NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|240254629|ref|NP_181779|]
View 

survival motor neuron interacting protein [Arabidopsis thaliana]

Protein Classification

SIP1 domain-containing protein( domain architecture ID 10522868)

SIP1 domain-containing protein similar to human gem-associated protein 2 (also known as survival motor neuron (SMN) protein-interacting protein 1, SIP1) and Saccharomyces cerevisiae pre-mRNA-splicing factor BRR1

CATH:  1.20.58.1070
Gene Ontology:  GO:0000387|GO:0008380|GO:0006397
PubMed:  9323130
SCOP:  4005254

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SIP1 pfam04938
Survival motor neuron (SMN) interacting protein 1 (SIP1); Survival motor neuron (SMN) ...
 440-494 1.14e-12

Survival motor neuron (SMN) interacting protein 1 (SIP1); Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans.


:

Pssm-ID: 461493  Cd Length: 211  Bit Score: 67.09  E-value: 1.14e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 240254629  440 EPDFDsGPPEDGIEYLRRVRWEAKRIPNVKVAKVSGSKYREKEQSVYMPQIPRAP 494
Cdd:pfam04938   1 PDDFD-GPPTDGEEYLRRVRREARKLPSVVVASENPEEKPKEEVSSTTTADSVEP 54
 
Name Accession Description Interval E-value
SIP1 pfam04938
Survival motor neuron (SMN) interacting protein 1 (SIP1); Survival motor neuron (SMN) ...
 440-494 1.14e-12

Survival motor neuron (SMN) interacting protein 1 (SIP1); Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans.


Pssm-ID: 461493  Cd Length: 211  Bit Score: 67.09  E-value: 1.14e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 240254629  440 EPDFDsGPPEDGIEYLRRVRWEAKRIPNVKVAKVSGSKYREKEQSVYMPQIPRAP 494
Cdd:pfam04938   1 PDDFD-GPPTDGEEYLRRVRREARKLPSVVVASENPEEKPKEEVSSTTTADSVEP 54
 
Name Accession Description Interval E-value
SIP1 pfam04938
Survival motor neuron (SMN) interacting protein 1 (SIP1); Survival motor neuron (SMN) ...
 440-494 1.14e-12

Survival motor neuron (SMN) interacting protein 1 (SIP1); Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans.


Pssm-ID: 461493  Cd Length: 211  Bit Score: 67.09  E-value: 1.14e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 240254629  440 EPDFDsGPPEDGIEYLRRVRWEAKRIPNVKVAKVSGSKYREKEQSVYMPQIPRAP 494
Cdd:pfam04938   1 PDDFD-GPPTDGEEYLRRVRREARKLPSVVVASENPEEKPKEEVSSTTTADSVEP 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH