NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15227692|ref|NP_180566|]
View 

transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-286 6.08e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.08e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQM--DyyGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAWAHPkyGSILASCSYDGQVILW 85
Cdd:COG2319 159 TGHSGAVTSVAFspD--GKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLW 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  86 kegNQNQWTQDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVFTARadgGWDTSRIDQAHPVGVTSVSWAPataPG 165
Cdd:COG2319 232 ---DLATGKLLRTLTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSP---DG 300

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 166 ALvssglldpvykLASGGCDNTVKVWKLANGSwkmdCFPALQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIWTVGk 245
Cdd:COG2319 301 KL-----------LASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLWDLA- 360

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 15227692 246 egEQWEGKVLKDFMTPVWRVSWSLTGNLLAVSDGNNNVTVW 286
Cdd:COG2319 361 --TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-286 6.08e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.08e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQM--DyyGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAWAHPkyGSILASCSYDGQVILW 85
Cdd:COG2319 159 TGHSGAVTSVAFspD--GKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLW 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  86 kegNQNQWTQDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVFTARadgGWDTSRIDQAHPVGVTSVSWAPataPG 165
Cdd:COG2319 232 ---DLATGKLLRTLTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSP---DG 300

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 166 ALvssglldpvykLASGGCDNTVKVWKLANGSwkmdCFPALQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIWTVGk 245
Cdd:COG2319 301 KL-----------LASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLWDLA- 360

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 15227692 246 egEQWEGKVLKDFMTPVWRVSWSLTGNLLAVSDGNNNVTVW 286
Cdd:COG2319 361 --TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-287 3.32e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 3.32e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQMDYYGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAW-AHPKYgsiLASCSYDGQVILWK 86
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAAsADGTY---LASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  87 EGNQNQwtqDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVftaradggWDTSRID-----QAHPVGVTSVSWAPa 161
Cdd:cd00200  80 LETGEC---VRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSP- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 162 taPGALVSSGLLD----------------------PVY---------KLASGGCDNTVKVWKLANGSWKMDcfpaLQKHT 210
Cdd:cd00200 146 --DGTFVASSSQDgtiklwdlrtgkcvatltghtgEVNsvafspdgeKLLSSSSDGTIKLWDLSTGKCLGT----LRGHE 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227692 211 DWVRDVAWAPNLGLpkstIASGSQDGKVIIWTVGKEGEQwegKVLKDFMTPVWRVSWSLTGNLLAVSDGNNNVTVWK 287
Cdd:cd00200 220 NGVNSVAFSPDGYL----LASGSEDGTIRVWDLRTGECV---QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-86 1.33e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.33e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15227692     47 QQLATLTGHRGPVWEVAWAHpkYGSILASCSYDGQVILWK 86
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 21-241 3.55e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   21 YYGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAW--AHPkygSILASCSYDGQVILWkegNQNQWTQDHV 98
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARS---QLVTEMKEHEKRVWSIDYssADP---TLLASGSDDGSVKLW---SINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   99 FTDhKSSVNSIAWaPHDIGLSLACGSSDGNISVFTARadggwdTSRIDQAHPVGVT-SVSWAPATAPGALVSSGlldpvy 177
Cdd:PLN00181 614 IKT-KANICCVQF-PSESGRSLAFGSADHKVYYYDLR------NPKLPLCTMIGHSkTVSYVRFVDSSTLVSSS------ 679

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15227692  178 klasggCDNTVKVWKLANGSWKMDCFP--ALQKHTDWVRDVAwapnLGLPKSTIASGSQDGKVIIW 241
Cdd:PLN00181 680 ------TDNTLKLWDLSMSISGINETPlhSFMGHTNVKNFVG----LSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
46-85 1.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15227692    46 SQQLATLTGHRGPVWEVAWahPKYGSILASCSYDGQVILW 85
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-286 6.08e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.08e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQM--DyyGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAWAHPkyGSILASCSYDGQVILW 85
Cdd:COG2319 159 TGHSGAVTSVAFspD--GKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLW 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  86 kegNQNQWTQDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVFTARadgGWDTSRIDQAHPVGVTSVSWAPataPG 165
Cdd:COG2319 232 ---DLATGKLLRTLTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSP---DG 300

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 166 ALvssglldpvykLASGGCDNTVKVWKLANGSwkmdCFPALQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIWTVGk 245
Cdd:COG2319 301 KL-----------LASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLWDLA- 360

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 15227692 246 egEQWEGKVLKDFMTPVWRVSWSLTGNLLAVSDGNNNVTVW 286
Cdd:COG2319 361 --TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
8-286 2.96e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 2.96e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQMDYYGKRIATASSDCTIKITGVSnngGSQQLATLTGHRGPVWEVAWAHPkyGSILASCSYDGQVILWke 87
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLW-- 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  88 gNQNQWTQDHVFTDHKSSVNSIAWAPhDiGLSLACGSSDGNISVFTARADggwDTSRIDQAHPVGVTSVSWAPatapgal 167
Cdd:COG2319 148 -DLATGKLLRTLTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSP------- 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 168 vsSGLLdpvykLASGGCDNTVKVWKLANGSwkmdCFPALQKHTDWVRDVAWAPNlGlpkSTIASGSQDGKVIIWTVgKEG 247
Cdd:COG2319 215 --DGKL-----LASGSADGTVRLWDLATGK----LLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVRLWDL-ATG 278

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 15227692 248 EQWegKVLKDFMTPVWRVSWSLTGNLLAVSDGNNNVTVW 286
Cdd:COG2319 279 ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
8-243 1.35e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 1.35e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQMDYYGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAWAHpkYGSILASCSYDGQVILWke 87
Cdd:COG2319 201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRLW-- 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  88 gNQNQWTQDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVftaradggWDTS-----RIDQAHPVGVTSVSWAPAt 162
Cdd:COG2319 274 -DLATGELLRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRL--------WDLAtgkllRTLTGHTGAVRSVAFSPD- 341

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 163 apGALvssglldpvykLASGGCDNTVKVWKLANGSwkmdCFPALQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIWT 242
Cdd:COG2319 342 --GKT-----------LASGSDDGTVRLWDLATGE----LLRTLTGHTGAVTSVAFSPD----GRTLASGSADGTVRLWD 400


                .
gi 15227692 243 V 243
Cdd:COG2319 401 L 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-287 3.32e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 3.32e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQMDYYGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAW-AHPKYgsiLASCSYDGQVILWK 86
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAAsADGTY---LASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  87 EGNQNQwtqDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVftaradggWDTSRID-----QAHPVGVTSVSWAPa 161
Cdd:cd00200  80 LETGEC---VRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSP- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 162 taPGALVSSGLLD----------------------PVY---------KLASGGCDNTVKVWKLANGSWKMDcfpaLQKHT 210
Cdd:cd00200 146 --DGTFVASSSQDgtiklwdlrtgkcvatltghtgEVNsvafspdgeKLLSSSSDGTIKLWDLSTGKCLGT----LRGHE 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227692 211 DWVRDVAWAPNLGLpkstIASGSQDGKVIIWTVGKEGEQwegKVLKDFMTPVWRVSWSLTGNLLAVSDGNNNVTVWK 287
Cdd:cd00200 220 NGVNSVAFSPDGYL----LASGSEDGTIRVWDLRTGECV---QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-286 9.30e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 9.30e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  49 LATLTGHRGPVWEVAWaHPKyGSILASCSYDGQVILWkegNQNQWTQDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGN 128
Cdd:cd00200   2 RRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVW---DLETGELLRTLKGHTGPVRDVAASAD--GTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 129 ISVFTARADggwDTSRIDQAHPVGVTSVSWAPatapgalvsSGLLdpvykLASGGCDNTVKVWKLANGswkmDCFPALQK 208
Cdd:cd00200  75 IRLWDLETG---ECVRTLTGHTSYVSSVAFSP---------DGRI-----LSSSSRDKTIKVWDVETG----KCLTTLRG 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 209 HTDWVRDVAWAPNlglpKSTIASGSQDGKVIIWTVGkegeqwEGKVLKDFMT---PVWRVSWSLTGNLLAVSDGNNNVTV 285
Cdd:cd00200 134 HTDWVNSVAFSPD----GTFVASSSQDGTIKLWDLR------TGKCVATLTGhtgEVNSVAFSPDGEKLLSSSSDGTIKL 203


                .
gi 15227692 286 W 286
Cdd:cd00200 204 W 204
WD40 COG2319
WD40 repeat [General function prediction only];
8-286 1.16e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.16e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   8 TGHEDIVHDVQMDYYGKRIATASSDctiKITGVSNNGGSQQLATLTGHRGPVWEVAWAHPkyGSILASCSYDGQVILWke 87
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGD---LTLLLLDAAAGALLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLW-- 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692  88 gNQNQWTQDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVftaradggWDTS-----RIDQAHPVGVTSVSWAPat 162
Cdd:COG2319 106 -DLATGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRL--------WDLAtgkllRTLTGHSGAVTSVAFSP-- 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 163 apgalvsSGLLdpvykLASGGCDNTVKVWKLANGswkmDCFPALQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIWT 242
Cdd:COG2319 173 -------DGKL-----LASGSDDGTVRLWDLATG----KLLRTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRLWD 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 15227692 243 VGKegeQWEGKVLKDFMTPVWRVSWSLTGNLLAVSDGNNNVTVW 286
Cdd:COG2319 233 LAT---GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-287 9.43e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 9.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692 206 LQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIWTVGKEGEQWEGKVLKDfmtPVWRVSWSLTGNLLAVSDGNNNVTV 285
Cdd:cd00200   5 LKGHTGGVTCVAFSPD----GKLLATGSGDGTIKVWDLETGELLRTLKGHTG---PVRDVAASADGTYLASGSSDKTIRL 77


                ..
gi 15227692 286 WK 287
Cdd:cd00200  78 WD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-86 1.33e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.33e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15227692     47 QQLATLTGHRGPVWEVAWAHpkYGSILASCSYDGQVILWK 86
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 21-241 3.55e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   21 YYGKRIATASSDCTIKITGVSNNggsQQLATLTGHRGPVWEVAW--AHPkygSILASCSYDGQVILWkegNQNQWTQDHV 98
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARS---QLVTEMKEHEKRVWSIDYssADP---TLLASGSDDGSVKLW---SINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227692   99 FTDhKSSVNSIAWaPHDIGLSLACGSSDGNISVFTARadggwdTSRIDQAHPVGVT-SVSWAPATAPGALVSSGlldpvy 177
Cdd:PLN00181 614 IKT-KANICCVQF-PSESGRSLAFGSADHKVYYYDLR------NPKLPLCTMIGHSkTVSYVRFVDSSTLVSSS------ 679

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15227692  178 klasggCDNTVKVWKLANGSWKMDCFP--ALQKHTDWVRDVAwapnLGLPKSTIASGSQDGKVIIW 241
Cdd:PLN00181 680 ------TDNTLKLWDLSMSISGINETPlhSFMGHTNVKNFVG----LSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
46-85 1.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 15227692    46 SQQLATLTGHRGPVWEVAWahPKYGSILASCSYDGQVILW 85
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-241 2.28e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.28e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15227692    206 LQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIW 241
Cdd:smart00320   8 LKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-132 1.26e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15227692     92 QWTQDHVFTDHKSSVNSIAWAPHdiGLSLACGSSDGNISVF 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
206-241 1.70e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15227692   206 LQKHTDWVRDVAWAPNlglpKSTIASGSQDGKVIIW 241
Cdd:pfam00400   7 LEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 8-37 7.51e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.51e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 15227692      8 TGHEDIVHDVQMDYYGKRIATASSDCTIKI 37
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH