6.91e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  44 SRNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWL 122
Cdd:cd05797   1 NREKKEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAgVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240644 123 FVQTDEIpSAIKPYRSFQKERKleNNDFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPAR 201
Cdd:cd05797  81 FSEEDPV-AAAKVLKDFAKENK--KLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPAS 156
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 44-215 7.09e-42

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 139.82  E-value: 7.09e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  44 SRNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWL 122
Cdd:COG0244   2 TREEKKAVVAELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAgVEYKVVKNTLARIALEGTGFEGLDDLLKGPTAIA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644 123 FVQTDEIpSAIKPYRSFQKE-RKLEnndFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPAR 201
Cdd:COG0244  82 FSYEDPV-AAAKVLKDFAKEnEKLV---IKGGVLDGKVLDAEQVKALAKLPSREELLAKLLGLLQAPATKLVGVLNAPPR 157

                       170
                ....*....|....
gi 15240644 202 EVIMVLMAYIKKLE 215
Cdd:COG0244 158 KLARVLKAIAEKKE 171
Ribosomal_L10_P0 cd00379
Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in ...
 47-201 1.29e-40

Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 238222 [Multi-domain]  Cd Length: 155  Bit Score: 135.77  E-value: 1.29e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  47 KKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWLFVQ 125
Cdd:cd00379   2 KKEELVEELKELLKKYKSVVVVDYRGLTVAQLTELRKELRESgAKLKVGKNTLMRRALKGTGFEELKPLLKGPTALAFTN 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240644 126 TDEIpSAIKPYRSFQKERKlenNDFA-GAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPAR 201
Cdd:cd00379  82 EDPV-EVAKVLKDFAKENK---KLFAkGGVVAGKVLDPAGVTALAKLPSREELLAMLIGLLKAPIAKLARLLNALGI 154
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 45-215 5.18e-38

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 129.88  E-value: 5.18e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644   45 RNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDT-TKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWLF 123
Cdd:PRK00099   3 REEKKEIVAELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAgVEYKVVKNTLARRALEGTGFEGLDDLLKGPTAIAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  124 VqTDEIPSAIKPYRSFQKER-KLEnndFAGAVFEGKFYAPDNFKVLETMPTRAEVYAKMLGALQSPAINLVTTLQAPARE 202
Cdd:PRK00099  83 S-YEDPVAAAKVLKDFAKDNkKLE---IKGGAIEGKVLDAEEVKALAKLPSREELLAKLLGVLQAPATKLAGVLNAPPSK 158

                        170
                 ....*....|...
gi 15240644  203 VIMVLMAYIKKLE 215
Cdd:PRK00099 159 LARVLKALAEKKE 171
Ribosomal_L10 pfam00466
Ribosomal protein L10;
45-141 3.07e-18

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 76.43  E-value: 3.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644    45 RNKKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTL-PDTTKLIVAKNTLVFKAIEGTKWEALKPCMKGMNAWLF 123
Cdd:pfam00466   3 REKKEELVEELKELLKEYKSVVVVDYRGLTVAQLTELRKKLrENGAELKVGKNTLMRRALEETGEEKLEDYLKGPTALLF 82

                          90
                  ....*....|....*...
gi 15240644   124 VqTDEIPSAIKPYRSFQK 141
Cdd:pfam00466  83 T-NEDPVAVAKVLEDFAK 99
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 47-148 4.83e-11

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 59.12  E-value: 4.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644  47 KKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDTTKLIVAKNTLVFKAIEG-----TKWEALKPCMKGMNAW 121
Cdd:cd05795   2 WKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNlgdenPELEKLLPYLKGNVGF 81

                        90       100
                ....*....|....*....|....*..
gi 15240644 122 LFvqTDEIPSAIKpyrsfqkeRKLENN 148
Cdd:cd05795  82 IF--TNGDPFEIR--------KILEEN 98
rplP0 PRK04019
acidic ribosomal protein P0; Validated
 47-130 2.44e-08

acidic ribosomal protein P0; Validated


Pssm-ID: 179712 [Multi-domain]  Cd Length: 330  Bit Score: 52.95  E-value: 2.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644   47 KKEEtVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDTTKLIVAKNTLVFKAIE---GTKWEALKPCMKGMNAWLF 123
Cdd:PRK04019   8 KKEE-VEELKELIKSYPVVGIVDLEGIPARQLQEIRRKLRGKAELKVSKNTLIKRALEeagEEDLEKLEDYLEGQVALIF 86


                 ....*..
gi 15240644  124 vqTDEIP 130
Cdd:PRK04019  87 --TNMNP 91
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 47-135 2.11e-04

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 41.16  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240644   47 KKEETVEAVKSHLENCHLLAAINYKGLTVKQFQDLRRTLPDTTKLIVAKNTLVFKAI-----EGTKWEALKPCMKGMNAW 121
Cdd:PTZ00135   9 KKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALkqrleELPELEKLLPHVKGNVGF 88

                         90
                 ....*....|....
gi 15240644  122 LFVQTDeiPSAIKP 135
Cdd:PTZ00135  89 VFTKDD--LFEVKP 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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