Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 66082554   382 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 422
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*
gi 66082554  47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 66082554    406 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 448
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 66082554   469 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 509
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 66082554    206 DIDECKDPDACSQ--ICVNYKGYFKCECYPGYE 236
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 66082554   527 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 564
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 66082554   382 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 422
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 66082554   340 HIYWTDSGNK-TISVATVDGGRRRTLFSRNLSEPRAIAVDP 379
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66082554    362 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGdQAKIEKSGLNGVDR 405
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 66082554     47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE 78
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|..
gi 66082554  86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 323 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRT-----LFSRNLSEPRAIAVDPlRGFMYWSDWGDQaKIEK 397
Cdd:cd05819  51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 398 SGLNGVDRQTLVSDNIEW-----PNGITLDlLSQRLYWVDSKLHQLSSIDfSGGNRKTLISSTDF----LSHPFGIAVFE 468
Cdd:cd05819 128 FDPDGEFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQVFD-PDGNFLTTFGSTGTgpgqFNYPTGIAVDS 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66082554 469 D-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 507
Cdd:cd05819 206 DgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 338 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNlSEPRAIAVDPLRGFMYWSDWGDQAkieksgLNGVDRQTL-VSDNI--- 413
Cdd:COG3391  79 GRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR------VSVIDTATGkVVATIpvg 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 414 EWPNGITLDLLSQRLYWVDSKLHQLS----SIDFSGGnrkTLISSTDFLSHPFGIAVFED--KVFWTDLENEaifSANRL 487
Cdd:COG3391 152 AGPHGIAVDPDGKRLYVANSGSNTVSvivsVIDTATG---KVVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGG 225

                ....*...
gi 66082554 488 NGlEISIL 495
Cdd:COG3391 226 SN-TVSVI 232

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 66082554   469 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 509
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 66082554 127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 66082554   127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|...
gi 66082554 206 DIDECKDPDACS--QICVNYKGYFKCECYPGYE 236
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 66082554   527 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 564
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66082554 325 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATVDGGRRRTL---------FSRnlsePRAIAVDPlRGFMYWSDWGDQ 392
Cdd:cd14954 163 QLDSPRGVAVNPDG-NIVVSDFNNHRLQVFDPDGQFLRFFgsegsgngqFKR----PRGVAVDD-EGNIIVADSGNH 233

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 66082554   382 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 422
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 66082554   340 HIYWTDSGNK-TISVATVDGGRRRTLFSRNLSEPRAIAVDP 379
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66082554    362 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGdQAKIEKSGLNGVDR 405
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 66082554     47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE 78
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|..
gi 66082554  86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 323 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRT-----LFSRNLSEPRAIAVDPlRGFMYWSDWGDQaKIEK 397
Cdd:cd05819  51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 398 SGLNGVDRQTLVSDNIEW-----PNGITLDlLSQRLYWVDSKLHQLSSIDfSGGNRKTLISSTDF----LSHPFGIAVFE 468
Cdd:cd05819 128 FDPDGEFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQVFD-PDGNFLTTFGSTGTgpgqFNYPTGIAVDS 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66082554 469 D-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 507
Cdd:cd05819 206 DgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 323 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-----NLSEPRAIAVDPlRGFMYWSDWG------- 390
Cdd:cd05819   4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFgsgdgQFNEPAGVAVDS-DGNLYVADTGnhriqkf 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 391 --DQAKIEKSGLNGVDRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFSGGNRKTL---ISSTDFLSHPFGIA 465
Cdd:cd05819  82 dpDGNFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVA 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66082554 466 VF-EDKVFWTDLENEAI--FSAnrlNGLEISILAEN------LNNPHDIVI 507
Cdd:cd05819 156 VDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 66082554   170 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 204
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 66082554   426 QRLYWVDSKLHQ-LSSIDFSGGNRKTLIssTDFLSHPFGIAVFE 468
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 323 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN-----LSEPRAIAVDPlRGFMYWSDWGDQaKIEK 397
Cdd:cd05819  98 DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVDS-DGNIYVADTGNH-RIQV 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 398 SGLNGvDRQTLVSDNIEW------PNGITLDlLSQRLYWVDSKLHQLSSIDFSGGNRKTL---ISSTDFLSHPFGIAVFE 468
Cdd:cd05819 175 FDPDG-NFLTTFGSTGTGpgqfnyPTGIAVD-SDGNIYVADSGNNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSGLAVDS 252

                ....*...
gi 66082554 469 D-KVFWTD 475
Cdd:cd05819 253 DgNLYVAD 260

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 66082554   127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 325 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATVDGGRRRTLFSR-----NLSEPRAIAVDPLrGFMYWSD-WGDqaKIEKS 398
Cdd:cd14956  11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86

                ....*....
gi 66082554 399 GLNGVDRQT 407
Cdd:cd14956  87 TLTGELQTI 95

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 290 ATNRIYWCDLSYRKIYSAymdkasDPKEQEV-LIDEQLHSPEGLAVD-----WVhkhiywTDSGNKtISVATVDGGRRRT 363
Cdd:COG3386  17 PDGRLYWVDIPGGRIHRY------DPDGGAVeVFAEPSGRPNGLAFDpdgrlLV------ADHGRG-LVRFDPADGEVTV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66082554 364 L---FSRNLSEPRAIAVDPlRGFMYWSDWGDQA------KIEKSGlngvdRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 434
Cdd:COG3386  84 LadeYGKPLNRPNDGVVDP-DGRLYFTDMGEYLptgalyRVDPDG-----SLRVLADGLTFPNGIAFSPDGRTLYVADTG 157

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 66082554 435 LHQLSSIDFSG----GNRKTLISSTDFLSHPFGIAV 466
Cdd:COG3386 158 AGRIYRFDLDAdgtlGNRRVFADLPDGPGGPDGLAV 193

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66082554    275 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 310
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 66082554   527 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 564
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 66082554   292 NRIYWCDLSYRKIYSayMDKASDpKEQEVLIDEQLHSPEGLAVDW 336
Cdd:pfam00058   1 GRLYWTDSSLRASIS--SADLNG-SDRKTLFTDDLQHPNAIAVDP 42

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 66082554    168 NECLHNNGgCSH--ICTDLKIGFECTCPAGFQllDQKTC 204
Cdd:smart00179   3 DECASGNP-CQNggTCVNTVGSYRCECPPGYT--DGRNC 38

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                          10        20
                  ....*....|....*....|.
gi 66082554   190 CTCPAGFQLL-DQKTCGDIDE 209
Cdd:pfam12662   2 CSCPPGYQLDpDGRTCVDIDE 22